Abstract: The disclosure relates to derivatives of tetrahydro-1H-1,3-diazepine and hexahydro-1,3-diazocine of the general formula ##STR1## or pharmaceutically acceptable acid addition salts thereof wherein n represents 2 or 3, R.sup.3 and R.sup.4 which may be the same or different each represent hydrogen or lower alkyl, Ph represents phenyl, halophenyl, lower alkyl phenyl, di(lower alkyl) phenyl or lower alkoxy phenyl, R is hydroxyl, lower alkoxy or halogen, R.sup.1 is phenyl, halophenyl, lower alkyl phenyl, di(lower-alkyl phenyl, lower alkoxyphenyl or naphthyl and R.sup.6 is hydrogen or lower alkyl. The compounds have hypoglycemic activity.

Abstract: A group of heterocyclic compounds useful in the treatment of disorders and diseases of the cardiovascular system and/or in the treatment of superficial and deep allergic phenomena is described. These compounds are piperidine compounds linked by the nitrogen atom to a substituted or unsubstituted phenyl radical through the intermediary of a group selected from a lower-alkylene radical, a mono-keto lower alkylene radical or a hydroxy-lower-alkylene radical, or a bivalent radical of the formula ##EQU1## or --O--(lower-alkylene)-. The piperidine rings are further substituted by a benzamido, substituted benzamido or cyclohexylcarboxamido residue.

Abstract: The invention concerns a novel process for preparing 5,6,7,8-tetrahydroquinolines and related compounds substituted by a monosubstituted thioamide group in which a metal derivative of the 5,6,7,8-tetrahydroquinoline or related compound is reacted with an alkyl, aryl or aralkyl isothiocyanate and the product is treated with hydrogen ions.

Abstract: Certain novel 4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c] pyridine derivatives and their pharmacologically acceptable salts are described. These compounds provide potent and non-toxic compositions for the treatment of hypertension. Certain of the disclosed compounds also display activity as anti-tremor agents.

Abstract: The invention provides a compound of formula I ##SPC1##or an acid addition salt thereof, wherein R.sup.1, R.sup.2 and R.sup.4 are the same or different and represent hydrogen, or a lower alkyl radical, R.sup.5 represents hydrogen or single or multiple substitution by lower alkyl radicals, X is cyano, CONHR.sup.3, CSNHR.sup.3 or CO.sub.2 R.sup.3 wherein R.sup.3 is hydrogen or a lower alkyl radical, m is 1, 2 or 3 and R.sup.6 is hydrogen, a lower alkyl radical or a lower alkanoyl radical or an alkali-metal salt of a compound in which X is CO.sub.2 H.Compounds of formula I wherein X is CN or CSNHR.sup.3 and R.sup.6 is lower alkyl are anti-ulcer agents. The other compounds of formula I are intermediates.

Abstract: The invention provides 5,6,7,8-tetrahydroquinoline derivatives which are substituted at the 8-position by an amino group or the group NHCSNHR.sup.5 where R.sup.5 is hydrogen, alkyl of 1 - 3 carbon atoms which may be substituted by dialkylamino; lower alkanoyl or aroyl. The 8-amino cmpounds and those where R.sup.5 is lower alkanoyl or aroyl are intermediates. The other compounds are anti-ulcer agents.

Abstract: The invention relates to compounds of the formula (I) ##SPC1##and their pharmaceutically acceptable acid addition salts. In the formula R.sup.1 and R.sup.2 are each hydrogen, hydroxyl, lower alkyl, lower alkoxy, trifluoromethyl or halogen. The compounds have hypotensive activity. Some also have hypoglycaemic activity.

Abstract: Thioureas of the formula ##SPC1##Wherein R represents hydrogen, halogen, lower alkyl or lower alkoxy, R.sup.1 represents hydrogen or lower alkyl and R.sup.2 represents aroyl can be hydrolysed to compounds in which R.sup.2 is hydrogen. The compounds in which R.sup.2 is hydrogen exhibit anorectic activity.

Abstract: This invention relates to novel thiohydantoins having the formula: ##SPC1##Wherein R represents lower alkyl or a phenyl or phenyl lower alkyl radical in either of which the phenyl portion may be substituted by halogen, lower alkyl or lower alkoxy; A is oxygen or a direct bond; B represents lower alkylene, R.sup.1 represents hydrogen, or lower alkyl; and R.sup.2 represents lower alkyl or phenyl which may be substituted by halogen, lower alkyl or lower alkoxy, which possess anti-ulcer activity.

Abstract: The invention provides a compound of formula I ##SPC1##wherein the dotted lines in the ring indicate an optional double bond, X, which is present only when the ring is saturated, is S-Phenyl, R is selected from loweralkyl and phenylloweralkyl and R.sup.1 is selected from hydrogen and loweralkyl and when X is absent R.sup.1 is loweralkyl and the acid addition salts thereof. The new compounds provided are useful as anti-ulcer pharmaceuticals.

Abstract: This invention relates to novel thiazole derivatives having the formula: ##SPC1##Wherein R represents an unsubstituted or substituted aryl radical; R.sup.1 and R.sup.2 independently represent hydrogen or lower alkyl; R.sup.3 represents hydrogen or lower alkyl; and --COZ represents an amide group; a carboxylic acid group or an ammonium or pharmaceutically acceptable alkali metal or alkaline earth metal salt thereof; or an ester group of formula --COOR.sup.4 wherein R.sup.4 represents an alkyl, aralkyl or aryl radical, which exhibit antilipemic activity.

Abstract: The invention concerns a process for preparing pyrimido[1,2-a]indoles of general formula (I) ##SPC1##wherein R is hydrogen or lower alkyl and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each hydrogen, hydroxyl, lower alkyl, lower alkoxy, trifluoromethyl or halogen by cyclodehydrating an indole derivative of general formula (II) ##SPC2##The products of formula (I) are useful as antidepressants.

Abstract: The invention relates to thioamides of formula I ##SPC1##and acid addition salts thereof wherein R.sub.1 and R.sub.2 are selected from the group consisting of hydrogen, lower alkyl, and phenyl and R.sub.3 and R.sub. 4 are selected from the group consisting of hydrogen and lower alkoxy, with proviso that when R.sub.3 and R.sub.4 are both hydrogen at least one of R.sub.1 and R.sub.2 is other than hydrogen.

Abstract: This invention relates to piperazine diones having the formula: ##SPC1##Wherein R represents a phenyl lower alkyl radical in which the phenyl portion may be substituted by halogen, lower alkyl or lower alkoxy; A represents a straight or branched chain lower alkylene radical; R.sup.1 represents hydrogen or lower alkyl; and R.sup.2 and R.sup.3 independently represent hydrogen or alkyl of 1 to 3 carbon atoms, which possess anti-ulcer activity.

Abstract: A method for transferring a coverslip from one location to another comprises placing a suction pad on to one surface of the coverslip, applying suction to the suction pad so that the coverslip adheres temporarily to the suction pad and transferring the suction pad with the adhering coverslip from a first location to a second location. The invention also provides a specific apparatus for carrying out the method. Also provided is an apparatus for feeding coverslips singly from a stack of coverslips employing an open bottomed hopper for the stack of coverslips which rests on a plate having a depression, to accommodate a single coverslip, in its upper surface. The invention further provides a substantially automatic apparatus for placing mounting medium and coverslips on to microscope slides which apparatus can include the apparatus for transferring coverslips and the apparatus for feeding coverslips singly from a stack of coverslips.

Abstract: The invention relates to 3,5-dicyano-1,4-dihydro-2,6-di(lower)alkyl-4-methyl-4-phenylpyridines which have hypotensive activity.

Abstract: The invention relates to fluorene derivatives of the formula ##SPC1##And their pharmaceutically acceptable acid addition salts. In the formula R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each represent hydrogen, hydroxyl, lower alkyl, lower alkoxy or halogen, R.sup.5 and R.sup.6 each represent hydrogen or lower alkyl and n represents 1 or 2. The compounds have hypoglycaemic activity.

Abstract: 3-(7-Halo-4-quinolyl)-N-[di(loweralkyl)amino(lower alkyl)]-N-(lower alkyl)benzamides and 4-(7-halo-4-quinolyl)-N-[di(lower alkyl)amino(loweralkyl)]-N-(lower alkyl)benzamides and their pharmaceutically acceptable acid addition salts exhibit interesting anti-inflammatory activity. They also exhibit anti-malarial activity and anti-hypertensive activity.

Abstract: The disclosure describes new 4-aminoquinoline derivatives of general formula ##SPC1##And their acid addition salts, where X is a halogen atom or a trifluoromethyl group, Z is a hydrogen atom or a defined substituent, R is group of the formula--R.sub.3 N--A--NR.sub.1 R.sub.2 (II), ##SPC2##where A in formula II is a chain of 1 to 5 methylene groups which may be substituted with alkyl, the ring in formula IIIa and IIIb is a piperidine or pyrrolidine ring that may be substituted with alkyl and R.sub.1, R.sub.2 and R.sub.3 represent hydrogen or certain defined substituents. The new 4-aminoquinoline derivatives show anti-malarial activity and, in some cases, show one or more of the following activities:- anti-inflammatory activity, anti-hypertensive activity, anti-trichomonal activity, inhibition of blood platelet aggregation, anti-ulcer activity and activity against allergic asthma.

Abstract: The invention relates to bases of the formula ##SPC1##And their acid addition salts with pharmaceutically acceptable acids. In the formula R.sup.1 represents phenyl or phenyl substituted by one or more hydroxyl, lower alkyl lower alkoxy, trifluoromethyl or halogen groups. The compounds have hypoglycemic activity.