Patents Assigned to Wyeth
  • Methods for preventing or ameliorating West Nile encephalitis
    Patent number: 7445787
    Abstract: The present invention provides a safe and effective vaccine composition against West Nile virus disease. An immunogenically active component of West Nile virus or plasmid DNA, an adjuvant such as a metabolizable oil, and a pharmacologically acceptable carrier are formulated into an immunizing vaccine. The invention also provides a method for the prevention or amelioration of West Nile disease, such as encephalitis, in equidae by administering the vaccine composition herein set forth.
    Type: Grant
    Filed: October 30, 2006
    Date of Patent: November 4, 2008
    Assignee: Wyeth
    Inventor: Hsien-Jue Chu
  • Member of the lysyl oxidase gene family
    Patent number: 7445920
    Abstract: The present invention relates to a novel lysyl oxidase genes, termed EER-7. The invention relates to the protein and nucleic acids encoding the protein. The invention further relates to an assay system to identify compounds that selectively modulate EER-7 protein activity by interaction with estrogen receptors.
    Type: Grant
    Filed: June 6, 2003
    Date of Patent: November 4, 2008
    Assignee: Wyeth
    Inventors: Mark J. Evans, Marshall S. Scicchitano, Ashok R. Bapat, Ramesh A. Bhat, Robert Mastroeni, Sotirios K. Karathanasis
  • ANTHRANILIC ACID DERIVATIVES USEFUL IN TREATING INFECTION WITH HEPATITIS C VIRUS
    Publication number: 20080269333
    Abstract: The present invention provides pharmaceutical compositions useful in treating hepatitis C infection. The present invention also provides methods of treating hepatitis C infection by administering to a mammal the pharmaceutical compositions of the present invention.
    Type: Application
    Filed: July 7, 2008
    Publication date: October 30, 2008
    Applicants: Wyeth, ViroPharma Incorporated
    Inventors: Jonathan D. Bloom, Thomas R. Bailey
  • PHARMACEUTICAL COMPOSITIONS OF ESTROGENIC AGENTS
    Publication number: 20080269198
    Abstract: This invention relates to novel pharmaceutical carrier or excipient systems and oral pharmaceutical compositions comprising 1-[4-(2-Azepan-1yl-ethoxy)-benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol or 2-(4-Hydroxy-phenyl)-3-methyl-1-(4-(2-piperidin-1-yl-ethoxy)benzyl]-1H-indol-5-ol, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: November 20, 2007
    Publication date: October 30, 2008
    Applicant: WYETH
    Inventors: Eric Joel BENJAMIN, Wendy Ann DULIN, Jiwaji Gulabrao SURYAWANSHI
  • Therapeutic Combinations for the Treatment or Prevention of Depression
    Publication number: 20080269321
    Abstract: Therapeutic combinations useful in the treatment or prevention of depression or other mood disorders, to pharmaceutical compositions containing said combinations, and to their use in the treatment or prophylaxis of depression or other mood disorders are provided. Such compounds are of formula I: or a pharmaceutically acceptable salt thereof, wherein each of R1, R2, R3, n, y, and Ar are as defined and described herein.
    Type: Application
    Filed: May 30, 2008
    Publication date: October 30, 2008
    Applicant: Wyeth
    Inventors: Janet Jandura, Sharon Rosenzweig-Lipson
  • 8-Hydroxyquinoline compounds and methods thereof
    Publication number: 20080269213
    Abstract: The present invention relates to 8-Hydroxyquinoline Compounds; compositions comprising an 8-Hydroxyquinoline Compound; and methods for treating or preventing a metalloproteinase-related disorder, such as, an arthritic disorder, osteoarthritis, malignant neoplasm, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, atherosclerosis, age-related macular degeneration, myocardial infarction, a corneal ulceration, an ocular surface disease, hepatitis, an aortic aneurysm, tendonitis, a central nervous system disorder, abnormal wound healing, angiogenesis, restenosis, cirrhosis, multiple sclerosis, glomerulonephritis, graft versus host disease, diabetes, an inflammatory bowel disease, shock, invertebral disc degeneration, stroke, osteopenia or a periodontal disease or comprising administering an effective dose of an 8-Hydroxyquinoline Compound to a mammal in need thereof.
    Type: Application
    Filed: August 23, 2007
    Publication date: October 30, 2008
    Applicant: Wyeth
    Inventors: Matthew G. Bursavich, Sabrina Lombardi, Adam M. Gilbert, Leif Mark Laakso, Gulnaz Khafizova, David Brian How, Joshua James Sabatini, Phaik-Eng Sum, Jeremy Clemens
  • Assays to Identify Irreversibly Binding Inhibitors of Receptor Tyrosine Kinases
    Publication number: 20080268460
    Abstract: The present invention relates to a method of identifying an inhibitor of a receptor tyrosine kinase that irreversibly binds to the kinase. Specifically, the method comprises using a variety of assays, either alone or in combination, to identify compounds that irreversibly bind to tyrosine kinases. More specifically, there are four assays, which are novel variations of a basic enzyme assay and identify irreversible binding inhibitors.
    Type: Application
    Filed: May 11, 2005
    Publication date: October 30, 2008
    Applicant: Wyeth
    Inventors: Frank Loganzo, Lee M. Greenberger, Xingshi Tan, Allan Wissner
  • USE OF LOW TEMPERATURE AND/OR LOW PH IN CELL CULTURE
    Publication number: 20080269132
    Abstract: The present invention provides a novel method of reducing protein misfolding and aggregation in the cell culture by growing the cell culture at a reduced temperature and/or reduced pH. As a result, the quality of the protein produced in the cell culture is greatly improved. Thus, the present invention facilitates improvements in the efficacy of therapeutic proteins produced in cell culture.
    Type: Application
    Filed: April 22, 2008
    Publication date: October 30, 2008
    Applicant: WYETH
    Inventors: Jose Manuel Gomes, Gregory Walter Hiller
  • Substituted sulfonamide-indoles
    Patent number: 7442805
    Abstract: The present invention relates generally to substituted sulfonamide indoles such as substituted sulfonamide indoles, and methods of using them.
    Type: Grant
    Filed: September 23, 2004
    Date of Patent: October 28, 2008
    Assignee: Wyeth
    Inventor: Baihua Hu
  • ?calcium channel expressed in atrium
    Patent number: 7442767
    Abstract: Novel calcium channel nucleic acids and polypeptides are disclosed herein. Methods of using the novel nucleic acids and polypeptides are also disclosed.
    Type: Grant
    Filed: June 23, 2004
    Date of Patent: October 28, 2008
    Assignee: Wyeth
    Inventor: Rodrigo Franco
  • CCI-779 polymorph and use thereof
    Patent number: 7442707
    Abstract: The present invention provides CCI-779 polymorph Form II. This invention also provides processes for preparing CCI-779 polymorph Form II and pharmaceutical compositions including CCI-779 polymorph Form II.
    Type: Grant
    Filed: January 25, 2006
    Date of Patent: October 28, 2008
    Assignee: Wyeth
    Inventor: Subodh S. Deshmukh
  • Metabolites of 5-fluoro-8- quinoline and methods of preparation and uses thereof
    Publication number: 20080262228
    Abstract: The present invention relates to novel metabolites of 5-Fluoro-8-{4-[4-(6-methoxyquinolin-8-yl)piperazin-1-yl]piperidin-1-yl}quinoline, which can be useful in treating CNS disorders. The present invention further relates to processes for their preparation, to pharmaceutical compositions comprising them, and to methods of using them.
    Type: Application
    Filed: November 27, 2007
    Publication date: October 23, 2008
    Applicant: Wyeth
    Inventors: Jianyao Wang, Alana Upthagrove, Lin Deng, Wayne Everett Childers, Zhongqi Shen, William Demaio, Robin D. Moore, Zeen Tong, Li Shen, Pixu Li, Michael K. May
  • CRYSTALLINE FORMS AND POLYMORPHS OF N-(3-(DIMETHYLAMINO)PROPYL)-4-(4-(3-FLUORO-4-METHOXYPHENYL) PYRIMIDIN-2-YLAMINO) BENZENESULFONAMIDE AS SUCCINATE SALTS
    Publication number: 20080262008
    Abstract: The present invention relates to methods for preparing and manufacturing a crystalline form or polymorph of a compound of formula I: in the form of pharmaceutically acceptable salts and polymorphs thereof. The present invention is directed to methods for preparing and manufacturing crystalline polymorphs or forms of specific anilino-pyrimidine benzenesulfonamide compounds. Methods for converting one crystalline form or polymorph of compounds of formula I as their pharmaceutically acceptable salt polymorph to other different crystalline polymorphs of compounds of formula I as their corresponding pharmaceutically acceptable salt are also disclosed.
    Type: Application
    Filed: April 18, 2008
    Publication date: October 23, 2008
    Applicant: Wyeth
    Inventors: Mahmoud Mirmehrabi, Sreenivasulu Megati, Abdolsamad Tadayon, Subodh Deshmukh
  • CRYSTALLINE POLYMORPHS OF N-(3-(DIMETHYLAMINO)PROPYL)-4-(4-(3-FLUORO-4-METHOXYPHENYL) PYRIMIDIN-2-YLAMINO) BENZENESULFONAMIDE AS D-GLUCORONATE SALTS
    Publication number: 20080262010
    Abstract: The present invention relates to methods for preparing one or more crystalline polymorphs of a compound of formula I: and structurally related compounds. The present invention is also directed to methods for converting one polymorph to other different polymorphs of formula I and structurally related compounds.
    Type: Application
    Filed: April 18, 2008
    Publication date: October 23, 2008
    Applicant: Wyeth
    Inventors: Mahmoud Mirmehrabi, Abdolsamad Tadayon, Subodh Deshmukh
  • CRYSTALLINE POLYMORPHS OF N-(3-(DIMETHYLAMINO)PROPYL)-4-(4-(3-FLUORO-4-METHOXYPHENYL) PYRIMIDIN-2-YLAMINO) BENZENESULFONAMIDE AS ACETATE SALTS
    Publication number: 20080262009
    Abstract: The present invention relates to methods for preparing one or more crystalline forms and polymorphs of a compound of formula I: and structurally related compounds. The present invention is also directed to methods for converting one polymorph to other different polymorphs of formula I and structurally related compounds.
    Type: Application
    Filed: April 18, 2008
    Publication date: October 23, 2008
    Applicant: Wyeth
    Inventors: Mahmoud Mirmehrabi, Abdolsamad Tadayon, Subodh Deshmukh
  • Human 9q polypeptides method
    Patent number: 7439029
    Abstract: The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
    Type: Grant
    Filed: March 25, 2002
    Date of Patent: October 21, 2008
    Assignees: Wyeth, Millennium Pharmaceuticals, Inc.
    Inventors: Kenneth Rhodes, Maria Betty, Huai-Ping Ling, Wenqian An
  • Process for the synthesis of derivatives of halo-[2,3-F] quinoline
    Patent number: 7439364
    Abstract: Methods of preparing compounds of Formula I are provided.
    Type: Grant
    Filed: December 4, 2006
    Date of Patent: October 21, 2008
    Assignee: Wyeth
    Inventors: Anita W. Chan, Timothy T. Curran, Silvio Iera, Warren Chew, John H. Sellstedt, Galina Vid, Greg Feigelson, Zhixian Ding
  • INDOLE ACETIC ACIDS EXHIBITING CRTH2 RECEPTOR ANTAGONISM AND USES THEREOF
    Publication number: 20080255100
    Abstract: The invention relates to indole acetic acid compounds which function as antagonists of the CRTH2 receptor. The invention also relates to the use of these compounds to inhibit the binding of prostaglandin D2 and its metabolites or certain thromboxane metabolites to the CRTH2 receptor and to treat disorders responsive to such inhibition.
    Type: Application
    Filed: June 2, 2008
    Publication date: October 16, 2008
    Applicant: Wyeth
    Inventors: Youssef L. Bennani, Lawrence Nathan Tumey, Elizabeth Ann Gleason, Michael Joseph Robarge
  • Phenylaminopropanol Derivatives and Methods of Their Use
    Publication number: 20080255102
    Abstract: The present invention is directed to phenylaminopropanol derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromyalgia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.
    Type: Application
    Filed: June 23, 2008
    Publication date: October 16, 2008
    Applicant: Wyeth
    Inventors: An Thien Vu, Paige Erin Mahaney, Stephen Todd Cohn
  • PRODRUG SUBSTITUTED BENZOXAZOLES AS ESTROGENIC AGENTS
    Publication number: 20080255057
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein Q, Q2, R1, R2, R2a, R3, R3a, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: April 28, 2008
    Publication date: October 16, 2008
    Applicant: WYETH
    Inventors: Sayed Elmarakby, Ping Cai, Appavu Chandrasekaran, Mark Ruppen, Rasmy Talaat