Patents Assigned to Wyeth
  • Restricted glucose feed for animal cell culture
    Patent number: 7429491
    Abstract: Methods of improving protein production in animal cell cultures are provided. Cell culture methods are presented wherein glucose is fed in a restricted manner to cell culture; this restricted feeding of glucose to the cell culture results in lactate production being controlled to a low level. The restricted feeding of glucose in a fed-batch process is not accomplished through a constant-rate feeding of glucose, and the restricted feeding need not depend on sampling. Instead, restricted feeding of glucose to the culture is accomplished through feeding of glucose to the culture at a rate that is a function of an expected or a premodeled rate of glucose consumption by the animal cells when exposed to medium containing a high level of glucose. Because lactate production is controlled to low levels, recombinant protein production is increased.
    Type: Grant
    Filed: May 17, 2004
    Date of Patent: September 30, 2008
    Assignee: Wyeth
    Inventors: Yen-Tung Luan, Terry Cardoza Stanek, Denis Drapeau
  • IMIDAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS PI3 KINASE AND MTOR INHIBITORS
    Publication number: 20080233127
    Abstract: The present invention relates to Imidazolopyrimidine Analogs, methods of making Imidazolopyrimidine Analogs, compositions comprising an Imidazolopyrimidine Analog, and methods for treating or preventing a PI3K-related disorder comprising administering to a subject in need thereof an effective amount of an Imidazolopyrimidine Analog. The invention also relates to methods for treating or preventing mTOR-related disorders comprising administering to a subject in need thereof an effective amount of an Imidazolopyrimidine Analog.
    Type: Application
    Filed: March 7, 2008
    Publication date: September 25, 2008
    Applicant: Wyeth
    Inventors: Matthew Gregory Bursavich, Aranapakam Mudumbai Venkatesan, Pawel Wojciech Nowak, Sabrina Lombardi, Adam Matthew Gilbert, Christoph Martin Denhardt, Osvaldo Dos Santos, Efren Guillermo Delos Santos, Natasja Brooijmans, Semiramis Ayral-Kaloustian, Zecheng Chen, Jeroen Cunera Verheijen, Joshua Kaplan, Arie Zask
  • PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS
    Publication number: 20080234262
    Abstract: The present invention relates to Pyrazolopyrimidine Analogs, methods of making Pyrazolopyrimidine Analogs, compositions comprising a Pyrazolopyrimidine Analog, and methods for treating mTOR-related disorders comprising administering to a subject in need thereof an effective amount of a Pyrazolopyrimidine Analog. The invention also relates to treating PI3K-related disorders comprising administering to a subject in need thereof an effective amount of a Pyrazolopyrimidine Analog.
    Type: Application
    Filed: March 18, 2008
    Publication date: September 25, 2008
    Applicant: Wyeth
    Inventors: Arie Zask, Pawel Wojciech Nowak, Jeroen Cunera Verheijen, Kevin J. Curran, Joshua Kaplan, David Malwitz, Matthew Gregory Bursavich, Derek Cecil Cole, Semiramis Ayral-Kaloustian, Ker Yu, David James Richard, Mark Lefever
  • Synthesis and characterization of polymorph form II of 4-(2-(4,4-dimethyl-2-oxooxazolidin-3-YL)thiazol-4-YL)benzonitrile
    Publication number: 20080234340
    Abstract: A polymorph Form II of 4-(2-(4,4-dimethyl-2-oxooxazolidin-3-yl)thiazol-4-yl)benzonitrile and methods of preparing Form II are described. Also provided are methods of contraception, treating or preventing fibroids, uterine leiomyomata, endometriosis, dysfunctional bleeding, polycystic ovary syndrome, and hormone-dependent carcinomas, providing hormone replacement therapy, stimulating food intake, and synchronizing estrus including using polymorph Form II of 4-(2-(4,4-dimethyl-2-oxooxazolidin-3-yl)thiazol-4-yl)benzonitrile. Further provided are methods for preparing polymorph Form I of 4-(2-(4,4-dimethyl-2-oxooxazolidin-3-yl)thiazol-4-yl)benzonitrile from polymorph Form II of 4-(2-(4,4-dimethyl-2-oxooxazolidin-3-yl)thiazol-4-yl)benzonitrile.
    Type: Application
    Filed: March 10, 2008
    Publication date: September 25, 2008
    Applicant: Wyeth
    Inventors: Mahmoud Mirmehrabi, Yuping Niu, Abdolsamad Tadayon, Subodh Deshmukh, Mannching Sherry Ku
  • Pyrimido[5,4-c] Quinoline-2, 4-Diamine Derivatives and Methods of Use Thereof
    Publication number: 20080234300
    Abstract: The present invention relates to pyrimido[5,4-c]quinoline-2,4-diamine derivatives, compositions comprising an effective amount of a Pyrimido[5,4-c]quinoline-2,4-diamine Derivative, methods for treating or preventing a proliferative disorder, comprising administering to a subject in need thereof an effective amount of an Pyrimido[5,4-c]quinoline-2,4-diamine Derivative, methods for modulating PDK-1 activity, comprising administering to a subject in need thereof an effective amount of a Pyrimido[5,4-c]quinoline-2,4-diamine Derivative. The invention also relates to a process for preparing a Pyrimido[5,4-c]quinoline-2,4-diamine Derivative.
    Type: Application
    Filed: March 4, 2008
    Publication date: September 25, 2008
    Applicant: WYETH
    Inventors: Allan WISSNER, Aranapakam M. VENKATESAN
  • Determination of antibiotic concentration in bone
    Patent number: 7427507
    Abstract: A method of determining the concentration of antibiotic in bone comprising crushing the bone, adding a stabilizing agent to the bone, homogenizing the bone in an extraction solvent to obtain a homogenous suspension, and analyzing the suspension supernatant to determine the concentration of antibiotic in bone.
    Type: Grant
    Filed: May 2, 2007
    Date of Patent: September 23, 2008
    Assignee: Wyeth
    Inventors: Allena J. Ji, James P. Saunders
  • AUTOMATED COLORIMETRIC POLYSACCHARIDE ASSAYS
    Publication number: 20080227207
    Abstract: A method of automated determination of saccharide concentration is provided herein. The method includes preparing one or more saccharide standards and one or more diluted polysaccharide test samples, transferring a portion of the one or more saccharide standards and the one or more diluted polysaccharide test samples along with a diluent to a series of wells in a multiwell plate, transferring a portion of an acid reagent to the series of wells in the multiwell plate, mixing the contents of the series of wells in the multiwell plate, heating and cooling the contents of the series of wells in the multiwell plate, shaking the multiwell plate, and measuring the radiant energy absorbance of the contents of the series of wells in the multiwell plate, where all steps are performed in the absence of human intervention.
    Type: Application
    Filed: March 13, 2008
    Publication date: September 18, 2008
    Applicant: Wyeth
    Inventors: Vincent E. Turula, Shaune Walters, Suddham Singh, Rasappa Arumugham
  • Multivalent avian influenza vaccines and methods
    Publication number: 20080226676
    Abstract: The present invention provides vaccine compositions comprising at least two strains of avian influenza virus, wherein one of the strains has an H5 hemagglutinin subtype and the other strain has an H7 hemagglutinin subtype, and wherein at least one of the strains has an N4 neuraminidase subtype and neither strain has an N1 subtype. Also provided are vaccination methods that utilize the novel vaccine compositions of the invention. The compositions and methods of the present invention provide protection against infection with H5 and H7 influenza strains (e.g., H5N1 and H7N1) while at the same time facilitating the distinction between infected and vaccinated animals.
    Type: Application
    Filed: March 14, 2008
    Publication date: September 18, 2008
    Applicant: Wyeth
    Inventors: Joan Plana Duran, Mahesh Kumar
  • USE OF NOREPINEPHRINE REUPTAKE MODULATORS FOR PREVENTING AND TREATING VASOMOTOR SYMPTOMS
    Publication number: 20080227850
    Abstract: The present invention relates to the use of compounds and composition of compounds that modulate norepinephrine levels for the prevention and treatment of vasomotor symptoms, such as hot flush, caused by, inter alia, thermoregulatory dysfunctions.
    Type: Application
    Filed: January 21, 2008
    Publication date: September 18, 2008
    Applicant: Wyeth
    Inventors: Darlene Coleman Deecher, Istvan Jozsef Merchenthaler, Liza Leventhal, Kimberly Jean Sipe, Lawrence Thomas O'Connor
  • Methods and compositions for assessment and treatment of asthma
    Publication number: 20080226645
    Abstract: The present invention provides methods and compositions for the assessment and treatment of asthma and other inflammatory diseases, particularly those mediated by interleukin-13 (IL-13). The present invention also provides arrays comprising markers for asthma as well as IL-13 responsiveness. The markers of the present invention can be used in methods to diagnose a patient as having asthma or an IL-13-mediated condition, to evaluate the effectiveness of potential therapeutic agents, to identify or evaluate agents capable of modulating marker expression levels, and to select a treatment for a patient suffering from asthma or an IL-13-mediated condition.
    Type: Application
    Filed: January 10, 2008
    Publication date: September 18, 2008
    Applicant: Wyeth
    Inventors: Margot Mary O'Toole, Frederick William Immermann, Andrew Arthur Hill, Padmalatha Sunkara Reddy, Michael Edward Burczynski, Douglas Kenneth Miller, Karl Henry Nocka, Stanley Francis Wolf, Michael Ronald Bowman, Andrew Joseph Dorner, I-Ming Wang
  • SUSTAINED-RELEASE TABLET FORMULATIONS OF PIPERAZINE-PIPERIDINE ANTAGONISTS AND AGONISTS OF THE 5-HT1A RECEPTOR HAVING ENHANCED INTESTINAL DISSOLUTION
    Publication number: 20080226714
    Abstract: The present invention relates to sustained-release tablet formulations of piperazine-piperidine compounds, which can be useful in treating central nervous system disorders; to processes for their preparation; and to methods of using them.
    Type: Application
    Filed: February 15, 2008
    Publication date: September 18, 2008
    Applicant: WYETH
    Inventors: Hong Wen, Chimanlall Goolcharran, Krishnendu Ghosh, Arwinder Nagi
  • (Diaryl-methyl)-malononitriles and their use as estrogen receptor ligands
    Patent number: 7425580
    Abstract: The present invention concerns compounds of formula: where R1, R2, R3 and R4 are defined in the specification.
    Type: Grant
    Filed: May 9, 2005
    Date of Patent: September 16, 2008
    Assignee: Wyeth
    Inventors: Thomas Joseph Caggiano, Antony Aldo Brazzale
  • Serotonergic agents for treating sexual dysfunction
    Patent number: 7425558
    Abstract: Methods and compositions are provided for treating sexual dysfunction, e.g., sexual dysfunction associated with drug treatment, using 5-HT1A receptor antagonists.
    Type: Grant
    Filed: August 18, 2006
    Date of Patent: September 16, 2008
    Assignee: Wyeth
    Inventors: Stacey J. Sukoff Rizzo, Sharon Joy Rosenzweig-Lipson, Wayne Everett Childers, Michael Kelly, Lee Erwin Schechter
  • CD25+ DIFFERENTIAL MARKERS AND USES THEREOF
    Publication number: 20080221016
    Abstract: The present invention is directed to methods and compositions for the identification of novel targets for diagnosis, prognosis, therapeutic intervention and prevention of autoimmune disorders, transplant rejection and cancer. In particular, the present invention is directed to the identification of novel targets which are CD25+ differential markers. The present invention is further directed to methods of high-throughput screening for test compounds capable of modulating the activity of proteins encoded by the novel targets. Moreover, the present invention is also directed to methods that can be used to assess the efficacy of test compounds and therapies for the ability to inhibit an autoimmune disorder or transplant rejection. Methods for determining the long term prognosis in a subject are also provided.
    Type: Application
    Filed: January 31, 2008
    Publication date: September 11, 2008
    Applicants: WYETH, The Government USA, as respresented by the Secretary, Department of Health
    Inventors: Michael Chapman Byrne, Ethan Menahem Shevach, Mary Collins, Rebecca Suzanne McHugh, Matthew James Whitters, Deborah Ann Young
  • SECRETED PROTEIN CCDC80 REGULATES ADIPOCYTE DIFFERENTIATION
    Publication number: 20080221057
    Abstract: Disclosed herein are methods of modulating adipogenesis. The methods include contacting a cell expressing the Ccdc80 gene with an agent that modulates the expression or activity of the Ccdc80 gene or Ccdc80 protein. Further disclosed herein are methods of treating conditions such as obesity, insulin resistance, and/or type 2 diabetes with Ccdc80 modulators. Also disclosed herein are methods of identifying Ccdc80 modulators.
    Type: Application
    Filed: February 13, 2008
    Publication date: September 11, 2008
    Applicant: Wyeth
    Inventors: Ruth Elisabeth Gimeno, Frederic Tremblay
  • 3-AMINO CHROMANE DERIVATIVES
    Publication number: 20080221193
    Abstract: The present invention relates to 3-amino chromane derivatives; to compositions containing such compounds; to methods of synthesizing such compounds; and to methods of using such compounds and compositions containing such compounds in the treatment of serotonin disorders, such as depression and anxiety.
    Type: Application
    Filed: December 21, 2007
    Publication date: September 11, 2008
    Applicant: Wyeth
    Inventors: Minsheng Zhang, Charles J. Stanton, Nicole T. Hatzenbuhler, Boyd Lynn Harrison
  • COMPOUNDS FOR TREATING TUMORS
    Publication number: 20080221181
    Abstract: The invention provides compounds of formula (I): wherein E, A, B?, R6, R7, R8, and R9 are defined in the specification which compounds exhibit anticancer activity and are useful for treating cancer.
    Type: Application
    Filed: April 17, 2008
    Publication date: September 11, 2008
    Applicant: Wyeth Holdings Corporation
    Inventors: Arie Zask, Joshua Kaplan, Ayako Yamashita, Chuan S. Niu, Gary Harold Birnberg, Emily Norton, Kinwang Cheung, Ronald Suayan, Vincent Sandanayaka, Philip Ross Hamann, Semiramis Ayral-Kaloustian
  • SULFONYLATED HETEROCYCLES USEFUL FOR MODULATION OF THE PROGESTERONE RECEPTOR
    Publication number: 20080221160
    Abstract: Compounds of the following structure are provided, wherein n, R1-R3 and R6-R9 are defined below, as are methods of preparing and using these compounds for contraception; treating or preventing fibroids, uterine leiomyomata, endometriosis, dysfunctional bleeding, polycystic ovary syndrome, and hormone-dependent carcinomas; providing hormone replacement therapy; stimulating food intake; synchronizing estrus; and treating cycle-related symptoms.
    Type: Application
    Filed: March 4, 2008
    Publication date: September 11, 2008
    Applicant: Wyeth
    Inventors: Casey Cameron McComas, Andrew Fensome
  • ARYL SULFONAMIDES USEFUL FOR MODULATION OF THE PROGESTERONE RECEPTOR
    Publication number: 20080221201
    Abstract: In one embodiment, compounds of the following structure are described, wherein R1 to R7 are described herein. Also provided are methods for preparing these compounds and methods of contraception; treating or preventing fibroids; treating or preventing uterine leiomyomata; treating or preventing endometriosis, dysfunctional bleeding, and polycystic ovary syndrome; treating or preventing hormone-dependent carcinomas; providing hormone replacement therapy; stimulating food intake; synchronizing estrus; and treating cycle-related symptoms using the compounds described herein.
    Type: Application
    Filed: March 4, 2008
    Publication date: September 11, 2008
    Applicant: Wyeth
    Inventors: Casey Cameron McComas, Andrew Fensome, Michael Anthony Marella
  • Compositions and methods for the treatment and/or prevention of osteoporosis
    Publication number: 20080220094
    Abstract: The invention of this application relates to compositions and methods for the treatment and/or prevention of osteoporosis; improving and/or enhancing bone formation; and prevention and/or reducing bone mineral density loss. More particularly, the invention relates to a composition comprising vitamin K, in any form and betacryptoxanthin. A further aspect of this invention is a composition comprising vitamin K, in any form, betacryptoxanthin, and/or vitamin D and/or calcium.
    Type: Application
    Filed: October 30, 2007
    Publication date: September 11, 2008
    Applicant: Wyeth
    Inventors: Gregory Eugene Bobyock, Judith Diane Kendler Moreines, Lynda Sun Lee