Patents Assigned to Wyeth
  • Nucleic acid and amino acid sequences relating to for diagnostics and therapeutics
    Patent number: 7416862
    Abstract: The invention provides isolated polypeptide and nucleic acid sequences derived from Staphylococcus epidermidis that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.
    Type: Grant
    Filed: July 30, 2004
    Date of Patent: August 26, 2008
    Assignee: Wyeth
    Inventors: Lynn A. Doucette-Stamm, David Bush
  • Controlled-release formulation of piperazine-piperidine antagonists and agonists of the 5-HT1A receptor having enhanced intestinal dissolution
    Publication number: 20080199518
    Abstract: The present invention relates to controlled-release beads comprising diquinoline-substituted piperazine-piperidine compounds, such as 5-fluoro-8-{4-[4-[(6-methoxyquinolin-8-yl)piperazin-1-yl]piperidin-1-yl}quinoline, or pharmaceutically acceptable salts thereof; to multiple particulate formulations comprising such beads; to methods of preparing such beads; and to methods of treating 5-HT1A-related disorders using such beads and/or multiple particulate formulations.
    Type: Application
    Filed: November 27, 2007
    Publication date: August 21, 2008
    Applicant: Wyeth
    Inventors: Mannching Sherry Ku, Wendy Ann Dulin, Yanning Lin
  • 1-Aryl- or 1-Alkylsulfonyl-Heterocyclylbenzazoles As 5-Hydroxytryptamine-6 Ligands
    Publication number: 20080200455
    Abstract: The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor.
    Type: Application
    Filed: August 20, 2007
    Publication date: August 21, 2008
    Applicant: Wyeth
    Inventors: Michael Gerard Kelly, Derek Cecil Cole
  • Stability in vitamin and mineral supplements
    Publication number: 20080199534
    Abstract: The invention provides a multivitamin and mineral nutritional supplement composition comprising at least one polyvalent metal and at least one oxidizable vitamin with substantially improved resistance to reactions that lead to darkening and/or spotting and reactions that may reduce the potency of oxidizable vitamins. The composition is a multivitamin and mineral composition comprising at least one polyvalent metal and at least one oxidizable vitamin wherein the composition is substantially free of mobile bound water. The invention also includes methods for making such a composition and methods of preventing or reducing oxidation, improving the stability of oxidizable vitamins, and stabilizing the disintegration time of a multi-vitamin and mineral nutritional supplement composition.
    Type: Application
    Filed: February 15, 2007
    Publication date: August 21, 2008
    Applicant: Wyeth
    Inventors: Alan M. Goldberg, Steven Dills, William Mark, Bruce Sutton, Chad Byerley
  • Protein Formulations Containing Sorbitol
    Publication number: 20080200655
    Abstract: The present invention provides a method for suppressing protein aggregation in a liquid formulation during freeze-thaw by including sorbitol in the liquid formulation. The present invention also provides methods for storing and preparing a liquid formulation containing a protein and sorbitol such that the presence of sorbitol suppresses protein aggregation during freezing and/or thawing.
    Type: Application
    Filed: February 15, 2008
    Publication date: August 21, 2008
    Applicant: Wyeth
    Inventor: David C. Sek
  • Benzofuranyl Alkanamine Derivatives and Uses Thereof
    Publication number: 20080200541
    Abstract: Compounds of formula I or pharmaceutically acceptable salts thereof are provided: wherein each of R1, R1?, R2, R3, R4, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.
    Type: Application
    Filed: April 18, 2008
    Publication date: August 21, 2008
    Applicant: Wyeth
    Inventors: Jonathan Laird Gross, Gary Paul Stack, Dahui Zhou, Hong Gao
  • Use Of Sucrose To Suppress Mannitol-Induced Protein Aggregation
    Publication number: 20080200656
    Abstract: The present invention provides a method for suppressing mannitol-induced protein aggregation by providing sucrose to a liquid formulation containing a protein. The present invention also provides methods for storing and preparing a liquid formulation containing a protein and a combination of mannitol and sucrose such that the presence of sucrose suppresses mannitol-induced protein aggregation.
    Type: Application
    Filed: February 15, 2008
    Publication date: August 21, 2008
    Applicant: WYETH
    Inventors: David C. Sek, Nicholas W. Warne, Kin Ho, Donna L. Luisi, Angela Kantor
  • Methods and compositions for regulating bone and cartilage formation
    Publication number: 20080200381
    Abstract: The invention provides methods and compositions for diagnostic assays for detecting bone and cartilage formation and therapeutic methods and compositions for treating disease and disorders related to bone and cartilage formation or resorption, such as osteoporosis and bone fractions. The invention also provides therapeutic methods for diseases related to bone or cartilage formation or resorption. Methods for identifying therapeutics for such diseases are also provided.
    Type: Application
    Filed: July 30, 2007
    Publication date: August 21, 2008
    Applicant: Wyeth
    Inventors: Debra D. Pittman, Brian M. Clancy
  • 5-aryl-indan-1-one oximes and analogs useful as progesterone receptor modulators
    Patent number: 7414142
    Abstract: Compounds of formula I, wherein R1-R9 and n are defined herein, and pharmaceutical compositions and kits containing these compounds are provided. Also provided are methods of inducing contraception, providing hormone replacement therapy, treating cycle-related symptoms, or treating or preventing benign or malignant neoplastic disease using the compounds of formula I or formula II, wherein R3-R5, R10, and R11 are defined herein.
    Type: Grant
    Filed: September 18, 2006
    Date of Patent: August 19, 2008
    Assignee: Wyeth
    Inventors: Puwen Zhang, Jeffrey Curtis Kern, Eugene Anthony Terefenko, Eugene John Trybulski
  • Phenylaminopropanol derivatives and methods of their use
    Patent number: 7414052
    Abstract: The present invention is directed to phenylaminopropanol derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.
    Type: Grant
    Filed: March 28, 2005
    Date of Patent: August 19, 2008
    Assignee: Wyeth
    Inventors: An Thien Vu, Paige Erin Mahaney, Stephen Todd Cohn
  • Substituted-dihydro[1,4]oxazino[2,3,4-hi]indazole derivatives as 5-hydroxytryptamine-6 ligands
    Patent number: 7414051
    Abstract: The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
    Type: Grant
    Filed: April 11, 2007
    Date of Patent: August 19, 2008
    Assignee: Wyeth
    Inventors: Hassan Mahmoud Elokdah, Alexander Alexei Greenfield, Cristina Grosanu, Albert Jean Robichaud
  • Calcium phosphate delivery vehicles for osteoinductive proteins
    Patent number: 7413753
    Abstract: A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the osteogenic compositions to treat osteoporotic and/or osteopenic bone are also disclosed.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: August 19, 2008
    Assignees: Wyeth, Etex Corporation
    Inventors: Rebecca H. Li, Howard Seeherman
  • Small organic molecule regulators of cell proliferation
    Publication number: 20080194637
    Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a compound. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal patched pathway or agonizing smoothened or hedgehog activity.
    Type: Application
    Filed: November 2, 2007
    Publication date: August 14, 2008
    Applicants: Curis, Inc., Wyeth
    Inventors: Shirley Ann Brunton, Oivin M. Guicherit, Simon N. Haydar, Lawrence I. Kruse, Dane Springer
  • HIGH DOSE, LONG-ACTING ECTOPARASITICIDE FOR EXTENDED CONTROL
    Publication number: 20080194642
    Abstract: The present invention provides a topical, high-dose, long-acting ectoparasiticide composition, kit and method for protecting against ectoparasite infestations in a warm-blooded animal for a period of greater than about 6 weeks.
    Type: Application
    Filed: February 8, 2008
    Publication date: August 14, 2008
    Applicant: Wyeth
    Inventors: Robert Bruce Albright, Shobhan Shashikant Sabnis, Larry A. Kraft, Susan Joan Holzmer, Robert Alan Pollet, Ramune Marija Cobb
  • HYDROXY-SUBSTITUTED ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE
    Publication number: 20080194654
    Abstract: The present invention is directed to hydroxy-substituted aryl sulfamide derivatives of formula I: or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.
    Type: Application
    Filed: December 12, 2007
    Publication date: August 14, 2008
    Applicant: Wyeth
    Inventors: Casey Cameron McComas, Andrew Fensome, Joel Adam Goldberg, Charles William Mann, David John O'Neill, Joseph Peter Sabatucci, Eugene Anthony Terefenko, Eugene John Trybulski, An Thien Vu, Puwen Zhang
  • Antibiotic product formulation
    Publication number: 20080193532
    Abstract: This invention discloses an antibiotic formulation in an immediate release antibiotic dosage form, comprising an antibiotic, colloidal silicon dioxide, povidone, silicified microcrystalline cellulose, croscarmellose sodium, magnesium stearate and a coating, said formulation having a release profile wherein the Cmax is reached in less than five hours.
    Type: Application
    Filed: April 18, 2008
    Publication date: August 14, 2008
    Applicant: Wyeth
    Inventors: Douglas C. Becker, Paul E. Stach
  • Infectious Bursal Disease Virus antigenic isolates and vaccines
    Publication number: 20080193480
    Abstract: Antigenic isolates and vaccines for Infectious Bursal Disease Virus include variants of the molecular Group 6 family of IBDV isolates, in particular the 28-1 isolate.
    Type: Application
    Filed: June 8, 2007
    Publication date: August 14, 2008
    Applicant: Wyeth
    Inventors: Jeffrey Harold Rodenberg, Mahesh Kumar, Kalen Cookson
  • PROCESS FOR SELECTIVE SULFATION OF AROMATIC HYDROXYL GROUPS
    Publication number: 20080194533
    Abstract: The present invention relates to processes for selective sulfation of an aromatic hydroxyl group over an aliphatic hydroxyl group where both are present in the same molecule. This invention also relates to processes for selective sulfation of the aromatic hydroxyl group of equilin, equilenin, estradiol, estra(1,3,5-triene)-3,16,17-triol, dihydroequilenin or dihydroequilin. This invention further relates to alkali metal salts of dihydroequilenin sulfates, dihydroequilin sulfates, estradiol sulfates, and estriol sulfates, processes for making thereof, stable compositions comprising thereof, and the use thereof.
    Type: Application
    Filed: February 7, 2008
    Publication date: August 14, 2008
    Applicant: WYETH
    Inventors: Sreenivasulu MEGATI, Panolil RAVEENDRANATH, Girija Raveendranath, Vijay Raveendranath, Sanjay Raveendranath
  • 1-Heterocyclylalkyl-3-sulfonylazaindole or -azaindazole derivatives as 5-hydroxytryptamine-6 ligands
    Patent number: 7411064
    Abstract: The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor
    Type: Grant
    Filed: February 15, 2006
    Date of Patent: August 12, 2008
    Assignee: Wyeth
    Inventors: Ronald Charles Bernotas, Steven Edward Lenicek, Hassan Mahmoud Elokdah, David Zenan Li
  • Substituted acetic acid derivatives
    Patent number: 7411083
    Abstract: The present invention relates generally to substituted acetic acid derivatives and methods of using them.
    Type: Grant
    Filed: September 23, 2004
    Date of Patent: August 12, 2008
    Assignee: Wyeth
    Inventors: Ariamala Gopalsamy, Scott Lee Kincaid