Abstract: The present disclosure discloses a functional fluid gating control system, which comprises a porous membrane and a functional fluid. The functional fluid at least partially infiltrates the porous membrane and cooperates to form a fluid gating pathway. The functional fluid and/or the porous membrane responds to at least one stimulus and undergoes a physical change or a chemical change to change the threshold pressure of the transport substance. A transport fluid being immiscible with the functional fluid is controlled to pass through the fluid gating system, and thus controllable transport and multiphase separation of materials are achieved. The stimulus of the present disclosure comprises a wide range of sources, and the stimulus responsiveness of the functional fluid and the porous membrane can be randomly and freely combined to adapt to multiple stimuli from complex external conditions and achieve intelligent controllability.

Abstract: The present disclosure discloses a skin penetration enhancing composition and a use thereof in preparation of a skin delivery formulation. The skin penetration enhancing composition comprises sponge spicules and nanoparticles. The nanoparticles comprise at least one of one or more drugs or one or more cosmetic active ingredients.

Abstract: A type of substituted penta-fused hexa-heterocyclic compounds having selective inhibition for PIKfyve kinase, a pharmaceutically acceptable salt and pharmaceutically acceptable solvate thereof, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with PIKfyve in vivo, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis.

Abstract: The invention relates to a truncated rotavirus VP4 protein, a sequence encoding the same, a method for preparing the same, and a pharmaceutical composition and a vaccine comprising the protein, wherein the protein, the pharmaceutical composition and the vaccine are useful for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea. The invention further relates to use of the protein in the manufacture of a pharmaceutical composition or a vaccine for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea.

Abstract: The present invention relates to a compound having the following formula, or a stereoisomer thereof, a prodrug thereof, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, preparation method thereof, pharmaceutical composition comprising the same and use of the compound in the manufacture of a medicament for preventing or treating tumor, wherein the substituents are as defined in the specification.

Abstract: The present disclosure discloses an antimicrobial peptide AS-hepc3(48-56) of Acanthopagrus schlegelii and method thereof. A molecular formula of the antimicrobial peptide AS-hepc3(48-56) is C48H86N24O10S3, and an amino acid sequence of the antimicrobial peptide AS-hepc3(48-56) is SEQ ID NO: 01.

Abstract: The invention relates to the field of medicinal chemistry, and to five-membered-fused-six-membered aza-aromatic ring compound, preparation method thereof, pharmaceutical composition and application thereof. In particular, the invention relates to a type of compounds capable of specifically enhancing ubiquitination degradation of Ras proteins, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with Ras activity in vivo, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis.

Abstract: Provided is an antimicrobial peptide Sparamosin from Scylla paramamosain. The Sparamosin mature peptide and its functional domain Sparamosin26-54 were synthesized by solid-phase synthesis with a purity of over 95%. Both Sparamosin and Sparamosin26-54 exhibit strong antimicrobial activity. More importantly, Sparamosin26-54 has strong antifungal activity and could inhibit the growth of a variety of yeasts and filamentous fungi. Based on the potent antimicrobial activities of Sparamosin and Sparamosin26-54, both peptides could be developed as alternatives for conventional antibiotics, antimicrobial agents, feed additives in aquaculture and livestock, preservatives, and mold inhibitors.

Abstract: Provided are a method for inactivating respiratory syncytial virus (RSV) and stabilizing pre-F protein in RSV and inactivated RSV virus obtained thereby. Also provided are a vaccine comprising the inactivated RSV virus and a use of the vaccine in preventing or treating RSV infection or a disease related thereto.

Abstract: Provided are an ORF7 deficient varicella virus, an vaccine comprising the virus and use thereof, as well as a method for the production the virus.

Abstract: The present disclosure discloses a blue fluorescent powder for a three primary color warm white LED and a preparation method thereof. SrCO3, NH4Cl, H3BO3, Eu2O3, and NH4H2PO4 function as raw materials to obtain a chemical formula of a blue fluorescent powder Sr(2-x)Eux(BO3)y(PO4)(1-y)Cl in a reducing atmosphere by a solid-state sintering method, wherein 0.001?x?0.1 and 0.001?y?0.5. The blue fluorescent powder is mixed with CaAlSiN3:Eu2+ red fluorescent powder and (SrBa)2SiO4:Eu2+ green fluorescent powder at a certain proportion to emit warm white light with a light efficiency and a color rendering index under a violet light excitation. An application prospect is wide.

Abstract: Disclosed is a method for inducing orderly arrangement by means of polymer crystallization, and the use thereof in preparing a composite film. Firstly, monodisperse PS-DVB nano-microspheres of different sizes are prepared by means of soap-free emulsion polymerization; the PS-DVB nano-microspheres prepared above are used as raw material, and PEG aqueous solutions with different concentrations are added to induce an orderly arrangement of the nano-microspheres by means of solution-state PEG crystallization; and characterized by using scanning electron microscopy and polarizing microscopy. The method is simple in terms of operation and is widely applicable. By further modifying the orderly arrangement of the nano-microspheres, the composite material can be applied to different fields.

Abstract: Provided is use of E3 ubiquitin ligase Nedd4-1 in preparation of a drug for inhibiting the Ras protein level. Also provided is use in preparation of a drug for preventing and/or treating tumors or a drug for prolonging the life span of organisms.

Abstract: Disclosed are a fluorine-silicon-containing polyphosphate ester and method for preparation thereof, having a chemical structural formula of: wherein R1 is R2 is n=10˜100. The fluorine-silicon-containing polyphosphate ester of the present invention uses silicon phosphorus and fluorine for improving flame retardancy. Phosphorus catalyzes the system to form a phosphorus-rich carbon layer, performing a protective-layer function and thereby preventing further breakdown of the epoxy resin. The silicon-containing epoxy resin forms a silica-containing carbon layer during the process of combustion, strengthening the carbon-layer structure and further improving the protective function of the carbon-layer. The introduction of elemental fluorine improves the thermal stability of the epoxy resin, thereby improving the flame retardancy performance of the system.

Abstract: The present disclosure discloses a method of manufacturing silicon dioxide nanoparticles modified by a polymer containing phosphorus and nitrogen, which relates to organic/inorganic hybrid nanoparticles, dispersing SiO2 in an organic solvent, then adding THPS, stirring, and finally adding p-phenylenediamine, reacting, centrifuging, washing, and drying to obtain silicon dioxide nanoparticles modified by a polymer containing phosphorus and nitrogen. The silicon dioxide nanoparticles modified by the polymer containing phosphorus and nitrogen have effects in flame retardancy, strengthening effect of polymer matrixes, and are expected to be widely used in the halogen-free synergistic flame retardancy of polymer materials.

Abstract: A method and system for simultaneous quantitative multiparametric MRI are provided in the disclosure. The method includes: designing a magnetic resonance imaging (MRI) sequence which includes a signal excitation part, a shift gradient part, and a data acquisition part; generating training samples for a deep neural network according to the MRI sequence; training the deep neural network by using the training samples, to obtain a trained deep neural network; and reconstructing multiple magnetic-resonance parametric maps by using the trained deep neural network and k-space data acquired by the MRI sequence. The disclosure can implement quantitative multiparametric MRI, and can correct image distortions caused by magnetic field inhomogeneity.

Abstract: The present disclosure is concerned with N-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)benzamide compounds that are capable of inhibiting SPAK kinase function, methods of treating hypoxic brain injuries due to, for example, ischemic stroke. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The present invention discloses a deflector disc of a disc tube membrane module, including a deflector disc body, radial water distribution ribs, an inner support ring and an outer support ring. a first end and a second end of the radial water distribution rib are respectively fixedly connected with an inner edge of the deflector disc body and an outer edge of the inner support ring, an annular boss is arranged on the front side of the inner support ring, a seal ring groove is respectively arranged at corresponding positions of the front side and back side of the inner support ring multiple yielding water collecting grooves are annularly and uniformly distributed on the inner surface of the inner support ring and an inner edge of the outer support ring is fixedly connected with an outer edge of the deflector disc body.

Abstract: Provided are a mutated HPV58 L1 protein or a variant thereof, a sequence encoding the same, a method for preparing the same, and a virus-like particle comprising the same, wherein the protein or a variant thereof and the virus-like particle can induce the generation of neutralizing antibodies against at least two HPV types, and therefore can be used to prevent infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum. The invention further relates to the use of the protein and the virus-like particle in the manufacture of a pharmaceutical composition or a vaccine for preventing infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum.

Abstract: The disclosure relates to a mutant of hemagglutinin protein of H3N2 subtype influenza virus and use thereof. In addition, the disclosure also relates to a pharmaceutical composition (e.g., a vaccine) comprising the mutant, a method for preparing the mutant, and a method of using the mutant for prevention and/or treatment of an infection of influenza virus and/or a disease (e.g., an influenza) caused by the infection.