Abstract: The present invention relates to a detection mechanism for polymerase chain reaction and a polymerase chain reaction device, wherein the detection mechanism comprises at least one excitation module group, each of the excitation module groups comprising two excitation modules for providing excitation light with two wavelengths; an excitation optical fiber, connected to the excitation modules, the excitation optical fiber transmitting the excitation light to at least one reaction tube, each of the reaction tubes receiving excitation light with two wavelengths; a receiving optical fiber, for collecting and transmitting a fluorescent signal from the reaction tube; at least one receiving module group, connected to the receiving optical fiber, each of the receiving module groups comprising two receiving modules, to respectively receive the fluorescent signal of two wavelengths from the same said reaction tube, and convert the fluorescent signal into an electrical signal for output; the detection mechanism is config

Abstract: A background offset drift calibration circuit and method for comparator are proposed. The background calibration circuit and method are designed based on the approximate linear characteristic of the offset drift of a comparator caused by the variation of temperature and power supply. The calibration circuit for the comparators obtains the offset drift characteristic of each comparator by performing twice foreground calibration and selects the comparator with the largest drift as the reference comparator and other comparators as working comparators. The reference comparator is configured to track the offset drift and trigger the background calibration circuit of other working comparators. The working comparators compensate for the offset drift caused by the temperature or the power supply in the background by linear interpolation based on the offset drift characteristic of each comparator.

Abstract: A background offset drift calibration circuit and method for comparator are proposed. The background calibration circuit and method are designed based on the approximate linear characteristic of the offset drift of a comparator caused by the variation of temperature and power supply. The calibration circuit for the comparators obtains the offset drift characteristic of each comparator by performing twice foreground calibration and selects the comparator with the largest drift as the reference comparator and other comparators as working comparators. The reference comparator is configured to track the offset drift and trigger the background calibration circuit of other working comparators. The working comparators compensate for the offset drift caused by the temperature or the power supply in the background by linear interpolation based on the offset drift characteristic of each comparator.

Abstract: The present invention relates to heteroaryl amide compounds, a preparation method therefor, pharmaceutical compositions thereof and applications thereof, and specifically, relates to a type of compounds having broad-spectrum tumor resistant activity, a preparation method therefor, pharmaceutical compositions containing the compounds, and uses of the compounds in the preparation of drugs for treating tumors.

Abstract: A method for underwater acoustic communication includes steps of S1: capturing a synchronization signal using a replica correlation operation; S2: performing time reversal forward shift processing and time reversal backward shift processing, respectively, on the synchronization signal to obtain a forward shift time reversal coefficient and a backward shift time reversal coefficient; S3: performing a convolution operation of the forward shift time reversal coefficient and the backward shift time reversal coefficient, respectively, with a subsequently captured information sequence to obtain a forward shift time reversal output and a backward shift time reversal output; S4: processing the forward shift time reversal output and the backward shift time reversal output, respectively, with a forward shift equalizer and a backward shift equalizer to obtain two sets of equalizer outputs; and S5: selecting one of the two sets of equalizer outputs with a smaller error for data decoding to obtain a desired signal.

Abstract: Provided are an ORF7 deficient varicella virus, an vaccine comprising the virus and use thereof, as well as a method for the production the virus.

Abstract: A combined cycle propulsion system (CCPS) module combines a low-speed propulsion system (LSPS) such as a turbojet and a high-speed propulsion system (HSPS) such as dual mode ramjet engines with a mid-speed propulsion system (MSPS) such as a ejector ramjet engine to close a thrust gap between the upper operation limit of the LSPS and the lower operation limit of the HSPS in a flight vehicle. A cooling system ensures thermal protection of the non-operating LSPS during MSPS or HSPS operation by cooling tapped air from the MSPS or HSPS using a heat exchanger and expansion in a turbine/generator and directing cooled tapped air into the LSPS.

Abstract: The invention relates to a truncated rotavirus VP4 protein, a sequence encoding the same, a method for preparing the same, and a pharmaceutical composition and a vaccine comprising the protein, wherein the protein, the pharmaceutical composition and the vaccine are useful for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea. The invention further relates to use of the protein in the manufacture of a pharmaceutical composition or a vaccine for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea.

Abstract: A continuous combustion production equipment for synthesizing ton-grade fullerenes and a synthetic process therefor. The continuous combustion production equipment is equipped with a gas supply and flow control system, a liquid supply and flow control system, a vaporization and preheating system, a combustion furnace, a combustor, a spray nozzle, an ignition system, a filter tank, a product collection system, a vacuum control system, a vacuum measuring and displaying unit and a circulation water cooling system. Opening the supply line of gas fuels, arranging the tip of a metal electrode of the ignition system near the gas fuel outlet of the combustor, opening the ignition system, igniting the gas with an electric spark to generate a flame; initiating the vacuum pump set; opening the supply line of liquid raw materials, adjusting to a suitable flux with a constant flow pump; adjusting the pressure of the system to keep it below 5000 Pa.

Abstract: A type of substituted penta-fused hexa-heterocyclic compounds having selective inhibition for PIKfyve kinase, a pharmaceutically acceptable salt and pharmaceutically acceptable solvate thereof, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with PIKfyve in vivo, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis.

Abstract: The present invention relates to a compound having the following formula, or a stereoisomer thereof, a prodrug thereof, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, preparation method thereof, pharmaceutical composition comprising the same and use of the compound in the manufacture of a medicament for preventing or treating tumor, wherein the substituents are as defined in the specification.

Abstract: The present application provides a method for simultaneously synthesizing a biological flocculant with polysaccharide and ?-PGA as the active components by using Bacillus licheniformis. Bacillus licheniformis is inoculated to a slant culture medium to be cultured; a single colony on a fresh plate is inoculated to a seed culture medium to be cultured; and a seed fermentation broth is inoculated to a fermentation culture medium to be cultured, and then the biological flocculant having two different components is obtained. The flocculant synthesized in the present invention is high in activity and good in thermal stability; and especially, the flocculation effect of polysaccharide is relatively superior under acidic and neutral conditions, and the flocculation activity of ?-PGA is relatively higher under neutral and alkaline environments, which can satisfy a relatively large pH application range.

Abstract: Disclosed are a mutated HPV11 L1 protein (or a variant thereof), a sequence encoding the same, a method for preparing the same, and a virus-like particle comprising the same, wherein the protein (or a variant thereof) and the virus-like particle can induce the generation of neutralizing antibodies against at least two HPV types (e.g. HPV11 and HPV6), and therefore can be used to prevent infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum. Also disclosed is use of the protein and the virus-like particle in the manufacture of a pharmaceutical composition or a vaccine for preventing infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum.

Abstract: The present invention relates to a compound of formula I, a stereoisomer, a prodrug, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, and a process for preparing the same, a pharmaceutical composition comprising the same, and use of the compound in the preparation of medicine preventing and treating tumors, wherein the substituents are as defined in the specification.

Abstract: A method for extracting a gear tooth profile edge based on an engagement-pixel image edge tracking method includes defining a transmission ratio relationship between a cutter and an envelope tooth profile, setting a cutter profile step size and an envelope step size, acquiring instantaneous contact images at different engaging times, and performing a binarization processing on each curve envelope cluster image; sweeping a boundary of an envelope curve cluster, acquiring pixel points of the edge; preliminarily tracking a tooth profile edge, and then performing a secondary extraction and compensation on the pixel points; calibrating coordinates of a cutter profile; extracting a pixel coordinate of an instantaneous engaging point; converting the pixel points among different instantaneous engaging images; extracting a final tooth profile coordinate of the gear, and performing a tooth shape error analysis and a contact line error analysis.

Abstract: The invention provides novel compounds and methods of using such compounds to treat or prevent cancer.

Abstract: The invention belongs to the fields of medicine and immunology, particularly, the field of immunological diagnosis. In particular, the invention discloses a method for assessing whether a subject is at risk of developing human cytomegalovirus (HCMV) active infection and a kit therefore. The method comprises the steps of: (1) determining the level of an antibody against a HCMV protein in a body fluid sample from the subject; and (2) comparing the level with a predetermined reference value, wherein if the level is below the predetermined reference value, the subject is determined to be at risk of developing HCMV active infection. In addition, the invention also discloses a method for screening a candidate drug which is capable of improving the ability of a subject to resist human cytomegalovirus (HCMV) active infection, and a kit therefore.

Abstract: The present invention relates to fields of organic chemistry and organometallic chemistry. The present invention discloses a chain multiyne compound, a preparation method thereof and an application in synthesizing a fused-ring metallacyclic compound. A structure of the chain multiyne compound in the present invention is shown as Formula I below. The present invention also provides a preparation method of the chain multiyne compound and an application thereof in a synthesis of a fused-ring metallacyclic compound. The chain multiyne compound disclosed in the present invention has multiple functional groups and the structure of the chain multiyne compound is adjustable. The chain multiyne compound can also be used to synthesize the fused-ring metallacyclic compound efficiently. The preparation method of the chain multiyne compound disclosed in the present invention is simple, which can be used to prepare the chain multiyne compound rapidly and efficiently.

Abstract: The present invention relates to epitope peptides (or mutants thereof) for treating hepatitis B virus infection, recombinant proteins comprising such epitope peptides (or mutants thereof) and carrier proteins, and uses of such epitope peptides (or mutants thereof) and recombinant proteins. The present invention also relates to antibodies against such epitope peptides, cell lines producing said antibodies, and uses thereof. Furthermore, the present invention relates to vaccines or pharmaceutical compositions for treating or alleviating one or more symptoms associated with hepatitis B virus infection, which comprise the recombinant proteins or antibodies according to the invention, respectively.

Abstract: Disclosed are a mutated HPV11 L1 protein (or a variant thereof), a sequence encoding the same, a method for preparing the same, and a virus-like particle comprising the same, wherein the protein (or a variant thereof) and the virus-like particle can induce the generation of neutralizing antibodies against at least two HPV types (e.g. HPV11 and HPV6), and therefore can be used to prevent infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum. Also disclosed is use of the protein and the virus-like particle in the manufacture of a pharmaceutical composition or a vaccine for preventing infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum.