Abstract: Disclosed are antibodies to anti-hepatitis B surface antigen (HBsAg) (especially humanized antibodies), nucleic acid molecules encoding same, methods for preparing same, and pharmaceutical compositions containing same. The antibodies have higher affinity for HBsAg at neutral pH than at acidic pH, thereby significantly enhancing the virus clearance efficiency and prolonging the virus inhibition time. The antibodies and the pharmaceutical compositions can be used for preventing and/or treating HBV infections or diseases related to HBV infections (e.g., hepatitis B), for neutralizing the virulence of HBV in a subject (e.g., a human), for reducing the serum level of HBV DNA and/or HBsAg in the body of the subject, or for activating the humoral immune response of the subject (e.g., a chronic HBV infected or chronic hepatitis B patient) against HBV.

Abstract: A method for extracting a gear tooth profile edge based on an engagement-pixel image edge tracking method includes defining a transmission ratio relationship between a cutter and an envelope tooth profile, setting a cutter profile step size and an envelope step size, acquiring instantaneous contact images at different engaging times, and performing a binarization processing on each curve envelope cluster image; sweeping a boundary of an envelope curve cluster, acquiring pixel points of the edge; preliminarily tracking a tooth profile edge, and then performing a secondary extraction and compensation on the pixel points; calibrating coordinates of a cutter profile; extracting a pixel coordinate of an instantaneous engaging point; converting the pixel points among different instantaneous engaging images; extracting a final tooth profile coordinate of the gear, and performing a tooth shape error analysis and a contact line error analysis.

Abstract: A type of substituted penta-fused hexa-heterocyclic compounds having selective inhibition for PIKfyve kinase, a pharmaceutically acceptable salt and pharmaceutically acceptable solvate thereof, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with PIKfyve in vivo, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis.

Abstract: A method for treating domestic sewage includes: preliminarily treating the domestic sewage through a grating and a grit chamber, so as to remove large-particle solids in the domestic sewage; and subjecting the domestic sewage after the preliminary treatment to circulating anaerobic-oxic treatment in a membrane bioreactor (MBR). In the oxic treatment process, microorganisms oxidize nitrogen in the sewage into nitrite or nitrate. Under anaerobic conditions, denitrifying bacteria in the microorganisms reduce the nitrate, releasing molecular nitrogen or nitrous oxide. In the present invention, the MBR is filled with a quinone-based hollow fiber membrane. During the microbial denitrification, the quinone acts as an electron transfer carrier to participate in the denitrification to promote the reduction of the nitrate (nitrite), increasing the denitrification rate under anaerobic conditions, and achieving the purpose of efficient denitrification.

Abstract: The invention relates to a truncated rotavirus VP4 protein, a sequence encoding the same, a method for preparing the same, and a pharmaceutical composition and a vaccine comprising the protein, wherein the protein, the pharmaceutical composition and the vaccine are useful for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea. The invention further relates to use of the protein in the manufacture of a pharmaceutical composition or a vaccine for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea.

Abstract: A present invention provides a nitrite rubber composite, a preparation method thereof and a sealing ring using the composite are provided. The nitrile rubber composite provided by the present invention contains the following preparation raw materials in parts by mass: 100 parts of raw nitrile rubber, 0.1-5 parts of liquid nitrite rubber modified graphene oxide, 60-90 parts of liquid nitrite rubber modified carbon black, 1-3 parts of anti-aging agent, 2-6 parts of compound vulcanizing agent, and 1-3 parts of accelerant.

Abstract: The present invention relates to a compound having the following formula, or a stereoisomer thereof, a prodrug thereof, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, preparation method thereof, pharmaceutical composition comprising the same and use of the compound in the manufacture of a medicament for preventing or treating tumor, wherein the substituents are as defined in the specification.

Abstract: A pseudorabies virus (PRV) or a modified form thereof, or a genome sequence or a cDNA sequence containing the PRV or the modified form thereof, or nucleic acid molecules of a complementary sequence of the cDNA sequence, for treating tumors of subjects and/or reducing or inhibiting tumor recurrence, and for preparation of a pharmaceutical composition used for treating the tumors of the subjects and/or reducing or inhibiting the tumor recurrence. A method for treating tumors and/or reducing or inhibiting tumor recurrence, comprising a step of administering, on a subject having a need, the PRV or the modified form thereof, or nucleic acid molecules of the genome sequence containing the PRV or the modified form thereof.

Abstract: The present disclosure discloses an antimicrobial peptide AS-hepc3(48-56) of Acanthopagrus schlegelii and method thereof. A molecular formula of the antimicrobial peptide AS-hepc3(48-56) is C48H86N24O10S3, and an amino acid sequence of the antimicrobial peptide AS-hepc3(48-56) is SEQ ID NO: 01.

Abstract: The invention relates to the field of medicinal chemistry, and to five-membered-fused-six-membered aza-aromatic ring compound, preparation method thereof, pharmaceutical composition and application thereof. In particular, the invention relates to a type of compounds capable of specifically enhancing ubiquitination degradation of Ras proteins, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with Ras activity in vivo, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis.

Abstract: A method for treating dye wastewater includes: firstly, homogenizing the dye wastewater to balance the quality of the dye wastewater from different processes; then subjecting the homogenized dye wastewater to anaerobic treatment to remove most of chemical oxygen demand (COD) and total suspended solids (SS) in the wastewater; and finally subjecting the dye wastewater after the anaerobic treatment to circulating anaerobic-oxic treatment in a membrane bioreactor (MBR). In the present invention, the MBR is filled with a quinone-based hollow fiber membrane. The quinone acts as an electron mediator to accelerate an enzymatic reaction for dye decolorization during the anaerobic process, thereby achieving the purpose of efficient decolorization. The oxic treatment process further removes the COD and SS in the wastewater, so that the effluent meets a first-level discharge standard.

Abstract: Provided is an antimicrobial peptide Sparamosin from Scylla paramamosain. The Sparamosin mature peptide and its functional domain Sparamosin26-54 were synthesized by solid-phase synthesis with a purity of over 95%. Both Sparamosin and Sparamosin26-54 exhibit strong antimicrobial activity. More importantly, Sparamosin26-54 has strong antifungal activity and could inhibit the growth of a variety of yeasts and filamentous fungi. Based on the potent antimicrobial activities of Sparamosin and Sparamosin26-54, both peptides could be developed as alternatives for conventional antibiotics, antimicrobial agents, feed additives in aquaculture and livestock, preservatives, and mold inhibitors.

Abstract: The present invention discloses a copper-zinc-aluminum-iron single crystal alloy material having an ultra-large grain structure of 5-50 cm grade, obtained by annealing an as-cast alloy having a polycrystalline structure through a single phase region of 800-960° C. for 2-105 h, where the as-cast alloy includes, by weight percentage, 62-82% of copper, 6-29% of zinc, 5-12% of aluminum, and 2-5% of iron. In the present invention, the alloy compositions have an essential difference and are a copper-zinc-aluminum-iron quaternary alloy, and the iron element is an indispensable alloying element. The preparation process of the present invention is extremely simple and very easy to implement and has a very good application prospect.

Abstract: Provided are a method for inactivating respiratory syncytial virus (RSV) and stabilizing pre-F protein in RSV and inactivated RSV virus obtained thereby. Also provided are a vaccine comprising the inactivated RSV virus and a use of the vaccine in preventing or treating RSV infection or a disease related thereto.

Abstract: Provided are an ORF7 deficient varicella virus, an vaccine comprising the virus and use thereof, as well as a method for the production the virus.

Abstract: Provided are a mutated HPV16 L1 protein (or a variant thereof), a sequence encoding the same and a method for preparing the same, as well as a virus-like particle comprising the same. The protein (or variant thereof) and the virus-like particle are capable of inducing neutralizing antibodies against at least two types of HPV (e.g., HPV16 and HPV35, or HPV16, HPV35, and HPV31), and therefore can be used to prevent infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum. Also provided are a use of the above protein and virus-like particle in the manufacture of a pharmaceutical composition or vaccine for preventing infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum.

Abstract: The application discloses a multi-type acoustic feature integration method and system based on deep neural networks. The method and system include using labeled speech data set to train and build a multi-type acoustic feature integration model based on deep neural networks, to determine or update the network parameters of the multi-type acoustic feature integration model; the method and system includes inputting the multiple types of acoustic features extracted from the testing speech into the trained multi-type acoustic feature integration model, and extracting the deep integrated feature vectors in frame level or segment level. The solution supports the integrated feature extraction for multiple types of acoustic features in different kinds of speech tasks, such as speech recognition, speech wake-up, spoken language recognition, speaker recognition, and anti-spoofing etc.

Abstract: A modified ceramic composite separator includes an organic support layer and a ceramic layer coated on the surface of the support layer in a thickness of 0.1 ?m to 20 ?m, and further comprises a dopamine or other polymer grown in-situ on the surface and interior of the support layer and the ceramic layer. The inorganic power in the ceramic layer has a particle size of 5 nm to 10 ?m, and the material of the organic support layer has a molecular weight of 1000 to 100000000.

Abstract: A method and the device of the working bucket number identification technology during the shoveling-and-loading process of the loader uses multi-sensor fusion technology for the three kinds of pressure sensors during the shoveling-and-loading process of the loader to realize the automatic identification of the bucket number during the shoveling-and-loading process. It can effectively improve and ensure the accuracy of the test data, while effectively preventing drivers from overworking. The method and device is also beneficial to the recognition of the loader working stage, and provides a good foundation for accurately identifying the working stage and realizing the dynamic prediction and control of the working process.

Abstract: The present disclosure discloses a blue fluorescent powder for a three primary color warm white LED and a preparation method thereof. SrCO3, NH4Cl, H3BO3, Eu2O3, and NH4H2PO4 function as raw materials to obtain a chemical formula of a blue fluorescent powder Sr(2-x)Eux(BO3)y(PO4)(1-y)Cl in a reducing atmosphere by a solid-state sintering method, wherein 0.001?x?0.1 and 0.001?y?0.5. The blue fluorescent powder is mixed with CaAlSiN3:Eu2+ red fluorescent powder and (SrBa)2SiO4:Eu2+ green fluorescent powder at a certain proportion to emit warm white light with a light efficiency and a color rendering index under a violet light excitation. An application prospect is wide.