Abstract: The invention provides an antibody (in particular, a humanized antibody) against hepatitis B surface antigen (HBsAg), a nucleic acid molecule encoding the same, a method for preparing the same, and a pharmaceutical composition comprising the same. The invention also provides use of the antibody and pharmaceutical composition. The antibody and pharmaceutical composition according to the invention can be used for preventing and/or treating HBV infection or a disease associated with HBV infection (such as Hepatitis B), for neutralizing HBV virulence in a subject (such as human), or for reducing the serum level of HBV DNA and/or HBsAg in a subject.
Type:
Grant
Filed:
October 9, 2016
Date of Patent:
June 23, 2020
Assignees:
XIAMEN UNIVERSITY, YANG SHENG TANG COMPANY, LTD.
Inventors:
Wenxin Luo, Bing Zhou, Juan Zhang, Quan Yuan, Tianying Zhang, Jun Zhang, Ningshao Xia
Abstract: A type of substituted penta-fused hexa-heterocyclic compounds having selective inhibition for PIKfyve kinase, a pharmaceutically acceptable salt and pharmaceutically acceptable solvate thereof, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with PIKfyve in vivo, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis.
Type:
Application
Filed:
August 3, 2018
Publication date:
May 28, 2020
Applicant:
Xiamen University
Inventors:
Xianming Deng, Wei Huang, Xihuan Sun, Ting Zhang, Zhixiang He, Yan Liu, Xinrui Wu, Baoding Zhang, Xiaoyang Li, Jingfang Zhang, Yun Chen, Li Li, Qingyan Xu, Zhiyu Hu
Abstract: The invention relates to a polypeptide carrier for presenting a target polypeptide, and use thereof. In particular, the invention relates to a nucleic acid molecule, comprising a nucleotide sequence encoding a polypeptide carrier, and being used for insertion of a nucleotide sequence encoding a target polypeptide. In addition, the invention further relates to a recombinant protein comprising the polypeptide carrier and a target polypeptide. Furthermore, the invention further relates to use of the nucleic acid molecule and the recombinant protein. In addition, the invention further relates to a vaccine or a pharmaceutical composition useful for preventing, alleviating or treating HBV infection or a disease associated with HBV infection (e.g., hepatitis B), comprising a recombinant protein comprising the polypeptide carrier of the invention and an epitope from HBV.
Type:
Application
Filed:
February 5, 2018
Publication date:
May 14, 2020
Applicants:
XIAMEN UNIVERSITY, YANG SHENG TANG COMPANY, LTD.
Inventors:
Tianying ZHANG, Quan YUAN, Xueran GUO, Minxi WEI, Xiaozhen KANG, Jun ZHANG, Ningshao XIA
Abstract: The identification method of the difficulty level of the operating condition of the loader, takes the excavating operation segments extracted by the operation segment as the main objects of study to identify the operating conditions, and finally get the difficulty level value of the operating condition. The identification of the difficulty level of the operating condition is beneficial to control the power output mode of diesel engine and realize the distribution according to demand; simultaneously, as the judgement basis of intelligent shift control strategy, it has great significance for intelligent shift, power mode control and improving operation performance of engineering vehicles. It is also beneficial to the improvement of the performance and the energy saving and emission reduction; at the same time, the identification of the difficulty level of the operating condition is used to realize the change of power regulation, improve the application scope of engineering machinery.
Abstract: The present invention relates to a compound having the following formula, or a stereoisomer thereof, a prodrug thereof, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, preparation method thereof, pharmaceutical composition comprising the same and use of the compound in the manufacture of a medicament for preventing or treating tumor, wherein the substituents are as defined in the specification.
Abstract: Disclosed are a phosphaphenanthrene-structure reactive flame retardant and an application thereof. The preparation method comprises: enabling 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO), p-hydroxy benzaldehyde (4-HBA), and 5-aminomethyl-1,3-diphenyl-1,3,5-diphosphonitryl heterocycles to react under a certain condition to obtain the reactive flame retardant with a benzene ring rigid structure containing polyhydroxy. Compared with an ordinary flame retardant, the phosphaphenanthrene-structure reactive flame retardant has the characteristics that polyfunctionality is achieved, the molecular structure is stable, the hydrolysis resistance is better, and less migration in epoxy resin, moreover, the flame retardant property of the epoxy resin can be remarkably improved.
Abstract: The present application provides a method for simultaneously synthesizing a biological flocculant with polysaccharide and ?-PGA as the active components by using Bacillus licheniformis. Bacillus licheniformis is inoculated to a slant culture medium to be cultured; a single colony on a fresh plate is inoculated to a seed culture medium to be cultured; and a seed fermentation broth is inoculated to a fermentation culture medium to be cultured, and then the biological flocculant having two different components is obtained. The flocculant synthesized in the present invention is high in activity and good in thermal stability; and especially, the flocculation effect of polysaccharide is relatively superior under acidic and neutral conditions, and the flocculation activity of ?-PGA is relatively higher under neutral and alkaline environments, which can satisfy a relatively large pH application range.
Type:
Grant
Filed:
July 30, 2014
Date of Patent:
March 10, 2020
Assignee:
Xiamen University
Inventors:
Ning He, Haosheng Yao, Yu Liu, Wencheng Yu, Shan Yan, Yuanpeng Wang, Qingbiao Li
Abstract: The present invention provides a skin penetration enhancing method and its penetration enhancer which is comprised of sponge spicules or a biologically effective amount of sponge spicules or a combination containing sponge spicules. The penetration enhancer can be applied onto the skin to overcome the skin stratum corneum barrier, which can increase the percutaneous absorption of drugs, vaccines and cosmetics into different skin layers or can improve the transdermal delivery of all these therapeutics into the systemic blood circulation. This technology can be used for dermal delivery of therapeutics into the skin or for transdermal delivery of therapeutics across the skin into systemic blood circulation.
Abstract: The invention relates to a polypeptide carrier for presenting a target polypeptide, and use thereof. In particular, the invention relates to a nucleic acid molecule, comprising a nucleotide sequence encoding a polypeptide carrier, and being used for insertion of a nucleotide sequence encoding a target polypeptide. In addition, the invention further relates to a recombinant protein comprising the polypeptide carrier and a target polypeptide. Furthermore, the invention further relates to use of the nucleic acid molecule and the recombinant protein. In addition, the invention further relates to a vaccine or a pharmaceutical composition useful for preventing, alleviating or treating HBV infection or a disease associated with HBV infection (e.g., hepatitis B), comprising a recombinant protein comprising the polypeptide carrier of the invention and an epitope from HBV.
Type:
Grant
Filed:
August 24, 2016
Date of Patent:
February 4, 2020
Assignees:
XIAMEN UNIVERSITY, YANG SHENG TANG COMPANY, LTD.
Inventors:
Tianying Zhang, Quan Yuan, Xueran Guo, Ying Zhang, Qinjian Zhao, Jun Zhang, Ningshao Xia
Abstract: The invention relates to a truncated L1 protein of the Human Papillomavirus Type 11, a virus-like particle consisting of the protein, a vaccine comprising said virus-like particle, and the use of the vaccine in the prevention of condyloma acuminatum or HPV infections.
Abstract: A membrane photobioreactor for treating nitrogen and phosphorus that are out of limits in a biogas slurry and treating method thereof, relating to biogas slurry treatment. The membrane photobioreactor for treating nitrogen and phosphorus that are out of limits in a biogas slurry is provided with a biogas slurry storage tank, peristaltic pumps, a microalgae cultivating tank, an air pump, a membrane photobioreactor and a hollow fiber membrane.
Type:
Grant
Filed:
July 30, 2014
Date of Patent:
January 14, 2020
Assignee:
XIAMEN UNIVERSITY
Inventors:
Qingbiao Li, Xi Chen, Ning He, Yuanpeng Wang, Liang Shen, Haitao Wang
Abstract: The invention provides an antibody (in particular, a humanized antibody) against hepatitis B surface antigen (HBsAg), a nucleic acid molecule encoding the same, a method for preparing the same, and a pharmaceutical composition comprising the same. The invention also provides use of the antibody and pharmaceutical composition. The antibody and pharmaceutical composition according to the invention can be used for preventing and/or treating HBV infection or a disease associated with HBV infection (such as Hepatitis B), for neutralizing HBV virulence in a subject (such as human), or for reducing the serum level of HBV DNA and/or HBsAg in a subject.
Type:
Application
Filed:
October 9, 2016
Publication date:
December 26, 2019
Applicants:
XIAMEN UNIVERSITY, YANG SHENG TANG COMPANY, LTD.
Inventors:
Wenxin LUO, Bing ZHOU, Juan ZHANG, Quan YUAN, Tianying ZHANG, Jun ZHANG, Ningshao XIA
Abstract: Disclosed are a mutated HPV11 L1 protein (or a variant thereof), a sequence encoding the same, a method for preparing the same, and a virus-like particle comprising the same, wherein the protein (or a variant thereof) and the virus-like particle can induce the generation of neutralizing antibodies against at least two HPV types (e.g. HPV11 and HPV6), and therefore can be used to prevent infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum. Also disclosed is use of the protein and the virus-like particle in the manufacture of a pharmaceutical composition or a vaccine for preventing infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum.
Abstract: Disclosed are a phosphaphenanthrene-structure reactive flame retardant and an application thereof. The preparation method comprises: enabling 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO), p-hydroxy benzaldehyde (4-HBA), and 5-aminomethyl-1,3-diphenyl-1,3,5-diphosphonitryl heterocycles to react under a certain condition to obtain the reactive flame retardant with a benzene ring rigid structure containing polyhydroxy. Compared with an ordinary flame retardant, the phosphaphenanthrene-structure reactive flame retardant has the characteristics that polyfunctionality is achieved, the molecular structure is stable, the hydrolysis resistance is better, and less migration in epoxy resin, moreover, the flame retardant property of the epoxy resin can be remarkably improved.
Abstract: The present invention relates to a compound of formula I, a stereoisomer, a prodrug, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, and a process for preparing the same, a pharmaceutical composition comprising the same, and use of the compound in the preparation of medicine preventing and treating tumors, wherein the substituents are as defined in the specification.
Type:
Grant
Filed:
April 25, 2016
Date of Patent:
December 17, 2019
Assignee:
Xiamen University
Inventors:
Xianming Deng, Zhongji Zhuang, Zhou Deng, Xiaoxing Huang, Yan Liu, Ting Zhang, Wei Huang, Qingyan Xu, Zhiyu Hu
Abstract: A method for accurately producing the drilled hole in a wall of a component fabricated by investment casting process, such as for use in a blade or steam turbine includes the following steps. The 3D data of actual component is obtained from the measurements or from the numerical simulation. The actual model and the ideal model are aligned and compared, a series of cutting planes are given to establish a series of 2D cross-sections of the actual and ideal models after registration. Each cross-section is dispersed into discrete points, the distance between each corresponding points are calculated and formed into 2D displacement. The accurate parametric model consisting of the depth, hole center, and the nominal vector is obtained on the basis of considering the deviations in geometrical and positional values. The drilled hole is then produced according to the corrected parametric drilled-hole geometrical and positional value.
Abstract: Disclosed are a reaction tube for nucleic acid amplification capable of controlling a liquid circulation path, a reaction apparatus for nucleic acid amplification comprising the reaction tube, and a method for amplifying nucleic acid comprising a step of using the reaction tube. Also disclosed are a kit comprising the reaction tube, and use of the reaction tube in preparation of a kit.
Abstract: Provided are a broad-spectrum monoclonal anti-Flu B antibody, cell strains generating the antibody, and a composition comprising the antibody; also provided are uses of the antibody for diagnosing, preventing and/or treating an infection of the Flu B and/or diseases caused by the infection.
Abstract: Provided are use of a compound of Formula I as a ligand of orphan nulear receptor Nur77, and in the prevention or treatment of a orphan nulear receptor Nur77 associated disease,
Type:
Application
Filed:
July 4, 2017
Publication date:
October 31, 2019
Applicant:
XIAMEN UNIVERSITY
Inventors:
Xiaokun ZHANG, Xiangzhi LIN, Ying SU, Zhiping ZENG, Mengjie HU, Qiang LUO, Yi ZHU, Alitongbieke GULIMIRAN