Patents Assigned to Yale University
  • Accelerated MRI with nonlinear spatial encoding gradients
    Patent number: 9229081
    Abstract: In a method of magnetic resonance imaging, a set of nonlinear, mutually orthogonal magnetic gradient encoding fields are sequentially and separately generated in an imaging region [100]. Using multiple receiver coils having nonuniform sensitivity profiles, echo data representing signal intensities in the imaging region is sequentially acquired as the magnetic gradient encoding fields are sequentially generated [102]. A reconstructed image of the imaging region is computed from the acquired echo data [104], and the reconstructed image is then be stored and/or displayed on a display monitor [106].
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: January 5, 2016
    Assignee: Yale University
    Inventors: Robert T. Constable, Jason Stockmann, Lick-Kong Tam, Gigi Galiana
  • METHODS FOR MAKING A SUPERCONDUCTING DEVICE WITH AT LEAST ONE ENCLOSURE
    Publication number: 20150372217
    Abstract: Some embodiments are directed to a device including multiple substrates comprising one or more troughs. The substrates are disposed such that the one or more troughs form at least one enclosure. At least one superconducting layer covers at least portion of the at least one enclosure. Other embodiments are directed to a method for manufacturing a superconducting device. The method includes acts of forming at least one trough in at least a first substrate; covering at least a portion of the first substrate with a superconducting material; covering at least a portion of a second substrate with the superconducting material; and bonding the first substrate and the second substrate to form at least one enclosure comprising the at least one trough and the superconducting material.
    Type: Application
    Filed: January 17, 2014
    Publication date: December 24, 2015
    Applicant: Yale University
    Inventors: Robert J. Schoelkopf, III, Luigi Frunzio, Michel Devoret, Teresa Brecht
  • SUPERCONDUCTING DEVICE WITH AT LEAST ONE ENCLOSURE
    Publication number: 20150357550
    Abstract: Some embodiments are directed to a device including multiple substrates comprising one or more troughs. The substrates are disposed such that the one or more troughs form at least one enclosure. At least one superconducting layer covers at least a portion of the at least one enclosure. Other embodiments are directed to a method for manufacturing a superconducting device. The method includes acts of forming at least one trough in at least a first substrate; covering at least a portion of the first substrate with a superconducting material; covering at least a portion of a second substrate with the superconducting material; and bonding the first substrate and the second substrate to form at least one enclosure comprising the at least one trough and the superconducting material.
    Type: Application
    Filed: January 17, 2014
    Publication date: December 10, 2015
    Applicant: Yale University
    Inventors: Robert J. Schoelkopf III, Teresa Brecht, Luigi Frunzio, Michel Devoret
  • Conductivity based on selective etch for GaN devices and applications thereof
    Patent number: 9206524
    Abstract: This invention relates to methods of generating NP gallium nitride (GaN) across large areas (>1 cm2) with controlled pore diameters, pore density, and porosity. Also disclosed are methods of generating novel optoelectronic devices based on porous GaN. Additionally a layer transfer scheme to separate and create free-standing crystalline GaN thin layers is disclosed that enables a new device manufacturing paradigm involving substrate recycling. Other disclosed embodiments of this invention relate to fabrication of GaN based nanocrystals and the use of NP GaN electrodes for electrolysis, water splitting, or photosynthetic process applications.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: December 8, 2015
    Assignee: Yale University
    Inventors: Yu Zhang, Qian Sun, Jung Han
  • System, device and method for high-throughput multi-plexed detection
    Patent number: 9188586
    Abstract: The present invention relates to a system, device, and method for the high throughput multiplexed detection of a wide number of compounds. The invention comprises of a microwell array coupled to a capture agent array to form a plurality of interfaces between a microwell and a set of immobilized capture agents. The set of capture agents comprises a plurality of distinguishable features, with each feature corresponding to the detection of a particular compound of interest. In certain embodiments, each microwell is configured to contain a single cell. The invention is therefore capable of performing a high throughput analysis of single cell profiles, including profiles of secreted compounds.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: November 17, 2015
    Assignee: Yale University
    Inventors: Rong Fan, Yao Lu, Jonathan Chen
  • Nanoelectronic-enzyme linked immunosorbent assay system and method
    Patent number: 9188594
    Abstract: The present invention relates to a device and method for determining the presence of a specific compound in solution. The device includes a nanosensor having an electrically conducting pathway between at least a first and second contact. The device also includes a first receptor, suitable for binding a specific compound in the solution, attached to the nanosensor, and a second receptor also suitable for binding the specific compound while the specific compound is bound to the first receptor. The second receptor is attached to an enzyme added to the solution. When the solution having the second receptor is added to the device, and a second compound that is a substrate for the enzyme is subsequently added to the solution, a measured difference in an electrical property in the device before and after the application of the second compound is indicative of the presence of the specific compound in the solution.
    Type: Grant
    Filed: August 4, 2009
    Date of Patent: November 17, 2015
    Assignee: Yale University
    Inventors: Tarek M. Fahmy, Eric D. Stern, Mark A. Reed, Aleksandar Vacic, James F. Klemic
  • Intrauterine device
    Patent number: 9180039
    Abstract: An intrauterine device for applying force to a wall of a uterus to promote contraception without blocking the fallopian tubes may include an elongate member formed of a resilient material and having a default expanded configuration and a spring portion disposed approximately at a midpoint between two ends of the elongate member. The IUD may also include two tissue contact members, one tissue contact member disposed at one of the two ends of the elongate member and the other tissue contact member disposed at the other end. The tissue contact members may generate a laterally directed force against the wall of the uterus when the intrauterine device assumes its default expanded configuration.
    Type: Grant
    Filed: November 10, 2011
    Date of Patent: November 10, 2015
    Assignees: Yale University, ContraMed, LLC
    Inventors: Michael G. Tal, Patrick N. Gutelius, Mark J. DeBisschop, Oleg Shikhman, Pasquale Patrizio, Bob H. Katz
  • Dynamic Spine Stablizer
    Publication number: 20150313643
    Abstract: A dynamic spine stabilizer moves under the control of spinal motion providing increased mechanical support within a central zone corresponding substantially to the neutral zone of the injured spine. The dynamic spine stabilizer includes a support assembly and a resistance assembly associated with the support assembly. The resistance assembly generates greater increase in mechanical force during movement within the central zone and lesser increase in mechanical force during movement beyond the central zone. A method for using the stabilizer is also disclosed.
    Type: Application
    Filed: May 11, 2015
    Publication date: November 5, 2015
    Applicant: Yale University
    Inventor: Manohar M. Panjabi
  • ESTIMATION OF A MECHANICAL PROPERTY OF ANATOMY FROM MEDICAL SCAN DATA
    Publication number: 20150305706
    Abstract: A mechanical property of anatomy is estimated from a patient in vivo, such as estimating a patient-specific material property of a valve. A morphological model is used to determine anatomy dynamics. A biomechanical model, using the anatomy dynamics, predicts the dynamics, based, at least in part, on one or more material properties. Using an inverse solution based on comparison of dynamics predicted by the biomechanical model and the dynamics determined from the morphological model, values for the material properties are determined.
    Type: Application
    Filed: April 23, 2014
    Publication date: October 29, 2015
    Applicants: Siemens Corporation, Yale University
    Inventors: Jingjing Kanik, Puneet Sharma, Tommaso Mansi, Razvan Ionasec, Ali Kamen, Dorin Comaniciu, James S. Duncan
  • METHOD FOR A GAN VERTICAL MICROCAVITY SURFACE EMITTING LASER (VCSEL)
    Publication number: 20150303655
    Abstract: Methods and structures for forming vertical-cavity light-emitting devices are described. An n-side or bottom-side layer may be laterally etched to form a porous semiconductor region and converted to a porous oxide. The porous oxide can provide a current-blocking and guiding layer that aids in directing bias current through an active area of the light-emitting device. Distributed Bragg reflectors may be fabricated on both sides of the active region to form a vertical-cavity surface-emitting laser. The light-emitting devices may be formed from III-nitride materials.
    Type: Application
    Filed: April 15, 2015
    Publication date: October 22, 2015
    Applicant: Yale University
    Inventors: Jung Han, Chia-Feng Lin, Danti Chen
  • High flux thin-film composite forward osmosis and pressure-retarded osmosis membranes
    Patent number: 9156006
    Abstract: One aspect of the invention relates to customized thin-film composite membranes comprising: a porous support; a selective barrier; and one or more polymeric additives dispersed in the porous support in an amount from at least about 1% and about 50% by weight of the porous support. Another aspect of the invention relates to a method of fabricating a porous support comprising the steps of: preparing a polymer solution comprising a polymer, a polymeric additive, and a first liquid; contacting a surface with the polymer solution; and evaporating the liquid. Another aspect of the invention relates to the use of the thin-film composite membranes disclosed herein in osmotically driven membrane processes.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: October 13, 2015
    Assignee: Yale University
    Inventors: Ngai Yin Yip, William Anthony Phillip, Jessica Deborah Schiffman, Menachem Elimelech
  • Systems and methods for sketching and imaging
    Patent number: 9153062
    Abstract: A method, a system, and a computer program product for generating a three-dimensional representation of a scene within a three-dimensional space are disclosed. A plurality of two-dimensional planes to be positioned within the three-dimensional space are generated. The plurality of two dimensional planes include two-dimensional content that is capable of being modified. The generated two-dimensional planes are positioned within the three-dimensional space. The positioning of the planes is capable of being modified.
    Type: Grant
    Filed: December 4, 2012
    Date of Patent: October 6, 2015
    Assignee: Yale University
    Inventors: Julie Dorsey, Patrick Paczkowski, Andreas Kalpakci, Michael Nestler
  • Systems and methods for sketching designs in context
    Patent number: 9149309
    Abstract: A method, a system, and a computer program product for graphically representing physical objects in a contextual setting are disclosed. A first data for a predetermined location, at least one distance measurement between at least two location points at the predetermined location, and at least one image of at least one portion of the predetermined location can be received. Based on the receiving and information obtained from at least one publicly available resource, a spatial representation of the predetermined location configured to include at least one existing feature can be generated. Spatial representation of the predetermined location includes a detailed representation of the at least one portion of the predetermined location having the at least one existing feature.
    Type: Grant
    Filed: July 18, 2012
    Date of Patent: October 6, 2015
    Assignee: Yale University
    Inventors: Patrick Paczkowski, Julie Dorsey, Min Hyuk Kim, Holly Rushmeier
  • Identification of Small Molecule Inhibitors of Jumonji AT-Rich Interactive Domain 1A (JARID1A) and 1B (JARID1B) Histone Demethylase
    Publication number: 20150272939
    Abstract: The present invention includes a novel high-throughput screen capable of identifying compounds that inhibit JARID1B demethylase activity or JARID1A demethylase activity. The present invention further includes novel inhibitors of JARID1B demethylase activity and/or JARID1A demethylase activity, and methods using the same.
    Type: Application
    Filed: October 2, 2013
    Publication date: October 1, 2015
    Applicant: Yale University
    Inventors: Qin Yan, Joyce Sayegh
  • HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION
    Publication number: 20150274738
    Abstract: Provided are bifunctional small molecules of Formula (I): or pharmaceutically acceptable salts thereof, wherein M represents a small organic molecule which binds, covalently or non-covalently, a kinase, such as Her3 protein kinase; L1 represents a linker; and RH represents a hydrophobic group. An example of a compound of Formula (I) is a compound of Formula (II): Also provided are pharmaceutical compositions comprising a compound of Formula (I) or (II) and methods of using such compounds for treating proliferative diseases.
    Type: Application
    Filed: October 18, 2013
    Publication date: October 1, 2015
    Applicants: Dana-Farber Cancer, Institute, Inc., Yale University
    Inventors: Nathanael Gray, Ting Xie, Sang Min Lim, Pasi A. Janne, Craig M. Crews
  • Compositions and methods of preventing or ameliorating abnormal thrombus formation and cardiovascular disease
    Patent number: 9132191
    Abstract: The invention includes compositions and methods useful for treating preventing abnormal thrombus formation and subsequent cardiovascular disease in diabetic patients and patients with increased cardiovascular risk.
    Type: Grant
    Filed: June 5, 2012
    Date of Patent: September 15, 2015
    Assignee: Yale University
    Inventors: John Hwa, WaiHo Tang
  • WIRELESS JOSEPHSON BIFURCATION AMPLIFIER
    Publication number: 20150241481
    Abstract: A wireless Josephson-junction-based amplifier is described that provides improved tunability and increased control over both a quality factor Q and participation ratio p of the amplifier. The device may be fabricated on a chip and mounted in a waveguide. No wire bonding between the amplifier and coaxial cables or a printed circuit board is needed. At least one antenna on the chip may be used to couple energy between the waveguide and wireless JBA. The amplifier is capable of gains greater than 25 dB.
    Type: Application
    Filed: February 20, 2015
    Publication date: August 27, 2015
    Applicant: Yale University
    Inventors: Anirudh Narla, Katrina Sliwa, Michael Hatridge, Shyam Shankar, Luigi Frunzio, Robert J. Schoelkopf, III, Michel Devoret
  • Osmotic heat engine
    Patent number: 9115701
    Abstract: A method of converting thermal energy into mechanical work that uses a semi-permeable membrane to convert osmotic pressure into electrical power. A closed cycle pressure-retarded osmosis (PRO) process known as an osmotic heat engine (OHE) uses a concentrated ammonia-carbon dioxide draw solution to create high osmotic pressures which generate water flux through a semi-permeable membrane against a hydraulic pressure gradient. The depressurization of the increased draw solution volume in a turbine produces electrical power. The process is maintained in steady state operation through the separation of the diluted draw solution into a re-concentrated draw solution and deionized water working fluid, both for reuse in the osmotic heat engine.
    Type: Grant
    Filed: August 13, 2013
    Date of Patent: August 25, 2015
    Assignee: Yale University
    Inventors: Robert L. McGinnis, Menachem Elimelech, Jeffrey McCutcheon
  • IDENTIFICATION OF CANCER PROTEIN BIOMARKERS USING PROTEOMIC TECHNIQUES
    Publication number: 20150233929
    Abstract: The claimed invention describes methods to diagnose or aid in the diagnosis of cancer. The claimed methods are based on the identification of biomarkers which are particularly well suited to discriminate between cancer subjects and healthy subjects. These biomarkers were identified using a unique and novel screening method described herein. The biomarkers identified herein can also be used in the prognosis and monitoring of cancer. The invention comprises the use of leptin, prolactin, OPN and IGF-II for diagnosing, prognosis and monitoring of ovarian cancer.
    Type: Application
    Filed: January 22, 2015
    Publication date: August 20, 2015
    Applicant: Yale University
    Inventors: Gil G. Mor, David C. Ward, Patricia Bray-Ward
  • Defined culture conditions of human embryonic stem cells
    Patent number: 9101590
    Abstract: The present invention relates to compositions and methods for culturing stem cells, particularly embryonic stem cells. Specifically, the invention relates to a culture medium that supports proliferation of substantially undifferentiated stem cells, while maintaining potency of the cells. An an embodiment, the culture medium is defined and supports proliferation of substantially undifferentiated embryonic stem cells in essentially serum free and feeder cell free conditions. Compositions for making the medium and methods using the culture medium are also provided.
    Type: Grant
    Filed: July 28, 2006
    Date of Patent: August 11, 2015
    Assignee: Yale University
    Inventors: Michael P. Snyder, Joyce J. Lu