Patents Assigned to Yale University
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Patent number: 8868773Abstract: A method, system and computer program product for efficiently distributing video content. A peer-to-peer network and a content distribution network are used in combination to distribute video content. A content distribution network relies on servers distributed across the Internet to achieve high quality content delivery at a high cost. A peer-to-peer network distributes content among peers without incurring server side cost but may experience poor performance. The peer-to-peer network and the content distribution network are leveraged in a manner that achieves high content delivery and low cost by allowing the peer-to-peer network to serve as much content as possible while using the content distribution network to bootstrap the content in the peer-to-peer network and using it as a fallback whenever the peer-to-peer network has insufficient bandwidth, insufficient quality or when the missing piece of video content in the video buffer of the client device has an immediate deadline.Type: GrantFiled: January 15, 2013Date of Patent: October 21, 2014Assignees: SplendorStream, LLC, Yale UniversityInventors: Yin Zhang, Lili Qiu, Yang Richard Yang
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Patent number: 8859509Abstract: The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.Type: GrantFiled: May 13, 2009Date of Patent: October 14, 2014Assignee: Yale UniversityInventors: David Spiegel, Ryan Murelli, Andrew Zhang
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Patent number: 8859229Abstract: A method of mRNA production for use in transfection is provided, that involves in vitro transcription of PCR generated templates. This RNA can efficiently transfect different kinds of cells. This approach results in increased efficiency (fidelity and productivity) of mRNA synthesis and is less time consuming because it does not require cloning, and also consequently eliminates the unwanted errors and effects related to RNA made on DNA templates obtained with cloning techniques. The results of transfection of RNAs demonstrate that RNA transfection can be very effective in cells that are exceedingly difficult to transfect efficiently with DNA constructs. The method can be used to deliver genes into cells not- or only poorly transfectable for DNA, in vitro and in vivo.Type: GrantFiled: February 4, 2008Date of Patent: October 14, 2014Assignee: Yale UniversityInventors: Peter M. Rabinovich, Sherman M. Weissman, Marina E. Komarovskaya, Erkut Bahceci
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Publication number: 20140302523Abstract: The present invention includes compounds that are useful in perturbing or disrupting the function of a transmembrane or intracellular protein, whereby binding of a compound to the transmembrane or intracellular protein induces proteasomal degradation of the transmembrane or intracellular protein. The present invention further includes a method of inducing proteasomal degradation of a transmembrane or intracellular protein. The present invention further includes a method of identifying or validating a protein of interest as a therapeutic target for treatment of a disease state or condition.Type: ApplicationFiled: December 6, 2011Publication date: October 9, 2014Applicant: Yale UniversityInventors: Craig M. Crews, Hyun Seop Tae, Ashley R. Schneekloth, Taavi Neklesa, Thomas Sundberg
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Patent number: 8852240Abstract: A method for augmenting bone in a subject in need thereof including installing within an interior portion of a bone located in the subject a sufficient amount of a biocompatible material to form a scaffold within the bone interior, wherein the scaffold serves as a support for the formation of new bone within the bone interior portion, and administering to the subject a sufficient amount of at least one bone augmentation agent to elevate blood concentration of at least one anabolic agent in the subject. The method may further include administering at least one anti-resorptive agent to the subject in an amount sufficient to substantially prevent resorption of new bone growth. In another embodiment, the method may further include a step of mechanically inducing an increase in osteoblast activity in the subject, wherein the elevation in blood concentration of the anabolic agent and the increase in osteoblast activity at least partially overlap in time.Type: GrantFiled: April 27, 2007Date of Patent: October 7, 2014Assignees: Kieran Murphy, LLC, Yale UniversityInventors: Agnès Vignery, Nozer M. Mehta, James P. Gilligan, Kieran P. Murphy
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Patent number: 8852630Abstract: The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.Type: GrantFiled: June 30, 2011Date of Patent: October 7, 2014Assignee: Yale UniversityInventors: David Spiegel, Ryan Murelli, Andrew Zhang
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Patent number: 8850497Abstract: A method, system and computer program product for efficiently distributing video content. A peer-to-peer network and a content distribution network are used in combination to distribute video content. A content distribution network relies on servers distributed across the Internet to achieve high quality content delivery at a high cost. A peer-to-peer network distributes content among peers without incurring server side cost but may experience poor performance. The peer-to-peer network and the content distribution network are leveraged in a manner that achieves high content delivery and low cost by allowing the peer-to-peer network to serve as much content as possible while using the content distribution network to bootstrap the content in the peer-to-peer network and using it as a fallback whenever the peer-to-peer network has insufficient bandwidth, insufficient quality or when the missing piece of video content in the video buffer of the client device has an immediate deadline.Type: GrantFiled: January 15, 2013Date of Patent: September 30, 2014Assignees: SplendorStream, LLC, Yale UniversityInventors: Yin Zhang, Lili Qiu, Yang Richard Yang
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Patent number: 8846081Abstract: The present application relates to compositions comprising and methods of using a liposome comprising a pHLIP polypeptide, wherein a lipid bilayer of the liposome is substantially free of the pHLIP polypeptide.Type: GrantFiled: August 12, 2011Date of Patent: September 30, 2014Assignees: Rhode Island Board of Governors for Higher Education, Yale UniversityInventors: Yana K. Reshetnyak, Oleg A. Andreev, Donald M. Engelman
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Patent number: 8847004Abstract: Genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein are provided. Also provided are genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein that have been engrafted with human cells such as human hematopoietic cells, and methods for making such engrafted mice. These mice find use in a number of applications, such as in modeling human immune disease and pathogen infection; in in vivo screens for agents that modulate hematopoietic cell development and/or activity, e.g. in a healthy or a diseased state; in in vivo screens for agents that are toxic to hematopoietic cells; in in vivo screens for agents that prevent against, mitigate, or reverse the toxic effects of toxic agents on hematopoietic cells; in in vivo screens of human hematopoietic cells from an individual to predict the responsiveness of an individual to a disease therapy, etc.Type: GrantFiled: February 14, 2012Date of Patent: September 30, 2014Assignees: Regeneron Pharmaceuticals, Inc., Yale University, Institute for Research in Biomedicine (IRB)Inventors: Andrew J. Murphy, Sean Stevens, Chozhavendan Rathinam, Elizabeth Eynon, Markus Manz, Richard Flavell, George D. Yancopoulos
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Publication number: 20140275727Abstract: The present invention provides devices, systems, and methods for control of ventricular assist devices. The invention includes an implantable controller that is operatively programmed to direct physiological flow through a ventricular assist device that is substantially synchronized to the cardiac cycle of the subject. The implantable controller is also communicatively connected to an external control unit, such that the implantable controller can transmit data to the external control unit, and instructions can be sent from the external control unit to the implantable controller.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicants: University of Washington through its Center for Commercialization, Yale UniversityInventors: Pramod Bonde, Siavash Asgari, Joshua Reynolds Smith, Ben Waters
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Publication number: 20140276304Abstract: The present invention relates to an impedance modulation device for an orthotic application. The device includes a high-stiffness loading spring, a low-stiffness return spring, a shaft having an output connector, and an engagement mechanism. When the engagement mechanism engages the shaft, the device exhibits a high stiffness at the output connector, and wherein when the engagement mechanism disengages the shaft, the device exhibits a low stiffness at the output connector.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicant: Yale UniversityInventors: Aaron Dollar, Shamaei Ghahfarokhi
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Publication number: 20140256821Abstract: Methods and compositions for the treatment of treatment-resistant depression are described. More specifically, the invention demonstrates that intranasal administration of ketamine is effective to ameliorate the symptoms of depression in a patient who has not responded to an adequate trial of one antidepressant in the current episode and has recurrent or chronic depressive symptoms (>2 years).Type: ApplicationFiled: March 5, 2014Publication date: September 11, 2014Applicants: Icahn School of Medicine at Mount Sinai, National Institute of Health, Yale University School of MedicineInventors: Dennis S. Charney, Sanjay J. Mathew, Husseini K. Manji, Carlos A. Zarate, John H. Krystal
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Patent number: 8827889Abstract: A ventricular assist device (VAD) system includes one or more external subsystems including an amplifier energizing a drive loop with alternating current, and a Tx resonator inductively coupled to the drive loop. An implanted subsystem includes a VAD, an Rx resonator that forms a magnetically coupled resonator with the Tx resonator, and a load loop for providing power to the VAD that is inductively coupled to the Rx resonator. A sensor monitors the drive loop and a controller uses the sensor data to adjust a system parameter to optimize energy transfer performance. Distributing a plurality of the external subsystems throughout a defined space provides a patient with freedom of movement within the defined space.Type: GrantFiled: March 15, 2013Date of Patent: September 9, 2014Assignees: University of Washington Through Its Center for Commercialization, Yale UniversityInventors: Joshua R. Smith, Pramod Bonde, Benjamin H. Waters, Alanson P. Sample
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Patent number: 8827891Abstract: A device that can be delivered into a body cavity to manipulate tissue intracorporeally while being controlled extracorporeally and a method of using the device to perform a single-port laparoscopic or natural orifice surgery. The device is being capable of being passed through an interior diameter of a single port into the body cavity. The device comprises an anchor or suspension element that is attachable or mountable to the tissue intracorporeally, a guide element attached to the anchor or suspension element that allows for manipulation of at least one structure in at least one direction, and at least one structure attached to a suture or thread that is passable through the interior diameter of the port and positionable by the guide element. The structure is controllable extracorporeally by manipulating the suture or thread so that the structure moves in at least one direction intracorporeally.Type: GrantFiled: August 8, 2008Date of Patent: September 9, 2014Assignee: Yale UniversityInventor: Kurt Eric Roberts
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Publication number: 20140249212Abstract: Compositions for transient but prolonged exogenous mRNA expression through the use of the transcription system of negative strand RNA viruses, and methods of use thereof are disclosed. In some embodiments, the system contains only RNAs and does not include any DNA molecules. The compositions typically include an RNA template unit (rTeUn) that includes a virus regulatory sequences operably linked to a coding sequence of interest. The rTeUn is typically transfected to a host cell's cytoplasm in the presence of virus expression system proteins that mediate replication of the rTeUn and transcription of the transgene. The rTeUn RNA bonded to viral proteins exhibits high resistance to degradation, prolonged duration of expression, and is free of viral genes. The compositions can be used to reprogram cell. For example, the compositions and methods can be used to redirected lymphocytes to target cancer cells, or to dedifferentiate somatic cells into induce pluripotent stem cells.Type: ApplicationFiled: September 27, 2012Publication date: September 4, 2014Applicant: Yale UniversityInventors: Peter M. Rabinovich, Sherman M. Weissman
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Patent number: 8822524Abstract: Disclosed herein is a species of peptide and non-peptide inhibitors of Akt, an oncogenic protein. Beginning with a residue of Akt target substrate GSK-3, the functional domains of the GSK-3 residue were characterized. Functionally homologous non-peptide groups were substituted for the amino acids of the GSK-3 creating a hybrid peptide-non-peptide and non-peptide compounds capable of binding to Akt. The non-peptide compounds show increased stability and rigidity compared to peptide counterparts and are less susceptible to degradation. The bound non-peptide compounds exhibit an inhibitory effect on Akt, similar to peptide-based Akt inhibitors.Type: GrantFiled: June 8, 2009Date of Patent: September 2, 2014Assignees: University of South Florida, Yale UniversityInventors: Said M. Sebti, Jin Q. Cheng, Andrew D. Hamilton, Katherine Kayser-Bricker
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Publication number: 20140238917Abstract: An energy efficient desalination process that does not produce waste products involves the extraction of water from a first solution, such as seawater, by using a second concentrated solution to draw the water from the first solution across a semi-permeable membrane. By manipulating the equilibrium of the soluble and insoluble species of solute within the second solution in favor of the soluble species of the solute, a saturated second solution can be used to generate osmotic pressure on the first solution. Also, by adjusting the equilibrium in favor of the less soluble species after the water has been drawn from the first solution, a portion of the solute can easily be precipitated out. Heating the second solution decomposes the solute into its constituent gases. The constituent gases and precipitated solute may be recycled through the process to affect the changes in equilibrium and eliminate waste products.Type: ApplicationFiled: May 2, 2014Publication date: August 28, 2014Applicant: Yale UniversityInventor: Robert L. McGinnis
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Publication number: 20140238574Abstract: A mold structure having high-precision multi-dimensional components includes: depositing an oxide layer on a top surface of a plurality of semiconductor substrates, patterning a design integrated in one or more of the oxide layers; repositioning the substrates to enable the oxide layers make contact with one another; bonding in sequential order the repositioned substrates using a dielectric bonding, forming a three dimension (3D) mold; filling the 3D mold with filling material and removing the overburden filling material present on a top surface of the component.Type: ApplicationFiled: February 27, 2013Publication date: August 28, 2014Applicants: Yale University, International Business Machines CorporationInventors: Emily R. Kinser, Jan Schroers, Golden Kumar
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Patent number: 8815091Abstract: A spiral wound membrane module for forward osmotic use is disclosed. The membrane module may generally include a forward osmosis membrane in a spiral wound configuration. The module may include two inlets and two outlets, and may define first and second fluid flow paths. The inlets to each of the fluid flow paths may be generally isolated so as to prevent mixing. In some embodiments, the membrane module may include a distributer region and a collector region.Type: GrantFiled: March 20, 2009Date of Patent: August 26, 2014Assignee: Yale UniversityInventor: Robert L. McGinnis
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Publication number: 20140235507Abstract: The present invention relates to protein chips useful for the large-scale study of protein function where the chip contains densely packed reaction wells. The invention also relates to methods of using protein chips to assay simultaneously the presence, amount, and/or function of proteins present in a protein sample or on one protein chip, or to assay the presence, relative specificity, and binding affinity of each probe in a mixture of probes for each of the proteins on the chip. The invention also relates to methods of using the protein chips for high density and small volume chemical reactions. Also, the invention relates to polymers useful as protein chip substrates and methods of making protein chips. The invention further relates to compounds useful for the derivatization of protein chip substrates.Type: ApplicationFiled: March 15, 2013Publication date: August 21, 2014Applicant: Yale UniversityInventors: Michael Snyder, Mark Reed, Heng Zhu, James Frank Klemic