Abstract: The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are compounds that inhibit Rho-protein associated kinase function. Compounds of the invention include piperazinyl pyridines, piperazinylmethyl pyridines, piperazinyl ureas and carbamates, piperazinyl pyridines and quinoilines (including isoquinliones) as well as piperazinyl (including piperazinylmethyl) pyridines and quinolines (including isoquinolines). Compounds of the invention disrupt Rho-kinase activation and function and significantly inhibit tumor cell growth and induce tumor cell death.
Type:
Grant
Filed:
June 22, 2009
Date of Patent:
March 31, 2015
Assignees:
University of South Florida, Yale University
Abstract: The claimed invention describes methods to diagnose or aid in the diagnosis of cancer. The claimed methods are based on the identification of biomarkers which are particularly well suited to discriminate between cancer subjects and healthy subjects. These biomarkers were identified using a unique and novel screening method described herein. The biomarkers identified herein can also be used in the prognosis and monitoring of cancer. The invention comprises the use of leptin, prolactin, OPN and IGF-II for diagnosing, prognosis and monitoring of ovarian cancer.
Type:
Grant
Filed:
December 22, 2009
Date of Patent:
March 10, 2015
Assignee:
Yale University
Inventors:
Gil G. Mor, David C. Ward, Patricia Bray-Ward
Abstract: The present invention provides a mutant 27 kDa NIa proteinase having reduced self-cleavage activity relative to the self-cleavage activity of its wild-type proteinase. The mutant has the same substrate cleavage activity as the wild-type proteinase but is more stable than the wild-type proteinase. The present invention also provides a method of obtaining large quantities of active 27 kDa NIa proteinase for use as a tool for purification of other proteins.
Type:
Grant
Filed:
May 21, 2013
Date of Patent:
March 3, 2015
Assignee:
Yale University
Inventors:
Jennifer A. Doudna, Louise J. Lucast, Robert T. Batey
Abstract: A device for separating a sample of cells suspended in a bio-compatible ferrofluid is described. The device includes a microfluidic channel having a sample inlet, at least one outlet and a length between the same inlet and the at least one outlet, wherein a sample can be added to the sample inlet and flow along the microfluidic channel length to the at least one outlet. The device includes a plurality of electrodes and a power source for applying a current to the plurality of electrodes to create a magnetic field pattern along the microfluidic channel length. The present invention also includes a method of using said device for separating at least one cell type.
Abstract: Disclosed are compositions and methods for antimicrobial use. The compositions contain a small antimicrobial agent and a permeabilizing agent. The antimicrobial compositions can be antifungal or antibacterial compositions.
Abstract: The invention provides, in some embodiments, methods relating to assessing increased risk of developing atrial fibrillation (AF), and/or the likelihood of responding to particular AF therapies using imaging agents comprising an MMP inhibitor linked to an imaging moiety. The invention further provides methods for evaluating the presence of the risk of developing other cardiovascular conditions and assessing the effectiveness of treatment or other intervention for such conditions by determining MMP levels.
Type:
Application
Filed:
October 31, 2012
Publication date:
January 22, 2015
Applicants:
Lantheus Medical Imaging, Inc., Yale University
Inventors:
Albert J. Sinusas, Joseph G. Akar, Richard R. Cesati, Heike S. Radeke, Stephen B. Haber
Abstract: System, method, and computer program product for processing data are disclosed. The method includes receiving a query for processing of data, wherein the data is stored in a table in a plurality of tables, wherein the table is stored on at least one node within the database system, determining an attribute of the table and another table in the plurality of tables, partitioning one of the table and the another table in the plurality of tables using the determined attribute into a plurality of partitions, and performing a join of at least two partitions of the table and the another table using the determined attribute. The join is performed on a single node in the database system.
Abstract: The present invention relates to the discovery that the disruption of inflammasome function leads to an altered microbiota that affects the development and progression of inflammatory diseases and disorders. Thus, the invention relates to compositions and methods for detecting and determining the relative proportions of the constituents of a subject's microbiota, methods of modifying an altered microbiota population in a subject, and compositions and methods for treating inflammatory diseases and disorders in a subject in need thereof.
Type:
Application
Filed:
April 16, 2012
Publication date:
December 25, 2014
Applicant:
Yale University
Inventors:
Eran Elinav, Richard A. Flavell, Till Strowig, Jorge H. Mejia, Chengcheng Jin
Abstract: A very low pressure gas or blow forming process for shaping a bulk metallic glass (BMG) in its supercooled liquid state that avoids the fractional stick forces experienced by conventional shaping techniques by engineering the expansion of a pre-shape or parison of BMG material such that substantially all of the lateral strain required to form the final article is accomplished prior to the outer surface of the parison contacting the surface of the shaping apparatus is provided. The capability offered by the inventive shaping process to avoid the frictional forces exerted by the shaping apparatus surface allows for the formation of precision net-shape complex multi-scale parts and components using processing conditions inaccessible by conventional processes.
Abstract: Systems and methods for rapidly analyzing cell containing samples, for example to identify morphology or to localize and quantitate biomarkers are disclosed.
Abstract: The present invention provides compositions and methods for treating and preventing an A?-modulated disease. In certain embodiments, the invention provides an inhibitor of Fyn tyrosine kinase, and methods of using the same. In certain embodiments, the inhibitor of the invention inhibits A? oligomer induced signaling and reduces or halts the progression of Alzheimer's Disease.
Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
Type:
Grant
Filed:
June 21, 2013
Date of Patent:
December 16, 2014
Assignees:
Melinta Therapeutics, Inc., Yale University
Inventors:
Thomas A. Steitz, Peter B. Moore, Joyce A. Sutcliffe, Adegboyega K. Oyelere, Joseph A. Ippolito
Abstract: A computationally feasible encoding and decoding arrangement and method for transmission of data over an additive white Gaussian noise channel with average codeword power constraint employs sparse superposition codes. The code words are linear combinations of subsets of vectors from a given dictionary, with the possible messages indexed by the choice of subset. An adaptive successive decoder is shown to be reliable with error probability exponentially small for all rates below the Shannon capacity.
Abstract: Modular nanoparticle vaccine compositions and methods of making and using the same have been developed. Modular nanoparticle vaccine compositions comprise an antigen encapsulated in a polymeric particle and adaptor elements which modularly couple functional elements to the particle. The modular design of these vaccine compositions, which involves flexible addition and subtraction of antigen, adjuvant, immune potentiators, molecular recognition and transport mediation elements, as well as intracellular uptake mediators, allows for exquisite control over variables that are important in optimizing an effective vaccine delivery system.
Type:
Grant
Filed:
February 15, 2008
Date of Patent:
November 18, 2014
Assignee:
Yale University
Inventors:
Ira S. Mellman, Tarek M. Fahmy, William Mark Saltzman, Michael J. Caplan
Abstract: The present invention relates to mass spectrometry and infrared spectrometry and in particular, to a method of providing highly resolved infrared spectra of mass-selected, complex (e.g., biopolymer, polypeptide, organic chemical, an organometallic compound, a carbohydrate, a polynucleotide or oligonucleotide compound) ions to be obtained in a general fashion.
Type:
Grant
Filed:
October 11, 2011
Date of Patent:
November 18, 2014
Assignee:
Yale University
Inventors:
Mark A. Johnson, Michael Z. Kamrath, Etienne Garand
Abstract: The present invention relates to systems and methods for in situ inspection, interrogation, and maintenance of heart pump function in subjects with an implanted heart pump. In certain embodiments, the system comprises a catheter assembly deliverable to the inflow port and outflow port of the implanted heart pump. The system comprises additional components used to examine pump function and prevent malfunction. In certain embodiments, the invention allows for temporary, mid-term, or permanent exclusion of the implanted heart pump from cardiac function without surgically removing the pump.
Abstract: System, method and computer program product for processing a query are disclosed. Query processing includes partitioning the stored data into a plurality of partitions based on at least one vertex in the plurality of vertexes, storing at least another triple in the plurality of triples on the at least one node, assigning, based on the triple containing the at least one vertex, at least one partition in the plurality of partitions corresponding to the triple to at least one node in the plurality of nodes, and processing, based on the assigning, the query by processing the plurality of partitions.
Abstract: This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of cancer by administering the herbal composition PHY906 in combination with one or more chemotherapeutic compounds to a mammal undergoing such chemotherapy.
Type:
Grant
Filed:
June 10, 2009
Date of Patent:
October 28, 2014
Assignee:
Yale University
Inventors:
Yung-Chi Cheng, Shwu-Huey Liu, Zaoli Jiang, Robert Tilton
Abstract: The present invention provides methods and compositions related to the detection and/or monitoring of the levels of angiogenic factors, specifically VEGF, PlGF and sFlt-1, in urine samples obtained from pregnant women and the effects of such levels on the risk of developing complications of pregnancy, including hypertensive disorders such as preeclampsia, in the first, second, and/or third trimester of pregnancy. The present invention also provides kits for identifying and screening patients at risk of developing a complication of pregnancy, such as preeclampsia.
Type:
Grant
Filed:
March 21, 2011
Date of Patent:
October 28, 2014
Assignee:
Yale University
Inventors:
Catalin S. Buhimschi, Irina Buhimschi, Errol Norwitz
Abstract: The present invention encompasses methods, assays and kits for the diagnosis, screening and identification of Turner syndrome and other disorders of sexual differentiation in a human using single nucleotide polymorphisms present on the X and Y chromosomes.