Patents Assigned to Zaidan Hojin
  • Apparatus for growing GaAs single crystal by using floating zone
    Patent number: 4619811
    Abstract: An apparatus for growing a GaAs single crystal by relying on the floating zone technique in a cylinder charged with a GaAs polycrystal and a GaAs single seed crystal, comprising an As container communicating with the interior of the cylinder to supply an optimum vapor pressure of As into the cylinder under the condition that a continuous temperature variation is established between this As container and the GaAs crystals charged in the cylinder, whereby a GaAs single crystal having little deviation from stoichiometry and having a good crystal perfection is obtained.
    Type: Grant
    Filed: September 17, 1985
    Date of Patent: October 28, 1986
    Assignee: Zaidan Hojin Handotai Kenkyu Shinkokai
    Inventor: Jun-ichi Nishizawa
  • Semiconductor device having non-saturating I-V characteristics and integrated circuit structure including same
    Patent number: 4608582
    Abstract: The new kind of field effect transistor having a non-saturating characteristic, i.e. static induction transistor (SIT), proposed by the present inventor is modified to serve as a substitute of any conventional bipolar transistor in a given circuitry. That is, the gate-to-gate distance and the impurity concentration of the channel region of an SIT are so selected that the channel is pinched off by the depletion layer at a predetermined forward gate bias. When the forward gate bias applied is below a certain level, the drain current will increase fundamentally exponentially with an increase of the drain voltage above some threshold voltage, whereas when the gate bias applied is above the certain value, the drain current will increase rapidly with a small increase in the drain voltage.
    Type: Grant
    Filed: July 20, 1983
    Date of Patent: August 26, 1986
    Assignee: Zaidan Hojin Handotai Kenkyu Shinkokai
    Inventor: Jun-ichi Nishizawa
  • Physiologically active substance, arphamenine and production thereof
    Patent number: 4595698
    Abstract: New physiologically active substances, arphamenine A and arphamenine B which are generically termed arphamenine are produced from a new microorganism, BMG361-CF4 strain identified as FERM P-6521 or FERM BP-286 or ATCC No. 39373. Arphamenine is useful as a host defence stimulator having an activity to enhance cell-mediated immunity, and also as an anti-tumor agent.
    Type: Grant
    Filed: June 2, 1983
    Date of Patent: June 17, 1986
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Hamao Umezawa, Takaaki Aoyagi, Tomio Takeuchi, Masa Hamada, Masaaki Ishizuka
  • 23-C-Substituted mycaminosyl tylonolide, pharmaceutical compositions and method of use
    Patent number: 4576931
    Abstract: Novel 23-C-substituted mycaminosyl tylonolide of the general formula (I) ##STR1## wherein R.sup.1 represents a lower alkyl group, an aryl group, a lower alkenyl group or a lower alkynyl group, R.sup.2 represents a hydrogen atom or a hydroxyl group.These compounds have excellent antibacterial activities.
    Type: Grant
    Filed: April 3, 1985
    Date of Patent: March 18, 1986
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai (Microbial Chemistry Research Foundation)
    Inventors: Hamao Umezawa, Sumio Umezawa, Tsutomu Tsuchiya, Tomio Takeuchi, Akihiro Tanaka, Shuichi Sakamoto
  • Method and apparatus for performing epitaxial growth of ZnSe crystal from a melt thereof
    Patent number: 4572763
    Abstract: In conducting a liquid phase epitaxial growth of a Zn crystal on a substrate wherein a batch of Se melt serving as a solvent is used and relying on a vapor pressure controlling technique and a temperature difference method, a Zn vapor pressure controlling region is disposed, via the Se melt, in a direction vertical to the surface of the substrate which is contained in the growth region, and a ZnSe source crystal is disposed in such a way that it is supplied into the Se melt in a lateral direction of this melt. Whereby, a ZnSe single crystal having a good crystal perfection, and a good linearity of the thickness of the grown crystal relative to time can be obtained.
    Type: Grant
    Filed: July 13, 1983
    Date of Patent: February 25, 1986
    Assignee: Zaidan Hojin Handotai Kenkyu Shinkokai
    Inventor: Jun-ichi Nishizawa
  • Far-infrared electromagnetic wave generator
    Patent number: 4571727
    Abstract: A far-infrared electromagnetic wave generator comprises a semiconductor containing at least one impurity which has an energy difference, close to a quantum energy of optical phonon, between its transition levels; a resonator having two reflectors for effecting positive feedback of an electromagnetic wave corresponding to the quantum energy; and means for applying an electric current across the semiconductor. The semiconductor may have p-i, n-i, p-i-n, p-n, or n-p.sup.- junction. One of the reflectors of the resonator may have a diffraction grating so that the wavelength of the electromagnetic wave to be generated can be varied by adjusting an angle of the diffraction grating.
    Type: Grant
    Filed: August 9, 1983
    Date of Patent: February 18, 1986
    Assignee: Zaidan Hojin Handotai Kenkyu Shinkokai
    Inventors: Jun-ichi Nishizawa, Ken Suto
  • Aminopropylaminobleomycin derivatives and process for preparation thereof
    Patent number: 4568490
    Abstract: An aminopropylaminobleomycin represented by the following formula or a salt thereof, which is minimized in side effects such as pulmonary toxicity:[BX]--NH--(CH.sub.2).sub.3 --A--)CH.sub.2).sub.3 --Bwherein[BX] represents the acyl group of bleomycinic acid whose formula differs from that of bleomycin acid by the removal of the hydroxyl group from the carboxyl group of said acid;A represents a group of the general formula ##STR1## wherein R.sub.1 is a lower alkyl or benzyl,R.sub.2 is a lower alkyl or benzyl,R is a lower alkylene, andn is 0 or 1; andB represents a group of the formula ##STR2## wherein (i) R.sub.3 is hydrogen and R.sub.4 is(a) benzyl substituted by one or more halogen atoms, provided that the benzyl is substituted by two halogen atoms when R.sub.
    Type: Grant
    Filed: June 12, 1985
    Date of Patent: February 4, 1986
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Hamao Umezawa, Akio Fujii, Yasuhiko Muraoka, Tokuji Nakatani, Takeyo Fukuoka, Katsutoshi Takahashi
  • N-Methanesulfonic acid derivatives of 3-demethoxyistamycin B
    Patent number: 4567165
    Abstract: As new semi-synthetic antibiotic derivatives are provided N-methanesulfonic acid derivatives of 3-demethoxyistamycin B which are less toxic than the parent 3-demethoxyistamycin B but retain usefully high antibacterial activity of the parent antibiotic. The new derivatives are produced by a method of N-sulfomethylation where 3-demethoxyistamycin B is reacted with an aldehyde such as paraformaldehyde and sulfurous acid or sulfite reagent.
    Type: Grant
    Filed: May 8, 1984
    Date of Patent: January 28, 1986
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Hamao Umezawa, Shinichi Kondo
  • Apparatus for performing solution growth relying on temperature difference technique
    Patent number: 4565156
    Abstract: A solution growth apparatus for conducting an epitaxial growth of a compound semiconductor crystal from solution by relying on the temperature difference technique at a constant growth temperature and on a mass production scale without deranging the control of the growth temperature applied externally of the growth apparatus and with the application of only a small heating power and only a small cooling power, by enhancing the thermal exchange efficiency through the provision of heating means, via an insulator, for the melt-containing reservoir provided on the growth boat housed within a quartz reactor and by the provision of cooling means at the bottom of the boat within the reactor.
    Type: Grant
    Filed: February 28, 1983
    Date of Patent: January 21, 1986
    Assignee: Zaidan Hojin Handotai Kenkyu Shinkokai
    Inventors: Jun-ichi Nishizawa, Yasuo Okuno
  • Immunopotentiator
    Patent number: 4559362
    Abstract: This invention relates to an immunopotentiator or an immunopotentiating method using spermidine or its pharmacologically acceptable salt as an active ingredient.
    Type: Grant
    Filed: November 9, 1983
    Date of Patent: December 17, 1985
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Hamao Umezawa, Tomio Takeuchi, Masaaki Ishizuka
  • Spergualin-related compounds having a phenylene group as well as a process for producing the same
    Patent number: 4556735
    Abstract: The invention relates to Spergualin-related compounds of the formula: ##STR1## (wherein R.sub.1 is a lower alkylene group which may be substituted by a hydroxymethyl group; X is a hydrogen atom or a halogen atom; m and n are each 0 or an integer of 1 to 5) and salts thereof and a process for producing the same.
    Type: Grant
    Filed: February 27, 1985
    Date of Patent: December 3, 1985
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyukai
    Inventors: Hamao Umezawa, Tomio Takeuchi, Rinzo Nishizawa, Katsutoshi Takahashi, Teruya Nakamura, Yoshihisa Umeda
  • 1-N-(.omega.-Amino-.alpha.-hydroxyalkanoyl-2',3'-dideoxykanamycin A and pharmaceutical composition containing same
    Patent number: 4547492
    Abstract: 1-N-(L-3-amino-2-hydroxypropionyl)-2',-3'-dideoxykanamycin A and 1-N-(L-4-amino-2-hydroxybutyryl)-2',3'-dideoxykanamycin A are now provided which each is a new compound useful as antibacterial agent. The new compounds each is produced by acylating the 1-amino group of 2',3'-dideoxykanamycin A with L-3-amino-2-hydroxypropionic or L-4-amino-2-hydroxybutyric acid.
    Type: Grant
    Filed: August 10, 1984
    Date of Patent: October 15, 1985
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Hamao Umezawa, Sumio Umezawa, Tsutomu Tsuchiya, Toshio Yoneta, Shunzo Fukatsu
  • Derivatives of 4'-demethyl-4-epipodophyllotoxin
    Patent number: 4547567
    Abstract: This invention relates to novel 4'-demethyl-4-epipodophyllotoxin derivatives represented by the general formula (I), and salts thereof: ##STR1## wherein R is a lower alkyl group, and X.sub.1 and X.sub.2 are independently a hydroxyl group or an amino group, the one being an amino group and the other being a hydroxyl group. These novel derivatives have a high carcinostatic activity and a relatively high water solubility and hence are expected to be useful as carcinostatics.
    Type: Grant
    Filed: July 18, 1984
    Date of Patent: October 15, 1985
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Hamao Umezawa, Tomio Takeuchi, Shinichi Kondo, Wataru Tanaka, Tomohisa Takita, Yoshio Nishimura, Hiroshi Yoshikawa
  • Aminopropylaminobleomycin derivatives and process for preparation thereof
    Patent number: 4537880
    Abstract: An aminopropylaminobleomycin represented by the following formula or a salt thereof, which is minimized in side effects such as pulmonary toxicity:[BX]--NH--(CH.sub.2).sub.3 --A--(CH.sub.2).sub.3 --Bwherein[BX] represents the acyl group of bleomycinic acid whose formula differs from that of bleomycin acid by the removal of the hydroxyl group from the carboxyl group of said acid;A represents a group of the general formula ##STR1## wherein R.sub.1 is a lower alkyl or benzyl,R.sub.2 is a lower alkyl or benzyl,R is a lower alkylene, andn is 0 or 1; andB represents a group of the formula ##STR2## wherein (i) R.sub.3 is hydrogen and R.sub.4 is(a) benzyl substituted by one or more halogen atoms, provided that the benzyl is substituted by two halogen atoms when R.sub.
    Type: Grant
    Filed: July 27, 1984
    Date of Patent: August 27, 1985
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Hamao Umezawa, Akio Fujii, Yasuhiko Muraoka, Tokuji Nakatani, Takeyo Fukuoka, Katsutoshi Takahashi
  • 2'-Deoxyoxanosine
    Patent number: 4530998
    Abstract: This invention relates to 2'-deoxy-oxanosine represented by the following formula: ##STR1## and process for the preparation thereof. This new compound exhibits a growth inhibiting action to gram-negative bacteria and has a carcinostatic action.
    Type: Grant
    Filed: March 5, 1984
    Date of Patent: July 23, 1985
    Assignee: Zaidan Hojin Biseibutsu Kagaku KenkyuKai
    Inventors: Hamao Umezawa, Tomio Takeuchi, Masaaki Ishizuka, Tomohisa Takita, Nobuyoshi Shimada, Kuniki Kato
  • Spergualin-related compounds and process for the preparation thereof
    Patent number: 4529549
    Abstract: This invention relates to a novel spergualin-related compound and a process for the production thereof. The novel compound, which has a high antitumor activity, is represented by the general formula ##STR1## wherein R.sub.1 represents a hydrogen atom, hydroxyl group, or an aliphatic acyloxy group having 1 to 10 carbon atoms, R.sub.2 represents an amino acid residue (except for the residue of .alpha.-hydroxyglycine) formed by removing one hydrogen atom and hydroxyl group from respectively the .alpha.- or .omega.-amino group and the .alpha.-carboxyl group of an .alpha.- or .omega.-amino acid, said amino acid residue forming acid amide linkages with the adjacent carbonyl group and amino group, and m is an integer of 4 to 6.
    Type: Grant
    Filed: August 18, 1983
    Date of Patent: July 16, 1985
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Hamao Umezawa, Tomio Takeuchi, Rinzo Nishizawa, Katsutoshi Takahashi, Teruya Nakamura, Yoshihisa Umeda
  • (-)-15-Deoxyspergualin, process for the preparation thereof, and intermediate of the same
    Patent number: 4525299
    Abstract: (-)-15-Deoxyspergualin represented by the following formula ##STR1## a salt thereof having antitumor activity, process for the preparation thereof and intermediate thereof.
    Type: Grant
    Filed: May 10, 1983
    Date of Patent: June 25, 1985
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Hamao Umezawa, Tomio Takeuchi, Shinichi Kondo
  • N-[4-[(3-aminopropyl)amino]butyl]-2,2-dihydroxyethanamide
    Patent number: 4518802
    Abstract: N-[4-[(3-aminopropyl)amino]butyl]-2,2-dihydroxyethanamide is an immunostimulant in animals and an intermediate for synthesis of the antibiotic BMG162-aF2.
    Type: Grant
    Filed: February 27, 1984
    Date of Patent: May 21, 1985
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Hamao Umezawa, Tomio Takeuchi, Shinichi Kondo, Hironobu Iinuma, Daishiro Ikeda, Teruya Nakamura, Akio Fujii
  • N-[4-(3-aminopropyl)-aminobutyl]-2-(.omega.-gua nidino-fatty-acid-amido)-2-substituted-ethanamide and salt thereof
    Patent number: 4518532
    Abstract: N-[4-(3-Aminopropyl)aminobutyl]-2-(.omega.-guanidino-fatty acid-amido)-2-substituted-ethanamides represented by the general formula ##STR1## wherein Y represents --(CH.sub.2 --CH.sub.2 --, --CH.dbd.CH or ##STR2## R represents a hydrogen atom, an alkyl group of 1 to 4 carbon atoms which may have a hydroxyl group as substituent, or a benzyl group, and n is an integer of from 1 to 8, provided that when Y is ##STR3## and n is 4, R represents the groups other than the hydrogen atom; a salt thereof having antitumor activity in experimental animal tumors and a process for the preparation thereof is provided.
    Type: Grant
    Filed: September 29, 1982
    Date of Patent: May 21, 1985
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Hamao Umezawa, Tomio Takeuchi, Shinichi Kondo, Hironobu Iinuma, Daishiro Ikeda, Teruya Nakamura, Akio Fujii
  • Antihypertensive agents and process for producing the same
    Patent number: 4510161
    Abstract: An aqueous extract product which is effective for prevention or treatment of hypertension is produced by: concentrating an aqueous extract obtained by: extracting water-soluble components from vegetable oils such as soybean oil, corn oil, rapeseed oil and cotton seed oil; adding a lower alcohol to the resulting extract to prepare an alcoholic solution having an alcohol concentration above 85%, thereby precipitating the insoluble matter; then removing the precipitates; and thereafter removing the alcohol. A powdered product having an antihypertensive activity is also produced by: subjecting said aqueous extract product to an additional optional purification step and thereafter concentrating the resulting product to obtain a powder. An antihypertensive agent containing a novel substance OSG as an effective component is also disclosed.
    Type: Grant
    Filed: October 20, 1982
    Date of Patent: April 9, 1985
    Assignee: Zaidan Hojin Minsei Kagaku Kyokai
    Inventor: Akira Fujimaki