Abstract: Devices and methods that allow a user to elect between performing treament planning by inverse planning or to be accomplished by utilizing one or more parameters input that are typically associated with forward planning are described herein. The systems can be configured to produce a treatment plan in a single iteration upon initiation of treatment planning or in response to determining or receiving a target geometry. While the system may be used iteratively in an extensively interactive fashion, viable inverse plans can be generated with a single user interaction, such as a single click, or optionally with no click at all. Advantageously, the system can optionally allows a clinnician to add or adjust parameters or constraints, for example in another iteration, to provide additional autonomy if desired.

Abstract: A portable mist blower system, which has a housing assembly, a tank assembly, a handle assembly, a battery assembly, a pump motor assembly, a blower panel assembly, a manifold assembly, a blower assembly, and a solenoid assembly. The housing assembly has a front panel, a rear panel, a top panel, a bottom panel, and lateral panels. The tank assembly is secured to the top panel and trapped by the front panel, the battery assembly is secured to the top panel, the handle assembly is mounted onto the top panel, the pump motor assembly is secured to the rear panel, the blower panel assembly is mounted onto the front panel, the manifold assembly is connected to the blower panel assembly, and the blower assembly and the solenoid assembly are mounted onto the bottom panel.

Abstract: A method for providing directed transmission of sound waves, through modulation on an ultrasonic carrier, may comprise connecting, at least one directed sound source to an audio system, emitting, via the at least one directed sound source, audio from the audio system, wherein the emitting comprises emitting medium frequency audio sound waves and higher frequency audio sound waves. The audio may be selected via a master control unit, which may be operatively coupled to a mobile application. In many embodiments, a first audio selection is configured to be heard only through a first directed sound source, and a second audio selection is configured to be heard only through a second directed sound source.

Abstract: A self-shielded and computer controlled system for performing non-invasive stereotactic radiosurgery and precision radiotherapy using a linear accelerator mounted within a two degree-of-freedom radiation shield coupled to a three-degree of freedom patient table is provided. The radiation shield can include an axial shield rotatable about an axial axis and an oblique shield independently rotatable about an oblique axis, thereby providing improved range of trajectories of the therapeutic and diagnostic radiation beams. Such shields can be balanced about their respective axes of rotation and about a common support structure to facilitate ease of movement. Such systems can further include an imaging system to accurately deliver radiation to the treatment target and automatically make corrections needed to maintain the anatomical target at the system isocenter.

Abstract: Devices, systems and method that allow for delivery of therapeutic radiation beams of differing sizes or shapes during a radiation treatment are provided herein. Such devices can include a rotatable collimator body having multiple collimator channels of differing size or shape defined therein, the channels extending through the collimator body substantially perpendicular to the axis of rotation. The collimator body can include markers thereon to facilitate detection of an alignment position by a sensor of a control system to allow the collimator body to be rapidly and accurately moved between alignment positions to facilitate delivery of differing therapy beams during a treatment.

Abstract: Devices, systems and method that allow for delivery of therapeutic radiation beams of differing sizes or shapes during a radiation treatment are provided herein. Such devices can include a rotatable collimator body having multiple collimator channels of differing size or shape defined therein, the channels extending through the collimator body substantially perpendicular to the axis of rotation. The collimator body can include markers thereon to facilitate detection of an alignment position by a sensor of a control system to allow the collimator body to be rapidly and accurately moved between alignment positions to facilitate delivery of differing therapy beams during a treatment.

Abstract: An expandable solenoid system having a sequence controller assembly and at least two zone expander solenoid valve assemblies fastened in a staggered configuration. Each zone expander solenoid valve assembly has a zone expander solenoid and a flanged valve body assembly. The valve block has threaded bolt holes, unthreaded bolt holes, an output port, and a threaded pressure source port having an O-ring groove. The threaded bolt holes and the unthreaded bolt holes have different depths and are alternately positioned around a perimeter of the valve block. The first flanged valve body assembly is fastened to the second flanged valve body assembly and so on, in a staggered configuration, whereby respective zone expander solenoids are in a zigzag geometry and creating an expandable manifold.

Abstract: A multifunctional misting system having a housing assembly, a frame assembly, a recessed mist blower assembly, a valve assembly, a recess control panel assembly, a pump-motor assembly, a tank assembly, a puck assembly, and a handle assembly. The housing assembly has first and second flat panels, a front panel, a rear panel, a top panel, a bottom panel, and locking corners. The frame assembly has a solenoid side frame and a blower side frame, a mix solenoid, and a battery with a battery retainer. The recessed mist blower assembly has a blower and nozzles. The pump-motor assembly has a pump motor, a pump housing and a motor-battery bracket. The handle assembly is positioned onto the top panel of the housing assembly. The multifunctional misting system may operate as a mist blower.

Abstract: A multifunctional misting system having a housing assembly, a frame assembly, a mist blower assembly, a valve assembly, a recess control panel assembly, a pump-motor assembly, a tank assembly, and a handle assembly. The housing assembly has first and second flat panels, a front panel, a rear panel, a top panel, a bottom panel, and locking corners. The frame assembly has first and second frames, and a battery with a battery retainer. The mist blower assembly has a blower and nozzles. The pump-motor assembly is a motor attached to a pump. The motor has a motor-battery bracket fixed to the motor and a spacer. The handle assembly is positioned onto the top panel of the housing assembly. The multifunctional misting system may operate as a mist blower.

Abstract: Removable marker implants having fiducial markers disposed on multiple elongate members extend and splay laterally outward when deployed thereby providing improved 3D localization and tracking of a portion of the patient's body for stereotactic radiosurgery. Such an approach is particularly useful for tracking of the uterus during radiosurgery treatment of uterine fibroids. Such implants can include an outer sheath that contains the multiple elongate members during delivery into the portion of the body. The elongate members can be slidably disposed within the shaft and advanced into an expanded deployed position by advancement of an applicator shaft or rod within the sheath. Marker implant can also be integrally formed implants with flexible arms having fiducial markers thereon that can be constrained in a sheath for delivery and resiliently splay laterally outward when released from the shaft. Methods of delivery and deployment are also provided.

Abstract: Radiosurgical techniques and systems treat behavioral disorders (such as depression, Obsessive-Compulsive Disorder (“OCD”), addiction, hyperphagia, and the like) by directing radiation from outside the patient toward a target tissue within the patient's brain, typically without imposing surgical trauma. The target will often be included in a neural circuit associated with the behavioral disorder. A cellularly sub-lethal dose of the radiation may be applied and the radiation can mitigate the behavioral disorder, obesity, or the like, by modulating the level of neural activity within the target and in associated tissues. Hypersensitive and/or hyperactive neuronal tissue may be targeted, with the radiation downwardly modulating hyperactive neuronal activity. By down-regulating the activity of a target that normally exerts negative feedback or a limiting effect on a relevant neural circuit, the activity of the circuit may be increased.

Abstract: A self-shielded and computer controlled system for performing non-invasive stereotactic radiosurgery and precision radiotherapy using a linear accelerator mounted within a two degree-of-freedom radiation shield coupled to a three-degree of freedom patient table is provided. The radiation shield can include an axial shield rotatable about an axial axis and an oblique shield independently rotatable about an oblique axis, thereby providing improved range of trajectories of the therapeutic and diagnostic radiation beams. Such shields can be balanced about their respective axes of rotation and about a common support structure to facilitate ease of movement. Such systems can further include an imaging system to accurately deliver radiation to the treatment target and automatically make corrections needed to maintain the anatomical target at the system isocenter.

Abstract: An array of force sensors for determining a position of an object, detecting motion of object, and tracking motion of objects in 3D space are described herein. In particular, an array of force sensors can be used to monitor anatomical motion during medical procedures, such as head motion during cranial radiosurgery, to maintain a desired alignment with the anatomical feature. Alerts can be posted to the medical machine operator and the radiosurgery system or scanner can make compensatory adjustments to maintain the desired alignment either after suspension of treatment or dynamically during treatment. Methods of detecting a position, movement or tracking motion of an anatomical feature are also provided herein.

Abstract: A self-shielded and computer controlled system for performing non-invasive stereotactic radiosurgery and precision radiotherapy using a linear accelerator mounted within a two degree-of-freedom radiation shield coupled to a three-degree of freedom patient table is provided. The radiation shield can include an axial shield rotatable about an axial axis and an oblique shield independently rotatable about an oblique axis, thereby providing improved range of trajectories of the therapeutic and diagnostic radiation beams. Such shields can be balanced about their respective axes of rotation and about a common support structure to facilitate ease of movement. Such systems can further include an imaging system to accurately deliver radiation to the treatment target and automatically make corrections needed to maintain the anatomical target at the system isocenter.

Abstract: Methods of treatment and treatment systems for performing radiomodulatory stereotactic radiosurgery to treat brain disorders in which target neural tissues associated with the brain disorder are sensitized to radiation by administration of a molecular substance and/or non-targeted critical structures are protected from radiation by a molecular substance, in order to treat disorders of brain circuitry. Specific embodiments disclose means for treating pain, obesity and drug addiction.