Patents Assigned to Zeneca
  • Azospiro compounds as NK1 or NK2 antagonists
    Patent number: 6147083
    Abstract: Compounds of formula I: ##STR1## wherein Q.sup.1, Q.sup.2, Q.sup.3, Q.sup.4, and Q.sup.5 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of SP and NKA are useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
    Type: Grant
    Filed: August 27, 1999
    Date of Patent: November 14, 2000
    Assignee: Zeneca Limited
    Inventor: Keith Russell
  • Process for preparing pharmaceutical composition containing a heterocyclic amide
    Patent number: 6143775
    Abstract: The invention provides a pharmaceutical composition comprising a particular physical form of N-[4-[5-(cyclopentyloxy-carbonyl)amino-1-methylindol-3-yl-methyl]-3-methox ybenzoyl]-2-methyl-benzenesulphonamide and polyvinylpyrrolidone. It also provides methods for preparing this physical form, and another physical form of N-[4-[5-(cyclopentyloxycarbonyl)amino-1-methylindol-3-yl-methyl]-3-methoxy benzoyl]-2-methylbenzenesulphonamide useful in the preparation of the first mentioned physical form. The compositions are useful in the treatment of diseases in which leukotrienes are implicated, for example asthma.
    Type: Grant
    Filed: November 23, 1999
    Date of Patent: November 7, 2000
    Assignee: Zeneca Limited
    Inventors: James Joseph Holohan, Ieuan John Edwards
  • Chemical process
    Patent number: 6143899
    Abstract: A process for the preparation of 2-hydroxy-6-trifluoromethylpyridine which comprises reacting 2-fluoro-6-trifluomethylpyridine or a mixture of 2-fluoro-6-trifluoromethylpyridine and 2-chloro-6-trifluoromethylpyridine with an alkali metal hydroxide at a temperature of from 50.degree. C. to 160.degree. C. and acidifying the product so formed.
    Type: Grant
    Filed: September 3, 1999
    Date of Patent: November 7, 2000
    Assignee: Zeneca Limited
    Inventors: Alexander Pai-Yung Fung, David Dale Friese, Erwin Michael Seidel, Alan John Whitton, Alastair lain Currie Stewart, Jennifer Ann White, Raymond Vincent Heavon Jones, John Desmond Hunt
  • Composition and method for selectively removing metal ions from an aqueous solution
    Patent number: 6139752
    Abstract: A composition of matter is provided in which a phosphonic acid or phosphonic acid ester group is linked through a thioether residue to a silicon atom which is further covalently bonded to a solid inorganic support. The compositions can be employed to selectively separate metal ions having high cationic charge from a solution containing lower-charged cations, and also to selectively separate highly charged cations having a relatively high charge density from cations having the same charge, but a lower charge density.
    Type: Grant
    Filed: April 17, 1998
    Date of Patent: October 31, 2000
    Assignee: Zeneca Limited
    Inventors: Leonard Francis Lindoy, Peter Anthony Tasker, Ian Murray Atkinson, Derek Thorp
  • Production of proteins, plasmids coding therefor and organisms containing such plasmids
    Patent number: 6136567
    Abstract: Plasmids which comprise: (1) an origin of replication; (2) an additional sequence required for plasmid replication or preferably a gene giving a selective advantage; and (3) two expression cassettes each of which are located between (1) and (2) but are separated by (1) and (2) from each other; and which are free from inverted repeat sequences (other than in (3)) are highly persistent though successive generations of microbes containing them.
    Type: Grant
    Filed: August 21, 1998
    Date of Patent: October 24, 2000
    Assignee: Zeneca Limited
    Inventors: Matthew Guy Duchars, Andrew William Topping
  • Compound, preparation and use
    Patent number: 6133366
    Abstract: A dispersant which is a phosphate ester of a block copolymer of formula MeO(C.sub.2 H.sub.4 O).sub.m (PES).sub.n --H wherein PES is derived from .epsilon.-caprolactone, m is 5-60, n is 2-30 and the MW of MeO(C.sub.2 H.sub.4 O).sub.m is greater than the MW of (PES).sub.n and use in aqueous-based paints and printing inks.
    Type: Grant
    Filed: June 1, 1998
    Date of Patent: October 17, 2000
    Assignee: Zeneca Limited
    Inventors: Dean Thetford, Mark Holbrook
  • Microencapsulated compositions
    Patent number: 6133197
    Abstract: Polyurea microcapsules particularly suitable for foliar application are prepared by an interfacial polymerization process in which the polyurea is formed from an aromatic diisocyanate and optionally an aromatic polyisocyanate having 3 or more isocyanate groups, in a weight ratio (when both types of isocyanate are present) of polyisocyanate:diisocyanate of from about 1:100 to about 1:1.5, and in which the microcapsules are produced having an average particle size of from about 1 to about 5 microns.As compared to conventional liquid (e.g., emulsifiable concentrate) compositions of pesticides, the microcapsules can provide safer handling and higher loading of active ingredients, while providing substantially equivalent biological activity to the liquid compositions.
    Type: Grant
    Filed: May 21, 1997
    Date of Patent: October 17, 2000
    Assignee: ZENECA Limited
    Inventors: Jin-Ling Chen, Marius Rodson, Herbert B. Scher, Kuo-Shin Lee, deceased
  • Process for forming a colored three-dimensional article
    Patent number: 6133336
    Abstract: Process for forming a selectively colored polymeric layer, or a three-dimensional article made of polymeric layers, wherein a photocurable, photocolorable composition is irradiated with a low dose of light to cure and a different, preferably higher, dose of light to color. The process is particularly useful for preparing selectively colored ornamental and industrial articles and models of plant and animal parts, especially medical models.
    Type: Grant
    Filed: August 30, 1996
    Date of Patent: October 17, 2000
    Assignee: Zeneca Limited
    Inventors: Ajay Haridas Popat, Martin Russell Edwards
  • Method of genetically transforming banana plants
    Patent number: 6133035
    Abstract: The present invention provides a method of producing a transformed banana plant (genus,Musa), in particular by tranforming embroygenic material, or the somatic embryos derived from a banana plant, through incubation with Agrobacterium cells carrying exogenous DNA sequence(s), and obtaining regenerated plants.
    Type: Grant
    Filed: July 16, 1997
    Date of Patent: October 17, 2000
    Assignees: DNA Plant Technology Corporation, Zeneca, Ltd.
    Inventors: Dean Engler, Neal Gutterson, Garry S. Nisbet
  • Fluorination process
    Patent number: 6127587
    Abstract: The present invention provides a process for the preparation of 1,1-difluoro-1,4-dichlorobutane by reacting 1,1,1,4-tetrachlorobutane or 1,1,4-trichlorobut-1-ene with hydrogen fluoride in the vapor phase.
    Type: Grant
    Filed: September 10, 1999
    Date of Patent: October 3, 2000
    Assignee: Zeneca Limited
    Inventor: Alfred Glyn Williams
  • Therapeutic heterocycles
    Patent number: 6124279
    Abstract: Compounds of formula I ##STR1## wherein G, J, L, M, m and D have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
    Type: Grant
    Filed: June 18, 1999
    Date of Patent: September 26, 2000
    Assignee: Zeneca Limited
    Inventor: Scott Carson Miller
  • Fungicides
    Patent number: 6124356
    Abstract: A fungicidal compound of formula (I): or a stereoisomer thereof, wherein A is CH or N, B is OCH.sub.3 or NHCH.sub.3, E is --NR.sup.1 --C(CH.sub.3).dbd.N-- or --N.dbd.C(CH.sub.3)--NR.sup.1 --, R.sup.1 is H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl or optionally substitute benzyl, R.sup.2 is H, C.sub.1-4 alkyl, halo(C.sub.1-4)alkyl, C.sub.3-6 cycloalkyl, C.sub.2-4 alkenyl or C.sub.2-4 alkynyl, and R.sup.3 is optionally substituted aryl or optionally substituted heterocyclyl.
    Type: Grant
    Filed: January 6, 1999
    Date of Patent: September 26, 2000
    Assignee: Zeneca Limited
    Inventors: George Tseriotis, Ian Henry Aspinall, Paul Anthony Worthington
  • Azolobenzazepine derivatives as neurologically active agents
    Patent number: 6124281
    Abstract: The invention relates to azolobenzazepine derivatives of formula (I), wherein: X is O or S; R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently hydrogen, perfluorolower-alkyl, halogen, nitro or cyano; and C together with the carbon atoms to which it is attached forms a 5-membered aromatic heterocycle selected from the group consisting of a pyrazol and triazole, to pharmaceutical compositions containing them and to methods for the treatment of neurological disorders utilizing them.
    Type: Grant
    Filed: September 3, 1998
    Date of Patent: September 26, 2000
    Assignee: Zeneca Limited
    Inventors: Joseph James Lewis, Kelly Anne Brush, Laura Enid Garcia-Davenport, William Jackson Frazee, Marc Jerome Chapdelaine
  • Binder resin, process for its manufacture and composition containing it
    Patent number: 6121364
    Abstract: A polymeric material comprising at least first and second polymer parts, which first part has a number average molecular weight higher than that of the second part and which first and second polymer parts each comprise a respective polymer part derived from at least one ethylenically unsaturated monomer, is prepared by a process which comprises the steps of (1) preparing, by aqueous suspension polymerisation the first, higher molecular weight polymer part in the presence of a free radical initiator, but in the absence of a chain transfer agent to form a suspension of the first, higher molecular weight part and thereafter (2) preparing by aqueous suspension polymerisation the second, lower molecular weight part, which preparation step (2) is carried out in the presence of the suspension of the first, higher molecular weight part, a free radical initiator and a catalytic chain transfer agent (CCTA).
    Type: Grant
    Filed: April 13, 1998
    Date of Patent: September 19, 2000
    Assignee: Zeneca Limited
    Inventors: Stephen George Yeates, Anita Margaret De La Motte
  • Agrochemical formulation
    Patent number: 6117820
    Abstract: An aqueous agrochemical concentrate formulation comprises a) an agrochemical electrolyte such as salts of glyphosate, fomesafen, glufosinate, paraquat or bentazone, b) an alkoxylated adjuvant, c) an alkylglycoside and d) a co-surfactant which interacts with the alkylglycoside to form a structured aqueous system. Preferred co-surfactants are:- (i) a linear or branched chain aliphatic or aromatic alcohol, (ii) an alcohol or ester or alkyl phenol alkoxylate having a degree of alkoxylation lower than that of the alkoxylated adjuvant present in the formulation as component (b), (iii) a glyceryl alkyl or alkenyl ester and (iv) a sorbitan alkyl or alkenyl ester.
    Type: Grant
    Filed: August 11, 1998
    Date of Patent: September 12, 2000
    Assignee: ZENECA Limited
    Inventors: Julia Lynne Cutler, Michael John Bean
  • Rheology modifier for solvent-based coatings
    Patent number: 6117935
    Abstract: A rheology modifier for solvent-based coatings which is a polyacrylic acid or a poly(C.sub.1-4)-alkyl acrylic acid wherein at least 30% of the --COOH groups are converted to ester and/or amide groups. Preferred compounds are esters of polyacrylic acid where about 50% of the --COOH groups are esterified with a C.sub.4-12 -alcohol.
    Type: Grant
    Filed: April 4, 1997
    Date of Patent: September 12, 2000
    Assignee: Zeneca Limited
    Inventors: John David Schofield, Paul Gough
  • Pharmaceutical compositions for freeze drying
    Patent number: 6114313
    Abstract: A pharmaceutical composition comprising a nucleotide analogue, mannitol and a modifying additive which is sodium chloride or a polyol which is suitable for freeze drying.
    Type: Grant
    Filed: March 13, 1998
    Date of Patent: September 5, 2000
    Assignee: Astra Zeneca UK Limited
    Inventors: Chris Bland, Gerald Steele
  • Water-in-oil microencapsulation process and microcapsules produced thereby
    Patent number: 6113935
    Abstract: A suspension of microcapsules in an organic liquid, the microcapsules containing an aqueous phase, is produced by interfacial polymerization in the presence of a proton transfer catalyst of a water-in-oil emulsion in which the aqueous phase contains a urea/formaldehyde or melamine/formaldehyde prepolymer.
    Type: Grant
    Filed: December 19, 1997
    Date of Patent: September 5, 2000
    Assignee: ZENECA Limited
    Inventors: Maurius Rodson, Herbert B. Scher
  • Nasal spray
    Patent number: D433123
    Type: Grant
    Filed: July 9, 1998
    Date of Patent: October 31, 2000
    Assignee: Zeneca Limited
    Inventors: John Edward Sheppard, Richard John Stevens
  • Nasal spray
    Patent number: D433124
    Type: Grant
    Filed: July 9, 1998
    Date of Patent: October 31, 2000
    Assignee: Zeneca Limited
    Inventors: John Edward Sheppard, Richard John Stevens