Patents Assigned to Zeneca
  • Patent number: 6025486
    Abstract: A compound of formula (1) and salts thereof, wherein: M is a metal or hydrogen; Pc is a phthalocyanine nucleus; each R.sup.1 independently is H or optionally substituted alkyl aryl or aralkyl; each L.sup.1 independently is a divalent organic linking group; Z is an optionally substituted piperazinyl group; q is 1 or 2; x and y each independently have a value of 0.5 to 3.5; and (x+y) is from 2 to 5. A process for making the compounds of formula (1). The compounds of formula (1) are useful as colorants for inks which are used in for example ink jet printing of substrates such as paper, plastics, textile materials, metal or glass.
    Type: Grant
    Filed: April 7, 1998
    Date of Patent: February 15, 2000
    Assignee: Zeneca Limited
    Inventors: Prahalad Manibhai Mistry, Ronald Wynford Kenyon
  • Patent number: 6025114
    Abstract: 1. This invention relates to a liquid composition comprising:a) 2 to 20 parts of a monomeric poly(meth)acrylate having a functionality of at least 3 and a MW of at least 650;b) 20 to 60 parts of a urethane(meth)acrylate having a functionality of 2 to 4 and a MW of 400 to 10,000;c) 20 to 80 parts of a monomeric or oligomeric di(meth)acrylate based on bisphenol A or bisphenol F; andd) 0.1 to 10 parts of a photoinitiator;wherein all parts are by weight and the total number of parts of a)+b)+c)+d) add up to 100.The compositions are suitable for the stereolithographic production of three-dimensional articles such as models of mechanical and body parts and are particularly notable for their low curl & shrinkage coupled with fast rate of cure.
    Type: Grant
    Filed: September 11, 1997
    Date of Patent: February 15, 2000
    Assignee: Zeneca Limited
    Inventors: Ajay Haridas Popat, John Robert Lawson
  • Patent number: 6022686
    Abstract: Assay method for the detection of nucleic acid sequences in homogeneous solution. The method comprises the use of fluorescence polarisation to detect hybridisation of a fluorescent nucleic acid probe or to detect fluorescent primer extension products. Assay kits for use in the above methods.
    Type: Grant
    Filed: August 3, 1993
    Date of Patent: February 8, 2000
    Assignee: Zeneca Limited
    Inventors: Andrew John Garman, Robert Stanley Moore
  • Patent number: 6022869
    Abstract: The invention relates to compounds of formula (I), and pharmaceutically-acceptable salts thereof, which possess antithrombotic and anticoagulant properties; processes for preparing compounds of formula (I) and pharmaceutical compositions.
    Type: Grant
    Filed: August 4, 1998
    Date of Patent: February 8, 2000
    Assignee: Zeneca Limited
    Inventor: Alan Wellington Faull
  • Patent number: 6022384
    Abstract: The present invention relates to a water-soluble reactive dye of the formula N(Z).sub.3, wherein each Z independently has the formula (III): ##STR1## wherein m, Q, Y and D are defined in the claims. The present invention also relates to a process for coloring a substrate that includes applying to the substrate the water-soluble reactive dye of the above formula at a pH above 7.
    Type: Grant
    Filed: February 24, 1999
    Date of Patent: February 8, 2000
    Assignee: Zeneca Limited
    Inventor: John Anthony Taylor
  • Patent number: 6022976
    Abstract: A process for the production of hydroxy-substituted oxazolidinones, particularly 5-hydroxyoxazolidinones, which are useful as intermediates in the synthesis of herbicidally active compounds, comprising treating a hydroxythiazolidinone with an oxidizing agent.
    Type: Grant
    Filed: July 28, 1998
    Date of Patent: February 8, 2000
    Assignee: ZENECA Limited
    Inventors: Glynn Mitchell, John Michael Cox, Shaheen Khatoon Vohra
  • Patent number: 6019745
    Abstract: A medical syringe comprises a cylindrical barrel 1 having therein a plunger 4 which can be axially driven by a plunger rod 3. The plunger rod 3 passes through an aperture in the centre of a finger grip 2 having two finger grip projections 2b at opposite sides thereof. A data carrier means in the form of an electrically or magnetically operable device 2c is mounted near the end of one of the two finger grip projections 2b, with preferably a device 2c mounted near the end of each finger grip projection 2b. The device 2c carries data relating to the medicament contained or to be contained within the syringe, and can be read by a suitably adapted syringe pump when the syringe is mounted thereon to be driven by the syringe pump.
    Type: Grant
    Filed: December 9, 1998
    Date of Patent: February 1, 2000
    Assignee: Zeneca Limited
    Inventor: John Martyn Gray
  • Patent number: 6020524
    Abstract: A compound of the following formula ##STR1## wherein M is an alkali metal or alkaline earth metal atom and a process for the preparation of the compound is provided.
    Type: Grant
    Filed: March 29, 1999
    Date of Patent: February 1, 2000
    Assignee: ZENECA Limited
    Inventors: Alfred Glyn Williams, Gordon Richard Munns, Paul Anthony Worthington
  • Patent number: 6017992
    Abstract: Process for the production of an aqueous polymer emulsion which process comprises:a) preparing a low molecular weight polymer containing acid-functional groups using a free-radical polymerisation process which employs a free-radical initiator and, for the purpose of controlling molecular weight, a transition metal chelate complex, wherein said low molecular weight polymer has a number average molecular weight within the range of from 500 to 50,000;b) conducting an aqueous emulsion polymerisation process to form an aqueous emulsion of a hydrophobic polymer from at least one olefinically unsaturated monomer, wherein the low molecular weight polymer of step a) is introduced to the aqueous medium of said emulsion polymerisation process before the start of and/or during said emulsion polymerisation process and becomes dissolved or dispersed in said aqueous medium.
    Type: Grant
    Filed: June 30, 1998
    Date of Patent: January 25, 2000
    Assignees: Zeneca Limited, Zeneca Resins BV
    Inventors: David Mark Haddleton, John Christopher Padget, Gerardus Cornelis Overbeek
  • Patent number: 6018045
    Abstract: A process for preparing 4,6-dichloropyrimidine is described, comprising treating 4,6-dihydroxypyrimidine with phosphorus oxychloride in the presence of a saturated hindered amine, the hydrochloride salt of a saturated hindered amine, or an unsaturated 5-membered nitrogen containing ring or a mixture thereof, and, as a first step, directly extracting the 4,6-dichloropyrimidine so formed.
    Type: Grant
    Filed: July 17, 1997
    Date of Patent: January 25, 2000
    Assignee: Zeneca Limited
    Inventors: Alan John Whitton, David John Ritchie, Ewan Campbell Boyd, Raymond Vincent Heavon Jones
  • Patent number: 6015814
    Abstract: The invention concerns derivatives of the formula wherein n is 1, 2 or 3 and each R.sup.2 is independently halogeno; and R.sup.1 is amino-(2-4C)alkylamino, (1-4C)alkylamino, (1-4C)alkylamino-(2-4C)alkylamino,di-[(1-4C)alkyl]amino-(2-4C) alkylamino, pyrrolidin-1-yl-(2-4C)alkylamino, piperidino-(2-4C)alkylamino, morpholino-(2-4C)alkylamino, piperazin-1-yl-(2-4C)alkylamino, or 4-(1-4C) alkylpiperazin-1-yl-(2-4C)alkylamino, or pharmaceutically acceptable salts thereof; processes for their preparation, pharmaceutical compositions containing them, and the use of the receptor tyrosine kinase inhibitory properties of the compounds in the treatment of proliferative disease such as cancer.
    Type: Grant
    Filed: September 26, 1997
    Date of Patent: January 18, 2000
    Assignee: Zeneca Limited
    Inventor: Andrew John Barker
  • Patent number: 6015571
    Abstract: Microcapsules containing a suspension of a soild, biologically active compound in an organic, water-immiscible liquid and processes for their preparation.
    Type: Grant
    Filed: December 12, 1994
    Date of Patent: January 18, 2000
    Assignee: Zeneca Limited
    Inventors: Herbert B. Scher, Jin Ling Chen
  • Patent number: 6015896
    Abstract: A compound of formula (1) and salts thereof, wherein: M is a metal or hydrogen; Pc is phthalocyanine nucleus; R.sup.1, R.sup.2, W.sup.1 and W.sup.2 are each independently H or optionally substituted alkyl, aryl or aralkyl; R.sup.3 is an aminoalkyl group; L is a divalent organic linking group; x, y and t are each independently 0.5 to 2.5; and (x+y+t) is from 3 to 4. A process for making the compounds of formula (1). The compounds of formula (1) are useful as colorants for inks which are used in for example ink jet printing of substrates such as paper, plastics, textile materials, metal or glass.
    Type: Grant
    Filed: April 7, 1998
    Date of Patent: January 18, 2000
    Assignee: Zeneca Limited
    Inventors: Prahalad Manibhai Mistry, Ronald Wynford Kenyon
  • Patent number: 6015905
    Abstract: A process for preparing 2-(6-substituted pyrid-2-yloxymethyl)phenyacetates especially useful as intermediates for producing agricultural fungicides. The invention provides a compound having the formula (I): wherein A and D are independently selected from the group comprising halo, hydroxy, halo(C.sub.1-4)alkyl, C.sub.1-4 alkoxy, thio(C.sub.1-4)alkoxy, halo(C.sub.1-4)alkoxy, phenyl, phenoxy, nitro, amino, aclyamino, cyano, carboxy, C.sub.1-4 alkoxycarbonyl and C.sub.1-4 alkylcarbonyloxy, or D is C.sub.1-4 alkyl, and m is 0 or an integer of from 1 to 3. The process comprises treating a compound of formula (II): ##STR1## wherein A, D and m are defined as above and M is a metal atom, with a compound of formula (III): ##STR2## wherein L is a leaving group.
    Type: Grant
    Filed: December 2, 1997
    Date of Patent: January 18, 2000
    Assignee: Zeneca Limited
    Inventors: David John Ritchie, Gordon Richard Munns, Julie Forrester, Michael Charles Henry Standen, Paul Anthony Worthington, Raymond Vincent Heavon Jones
  • Patent number: 6013861
    Abstract: Plants, particularly cereal plants, which have improved ability to synthesise starch at elevated or lowered temperatures and/or to synthesise starch with an altered fine structure are produced by inserting into the genome of the plant (i) a gene(s) encoding a form of an enzyme of the starch or glycogen biosynthetic pathway, particularly soluble starch synthase and/or branching enzyme and/or glycogen synthase, which display an activity which continues to increase over a temperature range over which the activity would normally be expected to decrease, and/or (ii) a gene(s) encoding sense and anti-sense constructs of enzymes of the starch biosynthetic pathway, particularly soluble starch synthase and/or branching enzyme and/or glycogen synthase, which alters the natural ratios of expression of the said enzymes or inserts enzymes with special structural characteristics which alter the natural branching pattern in starch.
    Type: Grant
    Filed: October 23, 1996
    Date of Patent: January 11, 2000
    Assignee: Zeneca Limited
    Inventors: Colin R. Bird, Philip A. Fentem, Peter L. Keeling, George Singletary
  • Patent number: 6013604
    Abstract: Control of weeds in a rice crop is obtained by applying to the crop, the weeds, or the locus of either or both, a herbicidal composition containing molinate and carfentrazone-ethyl in a weight ratio of from about 60:1 to about 6:1.
    Type: Grant
    Filed: April 7, 1999
    Date of Patent: January 11, 2000
    Assignee: Zeneca Limited
    Inventors: Richard Lynn Franz, Khosro Khodayari
  • Patent number: 6010979
    Abstract: New and useful herbicidal compositions comprising N-phosphonomethylglycineor an agriculturally acceptable salt thereof, an ethoxylated alkyl glycoside surfactant, and an ethoxylated alcohol are provided.
    Type: Grant
    Filed: May 8, 1998
    Date of Patent: January 4, 2000
    Assignee: Zeneca Limited
    Inventors: Martin Keith Osborn, Michael John Bean, Philip Simon Wikeley
  • Patent number: 6011201
    Abstract: A full length cDNA of rape seed .beta.-ketoreductase pJRS 10.1 having the Sequence ID-1.
    Type: Grant
    Filed: July 28, 1997
    Date of Patent: January 4, 2000
    Assignee: Zeneca Limited
    Inventors: Antoni Ryszard Slabas, Andrew White, Dianne Chase, Keiran Elborough, Philip Anthony Fentem
  • Patent number: 6008381
    Abstract: 3-Isochromanone is prepared by reacting o-tolyacetic acid with sulphuryl chloride in the presence of a free radical initiator, e.g. AIBN, followed by ring closure of the 2-chloromethylphenylacetic acid so formed with a base, e.g. potassium bicarbonate.
    Type: Grant
    Filed: December 14, 1998
    Date of Patent: December 28, 1999
    Assignee: Zeneca Limited
    Inventors: Alfred Glyn Williams, Michael Charles Henry Standen, Nicholas Russell Foster, Raymond Vincent Heavon Jones
  • Patent number: 6008223
    Abstract: Compounds of formula I ##STR1## wherein Q.sup.1, Q.sup.2, Q.sup.3, and Q.sup.4 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of SP and NKA are useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
    Type: Grant
    Filed: January 20, 1998
    Date of Patent: December 28, 1999
    Assignee: Zeneca Limited
    Inventors: Peter R. Bernstein, Scott C. Miller