Abstract: A compound of formula (1) and salts thereof, wherein: M is a metal or hydrogen; Pc is a phthalocyanine nucleus; each R.sup.1 independently is H or optionally substituted alkyl aryl or aralkyl; each L.sup.1 independently is a divalent organic linking group; Z is an optionally substituted piperazinyl group; q is 1 or 2; x and y each independently have a value of 0.5 to 3.5; and (x+y) is from 2 to 5. A process for making the compounds of formula (1). The compounds of formula (1) are useful as colorants for inks which are used in for example ink jet printing of substrates such as paper, plastics, textile materials, metal or glass.
Type:
Grant
Filed:
April 7, 1998
Date of Patent:
February 15, 2000
Assignee:
Zeneca Limited
Inventors:
Prahalad Manibhai Mistry, Ronald Wynford Kenyon
Abstract: 1. This invention relates to a liquid composition comprising:a) 2 to 20 parts of a monomeric poly(meth)acrylate having a functionality of at least 3 and a MW of at least 650;b) 20 to 60 parts of a urethane(meth)acrylate having a functionality of 2 to 4 and a MW of 400 to 10,000;c) 20 to 80 parts of a monomeric or oligomeric di(meth)acrylate based on bisphenol A or bisphenol F; andd) 0.1 to 10 parts of a photoinitiator;wherein all parts are by weight and the total number of parts of a)+b)+c)+d) add up to 100.The compositions are suitable for the stereolithographic production of three-dimensional articles such as models of mechanical and body parts and are particularly notable for their low curl & shrinkage coupled with fast rate of cure.
Abstract: Assay method for the detection of nucleic acid sequences in homogeneous solution. The method comprises the use of fluorescence polarisation to detect hybridisation of a fluorescent nucleic acid probe or to detect fluorescent primer extension products. Assay kits for use in the above methods.
Type:
Grant
Filed:
August 3, 1993
Date of Patent:
February 8, 2000
Assignee:
Zeneca Limited
Inventors:
Andrew John Garman, Robert Stanley Moore
Abstract: The invention relates to compounds of formula (I), and pharmaceutically-acceptable salts thereof, which possess antithrombotic and anticoagulant properties; processes for preparing compounds of formula (I) and pharmaceutical compositions.
Abstract: The present invention relates to a water-soluble reactive dye of the formula N(Z).sub.3, wherein each Z independently has the formula (III): ##STR1## wherein m, Q, Y and D are defined in the claims. The present invention also relates to a process for coloring a substrate that includes applying to the substrate the water-soluble reactive dye of the above formula at a pH above 7.
Abstract: A process for the production of hydroxy-substituted oxazolidinones, particularly 5-hydroxyoxazolidinones, which are useful as intermediates in the synthesis of herbicidally active compounds, comprising treating a hydroxythiazolidinone with an oxidizing agent.
Type:
Grant
Filed:
July 28, 1998
Date of Patent:
February 8, 2000
Assignee:
ZENECA Limited
Inventors:
Glynn Mitchell, John Michael Cox, Shaheen Khatoon Vohra
Abstract: A medical syringe comprises a cylindrical barrel 1 having therein a plunger 4 which can be axially driven by a plunger rod 3. The plunger rod 3 passes through an aperture in the centre of a finger grip 2 having two finger grip projections 2b at opposite sides thereof. A data carrier means in the form of an electrically or magnetically operable device 2c is mounted near the end of one of the two finger grip projections 2b, with preferably a device 2c mounted near the end of each finger grip projection 2b. The device 2c carries data relating to the medicament contained or to be contained within the syringe, and can be read by a suitably adapted syringe pump when the syringe is mounted thereon to be driven by the syringe pump.
Abstract: A compound of the following formula ##STR1## wherein M is an alkali metal or alkaline earth metal atom and a process for the preparation of the compound is provided.
Type:
Grant
Filed:
March 29, 1999
Date of Patent:
February 1, 2000
Assignee:
ZENECA Limited
Inventors:
Alfred Glyn Williams, Gordon Richard Munns, Paul Anthony Worthington
Abstract: Process for the production of an aqueous polymer emulsion which process comprises:a) preparing a low molecular weight polymer containing acid-functional groups using a free-radical polymerisation process which employs a free-radical initiator and, for the purpose of controlling molecular weight, a transition metal chelate complex, wherein said low molecular weight polymer has a number average molecular weight within the range of from 500 to 50,000;b) conducting an aqueous emulsion polymerisation process to form an aqueous emulsion of a hydrophobic polymer from at least one olefinically unsaturated monomer, wherein the low molecular weight polymer of step a) is introduced to the aqueous medium of said emulsion polymerisation process before the start of and/or during said emulsion polymerisation process and becomes dissolved or dispersed in said aqueous medium.
Type:
Grant
Filed:
June 30, 1998
Date of Patent:
January 25, 2000
Assignees:
Zeneca Limited, Zeneca Resins BV
Inventors:
David Mark Haddleton, John Christopher Padget, Gerardus Cornelis Overbeek
Abstract: A process for preparing 4,6-dichloropyrimidine is described, comprising treating 4,6-dihydroxypyrimidine with phosphorus oxychloride in the presence of a saturated hindered amine, the hydrochloride salt of a saturated hindered amine, or an unsaturated 5-membered nitrogen containing ring or a mixture thereof, and, as a first step, directly extracting the 4,6-dichloropyrimidine so formed.
Type:
Grant
Filed:
July 17, 1997
Date of Patent:
January 25, 2000
Assignee:
Zeneca Limited
Inventors:
Alan John Whitton, David John Ritchie, Ewan Campbell Boyd, Raymond Vincent Heavon Jones
Abstract: The invention concerns derivatives of the formula wherein n is 1, 2 or 3 and each R.sup.2 is independently halogeno; and R.sup.1 is amino-(2-4C)alkylamino, (1-4C)alkylamino, (1-4C)alkylamino-(2-4C)alkylamino,di-[(1-4C)alkyl]amino-(2-4C) alkylamino, pyrrolidin-1-yl-(2-4C)alkylamino, piperidino-(2-4C)alkylamino, morpholino-(2-4C)alkylamino, piperazin-1-yl-(2-4C)alkylamino, or 4-(1-4C) alkylpiperazin-1-yl-(2-4C)alkylamino, or pharmaceutically acceptable salts thereof; processes for their preparation, pharmaceutical compositions containing them, and the use of the receptor tyrosine kinase inhibitory properties of the compounds in the treatment of proliferative disease such as cancer.
Abstract: Microcapsules containing a suspension of a soild, biologically active compound in an organic, water-immiscible liquid and processes for their preparation.
Abstract: A compound of formula (1) and salts thereof, wherein: M is a metal or hydrogen; Pc is phthalocyanine nucleus; R.sup.1, R.sup.2, W.sup.1 and W.sup.2 are each independently H or optionally substituted alkyl, aryl or aralkyl; R.sup.3 is an aminoalkyl group; L is a divalent organic linking group; x, y and t are each independently 0.5 to 2.5; and (x+y+t) is from 3 to 4. A process for making the compounds of formula (1). The compounds of formula (1) are useful as colorants for inks which are used in for example ink jet printing of substrates such as paper, plastics, textile materials, metal or glass.
Type:
Grant
Filed:
April 7, 1998
Date of Patent:
January 18, 2000
Assignee:
Zeneca Limited
Inventors:
Prahalad Manibhai Mistry, Ronald Wynford Kenyon
Abstract: A process for preparing 2-(6-substituted pyrid-2-yloxymethyl)phenyacetates especially useful as intermediates for producing agricultural fungicides. The invention provides a compound having the formula (I): wherein A and D are independently selected from the group comprising halo, hydroxy, halo(C.sub.1-4)alkyl, C.sub.1-4 alkoxy, thio(C.sub.1-4)alkoxy, halo(C.sub.1-4)alkoxy, phenyl, phenoxy, nitro, amino, aclyamino, cyano, carboxy, C.sub.1-4 alkoxycarbonyl and C.sub.1-4 alkylcarbonyloxy, or D is C.sub.1-4 alkyl, and m is 0 or an integer of from 1 to 3. The process comprises treating a compound of formula (II): ##STR1## wherein A, D and m are defined as above and M is a metal atom, with a compound of formula (III): ##STR2## wherein L is a leaving group.
Type:
Grant
Filed:
December 2, 1997
Date of Patent:
January 18, 2000
Assignee:
Zeneca Limited
Inventors:
David John Ritchie, Gordon Richard Munns, Julie Forrester, Michael Charles Henry Standen, Paul Anthony Worthington, Raymond Vincent Heavon Jones
Abstract: Plants, particularly cereal plants, which have improved ability to synthesise starch at elevated or lowered temperatures and/or to synthesise starch with an altered fine structure are produced by inserting into the genome of the plant (i) a gene(s) encoding a form of an enzyme of the starch or glycogen biosynthetic pathway, particularly soluble starch synthase and/or branching enzyme and/or glycogen synthase, which display an activity which continues to increase over a temperature range over which the activity would normally be expected to decrease, and/or (ii) a gene(s) encoding sense and anti-sense constructs of enzymes of the starch biosynthetic pathway, particularly soluble starch synthase and/or branching enzyme and/or glycogen synthase, which alters the natural ratios of expression of the said enzymes or inserts enzymes with special structural characteristics which alter the natural branching pattern in starch.
Type:
Grant
Filed:
October 23, 1996
Date of Patent:
January 11, 2000
Assignee:
Zeneca Limited
Inventors:
Colin R. Bird, Philip A. Fentem, Peter L. Keeling, George Singletary
Abstract: Control of weeds in a rice crop is obtained by applying to the crop, the weeds, or the locus of either or both, a herbicidal composition containing molinate and carfentrazone-ethyl in a weight ratio of from about 60:1 to about 6:1.
Abstract: New and useful herbicidal compositions comprising N-phosphonomethylglycineor an agriculturally acceptable salt thereof, an ethoxylated alkyl glycoside surfactant, and an ethoxylated alcohol are provided.
Type:
Grant
Filed:
May 8, 1998
Date of Patent:
January 4, 2000
Assignee:
Zeneca Limited
Inventors:
Martin Keith Osborn, Michael John Bean, Philip Simon Wikeley
Abstract: 3-Isochromanone is prepared by reacting o-tolyacetic acid with sulphuryl chloride in the presence of a free radical initiator, e.g. AIBN, followed by ring closure of the 2-chloromethylphenylacetic acid so formed with a base, e.g. potassium bicarbonate.
Type:
Grant
Filed:
December 14, 1998
Date of Patent:
December 28, 1999
Assignee:
Zeneca Limited
Inventors:
Alfred Glyn Williams, Michael Charles Henry Standen, Nicholas Russell Foster, Raymond Vincent Heavon Jones
Abstract: Compounds of formula I ##STR1## wherein Q.sup.1, Q.sup.2, Q.sup.3, and Q.sup.4 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of SP and NKA are useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.