Patents Assigned to Zhejiang University
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Patent number: 9864356Abstract: The invention discloses an identification method of nonlinear parameter varying models (NPV) and belongs to the industrial identification field. The invention carries out identification tests and model identification for an identified object with nonlinear parameter varying characteristics. Firstly, the multi-input single-output nonlinear parameter varying model is identified through the steps of local nonlinear model tests, local nonlinear models identification, and operating point variable transition tests; after completing the identification of all the multi-input single-output nonlinear parameter varying models with respect to all the controlled variables, the completed multi-input multi-output nonlinear parameter varying models are built. The nonlinear parameter varying models of an identified object can be obtained by the identification method of the present invention with limited input/output data without detailed mechanism knowledge of the identified object.Type: GrantFiled: June 21, 2012Date of Patent: January 9, 2018Assignee: Zhejiang UniversityInventors: Jiangang Lu, Jie You, Qinmin Yang, Youxian Sun
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Patent number: 9861722Abstract: Disclosed is a method for preparing an oxidized cellulose hemostatic product, including using a sodium hydroxide solution with the concentration of 1 to 5% to pre-process a cellulose product; after removing lignins or impurities on the fiber surface, using an alkaline solution to activate the fiber surface further; after the activating treatment, using demin-water for washing until it is neutral and drying the obtained cellulose product in air to obtain a raw material; using a sodium hydroxide solution with the concentration of 5 to 20% as a solvent; adding the cellulose product, carbamide and ZnO that are 3 to 10%, 2% and 2% of the sodium hydroxide solution respectively.Type: GrantFiled: July 4, 2016Date of Patent: January 9, 2018Assignees: Hangzhou Singclean Medical Products Co., Ltd, Zhejiang University of Science and TechnologyInventors: Zhiguo Zhang, Yange Suo, Wei Huang, Weiqing Sun
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Publication number: 20170355657Abstract: A device and a process for producing undecylenic acid methyl ester using methyl ricinoleate as raw material are provided. The device comprises a feed pump, a raw material pre-heater, a microwave catalytic reactor, a microwave generator, a temperature controller and an infrared sensor, a condenser, a product tank and a discharge pump. The feed pump is connected with the raw material pre-heater, which is connected with the inlet of the microwave catalytic reactor. The outlet of the microwave catalytic reactor is connected with the condenser, which is connected to the product tank and the discharge pump. The microwave catalytic reactor is located in the microwave generator, which is connected with the temperature controller and the infrared sensor. The process is as follows: high-purity methyl ricinoleate, used as the raw material, is converted to methyl undecene and heptaldehyde by microwave-assisted pyrolysis process, followed by isolation and purification to produce methyl undecene.Type: ApplicationFiled: August 26, 2017Publication date: December 14, 2017Applicant: Zhejiang University of TechnologyInventors: Yong NIE, Ying DUAN, Ruchao GONG, Shangzhi YU, Meizhen LU, Jianbing JI
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Publication number: 20170355976Abstract: The disclosure provides a nitrilase from Arabis alpina, which belongs to genus Arabis, family brassicaceae. The disclosure further provides the encoding gene, vector, recombinant bacterial strain, and the application in the manufacturing of (S)-3-cyano-5-methylhexanoic acid. The wet resting cells containing nitrilase Aa-Nit can kinetically resolve racemic IBSN at 1.2 M with a 42% conversion rate in 15 hr and >99% ee value. The disclosure provides a regio- and stereoselective method for the preparation of (S)-3-cyano-5-methylhexanoic acid. This method provides an atom economical, mild, environmental friendly industrial method to manufacture (S)-3-cyano-5-methylhexanoic acid.Type: ApplicationFiled: August 28, 2017Publication date: December 14, 2017Applicants: Zhejiang University of Technology, Zhejiang Chiral Medicine Chemicals Co. Ltd.Inventors: Renchao ZHENG, Yuguo ZHENG, Qin ZHANG, Youming HUANG, Jianfeng WENG, Tianchun LIU, Weirong FAN
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Publication number: 20170355975Abstract: The disclosure provides a nitrilase from Arabis alpina, which belongs to genus Arabis, family brassicaceae. The disclosure further provides the encoding gene, vector, recombinant bacterial strain, and the application in the manufacturing of (S)-3-cyano-5-methylhexanoic acid. The wet resting cells containing nitrilase Aa-Nit can kinetically resolve racemic IBSN at 1.2 M with a 42% conversion rate in 15 hr and >99% ee value. The disclosure provides a regio- and stereoselective method for the preparation of (S)-3-cyano-5-methylhexanoic acid. This method provides an atom economical, mild, environmental friendly industrial method to manufacture (S)-3-cyano-5-methylhexanoic acid.Type: ApplicationFiled: August 28, 2017Publication date: December 14, 2017Applicants: Zhejiang University of Technology, Zhejiang Chiral Medicine Chemicals Co. Ltd.Inventors: Renchao ZHENG, Yuguo ZHENG, Qin ZHANG, Youming HUANG, Jianfeng WENG, Tianchun LIU, Weirong FAN
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Publication number: 20170288520Abstract: Provided is a broadband and large displacement angular vibrator, comprising an outer housing, a vibration table, a main spindle, a moving coil assembly, a magnetic circuit assembly, a holding brake assembly, a motor and closed loop control assembly thereof, an electric viscoelastic feedback control assembly, an air bearing, and an angular displacement sensor; the moving coil comprises a moving coil substrate and a coil; the moving coil substrate is fixed to the main spindle; the magnetic circuit assembly comprises a magnetic ring, a central magnetic pole, and magnets; the magnetic ring, central magnetic pole, magnets, and air gap form a closed magnetic circuit; the central magnetic pole is located inside the magnetic ring, the magnets are located between the magnetic ring and the central magnetic pole, and the magnets are attached to the central magnetic pole; the outer housing has the holding brake assembly; the holding brake assembly comprises a brake lining, an oil distribution sleeve, and an oil reservoirType: ApplicationFiled: July 3, 2015Publication date: October 5, 2017Applicant: Zhejiang UniversityInventors: Wen He, Bo Tang, JinLin Li, ShuShi Jia, Jie Zhou
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Publication number: 20170158729Abstract: The present invention discloses a method for synthesizing 25-hydroxy cholesterol. The method is as below: subjecting 24-dehydrocholesterol derivative as a raw material, which undergoes an addition reaction with a hydroxyl containing reagent in an organic solvent under catalysis, and then hydrolyzing the reaction product and separating to obtain 25-hydroxy cholesterol. The present invention adopts hydroxyl containing reagents such as water, formic acid, acetic acid, propionic acid, butyric acid, benzoic acid, p-methyl benzoic acid to replace the commonly used extremely toxic reagents such as Cr reagent, Hg reagent and polyfluorinated acetone in the prior art. The raw materials of the present invention are easily available, and have low effect on environment. The operation and post treatment are convenient.Type: ApplicationFiled: May 22, 2015Publication date: June 8, 2017Applicants: Zhejiang University of Technology, Zhejiang Garden Biochemical High-Tech Co., Ltd, Hangzhou Xiasha Biochemical Tech Co., LtdInventors: Can JIN, Weike SU, Ziqiang WANG, Jiangang LIU, Bin SUN, Wenhao XU
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Patent number: 9663794Abstract: Provided in the present invention are a separated endogenous rice gene resistant to high temperature (hereinafter referred to as the OsZFP gene for short) and a polypeptide encoded thereby, optimizing rice cells comprising the heat-resistant gene of the present invention or the polypeptide encoded thereby, and the plant cell preparation method thereof. Further provided are new methods and technologies for breeding new varieties of heat-resistant crops, comprising the related regulatory sequence for heat-resistance and a closely linked molecular marker denoting the heat-resistant gene and the sequence thereof.Type: GrantFiled: June 4, 2015Date of Patent: May 30, 2017Assignees: Zhejiang University, Rice Research Institute, Guangdong Academy of Agricultural SciencesInventors: Jumin Tu, Xuhua Zhong, Jianping Liu, Nongrong Huang
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Patent number: 9667177Abstract: A power converter for operating a three-phase AC electrical machine from a single phase AC power source includes an ASD having a rectifier and inverter, and an add-on power conversion module external to the ASD that is electrically connected to each of the power source and the ASD. The power conversion module includes one or more input inductors configured to store and filter single-phase AC power received from the power source and a pair of switching devices connected to each of the input inductors at an output end thereof. A controller operably connected to the power conversion module selectively controls switching of the pair of switching devices associated with each of the one or more input inductors so as to cause a sinusoidal single phase AC power to be output from the add-on power conversion module for rectification by the rectifier.Type: GrantFiled: December 15, 2015Date of Patent: May 30, 2017Assignees: Eaton Corporation, Zhejiang UniversityInventors: Huaqiang Li, Wenxi Yao, Zhengyu Lu
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Patent number: 9617326Abstract: Disclosed are an rTRAIL mutant and monomethyl auristatin E (MMAE) conjugate thereof. The amino acid sequence thereof is as represented by SEQ ID No.1. Also disclosed are a coding gene of the rTRAIL mutant and expression system, recombinant vector and expression unit containing the coding gene. Also disclosed are an rTRAIL mutant-vcMMAE conjugate and preparation and uses thereof. The conjugate of the present invention has the biological functions of both the rTRAIL mutant and the MMAE; the MMAE is directionally transferred to a tumor cell through the specific binding between the rTRAIL mutant and a death receptor on the surface of the tumor cell, and is released and takes effect in the tumor cell, thus killing the tumor cells less sensitive or even resistant to TRAIL, and reducing the toxicity generated by the separate administration of the MMAE.Type: GrantFiled: June 20, 2013Date of Patent: April 11, 2017Assignee: Zhejiang UniversityInventors: Shuqing Chen, Liqiang Pan
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Publication number: 20170058274Abstract: The disclosure provides a nitrilase from Arabis alpina, which belongs to genus Arabis, family brassicaceae. The disclosure further provides the encoding gene, vector, recombinant bacterial strain, and the application in the manufacturing of (S)-3-cyano-5-methylhexanoic acid. The wet resting cells containing nitrilase Aa-Nit can kinetically resolve racemic IBSN at 1.2 M with a 42% conversion rate in 15 hr and >99% ee value. The disclosure provides a regio- and stereoselective method for the preparation of (S)-3-cyano-5-methylhexanoic acid. This method provides an atom economical, mild, environmental friendly industrial method to manufacture (S)-3-cyano-5-methylhexanoic acid.Type: ApplicationFiled: August 25, 2016Publication date: March 2, 2017Applicants: Zhejiang University of Technology, Zhejiang Chiral Medicine Chemicals Co. Ltd.Inventors: Renchao ZHENG, Yuguo ZHENG, Qin ZHANG, Youming HUANG, Jianfeng WENG, Tianchun LIU, Weirong FAN
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Patent number: 9559572Abstract: A method for manufacturing a permanent-magnet motor rotor includes manufacturing a rotary shaft, a permanent magnet, a front end cover, a rear end cover, and a magnetic yoke unit, where the magnetic yoke unit contains multiple pole shoe parts and one iron core part, where each pole shoe part and the iron core part are connected therebetween via a connecting strip; manufacturing a rotor spacer; all positioning holes of the magnetic yoke unit correspond to the permanent-magnet through hole of the rotor spacer to form a permanent-magnet passage; inserting the permanent magnet into the permanent-magnet passage; inserting tightening bolts; cutting off the mid-section of each connecting strip, overlapping the pole shoe parts to form a rotor pole shoe, overlapping the iron core parts to form a rotor iron core; and arranging respectively the front end cover and the rear end cover on a front end and a rear end.Type: GrantFiled: April 26, 2012Date of Patent: January 31, 2017Assignee: Zhejiang UniversityInventors: Youtong Fang, Jien Ma, Xiaoyan Huang, Jian Zhang, Qinfen Lu, Jiancheng Zhang, Wei Chen, Jiabin Liu
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Patent number: 9505628Abstract: This disclosure provides a facial green method for metal cyanides preparation, including the following steps: 1) supported metal nanoparticles and Fenton's reagent are mixed with nitrile and then stirred to obtain suspension, wherein metal nanoparticles are selected from a nano metal, nano metal oxide and nano metal salt; 2) centrifuging the suspension to obtain a product and drying the product after stirring to obtain the metal cyanides. As prepared metal cyanides have broad application prospects in the fields of sensor, battery, medicine, electroplating and catalysis. This Fenton-improved cyanation (FIC) method may effectively exclude the toxicity from free cyanide anions and get rid of UV-light, being more energy-saving and more feasible for large-scale industrial production of MCs.Type: GrantFiled: October 27, 2014Date of Patent: November 29, 2016Assignee: Zhejiang UniversityInventors: Jie Fan, Wuzhong Yi, Renhong Li, Shihui Zou, Liping Xiao, Linfang Lu
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Patent number: 9475843Abstract: An antimicrobial peptide WY-21 has amino acid sequence of Val-Lys-Phe-Phe-Arg-Lys-Leu-Lys-Lys-Ser-Val-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg (SEQ ID NO: 1). The antimicrobial peptide WY-21 can be used as broad-spectrum antibacterial agents for the treatment of Gram-negative or Gram-positive bacterial infection. It can also be applied for reducing immune system regulated inflammation.Type: GrantFiled: May 25, 2016Date of Patent: October 25, 2016Assignee: Zhejiang UniversityInventors: Yizhen Wang, Hongbo Yi
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Patent number: 9174183Abstract: The invention provides a fluidized bed polymerization reactor, including: a column, in which a liquid distributor and a gas distributor above the liquid distributor are arranged, so that the reaction zone being divided into a first zone and a second zone through the gas distributor; and a circulating unit for circulating the gas material originated from the top zone of the column into the bottom zone thereof in a form of gas-liquid mixture. The gas-liquid mixture is undergone a gas-liquid separation in the bottom zone, the gas phase portion obtained being fed to the gas distributor and then into the second zone while the liquid phase portion obtained being entered into the first zone through the liquid distributor, so that the temperature in the first zone is lower than that in the second zone. Therefore, polymer with a molecular weight distributed in a relatively wide range can be obtained. The invention further provides a method for preparing polymer.Type: GrantFiled: September 29, 2011Date of Patent: November 3, 2015Assignees: China Petroleum & Chemical Corporation, Zhejiang University, Sinopec Engineering IncorporationInventors: Wenqing Wu, Yongrong Yang, Guanghai Luo, Jingdai Wang, Binbo Jiang, Shufang Wang, Guodong Han
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Patent number: 9133023Abstract: A nanopore sensor comprises second electrophoresis electrode or micropump, second fluidic reservoir, second micro-nanometer separation channel, substrate, sub-nanometer-thick functional layer, first micro-nanometer separation channel, first electrophoresis electrode or micropump, and first electrophoresis electrode or micropump that are sequentially assembled. An opening and a nanopore are provided through the substrate and the sub-nanometer-thick functional layer, respectively. A first electrode for measuring ionic current is provided in the first micro-nanometer separation channel, and a second electrode for measuring ionic current is provide in the second micro-nanometer separation channel. The present invention provides a simple method to prepare a sub-nanometer functional layer having a nanopore extending through the sub-nanometer-thick functional layer. The pore size is comparable to the spacing between two adjacent bases in a DNA strand required for single-base resolution sequencing.Type: GrantFiled: September 24, 2011Date of Patent: September 15, 2015Assignee: Zhejiang UniversityInventors: Ming-Sheng Xu, Hongzheng Chen, Gang Wu, Minmin Shi, Mang Wang
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Publication number: 20150239856Abstract: Disclosed in the present invention are 4-(5-amino-6-hydroxybenzoxazol-2-yl)ammonium benzoate shown in formula (I) and the preparation method and use thereof. The preparation method comprises: fully reacting 4-(5-amino-6-hydroxybenzoxazol-2-yl)benzoic acid shown in formula (II) or 4-(5-amino-6-hydroxybenzoxazol-2-yl)carboxamide benzoate, as a raw material, with ammonia in an aqueous solvent, and directly heating the obtained reaction liquid to remove excess ammonia, so as to obtain 4-(5-amino-6-hydroxybenzoxazol-2-yl)ammonium benzoate. The mass of the 4-(5-amino-6-hydroxybenzoxazol-2-yl)ammonium benzoate (ABAA) prepared in the present invention can reach a polymer grade (where the purity is above 99.Type: ApplicationFiled: February 9, 2013Publication date: August 27, 2015Applicants: Zhejiang University of technology, Yancheng Dragon Chemical Co., Ltd.Inventors: Ningren Jin, Biao He, Jing Jin
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Patent number: 9052291Abstract: An optical sensor based on a broadband light source and cascaded waveguide filters comprises a broadband light source, an input waveguide, a reference ring resonator coupled with the input waveguide, a common bus waveguide coupled with the reference ring resonator, a sensing ring resonator coupled with the common bus waveguide, an output waveguide coupled with the sensing ring resonator, and two optical power detectors. At least a portion of the sensing ring resonator is influenced by the physical parameter to be measured or in contact with an analyte. The variation of the physical parameter to be measured or the variation of the analyte induces a shift of the transmission spectrum of the sensing ring resonator. By using the cascaded filtering effect of the double resonators, the wavelength shift can be translated into a variation of the total output power. Consequently the physical parameter to be measured can be easily deduced.Type: GrantFiled: January 21, 2011Date of Patent: June 9, 2015Assignee: Zhejiang UniversityInventors: Jian-Jun He, Lei Jin, Mingyu Li
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Patent number: 9027221Abstract: A method for manufacturing a compound refractive lens for focusing X-rays in two dimensions. The method includes the following steps: 1) manufacturing a mother lens; 2) manufacturing a daughter lens; and 3) assembling the mother lens and the daughter lens. The assembly of the mother lens and the daughter lens includes: aligning square embedded lens bodies of the daughter lens with square holes of the mother lens, respectively, for allowing the first parabola-shaped holes on the mother lens and the second parabola-shaped holes on the daughter lens to form an orthogonal structure; and inserting and pressing the square embedded lens bodies into the corresponding square holes, respectively. The method of the invention has advantages of high-precision for manufacturing and calibration of optical axis, and meanwhile the compound refractive lens manufactured based the method has high X-rays focusing efficiency.Type: GrantFiled: September 14, 2013Date of Patent: May 12, 2015Assignee: Zhejiang University of TechnologyInventors: Zichun Le, Wen Dong
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Patent number: D730458Type: GrantFiled: June 11, 2014Date of Patent: May 26, 2015Assignee: Zhejiang UniversityInventor: Xiangjun Zhu