Abstract: This invention provides a multivalent immunogenic composition including a soluble portion of a Mycoplasma hyopneumoniae (M.hyo) whole cell preparation; a porcine circovirus type 2 (PCV2) antigen; and a Lawsonia intracellularis antigen, wherein the soluble portion of the M.hyo preparation is substantially free of both (i) IgG and (ii) immunocomplexes comprised of antigen bound to immunoglobulin.

Abstract: This invention provides an immunogenic composition including the supernatant of a Mycoplasma hyopneumoniae (M.hyo) culture, wherein the supernatant of the M.hyo culture has been separated from insoluble cellular material by centrifugation, filtration, or precipitation and is substantially free of both (i) IgG and (ii) immunocomplexes comprised of antigen bound to immunoglobulin.

Abstract: Methods and apparatus for processing eggs based upon a characteristic such as gender are provided. Material is extracted from each of a plurality of live eggs, the extracted material is assayed to identify eggs having the characteristic, and then eggs identified as having the characteristic are processed accordingly.

Abstract: An egg identification system for determining egg viability is provided. Such a system includes an emitter assembly for emitting electromagnetic radiation toward a plurality of eggs positioned proximate thereto. A detector assembly is positioned proximate to the emitter assembly. The detector assembly has a plurality of detectors fixedly positioned with respect to the emitter assembly and configured to detect electromagnetic radiation transmitted through the eggs. An optical shielding assembly is configured to move with respect to the detectors. A processor is in communication with detector assembly and is configured to determine viability of the eggs using the detected electromagnetic radiation. An associated method is also provided.

Abstract: The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals.

Abstract: The present disclosure relates generally to sol-gel polymer composites that comprise chitosan, a hydrophilic polymer, a gelation agent, and optional additional ingredients in a suitable medium. Advantageously, the sol-gel polymer composite can form a durable seal or strong solid in response to one or more physiological stimulus. The disclosure further relates to medical and veterinary uses of the composite, particularly, methods and delivery systems for reducing or preventing the incidence of a mammary disorder in a dairy animal. More particularly, the disclosure includes methods and sol-gel polymer composite compositions for creating a physical barrier on the teat surface or in the teat canal or cistern of a non-human animal for prophylactic treatment of mammary disorders such as mastitis wherein the sol-gel polymer creates a seal in response to one or more physiological stimulus.

Abstract: This invention provides a vaccine composition for protecting pigs against PCV2, including a highly virulent porcine circovirus type 2b (PCV2b) divergent strain, the composition including a PCV2b divergent ORF2 polypeptide, wherein the ORF2 polypeptide comprises Leucine (L) at position 89, Threonine (T) at position 90, and Aspargine (N) at position 134, according to the numbering of SEQ ID NO: 1 herein.

Abstract: The present disclosure relates to methods, compositions, and devices for treatments related to mammary tissue in subjects, including reducing the incidence of mastitis. In particular, the disclosure can relate to creating a physical barrier on a teat surface, in a teat canal, or in a teat cistern for prophylactic treatment of mammary disorders.

Abstract: An egg identification system for determining viability of an avian egg is provided. Such a system includes an emitter assembly configured to emit electromagnetic radiation toward an egg. A detector assembly is axially aligned with the emitter assembly to detect electromagnetic radiation transmitted through the egg. The detector assembly is spaced-apart from the egg during operation thereof such that the detector assembly does not contact the egg. The detected electromagnetic radiation is processed using transmission spectroscopy analysis to determine whether the egg is viable. An associated method is also provided.

Abstract: The present disclosure describes novel caninized anti-NGF antibodies, antigen binding proteins and polynucleotides encoding the same. The disclosure further describes use of the novel antibodies, antigen binding proteins and/or nucleotides of the invention for the treatment and/or prevention of NGF related disorders, particularly for the management of canine pain.

Abstract: Described herein are improved processes for the preparation of the 7H-pyrrolo[2,3-d]pyrimidine compound, N-methyl-1-{trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl}-methanesulfonamide, intermediates thereof, and veterinary acceptable salts thereof.

Abstract: An egg processing apparatus is provided. Such an apparatus includes a plurality of egg processing devices configured to interact with a plurality of eggs carried by an egg carrier. An egg support assembly is positioned beneath the egg processing devices such that an egg carrier is capable of being moved between the egg processing devices and the egg support assembly. The egg support assembly includes a plurality of pedestals, with each pedestal having a plurality of discrete egg support members cooperating to form a seating arrangement portion for contacting and supporting an end of an egg in the egg carrier. An associated assembly and method are also provided.

Abstract: The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a PWD circovirus, also are provided. Method for selecting compounds capable of modulating the viral infection are further provided. Pharmaceutical, including vaccine, compositions for preventing and/or treating viral infections caused by PWD circovirus and the use of vectors for preventing and/or treating diseases also are provided.

Abstract: An advancement system for an in ovo injection apparatus is provided. Such an advancement system is configured to advance an egg carrier carrying a plurality of avian eggs to an injection assembly. The advancement system includes a guide assembly configured to receive the egg carrier and provide support thereto during advancement of the egg carrier. A manual advancement device slidingly engages the guide assembly such that the manual advancement device is movable along the guide assembly. The manual advancement device is capable of interacting with a trailing end of the egg carrier to advance the egg carrier to an injection position. At least one stop is positioned to interact with the manual advancement device during advancement of the egg carrier so as to prevent progression of the manual advancement device beneath the injection assembly, thereby locating the egg carrier at the injection position. An associated method is also provided.

Abstract: An egg transfer system is provided. Such an egg transfer system includes a controller configured to receive a classification signal indicative of an egg classification status for each of a plurality of eggs carried by a flat. A transfer head assembly is in communication with the controller and is configured to remove a plurality of eggs from the flat. The eggs are grouped into at least a first and second subset based on the egg classification status. The controller is configured to direct the transfer head assembly to selectively release the first and second subsets separately based on the respective egg classification status of the eggs. An associated method is also provided.

Abstract: An egg processing apparatus is provided. Such an apparatus includes a plurality of egg processing devices configured to interact with an avian egg. A sanitization system is in fluid communication with the egg processing devices. The sanitization system is configured to deliver sanitizing fluid to the egg processing devices for sanitization thereof after interaction with an egg. The sanitization system has a valve-less manifold assembly. An associated method is also provided.

Abstract: A positioning device for presenting an avian bird is provided. Such a positioning device includes a frame and a plurality of positioning assemblies engaged with the frame. The positioning assemblies are configured to entirely support and restrain an avian bird in a flight-replicated position such that the avian bird is presented for various reasons, such as undergoing a vaccine delivery procedure, evaluation, or any other process. An associated method is also provided.

Abstract: An egg lifting device is provided. Such a device includes a body and a securing arrangement extending from the body. The securing arrangement is configured to engage and deflect about an egg such that the egg is seated within the securing arrangement for lifting thereof. A plurality of egg lifting devices is arranged on an egg removal system such that multiple eggs are capable of being removed from an egg flat. Associated systems and methods are also provided.

Abstract: The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a PWD circovirus, also are provided. Method for selecting compounds capable of modulating the viral infection are further provided. Pharmaceutical, including vaccine, compositions for preventing and/or treating viral infections caused by PWD circovirus and the use of vectors for preventing and/or treating diseases also are provided.

Abstract: An egg identification system for determining viability of an avian egg is provided. Such a system includes an emitter assembly configured to emit electromagnetic radiation toward an egg. A detector assembly is axially aligned with the emitter assembly to detect electromagnetic radiation transmitted through the egg. The detector assembly is spaced-apart from the egg during operation thereof such that the detector assembly does not contact the egg. The detected electromagnetic radiation is used to generate an output signal. The output signal is processed to determine whether there exists a periodic variation or an aperiodic perturbation in an intensity of the electromagnetic radiation transmitted through the egg corresponding to action of a heart or embryo movement, wherein the existence of the periodic variation or aperiodic perturbation indicates that the egg is viable. An associated method is also provided.