Patents Assigned to ZymoGenetics
  • Protease-deficient strains of Pichia methanolica
    Patent number: 6153424
    Abstract: Protease-deficient strains of the methylotrophic yeast Pichia methanolica and materials and methods for generating such strains are disclosed. The strains have a functional deficiency in a vacuolar protease, such as proteinase A or proteinase B. The strains are useful as hosts for the expression of heterologous genes encoding proteins of commercial or other interest.
    Type: Grant
    Filed: March 9, 1999
    Date of Patent: November 28, 2000
    Assignee: ZymoGenetics, Inc.
    Inventors: Christopher K. Raymond, Erica Vanaja
  • Lipocalin homologs
    Patent number: 6143720
    Abstract: The present invention is directed to polynucleotides and polypeptides for a novel member of the lipocalin family. The expression of this novel polynucleotide is restricted to testis and mammary gland, particularly breast tumor tissue. The polypeptide has been designated zlipo1. The present invention also includes antibodies to the zlipo1 polypeptides.
    Type: Grant
    Filed: November 2, 1999
    Date of Patent: November 7, 2000
    Assignee: ZymoGenetics, Inc.
    Inventor: Darrell C. Conklin
  • Human thyroid protein zsig45
    Patent number: 6140084
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zsig45, a novel human protein expressed in thyroid. The polypeptides, and polynucleotides encoding them, may be used for detecting human disease states and chromosomal abnormalities, and as a therapeutic. The present invention also includes antibodies to the zsig45 polypeptides.
    Type: Grant
    Filed: December 1, 1998
    Date of Patent: October 31, 2000
    Assignee: ZymoGenetics, Inc.
    Inventors: Theresa A. Deisher, Paul O. Sheppard
  • Human prohormone convertase 4
    Patent number: 6127162
    Abstract: The present invention provides polynucleotide and polypeptide molecules for a novel human prohormone convertase 4. The polynucleotides encoding human prohormone convertase 4, are located on chromosome 19, and may, for example, be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein and antibodies thereto.
    Type: Grant
    Filed: August 6, 1999
    Date of Patent: October 3, 2000
    Assignee: ZymoGenetics, Inc.
    Inventors: Si Lok, Stephen R. Jaspers
  • Calcitonin mimetics
    Patent number: 6124299
    Abstract: Compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. Included among the calcitonin mimetics of the present invention are substituted piperazines. The calcitonin mimetics of the present invention are also useful in libraries and in assays for the determination of calcitonin receptor activity.
    Type: Grant
    Filed: February 23, 1998
    Date of Patent: September 26, 2000
    Assignee: ZymoGenetics, Inc.
    Inventors: Nand Baindur, Virender Labroo, Steven Stroop, Stephanie Beigel, Theresa Martinez, Charles R. Petrie, Mark W. Orme, Patricia A. McKernan, Emma E. Moore
  • Methods for stimulating pancreatic islet cell regeneration
    Patent number: 6114307
    Abstract: The present invention provides compositions for stimulating an increase in islet proliferation and .beta.-cell mass using an insulin homolog polypeptide. The present invention also includes methods for treating diabetes by stimulating islet proliferation and .beta.-cell mass increases and affecting insulin levels.
    Type: Grant
    Filed: December 16, 1997
    Date of Patent: September 5, 2000
    Assignee: ZymoGenetics, Inc.
    Inventors: Stephen R. Jaspers, Katherine H. Sprugel, Hong Ping Ren, Jacqueline M. Humes, Darrell C. Conklin
  • Protese-activated receptor PAR4 (ZCHEMR2)
    Patent number: 6111075
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for PAR4, a novel member of the protease-activated receptor family. The polypeptides, and polynucleotides encoding them, mediate biological responses and/or cellular signaling in response to proteases. Protease cleavage of PAR4 exposes a PAR4 extracellular amino terminal portion that serves as a ligand for the PAR4 receptor. PAR4 may be used as a target in drug screening, and further used to identify proteinaceous or non-proteinaceous PAR4 agonists and antagonists. The present invention also includes antibodies to the PAR4 polypeptides.
    Type: Grant
    Filed: April 1, 1998
    Date of Patent: August 29, 2000
    Assignee: ZymoGenetics, Inc.
    Inventors: Wen-feng Xu, Scott R. Presnell, David P. Yee, Donald C. Foster
  • Human prohormone convertase 4
    Patent number: 6100041
    Abstract: The present invention provides polynucleotide and polypeptide molecules for a novel human prohormone convertase 4. The polynucleotides encoding human prohormone convertase 4, are located on chromosome 19, and may, for example, be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein and antibodies thereto.
    Type: Grant
    Filed: August 6, 1999
    Date of Patent: August 8, 2000
    Assignee: ZymoGenetics, Inc.
    Inventors: Si Lok, Stephen R. Jaspers
  • Methods for stimulating erythropoiesis using hematopoietic proteins
    Patent number: 6099830
    Abstract: Methods for stimulating erythropoiesis using the hematopoietic protein thrombopoietin, optionally in combination with erythropoietin, are provided. The methods provided may be used to stimulate erythropoiesis in bone marrow and peripheral blood cells and in vitro and in vivo. In addition, methods for treatment of thrombocytopenia and anemia in patients are disclosed.
    Type: Grant
    Filed: September 12, 1997
    Date of Patent: August 8, 2000
    Assignees: ZymoGenetics, Inc., University of Washington
    Inventor: Kenneth Kaushansky
  • Kunitz domain polypeptide and materials and methods for making it
    Patent number: 6087473
    Abstract: Proteinase inhibitors comprising a Kunitz domain are disclosed. The Kunitz domain comprises a sequence of amino acid residues as shown in SEQ ID NO:5, wherein the sequence is at least 90% identical to SEQ ID NO:2. Also disclosed are methods for making the proteinase inhibitors, and expression vectors and cultured cells that are useful within the methods. The proteinase inhibitors may be used as components of cell culture media, in protein purification, and in certain therapeutic and diagnostic applications.
    Type: Grant
    Filed: May 26, 1999
    Date of Patent: July 11, 2000
    Assignee: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Donald C. Foster, Zeren Gao
  • Polynucleotides encoding novel tumor antigens
    Patent number: 6084088
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for a secreted polypeptide designated zsig15. The polypeptides, and polynucleotides encoding them, may be used for mapping chromosome 19 and markers for tumor growth. The present invention also includes antibodies to the zsig15 polypeptides.
    Type: Grant
    Filed: May 6, 1998
    Date of Patent: July 4, 2000
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Angelika Grossmann
  • Hematopoietic cytokine receptor
    Patent number: 6080406
    Abstract: Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular ligand-binding domain of a cell-surface receptor that is expressed at high levels in lymphoid tissue, including B-cells and T-cels. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo.
    Type: Grant
    Filed: March 24, 1999
    Date of Patent: June 27, 2000
    Assignee: ZymoGenetics, Inc.
    Inventors: James W. Baumgartner, Donald C. Foster, Frank J. Grant, Cindy A. Sprecher
  • Compositions and methods for stimulating bone growth
    Patent number: 6080779
    Abstract: Compounds of the formula ##STR1## wherein X in each of formulas (1) and (2) represents a substituted or unsubstituted alkylene, alkenylene, or alkynylene linker of 2-6 C;Y represents one or more carbocyclic or heterocyclic rings; when two or more rings are present in Y, they may optionally be fused; andR' represents a cation, H or a substituted or unsubstituted alkyl group of 1-6 C; andthe dotted lines represent optional .pi.-bonds,promote bone formation and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation. These compounds can be used in combination with other bone growth-promoting compounds and/or estrogens and/or bisphosphonates for this purpose.
    Type: Grant
    Filed: June 12, 1998
    Date of Patent: June 27, 2000
    Assignees: OsteoScreen, Inc., ZymoGenetics Corporation
    Inventors: Shirley R. Gasper, Robert R. West, Theresa Martinez, Kirk G. Robbins, Patricia A. McKernan, Nand Baindur, Virender M. Labroo, Gregory R. Mundy
  • Polynucleotides encoding insulin homolog zins3
    Patent number: 6046028
    Abstract: The present invention relates to polynucleotides encoding for novel insulin homolog polypeptides that have been designated Zins3. The human and mouse polynucleotides and corresponding polypeptides are described, and comprise a B chain, A chain, and C-peptide, or portions thereof. The polynucleotide sequence maps to human chromosome 12.
    Type: Grant
    Filed: October 15, 1997
    Date of Patent: April 4, 2000
    Assignee: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Catherine E. Lofton-Day, Si Lok, Stephen R. Jaspers
  • Modified Factor VII
    Patent number: 6039944
    Abstract: The catalytic active site of Factor VII is modified to produce a compound which effectively interrupts the blood coagulation cascade. The modifications render Factor VIIa substantially unable to activate plasma Factors X or IX. Pharmaceutical compositions of the modified Factor VII are used to treat a variety of coagulation-related disorders.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: March 21, 2000
    Assignees: ZymoGenetics, Inc., Novo Nordisk A/S
    Inventors: Kathleen L. Berkner, Lars Christian Petersen, Charles E. Hart, Ulla Hedner, Claus Bregengaard
  • Cloning and expression of human islet glutamic acid decarboxylase autoantigen
    Patent number: 6025176
    Abstract: Human pancreatic islet cell glutamic acid decarboxylase (GAD), an autoantigen involved in the development of insulin-dependent diabetes mellitus (IDDM), has been cloned, sequenced and expressed by recombinant means. Recombinant human islet cell GAD polypeptides and antibodies specific to the GAD polypeptides can be used in methods of diagnosis and treatment, including use in immunoadsorptive therapy and the induction of immune tolerance.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: February 15, 2000
    Assignee: The Board of Regents of the University of Washington and ZymoGenetics, Inc.
    Inventors: Ake Lernmark, Allan E. Karlsen, Catherine E. Grubin, William Hagopian, Patrick J. O'Hara, Donald C. Foster
  • Secreted salivary zsig32 polypeptides
    Patent number: 6025197
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for secreted salivary zsig32 polypeptides. The polypeptides, and polynucleotides encoding them modulate adhesion or modulate or indicate salivary gland function. The present invention also includes antibodies and binding proteins for the zsig32 polypeptides.
    Type: Grant
    Filed: March 18, 1998
    Date of Patent: February 15, 2000
    Assignee: ZymoGenetics, Inc.
    Inventor: Paul O. Sheppard
  • Compositions and methods for stimulating bone growth
    Patent number: 6022887
    Abstract: Compounds of the formula ##STR1## wherein X in each of formulas (1) and (2) represents a substituted or unsubstituted alkylene, alkenylene, or alkynylene linker of 2-6C;Y represents one or more carbocyclic or heterocyclic rings; when two or more rings are present in Y, they may optionally be fused; andR' represents a cation, H or a substituted or unsubstituted alkyl group of 1-6C; andthe dotted lines represent optional .pi.-bonds,promote bone formation and are thus usefull in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation.
    Type: Grant
    Filed: December 12, 1997
    Date of Patent: February 8, 2000
    Assignees: OsteoScreen, Inc., ZymoGenetics Corporation
    Inventors: Shirley R. Gasper, Robert R. West, Theresa Martinez, Kirk G. Robbins, Patricia A. McKernan, Nand Baindur, Virender M. Labroo
  • Secreted salivary zsig32 polypeptides
    Patent number: 6022847
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for secreted salivary zsig32 polypeptides. The polypeptides, and polynucleotides encoding them modulate adhesion or modulate or indicate salivary gland function. The present invention also includes antibodies and binding proteins for the zsig32 polypeptides.
    Type: Grant
    Filed: May 19, 1998
    Date of Patent: February 8, 2000
    Assignee: ZymoGenetics, Inc.
    Inventor: Paul O. Sheppard
  • Lipocalin homolog
    Patent number: 6020163
    Abstract: The present invention is directed to polynucleotides and polypeptides for a novel member of the lipocalin family. The expression of this novel polynucleotide is restricted to testis and mammary gland, particularly breast tumor tissue. The polypeptide has been designated zlipo1. The present invention also includes antibodies to the zlipo1 polypeptides.
    Type: Grant
    Filed: August 6, 1998
    Date of Patent: February 1, 2000
    Assignee: ZymoGenetics, Inc.
    Inventor: Darrell C. Conklin