Patents Assigned to ZymoGenetics
  • Connective tissue growth factor homologs
    Publication number: 20020147328
    Abstract: This present invention is directed to polypeptide and polynucleotide molecules that encode a new connective tissue growth factor homolog polypeptide. The human polypeptides have been designated zCTGF4 and the mouse orthologs have been designated zCTGF2. The invention also includes antibodies, expression vectors, host cells expressing zCTGF4 and variants. Also included are methods for producing the polypeptides and using the polynucleotides and polypeptides.
    Type: Application
    Filed: November 5, 2001
    Publication date: October 10, 2002
    Applicant: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Stephen R. Jaspers, Zeren Gao
  • Secretory protein-48
    Publication number: 20020132996
    Abstract: Secretory Protein-48 (Zsig48), polypeptides, polynucleotides encoding said polypeptides, antibodies which specifically bind to Zsig48 and anti-idiotypic antibodies. Zsig48 polypeptides cause leukocytes to proliferate and thus can be used to elevate leukocytes in cancer treatments and in immunosuppressed patients.
    Type: Application
    Filed: September 19, 2001
    Publication date: September 19, 2002
    Applicant: ZymoGenetics, Inc.
    Inventors: Si Lok, Paul O. Sheppard, Wayne Kindsvogel, Susan J. Bort
  • Methods of promoting blood flow within the vasculature of a mammal
    Patent number: 6448221
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for use as inhibitors in hemostasis and immune function. Such inhibitors are members of the family of proteins bearing a collagen-like domain and a globular domain. The inhibitors are useful for promoting blood flow in the vasculature by reducing thrombogenic and complement activity. The inhibitors are also useful for pacifying collagenous surfaces and modulating wound healing.
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: September 10, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Gerald W. Lasser, Paul D. Bishop
  • Ring finger protein zapop3
    Patent number: 6440697
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zapop3, a novel human member of the RING finger protein family. The polypeptides, and polynucleotides encoding them, may be used for detecting human chromosomal abnormalities. The present invention also includes antibodies to the zapop3 polypeptides.
    Type: Grant
    Filed: November 4, 1999
    Date of Patent: August 27, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Domenick Venezia, Angelika Grossmann
  • Pichia methanolica glyceraldehyde-3-phosphate dehydrogenase 2 promoter and terminator
    Patent number: 6440720
    Abstract: Transcription promoter and terminator sequences from the Pichia methanolica glyceraldehyde-3-phosphate dehydrogenase 2 gene (GAP2 gene) are disclosed. The sequences are useful within DNA constructs for the production of proteins of interest in cultured P. methanolica cells. Within the expression vectors, a GAP2 promoter and/or a GAP2 terminator is operably linked to a DNA segment encoding the protein of interest.
    Type: Grant
    Filed: December 7, 2001
    Date of Patent: August 27, 2002
    Assignee: ZymoGenetics, Inc.
    Inventor: Christopher K. Raymond
  • Protease-activated receptor PAR4 ZCHEMR2
    Patent number: 6436400
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for PAR4, a novel member of the protease-activated receptor family. The polypeptides, and polynucleotides encoding them, mediate biological responses and/or cellular signaling in response to proteases. Protease cleavage of PAR4 exposes a PAR4 extracellular amino terminal portion that serves as a ligand for the PAR4 receptor. PAR4 may be used as a target in drug screening, and further used to identify proteinaceous or non-proteinaceous PAR4 agonists and antagonists. The present invention also includes antibodies to the PAR4 polypeptides.
    Type: Grant
    Filed: January 7, 2000
    Date of Patent: August 20, 2002
    Assignees: ZymoGenetics, Inc., University of Washington
    Inventors: Wen-feng Xu, Scott R. Presnell, David P. Yee, Donald C. Foster
  • Kunitz domain polypeptide zkun6
    Publication number: 20020110887
    Abstract: Proteinase inhibitors comprising a Kunitz domain are disclosed. The Kunitz domain comprises a sequence of amino acid residues as shown in SEQ ID NO:3, wherein the sequence is at least 80% identical to residues 6 through 56 of SEQ ID NO:2. Also disclosed are methods for making the proteinase inhibitors, and expression vectors and cultured cells that are useful within the methods. The proteinase inhibitors may be used as components of cell culture media, in protein purification, and in certain therapeutic and diagnostic applications.
    Type: Application
    Filed: December 14, 2001
    Publication date: August 15, 2002
    Applicant: ZymoGenetics, Inc.
    Inventor: Darrell C. Conklin
  • Growth factor homolog ZVEGF3
    Patent number: 6432673
    Abstract: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
    Type: Grant
    Filed: December 7, 1999
    Date of Patent: August 13, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Zeren Gao, Charles E. Hart, Christopher S. Piddington, Paul O. Sheppard, Kimberly E. Shoemaker, Debra G. Gilbertson, James W. West
  • Islet cell antigen 1851
    Publication number: 20020102616
    Abstract: A mammalian islet cell antigen polypeptide involved in the development of insulin-dependent diabetes mellitus (IDDM) is disclosed. This islet cell antigen polypeptide, 1851, was found to contain regions of homology to the protein tyrosine phosphatase family. Methods for diagnosis and treatment, including use in immunoprecipitation assays and the induction of immune tolerance using the recombinant mammalian polypeptides and antibodies specific to mammalian islet cell antigen 1851 polypeptides are presented.
    Type: Application
    Filed: June 7, 2001
    Publication date: August 1, 2002
    Applicant: ZymoGenetics, Inc.
    Inventors: Wayne Kindsvogel, Laura J. Jelinek, Paul O. Sheppard, William A. Hagopian, James M. LaGasse
  • Testis specific glycoprotein zpep10
    Publication number: 20020102704
    Abstract: The present invention relates to zpep10 polypeptides and polynucleotides encoding the same. Zpep10 polypeptide is a testis-specific membrane glycoprotein. Zpep10 polypeptides would be useful for modulating spermatogenesis and egg-sperm interaction and would be useful to study or modulate these functions in in vitro or in vivo systems. The present invention also includes antibodies to the zpep10 polypeptides.
    Type: Application
    Filed: February 20, 2001
    Publication date: August 1, 2002
    Applicant: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Christopher S. Piddington, Jeff L. Ellsworth
  • Human beta-1,3-galactosyltransferase
    Publication number: 20020098564
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for znssp6, a novel member of the galactosyltransferase family. The polypeptides, and polynucleotides encoding them, are cell-cell interaction and glycoprotein synthesis modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the znssp6 polypeptides.
    Type: Application
    Filed: October 22, 2001
    Publication date: July 25, 2002
    Applicant: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Gayle Yamamoto, Zeren Gao, Stephen R. Jaspers
  • Novel human kunitz-type inhibitors and methods relating thereto
    Publication number: 20020098560
    Abstract: The present invention provides isolated DNA molecules comprising a DNA segment encoding novel human Kunitz-type inhibitors. Also provided are DNA constructs comprising a first DNA segment encoding a novel human Kunitz-type inhibitor wherein said first DNA segment is operably linked to additional DNA segments required for the expression for the first DNA segment, as well as host cells containing such DNA constructs and methods for producing proteins from the host cells.
    Type: Application
    Filed: July 13, 2001
    Publication date: July 25, 2002
    Applicant: ZymoGenetics, Inc.
    Inventors: Cindy A. Sprecher, Walt Kisiel, Donald C. Foster
  • Human serine protease
    Patent number: 6423526
    Abstract: Members of the serine protease family play a role in carefully controlled processes, such as blood coagulation, fibrinolysis, complement activation, fertilization, and hormone production. These enzymes are also used in a variety of diagnostic, therapeutic, and industrial contexts. Zfaix1 is a new member of the serine protease family.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: July 23, 2002
    Assignee: ZymoGenetics, Inc.
    Inventor: James L. Holloway
  • Short gastrointestinal peptides
    Patent number: 6420521
    Abstract: The present invention is directed to polynucleotides, polypeptides, peptides, variants and uses thereof for novel peptide fragments which have homology to motilin. Tissue distribution of the mRNA for the novel polypeptide fragment is specific to the stomach, small intestine and pancreas. Binding of the peptide fragment has been shown in kidney and small intestine. The present invention further includes agonists, antagonists, variants, antibodies and host cells expressing the cDNA encoding the novel Short Gastrointestinal Peptides (SGIP) peptide.
    Type: Grant
    Filed: June 30, 2000
    Date of Patent: July 16, 2002
    Assignee: Zymogenetics, Inc.
    Inventors: Paul O. Sheppard, Stephen R. Jaspers, Theresa A. Deisher, Paul D. Bishop
  • Mammalian adhesion protease peptides
    Patent number: 6420154
    Abstract: The present invention relates to polynucleotide and polypeptide molecules, and variants thereof, for MAPP, a novel member of the Disintegrin Proteases. The polypeptides, and polynucleotides encoding them, are cell-cell interaction modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the MAPP polypeptides.
    Type: Grant
    Filed: August 2, 2000
    Date of Patent: July 16, 2002
    Assignee: Zymogenetics, Inc.
    Inventors: Paul O. Sheppard, Nand Baindur, Paul D. Bishop
  • Human transcription factor ZGCL-1
    Patent number: 6420525
    Abstract: Novel ZGCL-1 transcription factor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides, agonists and antagonists may be used within methods for promoting the proliferation and/or differentiation of testis cells, and may also be used in the development of male-specific contraceptives and infertility treatments.
    Type: Grant
    Filed: August 19, 1998
    Date of Patent: July 16, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: David P. Yee, Theresa A. Deisher
  • Beta-1,3-galactosyltransferase homologs
    Patent number: 6416988
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for znssp2, a novel member of the galactosyltransferase family. The polypeptides, and polynucleotides encoding them, are cell-cell interaction and glycoprotein synthesis modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the znssp2 polypeptides.
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: July 9, 2002
    Assignee: Zymogenetics, Inc.
    Inventors: Darrell C. Conklin, Gayle Yamamoto, Stephen R. Jaspers, Zeren Gao
  • PICHIA METHANOLICA GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE 2 PROMOTER AND TERMINATOR
    Publication number: 20020086366
    Abstract: Transcription promoter and terminator sequences from the Pichia methanolica glyceraldehyde-3-phosphate dehydrogenase 2 gene (GAP2 gene) are disclosed. The sequences are useful within DNA constructs for the production of proteins of interest in cultured P. methanolica cells. Within the expression vectors, a GAP2 promoter and/or a GAP2 terminator is operably linked to a DNA segment encoding the protein of interest.
    Type: Application
    Filed: December 7, 2001
    Publication date: July 4, 2002
    Applicant: ZymoGenetics, Inc.
    Inventor: Christopher K. Raymond
  • Mammalian calcitonin-like polypeptide-1
    Publication number: 20020077467
    Abstract: Novel mammalian calcitonin-like polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies.
    Type: Application
    Filed: May 1, 2001
    Publication date: June 20, 2002
    Applicant: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Emma E. Moore, Fenella Raymond
  • Helical cytokine zalpha33
    Patent number: 6406888
    Abstract: Novel cytokine polypeptides, materials and methods for making them, and method of use are disclosed. The polypeptides comprise at least nine contiguous amino acid residues of SEQ ID NO:2 or SEQ ID NO:4, and may be prepared as polypeptide fusions comprise heterologous sequences, such as affinity tags. The polypeptides and polynucleotides encoding them may be used within a variety of therapeutic, diagnostic, and research applications.
    Type: Grant
    Filed: June 14, 2000
    Date of Patent: June 18, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Zeren Gao