Patents Assigned to ZymoGenetics
  • Nucleic acid which encodes the tumor marker ZSIG62
    Patent number: 6403783
    Abstract: Studies indicate that mutations in tumor suppressor genes occur early in the process of carcinogenesis, and that these mutations are correlated with a subsequent development of cancer. The detection of such alterations would provide useful molecular markers for diagnosis, surveillance, early tumor identification and intervention, and prognosis. A novel human gene, designated as “Zsig62,” resides within a region of chromosome 16q that is associated with prostate and breast cancer, and that appears to contain tumor suppressor genes. Like a tumor suppressor gene, the Zsig62 gene is expressed in particular normal tissues, but not in tumors derived from those tissues.
    Type: Grant
    Filed: January 18, 2000
    Date of Patent: June 11, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Julia E. Novak, Fenella Raymond
  • Calcitonin mimetics
    Patent number: 6395740
    Abstract: Compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. Included among the calcitonin mimetics of the present invention are substituted piperazines. The calcitonin mimetics of the present invention are also useful in libraries and in assays for the determination of calcitonin receptor activity.
    Type: Grant
    Filed: July 14, 2000
    Date of Patent: May 28, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Nand Baindur, Virender Labroo, Steven Stroop, Stephanie Beigel, Theresa Martinez, Charles R. Petrie, Mark W. Orme, Patricia A. Mckernan, Emma E. Moore
  • Nucleic acids encoding connective tissue growth factor homologs
    Patent number: 6395890
    Abstract: This present invention is directed to polypeptide and polynucleotide molecules that encode a new connective tissue growth factor homolog polypeptide. The human polypeptides have been designated zCTGF4 and the mouse orthologs have been designated zCTGF2. The invention also includes antibodies, expression vectors, host cells expressing zCTGF4 and variants. Also included are methods for producing the polypeptides and using the polynucleotides and polypeptides.
    Type: Grant
    Filed: February 19, 1999
    Date of Patent: May 28, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Stephen R. Jaspers, Zeren Gao
  • Dialkyl ureas as calcitonin mimetics
    Patent number: 6391917
    Abstract: Dialkyl urea compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. The calcitonin mimetics of the present invention are also useful in assays for the determination of calcitonin receptor activity.
    Type: Grant
    Filed: April 19, 2001
    Date of Patent: May 21, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Charles R. Petrie, Patricia A. McKernan, Emma E. Moore, John M. Ostresh, Jean-Philippe Meyer, Richard A. Houghten, Clemencia Pinilla
  • Mammalian alpha helical protein-1
    Publication number: 20020058801
    Abstract: Novel mammalian alpha helical polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies.
    Type: Application
    Filed: August 16, 2001
    Publication date: May 16, 2002
    Applicant: ZymoGenetics, Inc.
    Inventors: Si Lok, Darrell C. Conklin, Julia E. Parrish
  • Human 2-19 protein homologue, z219a
    Patent number: 6388064
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for z219a, a novel member of the human 2-19 protein family. The polypeptides, and polynucleotides encoding them, may be used for detecting human chromosomal abnormalities. The present invention also includes antibodies to the z219a polypeptides.
    Type: Grant
    Filed: October 6, 1998
    Date of Patent: May 14, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Hal Blumberg
  • Disulfide core polypeptides
    Publication number: 20020052468
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for a disulfide core protein (Zdsc1). The polypeptides, and polynucleotides encoding them, are serine proteinase inhibitors. Also disclosed are expression vectors containing polynucleotides which encode a Zdsc1 polypeptide, antibodies which specifically bind to Zdsc1 polypeptides and anti-idiotypic antibodies which neutralize the antibodies which specifically bind to Zdsc1 polypeptides.
    Type: Application
    Filed: January 10, 2001
    Publication date: May 2, 2002
    Applicant: ZymoGenetics, Inc.
    Inventor: Darrell C. Conklin
  • Educational kit and method containing novel alpha helical protein-34
    Patent number: 6380361
    Abstract: An educational kit comprised of novel a novel polypeptide, alpha helical protein-34 (Zalpha34), polynucleotides that encode Zalpha34 and antibodies to Zalpha34. The present invention also relates to polynucleotide and polypeptide molecules for Zalpha34. The polypeptides, and polynucleotides encoding them, are hormonal and may be used to promote spermatogenesis. The present invention also includes antibodies to the Zalpha34 polypeptides, which can be used to inhibit spermatogenesis.
    Type: Grant
    Filed: October 24, 2000
    Date of Patent: April 30, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, David W. Taft
  • Method for treating cytokine mediated hepatic injury
    Patent number: 6380164
    Abstract: A method of modulating cytokine mediated hepatic injury by administering deltorphins to a mammal. Deltorphin I SEQ ID NO:1, deltorphin II SEQ ID NO:2 or combinations of deltorphins I SEQ ID NO:1 and II SEQ ID NO:2 may be administered. A deltorphin concentration in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade in a murine model of septic shock. A therapeutic method of modulating cytokine mediated acute inflammatory, trauma induced and toxin induced hepatic injury, particularly via tumor necrosis factor modulation, is thus disclosed.
    Type: Grant
    Filed: January 23, 2001
    Date of Patent: April 30, 2002
    Assignees: University of Kentucky Research Foundation, ZymoGenetics
    Inventors: Peter R. Oeltgen, Craig J. McClain, Shirish Barve, Paul D. Bishop
  • Kunitz domain polypeptide zkun6
    Patent number: 6380354
    Abstract: Proteinase inhibitors comprising a Kunitz domain are disclosed. The Kunitz domain comprises a sequence of amino acid residues as shown in SEQ ID NO:3, wherein the sequence is at least 80% identical to residues 6 through 56 of SEQ ID NO:2. Also disclosed are methods for making the proteinase inhibitors, and expression vectors and cultured cells that are useful within the methods. The proteinase inhibitors may be used as components of cell culture media, in protein purification, and in certain therapeutic and diagnostic applications.
    Type: Grant
    Filed: September 1, 1999
    Date of Patent: April 30, 2002
    Assignee: ZymoGenetics, Inc.
    Inventor: Darrell C. Conklin
  • Motilin homologs
    Patent number: 6380158
    Abstract: The present invention is directed to polynucleotides, polypeptides and uses thereof for a novel CDNA sequence which has homology to motilin. Tissue distribution of the mRNA for the novel polypeptide is specific to the stomach, small intestine and pancreas. The present invention further includes agonists, antagonists, antibodies and host cells expressing the cDNA encoding the novel motilin homologs.
    Type: Grant
    Filed: March 24, 1997
    Date of Patent: April 30, 2002
    Assignee: ZymoGenetics, Inc.
    Inventor: Paul O. Sheppard
  • Isoprenoid pathway inhibitors for stimulating bone growth
    Patent number: 6376476
    Abstract: Various embodiments of statin compounds are shown to enhance the formation of bone and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation.
    Type: Grant
    Filed: January 20, 2000
    Date of Patent: April 23, 2002
    Assignees: ZymoGenetics Corporation, OsteoScreen, Inc.
    Inventors: Shirley R. Gasper, Robert R. West, Theresa Martinez, Kirk G. Robbins, Patricia A. McKernan, Nand Baindur, Virender M. Labroo, Gregory R. Mundy
  • Mammalian cytokine-like receptor 5
    Publication number: 20020045733
    Abstract: Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions. The polypeptides of the present invention can be used to down-regulate their natural ligands. The polynucleotides and subsequences thereof can be used as diagnostic probes to determine if chromosome 19 is mutated. The antibodies which bind to the polypeptides can be used to purify the receptors and to inhibit the binding of the ligands onto the receptors.
    Type: Application
    Filed: June 13, 2001
    Publication date: April 18, 2002
    Applicant: ZymoGenetics, Inc.
    Inventors: Si Lok, Scott R. Presnell, Anna C. Jelmberg, Teresa Gilbert, Theodore E. Whitmore, Donald C. Foster, Robyn L. Adams, Joyce M. Lehner
  • Soluble protein ZTMPO-1
    Patent number: 6372889
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for ZTMPO-1, a novel soluble protein with homology to emerin and the thymopoietins. The polypeptides, and polynucleotides encoding them are useful for modulating cellular proliferation and differentiation and may be used for diagnostic purposes. The present invention also includes antibodies to the ZTMPO-1 polypeptides.
    Type: Grant
    Filed: April 19, 1999
    Date of Patent: April 16, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Darrell C. Conklin, Theresa M. Farrah, Mark F. Maurer, Angelika Grossmann
  • Antibodies to kunitz domain polypeptides
    Publication number: 20020039748
    Abstract: Proteinase inhibitors comprising a Kunitz domain are disclosed. The Kunitz domain comprises a sequence of amino acid residues as shown in SEQ ID NO: 5, wherein the sequence is at least 90% identical to SEQ ID NO: 2. Also disclosed are methods for making the proteinase inhibitors, and expression vectors and cultured cells that are useful within the methods. The proteinase inhibitors. may be used as components of cell culture media, in protein purification, and in certain therapeutic and diagnostic applications.
    Type: Application
    Filed: February 6, 2001
    Publication date: April 4, 2002
    Applicant: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Donald C. Foster, Zeren Gao
  • Antibodies to lipocalin homologs
    Patent number: 6365716
    Abstract: The present invention is directed to antibodies to polypeptides for a member of the lipocalin family. The expression of the polypeptide is restricted to testis and mammary gland, particularly breast tumor tissue. The polypeptide has been designated zlipo1.
    Type: Grant
    Filed: July 11, 2000
    Date of Patent: April 2, 2002
    Assignee: ZymoGenetics, Inc.
    Inventor: Darrell C. Conklin
  • Beta-1,3-galactosyltransferase homolog, ZNSSP6
    Patent number: 6361985
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for znssp6, a novel member of the galactosyltransferase family. The polypeptides, and polynucleotides encoding them, are cell-cell interaction and glycoprotein synthesis modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the znssp6 polypeptides.
    Type: Grant
    Filed: January 12, 2000
    Date of Patent: March 26, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Gayle Yamamoto, Zeren Gao, Stephen R. Jaspers
  • Follistatin-related protein zfsta2
    Patent number: 6355788
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zfsta2, a novel member of the follistatin family. The polypeptides, and polynucleotides encoding them are useful for binding to members of the TGF-&bgr; family and mediating central nervous system, reproductive, hematopoietic and bone-related activities. The present invention also includes antibodies to the zfsta2 polypeptides.
    Type: Grant
    Filed: October 5, 1999
    Date of Patent: March 12, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Jeff L. Ellsworth
  • FGF Homologs
    Patent number: 6352971
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zFGF-5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells and may be used for remodelling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF-5 polypeptides.
    Type: Grant
    Filed: August 5, 1999
    Date of Patent: March 5, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Theresa A. Deisher, Darrell C. Conklin, Fenella Raymond, Thomas R. Bukowski, Susan D. Holderman, Birgit Hansen, Paul O. Sheppard
  • Pichia methanolica glyceraldehyde-3-phosphate dehydrogenase 2 promoter
    Patent number: 6348331
    Abstract: Transcription promoter and terminator sequences from the Pichia methanolica glyceraldehyde-3-phosphate dehydrogenase 2 gene (GAP2 gene) are disclosed. The sequences are useful within DNA constructs for the production of proteins of interest in cultured P. methanolica cells. Within the expression vectors, a GAP2 promoter and/or a GAP2 terminator is operably linked to a DNA segment encoding the protein of interest.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: February 19, 2002
    Assignee: ZymoGenetics, Inc.
    Inventor: Christopher K. Raymond