Abstract: The invention provides compositions and methods for treating tuberous sclerosis complex (TSC). In particular, provided are condensed tuberins (cTuberins), cTuberin nucleic acids, and recombinant adeno-associated viruses (rAAVs) carrying a cTuberin nucleic acid for treating a patient with TSC.
Type:
Grant
Filed:
May 17, 2018
Date of Patent:
April 16, 2024
Assignee:
The General Hospital Corporation
Inventors:
Xandra Breakefield, Casey Maguire, Shilpa Prabhakar, David Yellen
Abstract: Vehicle roof arrangement with a movable roof element held by a frame for selectively closing a roof opening. The roof element may have a first strand-like seal profile and a second strand-like seal profile, which is formed separately from the first seal profile. The first seal profile is configured for sealing with respect to the movable roof element and can be fastened to the vehicle roof, and the second seal profile can be fastened to the frame by a plug connection and is configured for sealing between the frame and the vehicle roof. The plug connection may have a plug-in region of the frame, into which plug-in region a projection of the second seal profile may be plugged.
Type:
Grant
Filed:
May 10, 2022
Date of Patent:
April 16, 2024
Assignee:
WEBASTO SE
Inventors:
Samuel Schuster, Stefan Schäufler, Andreas Josef Zunzer
Inventors:
Mark Elliott, Neal Gallagher, Garett M. Leskowitz, Adam Paulson, Susanne D. Riegel, Colten Wright, Kent Davidson, Christian Gauvin, Andre Huard, Jean-Sebastien Langlois, Sebastien Larose, Stephane Sanschagrin