Abstract: A method of treating a subject having glaucoma comprises performing excimer laser trabeculostomy (ELT) on a subject having glaucoma and having previously undergone a failed treatment or a treatment that has been rendered ineffective by progression of the disease. In some examples, the failed treatment is a non-surgical treatment comprising administering medicated eye drops. In some examples, the failed treatment is a laser treatment or surgical treatment, such as a trabeculoplasty, iridotomy, iridectomy, trabeculectomy, trabeculotomy, goniotomy, surgical insertion of a shunt or implant, deep sclerectomy, viscocanalostomy, or a combination thereof.

Abstract: An ophthalmic measurement and laser surgery system includes: a laser source; a corneal topography subsystem; an axis determining subsystem; a ranging subsystem comprising an Optical Coherence Tomographer (OCT); and a refractive index determining subsystem. All of the subsystems are under the operative control of a controller. The controller is configure to: operate the corneal topography subsystem to obtain corneal surface information; operate the axis determining subsystem to identify one or more ophthalmic axes of the eye; operate the OCT to sequentially scan the eye in a plurality of OCT scan patterns, the plurality of scan patterns configured to determine an axial length of the eye; operate the refractive index determining subsystem so to determine an index of refraction of one or more ophthalmic tissues, wherein at least one of the corneal surface information, ophthalmic axis information, and axial length is modified based on the determined index of refraction.

Abstract: A guide system for indicating an activator of a defibrillator to a user including a motion detection circuit which determines motion of the defibrillator and generates at least one defibrillator motion mode signal, and a guide circuit which receives the defibrillator motion mode signal and causes the activator to be indicated to the user of the defibrillator.

Abstract: A photodynamic therapy technique for preventing damage to the fovea of the eye or another body portion of a patient is disclosed herein. In one embodiment, a treatment laser is applied to a body portion of a patient using a painting technique, the treatment laser being configured to provide paint brush-type photodynamic therapy (PPDT) using the painting technique to the body portion of the patient by emitting light of a predetermined wavelength that is absorbed by tissue of the body portion of the patient to which a photosensitizer has been applied, the body portion of the patient being afflicted by a medical condition. The application of the treatment laser to the body portion of a patient using the painting technique treats the medical condition, reduces the symptoms associated with the medical condition, and/or alleviates the medical condition.

Abstract: A therapeutic light delivery apparatus and method are disclosed. The apparatus includes a light source and an integrated optical applicator. The integrated optical applicator includes a plurality of light emitting devices and detector fibers fixedly spatially positioned within a flexible matrix material. The light emitting devices can be positioned a predetermined distance from an application side of the integrated optical applicator comprising an accurate and repeatable standoff position. A flexible matrix material is disclosed having a high scattering coefficient to produce a uniform irradiance pattern and predetermined fluence.

Abstract: A wearable device includes a housing with a window and an electronic module supported by the housing. The electronic module includes a photoplethysmography sensor, a motion sensor, and a signal processor that processes signals from the motion sensor and signals from the photoplethysmography sensor. The signal processor is configured to remove frequency bands from the photoplethysmography sensor signals that are outside of a range of interest using a band-pass filter to produce pre-conditioned signals, and to further process the pre-conditioned signals using the motion sensor signals to reduce motion artifacts from footsteps during subject running. The device includes non-air light transmissive material in optical communication with the photoplethysmography sensor and the window that serves as a light guide for the photoplethysmography sensor. The window optically exposes the photoplethysmography sensor to a body of a subject wearing the device via the non-air light transmissive material.

Abstract: A patient interface system is disclosed for positioning a patient's eye opposite a laser device for laser surgery. The system including a patient interface for coupling to the patient's eye and a patient interface holder for arranging the patient interface on the laser device. The patient interface holder includes a connection device for coupling a camera system. The patient interface holder and the patient interface have corresponding channels that delimit an optical path between the connection device and the patient interface. The channel of the patient interface is arranged such that is runs at least partially on an outer circumference of a suction cup part of the patient interface. Also disclosed are a camera system, a method for coupling a patient interface with a patient interface holder, as well as a patient interface and a patient interface holder, for a patient interface system.

Abstract: The present application is directed to devices, assemblies, systems and methods for targeting one or more sites with electromagnetic radiation. The devices, assemblies and systems are operationally configured to transform and convey electromagnetic radiation to one or more targeted sites. The devices, assemblies and systems may also convey one or more fluids or fluid solutions to the one or more targeted sites.

Abstract: A phototherapy treatment apparatus and methods are provided. In particular, the present disclosure provides a phototherapy treatment apparatus configured to diffusely transmit light emitted from a light source to a patient.

Abstract: The invention features methods and devices useful for stimulating brain tissue in a subject via electrodes within cranial bone. These methods and devices may be utilized for the detection, prevention, and/or treatment of neurological disorders via electric stimulation. Additionally, the methods and devices disclosed herein may be useful for the treatment, inhibition, and/or arrestment of the growth of tumors.

Abstract: A system includes a surgical device, an instrument coupled to the surgical device and defining an instrument axis, and a processor operatively coupled to the surgical device. The processor is configured to determine a current orientation angle of an instrument axis based on an orientation of a target axis, establish a virtual boundary, control the surgical device to apply a force to constrain the instrument axis within the virtual boundary, and collapse the virtual boundary as the instrument axis is brought into alignment with the target axis.

Abstract: Methods, apparatuses, and systems for robotic insertion of a screw, a rod, or another component of a surgical implant into a patient are disclosed. Clinical data from previous surgical procedures or information received from a supervising surgeon can be leveraged to minimize the risk of harm to the patient and improve outcomes. The methods disclosed thus provide more precise placement of implanted surgical components and implants.

Abstract: A method of enhancing penetration of a topical composition of 5-aminolevulinic acid (ALA) into tissue for photodynamic therapy includes topically applying ALA to a treatment area to be treated with photodynamic therapy. The method further includes, after the ALA is applied to the treatment area, covering the treatment area with a low density polyethylene barrier. The treatment area is covered with the low density polyethylene barrier prior to light treatment to minimize transepidermal water loss from the treatment area.

Abstract: A defibrillator is provided comprising an activation mechanism having an activator and a status indicator, wherein the activator is disposable in a first condition in which the defibrillator is deactivated and in a second condition in which the defibrillator is activated and the status indicator is operable in at least a first mode in which a ‘defibrillator ready’ status of the defibrillator is indicated and a second mode in which a ‘defibrillator not ready’ status of the defibrillator is indicated. By having an activation mechanism which includes the activator and the status indicator, users of the defibrillator are not confused between separate activation and status indication devices and are able to use the activator promptly.

Abstract: In some examples, a laser-based ophthalmological surgical system (hereinafter “system”) includes a therapeutic radiation source configured to emit therapeutic radiation with a first wavelength. The system may also include a probe radiation source configured to emit probe radiation with a second wavelength different than the first wavelength. The system may also include one or more optical elements configured to direct the therapeutic radiation and the probe radiation into an eye of a patient and to collect reflected probe radiation from the eye of the patient. The reflected probe radiation may be indicative of an amount of therapeutic radiation exposure of the eye of the patient. The system may also include a photodetector configured to receive the reflected probe radiation from the one or more optical elements and to generate a photocurrent indicative of the amount of therapeutic radiation exposure of the eye of the patient.

Abstract: Devices to perform femtolaser ablation and phacoemulsification are physically and/or operationally combined. In some embodiments the femtolaser ablation and phacoemulsification are housed together, and in other embodiments they are housed separately, but operated through a common display screen. At least some software can be shared by the femtolaser ablation and phacoemulsification functionalities. A non-transitory computer-readable memory can provide data that can be used to operate each of at least one femtolaser ablation functionality and at least one phacoemulsification functionality.

Abstract: A steerable guide. In an embodiment, the steerable guide comprises a needle, a shaft, a spring housing, and a translational screw. The needle comprises a wire tube and a wire configured to curve the needle when retracted relative to the wire tube. The wire tube is connected to the distal end of the shaft, and the wire is connected to the distal end of the spring housing. The screw extends into a cavity within the shaft, and is configured to move along a longitudinal axis. A spring is positioned within the cavity, between the proximal end of the spring housing and the distal end of the screw. Thus, when the screw moves in the proximal direction while a position of the spring housing is fixed by the wire, the spring is compressed between the proximal end of the spring housing and the distal end of the translational screw.

Abstract: Methods and apparatus for the inactivation of infectious agents in, on or around a catheter residing in a patient's body cavity. The method comprises a coupling adapter for facilitating the transmission of non-ultraviolet sterilizing electromagnetic radiation (EMR) substantially axially along an optical element into the catheter body. Through delivery of the sterilizing EMR to particular areas of highest infection, the present disclosure is able to inactivate the major sources of infection in catheters.

Abstract: An applicator comprising multiple laser assemblies connected to a power supply and a controller that switches each pulse to a different one of the laser assemblies. Each laser assembly deposits a laser spot on the skin and the result is to produce a large ‘aggregate’ spot without requiring extra power or extra lasers. In one embodiment, each pulse serves as a trigger to switch the next pulse to the next laser assembly.

Abstract: A light-emitting device (100) is disclosed. The light-emitting device (100) comprises a plurality of light-emitting elements (135) or light sources and a power module (120) adapted to selectively convey, supply or provide electrical power to the light-emitting elements (135). The power module (120) may be dimensioned such as to be able to power only a proper subset of the light-emitting elements (135) of the light-emitting device (100) at a given time, the subset having a maximum number of light-emitting elements (135) included therein with respect to the number of light-emitting elements (135) included in the all subsets of the light-emitting elements (135) of the light-emitting device (100).