Abstract: A portable electronic device includes a battery, a transcutaneous electrical nerve stimulation (TENS) circuit, a power management circuit, a first output unit, and a second output unit. The TENS circuit provides a TENS electrical current. The power management circuit is coupled to the battery and the TENS circuit for managing a power distribution of the portable electronic device. The first output unit receives the TENS electrical current from the TENS circuit and outputs the TENS electrical current to a user. The second output unit receives a power signal from the battery and outputs the power signal to an external electronic device.

Abstract: An ophthalmological apparatus includes a handle for manually holding and applying the ophthalmological apparatus, fastening abilities for fixing the ophthalmological apparatus at an eye, a light source, and a light projector for the focused projection of light pulses for punctiform tissue breakdown at a focal point in the interior of the eye tissue. The ophthalmological apparatus also includes a movement driver for moving the light projector. The movement of the light projector and therefore that of the focal point with the assistance of the movement driver permits a dimensioning of the optical projection system of the light projector which is substantially smaller than in the case of an ophthalmological apparatus where the focal point is moved exclusively by an optical projection system.

Abstract: At least one of at least one data-dependent scale factor or at least one data-dependent detection threshold is determined responsive to at least one block of time-series data of an auscultatory-sound signal generated by an auscultatory-sound sensor operatively coupled to a portion of the skin of a test-subject, wherein the at least one data-dependent scale factor or at least one data-dependent detection threshold provides a measure of a range of values of the at least one block of time-series data in relation to a predetermined metric, and is used to determine whether or not the auscultatory-sound sensor is either debonded or detached from the skin of the test-subject.

Abstract: The present disclosure is directed to a method of determining a position of a medical instrument. The method may include inserting a first material into a body and adjacent to the medical instrument, analyzing at least one characteristic of the inserted first material, and determining the position of the medical instrument based on the analysis of the at least one characteristic.

Abstract: A therapeutic intubation device may comprise a tube, a first probe channel, a second probe channel, a first probe and a second probe. In various embodiments, a tube may have an elongate body having a proximal end and a distal end. The body may define a first channel between the proximal end and the distal end. A first probe channel may be defined in the body. A second probe channel defined in the body. A first probe may comprise a first body portion and a first end portion, the first end portion comprising a first ultraviolet-c (“UVC”) light emitting device. The first probe may be installable the first probe channel such that the first end portion of the first probe is adjacent the distal end of the tub during operation.

Abstract: An apparatus is provided for irradiating at least a portion of a patient's brain with electromagnetic radiation to treat stroke, Parkinson's Disease, Alzheimer's Disease, or depression. The apparatus includes a source of the electromagnetic radiation. The apparatus further includes an output optical element including a rigid and substantially thermally conductive material and a surface configured to be in thermal communication with the patient's body. The apparatus further includes a cooler thermally coupled to the output optical element to remove heat from the output optical element. The apparatus further includes a heat sink thermally coupled to the cooler, wherein the heat sink is positioned so that the electromagnetic radiation from the source propagates through the heat sink and through the output optical element.

Abstract: A protective ferrule for an end-firing optical fiber arrangement combines a spherical or rounded shape with a planar end. The combination of the spherical or rounded shape and planar end provides protection for the working channel of an endoscope or catheter through which the fiber is inserted while confining and minimizing erosion of the active surface area of the fiber. The protective ferrule of may be fitted to the end of the optical fiber by the steps of heating the ferrule to expand an inside diameter so that it fits over the end of the fiber, with subsequent cooling of the ferrule causing it to contract and create a compression fit.

Abstract: An antimicrobial treatment system comprises a wearable photoactivation device. The wearable photoactivation device includes a body configured to be positioned on a head of a subject over one or more eyes of the subject. The body includes one or more windows or openings that allow the one or more eyes to see through the body. The body includes one or more photoactivating light sources coupled to the body and configured to direct photoactivating light to the one or more eyes according to illumination parameters. The illumination parameters determine a dose of the photoactivating light that activates, according to photochemical kinetic reactions, a photosensitizer applied to the one or more eyes and generates reactive oxygen species that provide an antimicrobial effect in the one or more eyes, without substantially inducing cross-linking activity that produces biomechanical changes in the one or more eyes.

Abstract: A system for corneal treatment includes a light source that activates cross-linking in at least one selected region of a cornea treated with a cross-linking agent. The light source delivers photoactivating light to the at least one selected region of the cornea according to a set of parameters. The system includes a controller that receives input relating to the cross-linking agent and the set of parameters. The controller includes computer-readable storage media storing: (A) program instructions for determining cross-linking resulting from reactions involving ROS including at least peroxides, superoxides, and hydroxyl radicals, and (B) program instructions for determining cross-linking from reactions not involving oxygen. The controller executes the program instructions to output a calculated amount of cross-linking in the at least one selected region of the cornea. In response to the calculated amount of cross-linking, the light source adjusts at least one value in the set of parameters.

Abstract: Provided are a means to detect a plurality of dynamics, a processing unit that calculates a temporal change in the detected dynamics, and an evaluation device that determines exacerbation of clinical conditions in heart failure of a patient based on the calculated change in the patient's dynamics over time. The present invention makes it possible to detect, early and with high accuracy, that the onset of acute heart failure is imminent.

Abstract: A support mechanism for a medical device may include an adjustable support that includes a plurality of elongate members movable relative to one another. The support mechanism may also include a bracket coupled to the adjustable support. The bracket may be adapted to be coupled to a first medical device that extends along a longitudinal axis. The support mechanism may also include an instrument holder that extends along a central axis. The instrument holder may be movably coupled to the bracket and adapted to be coupled to a second medical device. The bracket and the instrument holder may be oriented such that central axis of the instrument holder intersects the longitudinal axis at an angle.

Abstract: An implantable phototherapy device includes a power receiver element configured to receive power from an external power transmitter, a light delivery element powered by the power receiver, and configured to deliver phototherapy to a target treatment area, and a tether element is coupled to the light delivery element and the power receiver element. The tether element is configured to deliver power between the power receiver element and the light delivery element.

Abstract: A method of enhancing penetration of a topical composition of 5-aminolevulinic acid (ALA) into tissue for photodynamic therapy includes topically applying ALA to a treatment area to be treated with photodynamic therapy. The method further includes, after the ALA is applied to the treatment area, covering the treatment area with a low density polyethylene barrier. The treatment area is covered with the low density polyethylene barrier prior to light treatment to minimize transepidermal water loss from the treatment area.

Abstract: Systems and methods for a laser-assisted topical treatment of nail fungal infections are provided. The laser-assisted topical treatment includes a laser that is configured to output a beam that penetrates the infected nail and creates a channel therethrough. The laser-assisted topical treatment further includes a treatment agent comprising a vehicle and a drug. The treatment agent is applied to an exterior surface of the infected nail so that the treatment agent may flow into the channel.

Abstract: The present invention relates to the use of light-emitting, water soluble nanoparticles in the treatment of disorders of the central nervous system.

Abstract: A system for treating and/or monitoring a patient includes a patient physiological parameter monitoring patch and a companion device. The patient physiological parameter monitoring patch including an energy harvesting module, an energy storage module, a sensor module and a communication module. The energy harvesting module harvesting energy from one or more ambient sources, the energy being storable in the energy storage module and usable by one or more components of the patient physiological parameter monitoring patch. The sensor module senses one or more physiological parameters of the patient and the communication module can transmit the sensed data. The companion device can receive the sensed physiological parameters and can send the same to a remote device or store the same.

Abstract: An implantable active medical device system includes an active medical device and a lead extending between a proximal portion electrically coupled to the active medical device and a distal end portion configured to emit light. The distal end portion includes a solid state light source disposed within a light transmissive ring element. The light transmissive ring element forms an exterior segment of the distal end portion. The light transmissive ring element defines at least a portion of a hermetic cavity.

Abstract: The LEDs in a phototherapy LED pad are controlled so that the intensity of the light varies in accordance with a sinusoidal function, thereby eliminating the harmonics that are generated when the LEDs are pulsed digitally. This is accomplished analogically by using a sinusoidal wave to control the gate of a MOSFET connected in series with the LEDs or by using a digital-to-analog converter to control the gate of the MOSFET with a stair step function representative of the values of a sinusoidal function at predetermined intervals. Alternatively, pulse-width modulation is used to control the gate of the MOSFET in such a way that the average current through the LEDs simulates a sinusoidal function. In additional to using a simple sine wave function, the LED current may also be controlled in accordance with “chords” containing multiple sine waves of different frequencies.

Abstract: A photo-treatment device includes a non-opaque treatment substrate and a radiation-collector beside the substrate. The substrate is sized for a person at which radiation is to be emitted from above the substrate. The substrate has a front surface for receiving the person thereon and a back surface. The radiation-collector captures excess radiation peripheral to the substrate and redirects the excess radiation to the back surface of the substrate.

Abstract: An electrical stimulation device is provided. The electrical stimulation device includes a power management circuit and an electrical stimulation generation circuit. The power management circuit generates a first voltage and a second voltage to power the electrical stimulation generation circuit. The electrical stimulation generation circuit includes a working-electrode contact and a reference-electrode contact. The electrical stimulation generation circuit generates a first electrical signal at the working-electrode contact and further generates a second electrical signal at the reference-electrode contact. The first electrical signal comprises a plurality of first alternating-current (AC) pulses configuring to for electrically stimulate a target region of a target object.