Patents Examined by Aaron J Kosar
  • Patent number: 12216040
    Abstract: Provided are a sample analyzer and a sample analysis method. The sample analyzer includes: a sampling apparatus configured to collect a blood sample; a sample preparation apparatus configured to mix the blood sample with a hemolytic agent and a dye to prepare a test sample liquid; an optical detection apparatus configured to detect side-scattered light signals and fluorescence signals generated by particles in the test sample liquid; and a processor configured to: generate a scatter diagram based on at least the side-scattered light signals and the fluorescence signals, and obtain a predetermined feature region, wherein an intensity of side-scattered light corresponding to a central position of the predetermined feature region is greater than an intensity of side-scattered light corresponding to a central position of a region containing neutrophil granulocyte population; and obtain a blast cell parameter based on the predetermined feature region.
    Type: Grant
    Filed: April 7, 2022
    Date of Patent: February 4, 2025
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Wenbo Zheng, Bo Ye, Mingjin Guo, Chuanjian Wu, Huan Qi
  • Patent number: 12214006
    Abstract: Provided are a traditional Chinese medicine ointment for preventing and treating mastitis in dairy cows and a preparation method thereof, belonging to the technical field of veterinary traditional Chinese medicines. The traditional Chinese medicine ointment includes raw materials in parts by mass: 20-30 parts of dandelion, 20-30 parts of herba patriniae, 10-16 parts of Caulis Lonicerae Japonicae, 0.5-1 part of borneol, 0.03-0.05 part of polypeptide, 40-50 parts of auxiliary emulsifier, 40-50 parts of liquid paraffin and 100-130 parts of white vaseline. An amino acid sequence of the polypeptide is: Phe Phe Arg Lys Val Leu Lys Leu Ile Arg Lys Ile Trp Arg (SEQ ID NO. 1). In the application, dandelion, herba patriniae, Caulis Lonicerae Japonicae and borneol 1 are mixed, and polypeptide is added at the same time to prepare ointment.
    Type: Grant
    Filed: September 14, 2023
    Date of Patent: February 4, 2025
    Assignee: Hunan University of Science and Engineering
    Inventors: Zongcheng Wang, Yuanfei Xu, Zuodong Qin, Zhenmin Cao, Xiaofang Luo, Chen Gui, Shuwen Wang, Asad Nawaz, Manting Li
  • Patent number: 12215371
    Abstract: Disclosed herein are methods of producing hexoses from saccharides by improved enzymatic processes. The improved processes utilize enzymes with higher activities than those previously reported to convert starch or a starch derivative, cellulose or a cellulose derivative, or sucrose to a glucose 6-phosphate (G6P) intermediate.
    Type: Grant
    Filed: October 29, 2019
    Date of Patent: February 4, 2025
    Assignee: BONUMOSE, INC.
    Inventor: Daniel Joseph Wichelecki
  • Patent number: 12208122
    Abstract: In some embodiments provided herein is a method of treating a coagulopathy in a subject, the method including administering to the subject in need thereof an effective amount of a composition including platelets or platelet derivatives and an incubating agent including one or more salts, a buffer, optionally a cryoprotectant, and optionally an organic solvent, wherein the subject has been treated or is being treated with an antiplatelet agent.
    Type: Grant
    Filed: April 24, 2024
    Date of Patent: January 28, 2025
    Assignee: Cellphire, Inc
    Inventors: Keith Andrew Moskowitz, Braden Carl Ishler, William Matthew Dickerson, Narendra Nath Tandon, Amber Nicole Lee, Glen Michael Fitzpatrick
  • Patent number: 12208074
    Abstract: Compositions and methods for providing a person with an exogenous and therapeutically effective supply of ketones are disclosed. The compositions may consist essentially of (a) purified butyrate (or esters or propionate salts thereof) and (b) purified beta-hydroxybutyrate (or esters or propionate salts thereof). The compositions may further include other pharmacologically active agents, such as acetyl-L carnitine, R-alpha lipoic acid, green tea extract, vitamins, and various combinations of such agents. The methods include providing a person with an exogenous supply of ketones, by orally administering a pharmacologic composition, which is effective to deliver 2000-5000 mg of a short chain fatty acid (e.g., butyrate) and 5000-10,000 mg of ketone (e.g., beta-hydroxybutyrate) on a daily basis.
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: January 28, 2025
    Inventor: Franco Cavaleri
  • Patent number: 12209236
    Abstract: Described are compositions and methods relating to modified yeast that overexpress fumarate reductase. The yeast cells have an increased fermentation rate compared to their parental cells. Such yeast cells ae particularly useful for large-scale ethanol production from starch substrates where an increased rate of ethanol production is desirable.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: January 28, 2025
    Assignee: DANISCO US INC.
    Inventor: Celia Emily Gaby Payen
  • Patent number: 12209967
    Abstract: Disclosed is an apparatus for monitoring bioaerosols, which includes a capturer configured to capture bioaerosol particles in air in a capture solution; a first droplet discharger configured to electro-spray the capture solution, in which the particles are captured, in a form of first droplets; a second droplet discharger configured to electro-spray a reagent, capable of reacting with the particles of the first droplets, in a form of second droplets; a reactor in which the first and second droplets are mixed so that the particles react with the reagent; and a measurer configured to measure the particles reacted with the reagent, wherein a size of the first droplets discharged from the first droplet discharger is controlled such that the particles are individually included in the first droplets. In accordance with such a configuration, individual particles can react with a reagent, which allows accurate bioaerosol monitoring optically.
    Type: Grant
    Filed: February 22, 2021
    Date of Patent: January 28, 2025
    Assignee: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
    Inventors: Jung Ho Hwang, Hyeong Rae Kim, Sang Gwon An
  • Patent number: 12201920
    Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).
    Type: Grant
    Filed: January 17, 2023
    Date of Patent: January 21, 2025
    Assignee: Velico Medical, Inc.
    Inventors: Robert R. Andrews, Herman E. Snyder, William J. Merritt, Evan P. Ordway, Clair Strohl, Qiyong Peter Liu, Jihae Sohn, Lisa A. Buckley, Mark A Popovsky
  • Patent number: 12194191
    Abstract: A nanobandage solution having Faidherbia albida nanoparticles, olibanum gum, and polyvinyl alcohol and methods of making the nanobandage solution and topically applying the nanobandage to a subject in need thereof are provided.
    Type: Grant
    Filed: March 14, 2024
    Date of Patent: January 14, 2025
    Assignee: KING SAUD UNIVERSITY
    Inventors: Manal Ahmed Awad, Afrah Fahad Alkhuriji, Khalid Mustafa Ortashi
  • Patent number: 12178859
    Abstract: The present invention provides a method for treating or preventing inflammation caused by neutrophils and a pharmaceutical composition for such treatment or prevention. Specifically, provided is a pharmaceutical composition or the like for treating or preventing inflammation caused by neutrophils that contains a complex in which lysozyme and chitosan are bonded.
    Type: Grant
    Filed: January 14, 2020
    Date of Patent: December 31, 2024
    Assignees: WAKO FILTER TECHNOLOGY CO., LTD., TEIKYO UNIVERSITY
    Inventors: Hiroki Kageshima, Yoichi Murakami, Akira Saito, Shigeru Abe, Kazumi Hayama, Naho Maruyama
  • Patent number: 12171797
    Abstract: The present invention relates to a composition which is for preventing and ameliorating or treating premenstrual syndrome symptoms, and includes: (a) a Chrysanthemum zawadskii extract; (b) a mixture of the Chrysanthemum zawadskii extract and a malt extract; or (c) a mixture of the Chrysanthemum zawadskii extract, the malt extract, and an aloe extract. Specifically, the present compositions effectively inhibit the secretion of prolactin from pituitary cells, which is a phenomenon that appears during premenstrual syndrome, thereby increasing the secretion of progesterone, which is reduced during the luteal phase of women, and can thus be advantageously used as a composition for preventing and ameliorating or treating women's premenstrual syndrome.
    Type: Grant
    Filed: September 3, 2019
    Date of Patent: December 24, 2024
    Assignee: GENENCELL INC.
    Inventors: Yong Joon Jeong, Se Chan Kang, Jeong Eun Kwon, Da Eun Lee
  • Patent number: 12168031
    Abstract: Methods for treating a patient having constipation, the methods including consuming first, a prescribed daily first diet upon waking from sleep that can include specified: a liquid, an oil, a fruit, a vegetable, a first main meal, or a combination thereof; consuming second, a prescribed daily second diet including a salad, oil, and water; consuming third, a prescribed daily second main meal contemporaneously with consuming the salad, or at least 60 to 90 minutes after consuming the salad; consuming fourth, at least a minimum portion of additional water, after waiting a minimum of 45 minutes from consuming the salad, or after waiting 60 to 90 minutes after a main meal, or both; and then exercising or a sedentary waiting, for a period of time, while consuming additional water.
    Type: Grant
    Filed: January 11, 2024
    Date of Patent: December 17, 2024
    Inventor: Behrouz Maraghechi
  • Patent number: 12161744
    Abstract: The present disclosure relates to extracts of Cordyceps spp., topical formulations containing extracts of Cordyceps spp., methods of formulating the extract and formulations, and methods of use. In one embodiment the Cordyceps spp. is Cordyceps sinensis.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: December 10, 2024
    Assignee: NSE PRODUCTS, INC.
    Inventors: Remona Gopaul, Jin Namkoong, Aaron Ballantyne, Helen Knaggs, Deanna Carter, Dale Kern
  • Patent number: 12156895
    Abstract: A pharmaceutical composition includes a Quisqualis indica extract as an active ingredient, for preventing or treating prostatic hyperplasia, and to a food composition. The Quisqualis indica extract can be favorably used to treat and prevent prostatic hyperplasia by exhibiting effects of a reduction in prostate weight, a reduction in DHT as a prostatic hyperplasia inducing factor, and a reduction in prostate epithelial cell hyperplasia.
    Type: Grant
    Filed: November 22, 2022
    Date of Patent: December 3, 2024
    Assignee: The Industry & Academic Cooperation in Chungnam National University (IAC)
    Inventor: Hyo Jung Kwon
  • Patent number: 12146132
    Abstract: Genetically modified Zymomonas mobilis to utilize inorganic N source, methods and uses thereof are provided. The genetically modified Z. mobilis has a genome with the knockout of a locus ZMO1107 from Z. mobilis ZM4 could ferment inorganic N source.
    Type: Grant
    Filed: April 3, 2024
    Date of Patent: November 19, 2024
    Assignee: Hubei University
    Inventors: Shihui Yang, Mimi Hu, Qiaoning He
  • Patent number: 12144355
    Abstract: A method of preventing or inhibiting fungal infestation of plants using an extract of Pyropia yezoensis. In an embodiment, the fungal infestation is caused by Podosphera xanthii. In an embodiment, the plants comprise a cucurbit plant. In an embodiment, the cucurbit plant comprises cucumber.
    Type: Grant
    Filed: December 18, 2023
    Date of Patent: November 19, 2024
    Assignee: KING FAISAL UNIVERSITY
    Inventors: Ahmed Mahmoud Ismail, Eman Said Eshewy
  • Patent number: 12138290
    Abstract: The present invention relates to developing a plant-based composition for arresting the spread of pathogens from an infected person which can be sprayed in infected places, for rapidly decontaminating the affected areas thereby arresting the spread in larger areas which includes include, office complexes, hospitals, schools, mass transportation, prisons, care facilities, public housing, and mass transportation terminals. The present composition is a mixture containing herbs including lavender, Chinese skullcap, black seed oil, Sida acuta, cryptolepis, Isatis, licorice, sage, medicinal honey and ginger in a colloidal silver base.
    Type: Grant
    Filed: December 30, 2020
    Date of Patent: November 12, 2024
    Inventor: David Paul Kutchinski
  • Patent number: 12133930
    Abstract: Provided herein is an injectable composition including, in some embodiments, a soft-tissue augmenting agent and a vehicle for the soft-tissue augmenting agent formulated for augmenting one or more soft tissues of a human or animal. Also provided herein is a soft-tissue augmenting kit including, in some embodiments, a syringe and the injectable composition formulated for augmenting one or more soft tissues of a human or animal. Also provided herein is a method for augmenting one or more soft tissues of a human or animal including, in some embodiments, injecting the injectable composition into the one or more soft tissues of the human or animal.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: November 5, 2024
    Assignee: TheraMicro, LLC
    Inventors: Alan G. Taylor, Bruce R Lawrence, Rebecca Hawkins Wahl
  • Patent number: 12133522
    Abstract: The present invention is directed to methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts. It is also directed to autologous bone grafts, and methods of preparing them.
    Type: Grant
    Filed: November 18, 2022
    Date of Patent: November 5, 2024
    Assignee: LifeNet Health
    Inventors: Roberto Bracone, Jingsong Chen, Marilyn Gatin, Silvia Chen, James A. Clagett, Daniel Osborne
  • Patent number: 12121566
    Abstract: The disclosure provides methods of treating gout in patients comprising administering a PEGylated uricase. Also provided are methods of treating gout in patients comprising co-administering a PEGylated uricase and azathioprine immunosuppressive therapy. Also provided are methods of reducing intolerance or enhancing immuno-tolerance to a PEGylated uricase and prolonging the urate lowering effect comprising co-administration of the PEGylated uricase and azathioprine immunosuppressive therapy.
    Type: Grant
    Filed: January 30, 2020
    Date of Patent: October 22, 2024
    Assignee: Horizon Therapeutics USA, Inc.
    Inventors: Jeffrey D. Kent, Brian Lamoreaux