Patents Examined by Alexander S Noguerola
  • Patent number: 10888875
    Abstract: Devices, systems, and methods for applying a dielectrophoretic force on a particle include: a cell defining at least one channel for confining the particle; and a first electrode and a second electrode electrically isolated from the first electrode, at least one of the first and second electrodes being formed from a two-dimensional (2D) material providing an atomically sharp edge. The first and second electrodes are arranged sufficiently close to one another and sufficiently close to the channel such that application of a sufficient voltage across the first and second electrodes generates an electric field in at least part of the channel, the electric field having an electric field gradient sufficient to apply the dielectrophoretic force on the particle in the channel.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: January 12, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Sang-Hyun Oh, Steven John Koester
  • Patent number: 10889846
    Abstract: The invention provides a method of determining a predisposition to a condition associated with ATP depletion, such as an ischaemic event, in a subject comprising: a. measuring the concentration of one or more purines in a body fluid of the subject, the purines being selected from adenosine, inosine, hypoxanthine, xanthine and ATP, and b. comparing the measured concentration with a threshold concentration of the one or more purines, wherein the threshold concentration is preferably in the range 2 [micro]M to 8 [micro]M and wherein a measured concentration higher than the threshold concentration indicates the presence of ischaemia.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: January 12, 2021
    Assignee: SARISSA BIOMEDICAL LIMITED
    Inventors: Nicholas Dale, Chris Imray, Bruno Frenguelli
  • Patent number: 10883957
    Abstract: A magnesium sensing membrane is disclosed for use in a potentiometric ion selective electrode that exhibits improved stability upon exposure to surfactant-containing reagents. Kits containing same are disclosed, along with methods of production and use of the magnesium sensing membrane.
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: January 5, 2021
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Wei Zhang, Kevin Horan
  • Patent number: 10871464
    Abstract: There is provided a solid-contact ion-selective electrode having a high potential stability and potential reproducibility. The ion-selective electrode includes an ion sensitive film having a Group-1 element ion, a Group-2 element ion, a hydronium ion or an ammonium ion as a target ion, an ion occluding material layer, and a conductive electrode, wherein the ion occluding material contained in the ion occludes material layer occluding the target ion, the ion occluding material being a Prussian blue analog represented by the structure formula AaMx[M?(CN)6]y?z.kH2O. Herein, A is one type or a plurality of types of Group-1 elements, Group-2 elements, hydronium, or ammonium; M and M? are one type or a plurality of types of transition metals; M or M? includes at least one of nickel, cobalt, copper, silver, and cadmium; ? is a vacancy in a porous coordination polymer; x and y are greater than zero; and a, z, and k are numbers equal to or greater than zero.
    Type: Grant
    Filed: August 30, 2016
    Date of Patent: December 22, 2020
    Assignee: Hitachi High-Tech Corporation
    Inventors: Yu Ishige, Wolfgang Schuhmann, Stefan Klink
  • Patent number: 10871467
    Abstract: Embodiments profile cannabinoids using a nanopore detector. Embodiments use an applied potential to electrophoretically draw a nanopore blockade reporter molecule into a nanopore channel to establish an electrophoretic molecular channel-capture for the reporter molecule. The reporter molecule includes one of an aptamer or a monoclonal antibody and has a specific binding to at least one of: a specific cannabinoid, a particular cannabinoid isoform; or a specific cannabinoid family. Embodiments receive a blockade channel current signal in response to a nanoscale membrane channel of the nanopore detector being partially blockaded by a presence of the reporter molecule non-covalently bonded to the membrane channel. Embodiments receive a blockade signal for the reporter molecule that is toggling between more than one level.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: December 22, 2020
    Assignee: CANNAPTIC BIOSCIENCES, LLC
    Inventors: Robert Adelman, Stephen Winters-Hilt
  • Patent number: 10871465
    Abstract: A mixed-potential gas sensor includes: a first sensing electrode containing a Pt—Au alloy and a second sensing electrode containing Pt, the first and second sensing electrodes being provided on a surface of a sensor element made of an oxygen-ion conductive solid electrolyte on one leading end part side; a reference electrode provided inside the sensor element to be made contact with air; a protective cover that surrounds the one leading end part of the sensor element and into which measurement gas flows; and concentration identification element configured to identify a concentration of a sensing target gas component based on potential differences between both of the first sensing electrode and the second sensing electrode and the reference electrode. The first and second sensing electrodes are disposed so that the measurement gas flowing into the protective cover reaches the first sensing electrode earlier than the second sensing electrode.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: December 22, 2020
    Assignee: NGK INSULATORS, LTD.
    Inventor: Taku Okamoto
  • Patent number: 10870114
    Abstract: A microfluidic system includes: an electro-wetting on dielectric (EWOD) cartridge having an element array configured to receive liquid droplets, the element array including individual array elements each including array element circuity comprising sensing circuitry that is integrated into the array element circuitry; a microfluidic instrument that is configured to receive the EWOD cartridge and having an electrically conductive locator that is external to the EWOD cartridge; and a control system configured perform electrowetting operations by controlling actuation voltages applied to the element array to perform manipulation operations as to liquid droplets present on the element array. The control system further is configured to read an output from the sensing circuitry, determine a position of the locator relative to the element array based on the output, and determine a misalignment of the EWOD cartridge relative to the microfluidic instrument based on the position of the locator.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: December 22, 2020
    Assignee: Sharp Life Science (EU) Limited
    Inventors: Benjamin James Hadwen, Oliver James Beard, Chris Clarke
  • Patent number: 10866211
    Abstract: The present disclosure relates to a semiconductor device and a cell potential measuring apparatus capable of amplifying and reading a potential of solution with high accuracy. A reading electrode reads the potential of the solution. A differential amplifier includes a current mirror circuit. The reading electrode is connected to a first input terminal of the differential amplifier which is connected to a gate of a first input transistor connected to a diode-connected pMOS transistor of the current mirror circuit. An output terminal of the differential amplifier is connected to a second input terminal of the differential amplifier, which is connected to a gate of a second input transistor connected to a pMOS transistor of the current mirror circuit which is not diode-connected, via a capacitor. For example, the present disclosure is applied to the cell potential measuring apparatus and the like.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: December 15, 2020
    Assignee: SONY CORPORATION
    Inventors: Yuri Kato, Yusuke Oike
  • Patent number: 10859528
    Abstract: A mixed-potential type gas sensor includes: a first sensing electrode containing a Pt—Au alloy and a second sensing electrode containing Pt, both sensing electrodes being provided on the surface of a sensor element made of an oxygen-ion conductive solid electrolyte; a reference electrode provided inside the sensor element to be made contact with air; a first protective layer group covering the first sensing electrode; a second protective layer group covering the second sensing electrode; and concentration identification element configured to identify the concentration of a sensing target gas component based on potential differences between both of the first sensing electrode and the second sensing electrode and the reference electrode. The response times of the first and second sensing electrodes are both equal to or shorter than 10 seconds, and the response time difference therebetween is 2 seconds or shorter.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: December 8, 2020
    Assignee: NGK INSULATORS, LTD.
    Inventor: Taku Okamoto
  • Patent number: 10852268
    Abstract: An electrochemical sensor may include a common reference electrode, at least one counter electrode, and a work electrode platform including a plurality of respective work electrodes. Each respective work electrode of the plurality of respective work electrodes may be electrically coupled to the common reference electrode and include a respective reagent substrate configured to react with a respective analyte to produce a signal indicative of a concentration of the respective analyte.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: December 1, 2020
    Assignee: Medtronic, Inc.
    Inventors: Daniel Hahn, Mohsen Askarinya, James K. Carney, Patrick W. Kinzie, Jennifer Lorenz Marckmann, Randal C. Schulhauser, Santhisagar Vaddiraju, Akhil Srinivasan, David Probst, Alejo Chavez Gaxiola
  • Patent number: 10845323
    Abstract: An electronic component includes a field effect transistor that functions as a working electrode of an ion sensor and a driving circuit that causes a potential difference between a source electrode and a drain electrode of the field effect transistor. A reference electrode potential of the field effect transistor is fixed.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: November 24, 2020
    Assignees: WASEDA UNIVERSITY, YOKOGAWA ELECTRIC CORPORATION
    Inventors: Hiroshi Kawarada, Masafumi Inaba, Mohd Sukri Shaili Falina Binti, Takuro Naramura, Keisuke Igarashi, Yukihiro Shintani, Kotaro Ogawa
  • Patent number: 10845324
    Abstract: Electrochemical sensors for the detection of select analytes are provided. The electrochemical sensors include a barrier layer having a substantially uniformed thickness disposed between a sensing layer and an ion exchange membrane. The barrier layer includes a two-dimensional nanomaterial. The barrier layer has a thickness of less than or equal to about 1 nm. The sensing layer has a thickness of less than or equal to about 10 nm. The sensing layer generates ions in response to select analytes. The barrier layer allows the generation ions to pass therethrough and travel into the ion exchange membrane. The barrier layer acts as a physical barrier to contaminants and larger molecules.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: November 24, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Girish Kulkarni, Xudong Fan, Zhaohui Zhong, Ayush Pandey, Wenzhe Zang
  • Patent number: 10845334
    Abstract: A cell extraction method includes providing a mixed-cell sample having both target cells and non-target cells slurried in a trailing-electrolyte solution. A leading electrolyte solution is provided to contact the trailing electrolyte solution via a capillary and a pressure control device. Focusing of the target cells at an interface between the leading- and trailing-electrolyte solutions occurs by applying pressure to the capillary and concurrently applying an electric potential via electrodes. The target cells are extracted into the capillary by applying a negative pressure and transferred to a receptacle. A cell extraction system for use with a gradient elution isotachophoresis method includes a trailing electrolyte solution adapted to migrate slower than the target cells and a leading electrolyte solution adapted to migrate faster than the target cells. A mixed-cell sample containing the target and non-target cells is slurried in the trailing electrolyte solution prior to cell extraction.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: November 24, 2020
    Assignee: Applied Research Associates, Inc.
    Inventors: Alyssa C. Henry, Vanessa M. Thomas
  • Patent number: 10845336
    Abstract: A method for diagnosing COVID-19 infection of a person. The method includes acquiring a sputum sample of a person, measuring a level of ROS in the sputum sample, and detecting a COVID-19 infection status of the person based on the measured level of ROS. Measuring the level of ROS in the sputum sample includes recording a cyclic voltammetry (CV) pattern from the sputum sample and measuring a current peak of the recorded CV pattern. Detecting the COVID-19 infection status of the person includes detecting COVID-19 infection of the person responsive to the measured current peak being in a first range of more than 230 ?A and detecting COVID-19 non-infection of the person responsive to the measured current peak being in a second range of less than 190 ?A.
    Type: Grant
    Filed: July 9, 2020
    Date of Patent: November 24, 2020
    Inventors: Mohammad Abdolahad, Zohreh Sadat Miripour, Hassan Sanati koloukhi, Fatemeh Zahra Shojaeian Zanjani
  • Patent number: 10837956
    Abstract: A sensor technology comprising a single nano-material (gold nanoparticles and/or carbon nanotube) based sensor or a plurality of sensors in conjunction with a pattern recognition algorithm for non-invasive and accurate diagnosis of tuberculosis caused by M. tuberculosis bacteria in a subject. The sensor technology is suitable for population screening of tuberculosis, particularly in resource-poor and developing countries.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: November 17, 2020
    Assignee: Technion Research & Development Foundation LTD
    Inventors: Hossam Haick, Morad Nakhleh
  • Patent number: 10837940
    Abstract: An improvement in the method or technique of conditioning a gas sensor is provided through the application of Pulse Discharge Technique (PDT) in order to condition mixed-potential gas sensors. A modified planar sensor design to minimize sodium atom diffusion and platinum electrode poisoning under conditions of PDT are provided. Modification of the PDT hardware is provided without modification of the sensor design. The improvement method comprises: a) Replace a single polarity power supply with a power supply with floating positive and negative output; b) Connect one of the heater leads with the reference electrode lead and connect it to the ground.
    Type: Grant
    Filed: November 18, 2017
    Date of Patent: November 17, 2020
    Assignee: BJR SENSORS LLC
    Inventor: Boris Farber
  • Patent number: 10830727
    Abstract: The application relates to an electrode for use in the electrochemical detection of a target species, wherein the electrode has a planar surface disposed on which are probe molecules that are capable of binding selectively to the target species, wherein the electrode, prior to binding of the probe molecules with the target species, has an electron transfer resistance per area of the electrode of from 10 megaohms cm?2 to 95 megaohms cm?2.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: November 10, 2020
    Assignees: Universidade Estadual Paulista “Julio de Mequita Filho”, Oxford University Innovation Limited
    Inventors: Jason Davis, Paulo Roberto Bueno
  • Patent number: 10830732
    Abstract: Isotachophoresis (ITP) is exploited to control various aspects of chemical reactions. In a first aspect, at least one of the reactants of a chemical reaction is confined to an ITP zone, but the resulting product of the chemical reaction is separated from this ITP zone by the ITP process. In a second aspect, one or more reactants of a chemical reaction are confined to an ITP zone, and one or more other reactants of the chemical reaction are not confined to this ITP zone. In a third aspect, ITP is employed to confine at least one reactant of a chemical reaction to an ITP zone, and at least one reactant of the chemical reaction is delivered to the ITP zone in two or more discrete doses. These aspects are especially relevant to performing polymerase chain reactions using chemical denaturants as opposed to thermal cycling.
    Type: Grant
    Filed: September 4, 2018
    Date of Patent: November 10, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Juan G. Santiago, Alexandre Persat
  • Patent number: 10830725
    Abstract: Devices, systems, methods and products for measuring concentrations of analytes in-situ, including concentrations of ions, proteins, DNA, and, RNA in a variety of mediums including solutions, suspensions, soils, slurries, biological fluids and living organic material such as agricultural crops. Embodiments of the disclosed inventions measure analyte concentration in-situ without clogging reference electrodes, leaking reference solution or having to dilute a medium prior to taking the analyte measurements. In-situ analyte measurements are made without clogging reference electrodes using a combination of solid-state sensors connected to a transducer, a reference electrode enclosed by a non-porous enclosure and a metallic plug extending from the interior cavity of the non-porous enclosure outwardly exterior to the non-porous enclosure, contacting the medium being measured.
    Type: Grant
    Filed: November 12, 2018
    Date of Patent: November 10, 2020
    Assignee: International Business Machines Corporation
    Inventors: Sufi Zafar, Giulia Prone
  • Patent number: 10823699
    Abstract: An electrophoretic device for detecting biomarkers in collected bodily fluid and methods of using the same.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: November 3, 2020
    Assignee: Vital Biosciences, Inc.
    Inventors: Mounir A. Koussa, Calvin Domenico, Ronald L. Green, Joshua John Forman, Andrew Ward, Lisa Caldwell