Patents Examined by Alexander S Noguerola
  • Patent number: 12292404
    Abstract: The present disclosure discloses a voltammetric sensor for the detection of oxytocin. The voltammetric sensor comprises a gold electrode. The gold electrode comprises lead oxide (PbO) nanoparticles. The present disclosure also discloses a method of detecting oxytocin using a voltammetric sensor, the voltammetric sensor comprising a gold electrode, the gold electrode comprising lead oxide (PbO) nanoparticles. The method of detecting oxytocin comprises the steps of positioning a liquid droplet, comprising solvent and analyte, to be tested on a sensing area of the gold electrode; receiving a voltammetric response from the electrode; and analysing the voltammetric response to determine if oxytocin is present in the liquid droplet.
    Type: Grant
    Filed: April 5, 2024
    Date of Patent: May 6, 2025
    Assignee: United Arab Emirates University
    Inventors: Afzal Shah, Iltaf Shah
  • Patent number: 12292405
    Abstract: The invention disclosed herein relates to a dry sensor for measuring the concentration of an analyte in a liquid beverage sample. Described herein is a novel dry sensor which is able to receive a liquid sample and adjust the pH of the liquid to be suitable for assaying an analyte of interest without the need to add reagents to the sample and/or to perform manually timed operations and able to detect a redox reaction in the presence of a liquid sample. The meter disclosed herein, when connected to the sensor disclosed herein is able to adjust the temperature of the liquid to be suitable for the assay, apply a series of potentials, measure the current at several times, measure the diffusion coefficient of the limiting electrochemical species, calculate the concentration of one or more analytes, and rapidly provide the user with the required information on the liquid sample.
    Type: Grant
    Filed: September 30, 2020
    Date of Patent: May 6, 2025
    Inventors: Stanley Zhen-Jin Teo, Peter Michael Newman, Ronald Christopher Chatelier, Luke Robert Cossins, Alastair M. Hodges
  • Patent number: 12282000
    Abstract: The present invention aims to provide a biological sample analysis device which achieves an improvement in accuracy of an analysis result, a reduction in reagent cost, and shortening of a required time. The biological sample analysis device according to the present invention compares first measurement data acquired by measuring a biological sample and second measurement data acquired by measuring a reference sample and determines that when the difference between the two exceeds a threshold value, it is necessary to remeasure the reference sample before remeasuring the biological sample and reacquire a reference value (refer to FIG. 3A).
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: April 22, 2025
    Assignee: Hitachi High-Tech Corporation
    Inventors: Ayaka Okuno, Michiru Fujioka, Toru Yokoyama
  • Patent number: 12276635
    Abstract: The present invention aims to provide an electrophoresis device which detects the presence or absence of foreign matter in a flow path 111. In order to solve the above problems, the electrophoresis device of the present invention is characterized by including a flow path 111 filled thereinside with a migration medium, a migration medium container which stores a migration medium, a liquid feeding mechanism which feeds the migration medium to the flow path 111, a photographing device 115 which photographs the flow path 111, and a control unit which analyzes an image of the flow path 111 photographed by the photographing device 115 and in that the control unit determines the presence or absence of the foreign matter in the flow path 111 on the basis of the image of the flow path 111.
    Type: Grant
    Filed: November 11, 2019
    Date of Patent: April 15, 2025
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Masashi Tomiyoshi, Masashi Watanabe, Takeshi Ooura, Motohiro Yamazaki
  • Patent number: 12270779
    Abstract: Various examples are provided related to electrochemical phosphate/pH (P/pH) sensors, systems and related methods. In one example, a P/pH sensor includes a substrate and collocated phosphate (P) electrode and pH electrode formed on a surface of the substrate. The P electrode includes a cobalt (Co) sensing window disposed on a first copper (Cu) sensor pad; and the pH electrode includes an antimony (Sb) sensing window disposed on a second Cu sensor pad. The P/pH sensor can include a reference electrode, and may also include other sensor electrodes such as, e.g., a nitrate electrode.
    Type: Grant
    Filed: September 11, 2020
    Date of Patent: April 8, 2025
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Todd R. Schumann, Yong-Kyu Yoon, Renuka Bowrothu, Kyoung Tae Kim
  • Patent number: 12270783
    Abstract: A carrier plate and a liquid sample are provided for the use of a single cell gel electrophoresis device for screening a subject for at least a DNA-damage, in particular a specific DNA-damage, in relation to a predisposition for and/or the presence of a disease. The liquid sample has cells of the subject. A single cell gel electrophoresis on the sample of the subject is performed by positioning the sample accommodated on the carrier plate in the generated homogenous electrical field and controlling strength and direction of the electrical field while the sample is positioned in the gel electrophoresis device. The DNA-damage is determined with a high reproducibility, with a coefficient of variation (CV) of 15% or less, in particular 10% or less, in particular 5% or less.
    Type: Grant
    Filed: January 8, 2019
    Date of Patent: April 8, 2025
    Assignee: 4D LIFETEC AG
    Inventors: Oliver Schicht, Arne-Christian Faisst
  • Patent number: 12270800
    Abstract: An electrochemical gas sensor, for acid analyte gases, has an absorbent, which is suitable for absorbing a reaction product formed at the electrode. The electrochemical gas sensor further has a boron 5 compound, which is suitable for reacting chemically with the acid analyte gas. A process determines the concentrations of acid gases. A process uses an electrochemical gas sensor for determining the concentrations of acid gases.
    Type: Grant
    Filed: December 20, 2021
    Date of Patent: April 8, 2025
    Assignee: DRÄGER SAFETY AG & CO. KGAA
    Inventor: Frank Mett
  • Patent number: 12263483
    Abstract: Described herein are digital microfluidic (DMF) devices and corresponding methods for managing reagent solution evaporation during a reaction. Reactions on the DMF devices described here are performed in an air or gas matrix. The DMF devices include a means for performing reactions at different temperatures. To address the issue of evaporation of the reaction droplet especially when the reaction is performed at higher temperatures, a means for introducing a replenishing droplet has been incorporated into the DMF device. A replenishing droplet is introduced every time when it has been determined that the reaction droplet has fallen below a threshold volume. Detection and monitoring of the reaction droplet may be through visual, optical, fluorescence, colorimetric, and/or electrical means.
    Type: Grant
    Filed: January 18, 2024
    Date of Patent: April 1, 2025
    Assignee: INTEGRA Biosciences AG
    Inventors: Mais J. Jebrail, Ronald Francis Renzi, Steven Branda
  • Patent number: 12265017
    Abstract: The disclosure provides a method for establishing a hydrogen charging model for pipeline steel in an equivalent wet hydrogen sulfide environment and an application thereof, which belongs to the field of corrosion electrochemistry. The method includes the following steps: using a cathode hydrogen charging method and a wet hydrogen sulfide environment method respectively to perform hydrogen charging on each sample to be tested under different reaction conditions to obtain several first hydrogen charging samples and second hydrogen charging samples; measuring the hydrogen content of each of the first hydrogen charging sample and the second hydrogen charging sample; performing curve fitting on the variables in the two methods respectively according to the obtained hydrogen content, and the hydrogen charging model for pipeline steel in the equivalent wet hydrogen sulfide environment is obtained according to the fitting result.
    Type: Grant
    Filed: August 28, 2024
    Date of Patent: April 1, 2025
    Assignee: Tianjin University
    Inventors: Lianyong Xu, Yongdian Han, Jiajun Shao, Lei Zhao, Kangda Hao
  • Patent number: 12259357
    Abstract: An automotive exhaust gas sensor includes a gas chamber, an ultraviolet light source configured to emit ultraviolet light into the gas chamber and to photolyze an exhaust gas sample in the gas chamber, and an electrochemical detector disposed in the gas chamber and configured to detect a specified chemical in the photolyzed exhaust gas sample.
    Type: Grant
    Filed: April 20, 2022
    Date of Patent: March 25, 2025
    Assignee: Ford Global Technologies, LLC
    Inventors: David Bilby, Reinoud Felix Wolffenbuttel
  • Patent number: 12253491
    Abstract: Described are systems and methods for the simple and rapid measurement of an analyte, such as sulphur dioxide, in liquid samples, including beverages such as wine or beer. The systems and methods utilize voltammetry with a particulate carbon or copper electrode, and may be conducted outside of a laboratory in ten to sixty seconds using a small portable instrument or mobile device using, for example, 2nd harmonic Fourier Transform (FT) AC voltammetry.
    Type: Grant
    Filed: May 15, 2020
    Date of Patent: March 18, 2025
    Assignee: LA TROBE UNIVERSITY
    Inventors: Conor Hogan, Darrell Elton, Peter O'Conghaile
  • Patent number: 12247943
    Abstract: Amperometric gas sensors have unwanted signals that are avoided by using two working electrodes, each having a resistor between the electrode and the current sensing circuit. The resistor has a value of more than 10% of the Faradaic resistor of the electrode. Two different resistors in parallel are switched in and out. The lower value resistor provides fast response for leak detection and safety. A higher value resistor is used for accurate information. The lower value resistor is switched in periodically for diagnostics. Machine-learning uses the periodic switching for determining offset as a function of temperature and humidity.
    Type: Grant
    Filed: December 20, 2021
    Date of Patent: March 11, 2025
    Assignee: AEROQUAL LTD.
    Inventors: Anna Farquhar, Geoffrey Henshaw, David Williams
  • Patent number: 12241863
    Abstract: A controller sets a schedule in which an order of a plurality of electrophoresis processes is defined. The controller controls a storage device to store first information representing a result of an electrophoresis process that has ended among the plurality of electrophoresis processes and second information about setting for the plurality of electrophoresis processes. The controller receives a stop signal from an information processing apparatus while the plurality of electrophoresis processes defined in the schedule are being performed. When the controller receives the stop signal, the controller controls an electrophoresis mechanism to perform until the end, an electrophoresis process that is being performed among the plurality of electrophoresis processes.
    Type: Grant
    Filed: January 26, 2021
    Date of Patent: March 4, 2025
    Assignee: SHIMADZU CORPORATION
    Inventors: Hidesato Kumagai, Akihiro Arai, Akira Harada
  • Patent number: 12241855
    Abstract: A method of electrochemical sensing includes providing an electrochemical sensor comprising a glassy carbon substrate and gold nanoparticles located on a surface of the glassy carbon substrate; and sensing electrochemically a compound selected from the group consisting of polyfluoroalkyl compounds or perfluoroalkyl compounds using the electrochemical sensor. PFOA quantification was performed by Square Wave Adsorptive Cathodic Stripping Voltammetry (SW-AdCSV) in test solutions with a 100-5,000 ppt concentration. The concentration has a linear relationship with the stripping current within this range. Analysis of tap and groundwater samples performed by additions method demonstrated precision and accuracy above 95%. These electrodes show stability throughout 200 cycles, and reproducibility across similarly prepared but different electrodes above 97.5%.
    Type: Grant
    Filed: June 15, 2023
    Date of Patent: March 4, 2025
    Assignees: Board of Regents, The University of Texas System, Arizona Board of Regents on Behalf of Arizon State University
    Inventors: Dino Villagran, Paul Westerhoff, Jonathan Josue Calvillo Solis, Michael Wong
  • Patent number: 12235205
    Abstract: Methods and systems for measuring cathodic protection of a metallic structure using a plurality of coupons, the method including electrically coupling a first coupon to the metallic structure, the first coupon being electrically connected to a reference cell and including a first material, electrically coupling a second coupon to the metallic structure, the second coupon being electrically connected to the reference cell and including a second material, electrically coupling the first coupon to the second coupon, applying a first cathodic protection current to the metallic structure, interrupting the application of the first cathodic protection current, measuring voltage between the electrically coupled first and second coupons and the metallic structure while the application of the first cathodic protection current is interrupted, and determining whether a degree of cathodic protection applied to the metallic structure is sufficient based on the measured voltage.
    Type: Grant
    Filed: March 1, 2024
    Date of Patent: February 25, 2025
    Assignee: CHAPMAN ENGINEERING, INC.
    Inventors: Calvin C. Chapman, IV, Samuel F. Williams
  • Patent number: 12234569
    Abstract: A fabricating method of a non-enzyme sensor element includes a printing step, a coating step and an electroplating step. In the printing step, a conductive material is printed on a surface of a substrate to form a working electrode, a reference electrode and an auxiliary electrode, and a porous carbon material is printed on the working electrode to form a porous carbon layer. In the coating step, a graphene film material is coated on the porous carbon layer of the working electrode to form a graphene layer. In the electroplating step, a metal is electroplated on the graphene layer by a pulse constant current to form a catalyst layer including a metal oxide.
    Type: Grant
    Filed: February 7, 2022
    Date of Patent: February 25, 2025
    Assignee: NATIONAL TSING HUA UNIVERSITY
    Inventors: Hsiang-Yu Wang, Yi-Yu Chen, Shih-Hao Lin, Yu-Sheng Lin
  • Patent number: 12228541
    Abstract: An electrochemical sensor comprising first and second electrodes. The first electrode has a molecular imprinted polymer (MIP) immobilised thereon and the MIP comprises a redox label and is imprinted with an analyte. The disclosure also provides methods of producing such sensors, methods of detecting and determining the concentration of analytes and the use of the electrochemical sensors for the detection of analytes.
    Type: Grant
    Filed: June 5, 2019
    Date of Patent: February 18, 2025
    Assignee: UNIVERSITY OF LEICESTER
    Inventors: Sergey Piletsky, Omar Sheej Ahmad, Alvaro Garcia Cruz
  • Patent number: 12228542
    Abstract: The present disclosure relates to a composition for a crosslinking agent for the preparation of a sensing layer or a diffusion control layer of an electrochemical biosensor comprising genipin or a derivative thereof, in which due to the properties of genipin that can be extracted and used from plants, not only it has high biocompatibility compared to conventional crosslinking agents with high toxicity, but also it can easily confirm the progress of the reaction by measuring UV or measuring the amount of amine groups present when reacting with a compound having an amine group, for example, an electron transport medium, and additionally, it has the advantage of suppressing a rapid decrease in sensor life due to high concentration of glucose while maintaining an appropriate sensitivity to glucose.
    Type: Grant
    Filed: May 9, 2019
    Date of Patent: February 18, 2025
    Assignee: I-SENS, INC.
    Inventors: In Seok Jeong, Hyunhee Yang, Young Jea Kang
  • Patent number: 12222319
    Abstract: An embodiment provides a method for measuring a component of an aqueous sample using square wave voltammetry, including: introducing the aqueous sample to a chamber of a square wave voltammetry apparatus; applying a stimulus voltage step to the aqueous sample, wherein the stimulus voltage comprises a staircase voltage, wherein each step of the staircase voltage defines a group and comprises two or more repeated square wave modulations of equal voltage amplitude; measuring a resultant current output resulting from the stimulus voltage, wherein the measuring comprises square wave voltammetry; and averaging the resultant current output across at least two or more cycles of each group. Other aspects are described and claimed.
    Type: Grant
    Filed: March 18, 2022
    Date of Patent: February 11, 2025
    Assignee: HACH COMPANY
    Inventor: David Langley Rick
  • Patent number: 12222310
    Abstract: The present invention is directed to membranes, sensors, systems and process for the detection of magnesium ions in protein-containing samples. The novel membranes, sensors, systems, and processes are based upon the discovery that the lipophilicity of the plasticizer (or blend of plasticizers) utilized in the formulation of magnesium ion selective membranes for clinical use is inversely proportional to the sensitivity of the plasticizer(s) and directly proportional to the use life thereof.
    Type: Grant
    Filed: October 10, 2023
    Date of Patent: February 11, 2025
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: John Benco, Robert Bergquist