Abstract: Various cell analysis systems of the present teachings can measure the electrical and metabolic activity of single, living cells with subcellular addressability and simultaneous data acquisition for between about 10 cells to about 500,000 cells in a single analysis. Various sensor array devices of the present teachings can have sensor arrays with between 20 million to 660 million ChemFET sensors built into a massively paralleled array and can provide for simultaneous measurement of cells with data acquisition rates in the kilohertz (kHz) range. As various ChemFET sensor arrays of the present teachings can detect chemical analytes as well detect changes in cell membrane potential, various cell analysis systems of the present teachings also provide for the controlled chemical and electrical interrogation of cells.

Abstract: A method of detecting a state of a lipid membrane in a cell of a nanopore based sequencing chip is disclosed. A lipid membrane is coupled with an integrating capacitor, wherein the lipid membrane is between a working electrode and a counter electrode. An alternating current (AC) voltage is applied to the counter electrode. A voltage across the integrating capacitor is periodically sampled by an analog-to-digital converter (ADC). A change in the sampled voltage across the integrating capacitor in response to an intermediate change in the AC voltage is determined. A state of the lipid membrane is determined based on the determined change in the sampled voltage across the integrating capacitor in response to the intermediate change in the AC voltage.

Abstract: A sensor element includes: an element base including a gas distribution part communicating from a gas inlet; and a leading-end protective layer including an inner layer covering an end portion and four side surfaces of the element base and an outer layer covering the inner layer and having a lower porosity than the inner layer, and a total thickness representative value, defined as an average of total thicknesses of the protective layer at a plurality of positions including a starting point, an intermediate position, and an innermost end of the gas distribution part, is 250 ?m or more, and a film thickness variation degree, defined as a ratio of a difference between a maximum value and a minimum value of the total thicknesses with respect to the total thickness representative value when the value is based at 100, is 20 or less.

Abstract: The present invention relates to a method of sorting particles in a stream of carrier fluid, the method comprising: introducing a stream of carrier fluid containing a mixture of particles into a stream of sheath fluid flowing within a flow channel so as to focus the carrier fluid into a core stream; detecting a particle of interest within the core stream of carrier fluid at a point of detection within the flow channel; applying a potential difference between a first electrode and one or more additional electrodes so as to generate a divergent electric field localised around a tip of the first electrode, wherein the tip of the first electrode is positioned inside of the flow channel or adjacent to the flow channel in a position in which the divergent electric field is experienced by the sheath fluid and carrier fluid within the flow channel, and subsequently terminating application of the potential difference, wherein the potential difference is applied in response to the detection of a particle of interest, t

Abstract: The present invention relates to apparatuses for use in electrophoretic separation of macromolecules and/or cells.

Abstract: A method and system improving the accuracy and/or interpretability of measurements in a body fluid, such as saliva, sweat or urine involves measurement of multiple parameters in a sample with biosensors. One or more biosensors may reflect the concentration of a target biomarker, and one or more biosensors may describe a parameter of the fluid known to impact the function of the first biosensor the way the measurement of the first biosensor should be interpreted.

Abstract: A current measurement method for measuring a tunneling current in biopolymers passing through between a pair of electrodes includes arranging the electrodes in a liquid that contains an electrolyte and, while applying a voltage between the electrodes, measuring a current flowing between the electrodes via an electric double layer formed along surfaces of the electrodes. This enables measuring the current in consideration of the electric double layer. As a result, it is possible to more accurately measure the tunneling current in the biopolymers included in a liquid sample that contains an electrolyte.

Abstract: The present invention relates to a method for removing oxygen, used in an electrochemical biosensor, and to a measurement system and a method for electrochemically determining a concentration of an analyte using said method.

Abstract: A support body includes a concentrating portion, which concentrates an object, between a first end portion and a second end portion. When an area of a cut section of a flow path when cut at a predetermined position in a first direction along a plane orthogonal to the first direction is a flow path cross-sectional area, a flow path cross-sectional area of the concentrating portion is smaller than a flow path cross-sectional area in a first region closer to a first end portion side than the concentrating portion, and a flow path cross-sectional area of a second region closer to the second end portion side than the concentrating portion is larger than the flow path cross-sectional area of the concentrating portion.

Abstract: The present invention aims to provide an electrophoresis apparatus which makes it possible to execute protein analysis with a high throughput. The electrophoresis apparatus according to the present invention is equipped with a capillary array which is configured by arraying a plurality of capillaries, a measurement light irradiation unit which irradiates with measurement light, a first lens array which includes a plurality of first lenses which are arrayed in correspondence with the plurality of capillaries, a second lens array which includes a plurality of second lenses which are arrayed in correspondence with the plurality of capillaries, and a light receiving unit which receives light which is incident upon the capillaries via the first lens array from the measurement light irradiation unit via the second lens array.

Abstract: A system and a method for detecting biomolecules are provided. The method comprises disposing a first coating layer associated with a first target biomolecule on a first portion of a sensing film of a sensor and disposing a second coating layer associated with the first target biomolecule on the first portion of the sensing film. The method further comprises measuring a baseline electrical signal associated with a buffer solution by the sensor, disposing a first analyte solution on the sensor, and measuring the first electrical signal associated with the first analyte solution. The method further comprises determining whether the first target biomolecule are detected in the first analyte solution based on a comparison between the measured first electrical signal and a first threshold.

Abstract: In a device that measures biopotentials of cells in a solution, the solution is controlled at a constant temperature. A measurement device includes a substrate, a sensing control circuit, a temperature sensor, a front surface side heat radiating unit, a back surface side heat radiating unit, and a temperature control unit. A plurality of electrodes each detecting a potential in the solution is arranged on the front surface of the substrate. The sensing control circuit is arranged on the substrate and controls detection of potentials at the plurality of electrodes. The temperature sensor is arranged on the substrate and detects a temperature of the solution. The front surface side heat radiating unit is arranged on the front surface side of the substrate and radiates heat. The back surface side heat radiating unit is arranged on the back surface side that is a surface different from the front surface of the substrate, and radiates heat.

Abstract: A pH combination electrode includes inner and outer tubes, working and reference electrodes, and a hydrogel diaphragm between the tubes. A seal is disposed inside the inner tube closer to a first inner tube end than to the second inner tube end. An extended reference chamber is formed inside the inner tube between the seal and the second inner tube end. A first conductive fluid is contained in the inner tube between the seal and the first inner tube end. A second conductive fluid is contained in the extended reference chamber and in a reference chamber formed between the inner and outer tubes. A through-hole in the inner tube allows the second conductive fluid to flow between the reference chamber and the extended reference chamber. The working electrode extends into the inner tube, through the seal and into the first conductive fluid. The reference electrode contacts the second conductive fluid.

Abstract: Disclosed herein are methods and devices for a cell-free assay platform that enables measurement of membrane protein function by measuring the events that are induced by ligand binding or other stimuli.

Abstract: A trace metal analysis detector and method of operating the same to detect metals in various fluid samples using boron doped diamond working electrodes.

Abstract: An electrochemical sensor array for detecting analytes in water, including a frame; a plurality of sensor electrodes each mounted to the frame, including a free chlorine working electrode including a gold thin film and having a free chlorine sensing surface to be exposed to the water; and a reference electrode including a silver thin film and a silver and silver chloride layer and having a reference sensing surface to be exposed to the water. A method of manufacturing an electrochemical sensor array for detecting analytes in water, including forming a free chlorine electrode, including forming a gold thin film on a first base layer; forming a reference electrode, including forming a silver thin film on a second base layer and applying a silver and silver chloride paste to a portion of the silver thin film; and arranging the free chlorine electrode and the reference electrode on a common frame.

Abstract: An ion removal apparatus according to this disclosure performs a desalination treatment on a liquid and includes: a first electrode guide having an inlet allowing the liquid to flow in, a first electrode holder holding a first electrode that adsorbs an ion in the liquid, and an inflow passage serving as a flow passage connecting the inlet and the first electrode holder to one another; and a second electrode guide having an outlet allowing the liquid to flow out, a second electrode holder allowing the liquid passing through the first electrode holder to flow in and holding a second electrode that adsorbs the ion in the liquid, and an outflow passage serving as a flow passage connecting the outlet and the second electrode holder to one another.

Abstract: Reagents are disclosed for use with potentiometric magnesium ion selective electrodes, along with kits containing same as well as methods of use thereof.

Abstract: The present disclosure relates to a sensing device and methods for detecting, and quantifying the amount of, a target protein in a sample.

Abstract: Detection reagents, multi-analyte test elements, test systems, and multi-analyte measuring methods are provided. In particular, multi-analyte test elements have (1) a first working electrode and first counter electrode pair covered with a first analyte-specific reagent that includes an enzyme, a coenzyme and a first mediator and have (2) a second working electrode covered with a second analyte-specific reagent that includes an enzyme, a coenzyme and a second mediator, where the second mediator is different than the first mediator. The single counter electrode can be used as the counter electrode for both the first and second analyte measurements at their respective working electrodes. Moreover, the mediator concentrations, measurement ranges, and applied potential differences are not the same for each analyte-specific measurement.