Abstract: The present invention relates to a medical injection device for preventing a target substance contained in an injection solution from being lost when the target substance is not settled or floated, and for evenly agitating the injection solution to be safely injected. A medical injection device according to the present invention includes a container having an agitation means and a vibration sensing ball, an injection solution filter, an injection solution level controller, a bellows connector, and a guide tube.

Abstract: This invention relates to a device that uses microneedles to create pores in the skin of a subject and delivers the drug transdermally by inserting it into the pore as a solid or semi-solid mass alongside each needle. The device is sufficiently flexible to allow relative movement of the needle and the drug mass apart from one another. Preferably a chamber holding the drug mass comprises a relatively rigid wall to ensure that the drug remains aligned close to the needle, while an adjacent chamber holding the needle comprises a relatively flexible wall to allow lateral movement of the needle as the drug is inserted alongside it.

Abstract: A self-admixing disposable hypodermic needle (admixing needle) includes a reservoir containing an additive, such as a buffering agent, to facilitate homogeneous mixing of the additive with an injection fluid, such as Lidocaine, contained in a cartridge held within a mechanically conjoined syringe. The admixing needle establishes a fluid communication pathway for hypodermically delivering the injection mixture to a patient preceding a potentially painful dental or medical procedure. Prior to removal, a delivery needle cap is pushed toward the syringe to dispense the additive into the cartridge. The delivery needle is then placed within the patient's tissues and the syringe is operated to force the injection mixture from the cartridge. Mixing surfaces on the male body (reservoir plunger) and the female body (reservoir) and other mechanical features homogeneously combine the injection fluid with the additive as the injection mixture travels through the admixing needle during the hypodermic injection.

Abstract: Disclosed is a multi-lumen mixing device that includes a first and second lumen constructed and arranged to separately pass a first and second reagent to a mixing chamber in the device, where the mixing chamber includes a mixing feature that mixes the first and second reagents. The disclosed multi-lumen mixing device may also include a port in fluid communication with the reaction mixing to permit the product of the combined reagents to be injected into a patent.

Abstract: An apparatus and method for syringe plunger positioning employing an actuator for linear advancement and retraction of the support member along a predetermined axis, and a plurality of arm members each interconnected to the support for movement therewith, and each moveable relative to the support member in corresponding different directions towards and away from the predetermined axis. The actuator may be operable to advance the support member to an advanced position for movement of the arm members from an open position to a closed position, and to retract the support member from the advanced position so that of the arm members engage an inside surface of a plunger button of syringe having a barrel located in a fixed, axially aligned position on the predetermined axis. The apparatus and method may be employed in conjunction with syringe plunger positioning (e.g. for filling operations) that accommodates a variety of syringe plunger configurations.

Abstract: An apparatus for injecting a liquid into live animals, comprising a cradle plate (18) having a cradle (24) for accommodating at least a part of an animal, sensors (20-1, 20-2, 20-3) for detecting a force acting upon the cradle plate, an injection mechanism (16) for injecting liquid into the animal, and a control unit (38) for triggering the injection mechanism (16) in response to signals received from the sensors, wherein at least three sensors (20-1-, 20-2, 20-3) are arranged for measuring forces with which the cradle plate (18) is pressed against a base (12) in at least three non-aligned positions, and the control unit (38) is adapted to trigger the injection mechanism (16) when the forces measured by the sensors are distributed according to a predetermined pattern.

Abstract: A debris clearing system is provided that includes a tool having a suctioning intake positioned on an axis of the tool. A controller actuates the suctioning intake along the length of the axis of the tool. The suctioning intake is actuated while the tool is being operated and proximal to a surgical site on a patient's anatomy. A method of use is also provided for suctioning debris from a surgical field during a procedure.

Abstract: Some embodiments of a multi-layered dressing system for sealed wound treatment include various components used for sealing, dressing, suctioning and irrigating that are coupled together as a single, composite unit.

Abstract: A valve for use in connection with microfluidic devices includes a safety feature such that flow is controlled even in the case of a loss of power, thus having applications in critical applications such as the precise delivery of drugs overtime. The valve may be used in connection with multiple tubes delivering drugs, and may be used with a pump, such as an electrochemical pump, to provide the force to move the fluids containing drugs for delivery. In certain applications, more than one medicine may be delivered and metered independently using a single pump with multiple reservoirs and valves.

Abstract: A catheter may include a hypotube defining an inner circumferential surface, an outer circumferential surface, and an end. The hypotube may include a metal or alloy. The catheter also may include an inner liner attached to the inner circumferential surface of the hypotube and extending beyond the end of the hypotube, and the inner liner may include a fluoropolymer. The catheter further may include a hub and a single bonding layer attached to the outer circumferential surface of the hypotube and bonded to the hub. The single bonding layer may include a polyamide, a polyether-co-polyamide, or polyurethane and is the only layer between the outer circumferential surface of the hypotube and the hub.

Abstract: The invention relates to a supply system having at least one outlet for connecting to an applicator instrument, and having a controller (51) that controls at least one valve (50, 50?, 50?, 50??) such that, within an application time interval of less than 4 s, in particular less than 2 s: a) a first fluid during at least a first delivery interval (T1) with a first pressure (ph) is conveyed in a first feed line (11); b) a second fluid during a second delivery interval (T2) following the first conveying interval (T1) is conveyed with a second pressure (pz) in a second feed line (23); and c) the first fluid, during at least a third delivery interval (T3), is conveyed with a third pressure (pl) in the first feed line (11).

Abstract: The invention relates to an instrument head, comprising: an exit opening (23); a first feed line (11) for the feed of a first fluid; a second feed line (12) for the feed of a second fluid; a reservoir (24) for storing the fluid fed via the second feed line (12); wherein the reservoir (24) is in fluid communication with the first feed line (11) and/or is adapted to be brought in fluid communication with the first feed line (11) via at least a valve (25) arranged in the instrument head, to deliver fluid stored in the reservoir (24) via the exit opening (23).

Abstract: A system for anal irrigation is provided. The system includes a container, an anal probe, tubes and an electrical pump. The container has two configurations, a first collapsed configuration and a second expanded configuration. In the first configuration, a cavity for storing tubes and the anal probe is provided. In the second configuration, the container has a cavity for containing irrigation liquid. The pump and valves is stored in a cavity towards the bottom of the container.

Abstract: An injection device for use with a cartridge containing an injectate includes a housing. The housing includes an end wall at its distal end and an inner wall. The inner wall extends in a direction from the proximal end of the housing to the distal end of the housing and separates a first chamber from a second chamber in the housing. The housing includes a first opening disposed in the end wall and is in fluid communication with the first chamber. The housing includes a second opening is in fluid communication with the second chamber. A coupler is disposed in the first chamber for coupling to the cartridge. The first opening and the second opening are in fluid communication via a channel for transfer of fluid between the first chamber and the second chamber.

Abstract: A method for reducing small volume subcutaneous leaks of therapeutic fluids during procedures to refill an implantable medical device includes reducing pressure in a reservoir of the device. A refill needle can be percutaneously inserted into a fill port in communication with the reservoir and therapeutic fluid can be delivered through the needle into the reservoir. Reduced reservoir pressure upon withdrawal of the refill needle from the port can result in reduced subcutaneous leakage of the therapeutic fluid.

Abstract: An autoinjector comprising a body (1, 2), and a reservoir (S) containing fluid and including a piston (P) and a needle (A), such as a pre-filled syringe, said autoinjector further comprising a piston rod (5) that is suitable for co-operating with the piston (P) of said reservoir (S), said piston rod (5) being movable between a rest position and an injection position in which said piston rod (5) has moved the piston (P) of the reservoir (S) so as to inject the fluid through the needle (A), an actuator spring (6) being provided so as to urge said piston rod (5) towards its injection position, the autoinjector further comprising a force-adjustment system (7, 8) that exerts a force (F2) on said piston rod (5), said force (F2) adding to the force exerted by said actuator spring (6) on said piston rod (5) at the beginning of injection, so as to amplify the force exerted on said piston (P) by said piston rod (5) at the beginning of injection.

Abstract: A single use injector is a disposable injection device that is specifically optimized for production using the blow fill seal (BFS) manufacturing process and includes various mechanisms that render the device inoperable and facilitate its safe disposal after use. The single use injector incorporates an ampoule aseptically filled with a medication that is coupled to a hermetically sealed component system. The hermetically sealed component system incorporates various mechanisms that are actuated during the use of the injection device. The injection device is encased in a removable overtube that prevents contamination. upon removal of the overtube, the injection device is activated, by compression of a needle cap that irreversible punctures the ampoule in order to inject the medication through a needle. The injection device additionally incorporates a shield that deploys over the needle following injection of the medication into a patient.

Abstract: The disclosure relates to a sensor arrangement for an injection device to determine an axial position of at least one device component of the injection device inside a housing of the injection device. The sensor arrangement includes an elongated member located inside the housing, extending in an axial direction and having at least a first section and a second section of different magnetization. The first and second sections are separated in an axial direction. The sensor arrangement also includes at least one magnetic sensor element attached to the housing to detect the axial position of at least one of the first and second sections.

Abstract: The disclosure relates to medicament delivery device including an activating mechanism, wherein the activating mechanism includes a hollow injection needle, a cartridge containing a dosage of a medicament, a cartridge carrier including at least one resilient arm for holding the cartridge, a removable needle cap for covering the injection needle, and a drive element adapted to couple with the cartridge, wherein the cartridge is retained in a position spaced apart from the injection needle in a proximal direction (P) by the at least one resilient arm when the medicament delivery device is in an initial position (P1), and wherein by removing the needle cap, the cartridge is releasable to be pushed into a distal direction (D) by the drive element with respect to the cartridge carrier.

Abstract: A delivery sheath includes an outer tubular layer and an initially folded inner tubular layer. When an implant passes therethrough, the outer tubular layer expands and the inner tubular layer unfolds into an expanded lumen diameter. The sheath may also include selectively placed longitudinal support rods that mediate friction between the inner and outer tubular layers to facilitate easy expansion, thereby reducing the push force needed to advance the implant through the sheath's lumen.