Abstract: A guide extension catheter includes a push member and a distal shaft. The push member includes a segment having a first surface and a second surface opposite the first surface. The segment includes a groove in the first surface. The second surface is substantially flat. The distal shaft is coupled to the push member and includes a passageway. The segment of the push member including the groove is adjacent to the distal shaft.

Abstract: A device for clearing obstructions from a medical tube includes an enclosure having an interior and an exterior, the enclosure comprising a distal opening for providing access to the interior of the enclosure. The device further includes a spool provided within the enclosure that is rotatable about an axis and an elongated guide member coupled to the spool such that rotation of the spool causes the guide member to wind or unwind about the spool. The device further includes a drive mechanism that is operable to rotate the spool within the enclosure without compromising a sterile field within the enclosure.

Abstract: Described is an auto-injector comprising a syringe carrier adapted to contain a syringe. The syringe carrier has a ramp member with a first ramp and a second ramp. The auto-injector comprises a chassis including a resilient beam having a beam head adapted to engage the ramp member. The first ramp is adapted to deflect the beam head in a radial direction relative to the chassis and the second ramp is adapted to deflect the beam head in a tangential direction relative to the chassis.

Abstract: An acicular body includes a support plate having a brightness of 5.0 or less, and a needle disposed on the support plate. The needle includes a tip formed to pierce a skin and a light transmission area which is located in an area including the tip and has a total light transmittance of 20% or more.

Abstract: The invention relates to systems and methods for intracranial vessel access. In particular, a system including a co-axial combination of a steerable variable thickness microwire operatively supporting a tapered larger bore support and larger bore distal access catheter is described. Methods of advancing the intracranial access system through the vasculature are also described.

Abstract: A drug pellet delivery system includes a housing having a cavity. A cartridge is positioned within the cavity and includes a body having a channel. The body includes a first pair of rails and a second pair of rails. A plunger is slidably disposed in the housing and the cartridge. The plunger is configured to move a drug depot through the channel and out of the housing. Kits and methods of use are disclosed.

Abstract: An enteral dosing control coupling comprising a cylindrical collar defining a hollow internal chamber and a lumen extension tip projecting axially into the internal chamber, the lumen extension tip defining an internal lumen extending therethrough. In example forms, the lumen extension tip is integrally formed with the cylindrical collar. In other example forms, the lumen extension tip is a separate piece and is removably engageable within the cylindrical collar.

Abstract: A catheter that prevents excessive concentration of stress while providing sufficient flexibility to a distal end portion of the catheter, even when the catheter is inserted and curved in patient's a blood vessel. Thus, breakage of the catheter at a radiopaque marker is prevented/reduced. The catheter includes a catheter tube and the radiopaque marker, which is disposed in the catheter tube. The radiopaque marker is fixed in the catheter so that a gap is provided between the radiopaque marker and the catheter tube in a radial direction of the catheter tube.

Abstract: An introducer needle assembly including a compressible section between the rigid needle and the hub. Once the vessel is entered as determined by blood entering the syringe, the compressible section of the introducer needle is occluded by compressing the section with the thumb and a finger. Neither blood nor air can pass. Since the compressible section is in a flattened area it is easier to hold the needle while the syringe is unscrewed. The operator then can begin threading a guidewire down the device which is now easier to enter because blood is not coming out of the hub thus obscuring the lumen.

Abstract: An anal irrigation system including a control unit (2) is provided. The control unit (2) is connected to an external tube (4) by an extension cord (9), so that pivoting of the control unit (2) with respect to the external tube (4) is possible.

Abstract: A micromanipulation system includes a micromanipulator that includes a handpiece, and a micromanipulation tool that includes a tool shaft and is operatively connected to the handpiece. The micromanipulator further includes an actuator assembly connected to the micromanipulation tool to provide manual control of the micromanipulation tool, and a force sensing system comprising a force sensor attached to the tool shaft. The force sensing system is configured to provide an output signal that indicates a force imposed on the tool shaft. The micromanipulation system also includes a processor that is in communication with the force sensing system, and is configured to receive the output signal and compensate for forces due to actuation of the micromanipulation tool to determine a force due to interaction of the micromanipulation tool with a region of interest. The processor outputs an indication of at least one of a magnitude and a direction of the determined force.

Abstract: Embodiments include a fiducial deployment system with a handle configured for actuation of the same, the handle including a collet mechanism actuatable for controlled, one-at-a-time deployment of fiducials. A fiducial may include one or more protuberances configured to engage one or more slots in a needle of the system. The needle may be configured to deliver a plurality of fiducials to a target location in serial fashion, one at a time. In certain embodiments, echogenic placement of fiducials may present certain advantages. The handle includes an actuation mechanism with a collet and plunger actuation member configured for incrementally or otherwise controlledly deploy one or more fiducials at a time by advancing a sty let through and/or retracting the body of a slotted needle in which fiducials are disposed with a fiducial protrusion extending into the needle slot, which also includes retaining structures that do not impede the needle lumen.

Abstract: A medicament delivery device includes a tubular housing having opposite proximal and distal ends; an injection drive configured to exert force on a medicament container to expel medicament; and an injection drive holder configured to releasably hold the injection drive in a pre-tensioned state before injection of the medicament. The injection drive holder includes a tubular extension part for receiving the injection drive to be axially movable therein and a release ring coaxially arranged on the tubular extension part, the release ring being axially movable between proximal and distal positions along the outer surface of the tubular extension part. The tubular extension part is configured to engage with the injection drive when the release ring is at the proximal position and release the injection drive as the release ring moves distally from the proximal position.

Abstract: A barrel adapter mountable to a syringe barrel includes a barrel tip, a needle assembly, a stylet assembly slidably disposed within a needle lumen of the needle assembly, and a plug within the lumen of the needle. An implant delivery syringe includes a barrel, a plunger assembly, and the barrel adapter. The syringe may include a needle retraction mechanism having a biasing member and an actuable locking arrangement. When the actuable locking arrangement is actuated, the biasing member causes the needle to axially translate over the stylet during retraction to dislodge the plug and cause delivery of an implant to a target location. The plug may be a biodegradable polymer plug such as a water-soluble polymer, PLGA, and/or CARP. The stylet may be retracted following delivery. Methods of assembling implant delivery syringes with drug implants are also provided.

Abstract: An insertion device for an infusion set includes an advancement unit or a sliding element for moving the infusion set along a central axis from a proximal position into a distal position, a retaining element for retaining the infusion set that includes a guide element, a base part for accommodating the retaining element that includes a mating guide element and a contact surface for placing the insertion device on an application point of a patient's body, and a head part arranged rotatably about a central axis in relation to the base part. Upon relative rotation between the head part and the base part in one direction, the guide element of the retaining element can be guided with the mating guide element provided on the base part such that the retaining element is movable along the central axis relative to the base part from the distal position into the proximal position.

Abstract: A medicament delivery device includes a proximal sub-assembly and a distal sub-assembly configured to be connected to each other. The proximal sub-assembly includes a key member, and the distal sub-assembly includes a power pack unit having a lock mechanism for locking the power pack unit such that unintentional activation of the power pack unit during transportation is avoided. The key member is configured to interact with the lock mechanism during assembling of the proximal and distal sub-assemblies such that the lock mechanism is released.

Abstract: A medicament delivery device includes a housing adapted to receive a medicament container; an actuation member movable from a first position to a second position, such that the medicament is allowed to be expelled through the delivery member; and an interlock member movable between a locking position and a releasing position. The device has an indicator to show that it has been used provided by the actuation member's being retained in its second position. The actuation member includes at least one latching projection, and the drive mechanism includes corresponding latching surfaces, against which the latching projections latch when the actuation member is in its second position.

Abstract: A drive mechanism of a drug delivery device for dispensing of a dose of a medicament includes a housing extending in an axial direction, and a piston rod to operably engage with a piston of a cartridge to displace the piston in an axial distal direction. The drive mechanism further includes a last dose sleeve rotatably supported in the housing and being selectively engageable with a dose setting mechanism for setting of a dose, and a last dose member threadedly engaged to the housing, rotatably locked to the last dose sleeve and axially displaceable relative to the last dose sleeve.

Abstract: A valve assembly including a housing having a base and an outer shell, which forms a proximal cavity and a distal cavity joined by a canal; an inner housing configured for longitudinal movement within the distal cavity; a seal positioned within the distal cavity that together with the longitudinal movement of the inner housing regulates the flow of fluid through the valve assembly; and one or more selected from the group consisting of the base notched with one or more notches and the inner housing having one or more through slots aligned to permit access to the one or more notches, the seal being a reversibly deformable sealing pin, and a torque limiter mechanism configured to resist the longitudinal movement of the inner housing distally until a sufficient radial force is applied.

Abstract: An autoinjector having a body (1; 2), a reservoir (S), a piston (P), a needle (A), and a piston rod (5) co-operating with the piston. The piston rod is movable between a first rest position, a second pricking position, and a third injection position. An actuator spring (6) is provided to urge the piston rod towards its pricking position and then towards its injection position. A force-adjustment system (7, 8) exerts a force (F1, F2) on the piston rod (5). The force (F1) opposes the force exerted by the actuator spring at the end of pricking to decrease the force exerted on the reservoir by the piston rod at the end of pricking, and the force (F2) adding to the force exerted by the actuator spring at the beginning of injection, to amplify the force exerted on the piston by the piston rod at the beginning of injection.