Abstract: A combination plunger, a mixing device and a mixing syringe including the same are provided. The mixing syringe includes concentric outer and inner barrels that form an outer chamber, the inner barrel having an inner chamber. The combination plunger includes a mixing plunger and a delivery plunger and a biasing means. The mixing plunger is slidably located in the outer chamber and translated by coordinated depression of the delivery plunger to transfer a first substance from the outer chamber to mix with a second substance in the inner chamber. After the mixing stage is complete, the delivery plunger is disengaged from the mixing plunger and permitted, such as by rotation, to be further depressed in the axial direction to deliver fluid contents of the mixing syringe to a recipient. The mixing syringe needle is then retracted as result of engagement by the delivery plunger and activation of the biasing means.

Abstract: A cap for a drug delivery device is provided, the cap comprising a main body and at least one indication element which is moveably retained in the main body, wherein the indication element is configured to be moved from a first position to a second position with respect to the main body, and wherein an information indicated to a user by the cap is changed when the indication element is moved from the first position into the second position. Furthermore, a drug delivery device comprising the previously described cap and an interaction member is provided.

Abstract: An introducer is configured to distinguish an introducer provided with a sheath tube whose wall thickness is reduced, from an introducer provided with a sheath tube whose wall thickness is not reduced, and to recognize the relationship between the inner diameter and the outer diameter for the sheath tube in which the wall thickness is reduced. The introducer includes an introducer sheath which includes an elongated hollow sheath tube and a sheath hub at the proximal side of the sheath tube and provided with a dilator insertion port. A first information piece having an inner diameter dimension of the sheath tube as an index is shown on at least one of the sheath tube and the sheath hub. Furthermore, a second information piece having an outer diameter dimension of the sheath tube as an index is shown on at least one of the sheath tube and the sheath hub.

Abstract: A system and method for perfusing a liquid medicament into tissue of a patient requires a catheter having a distal barrier and a proximal barrier mounted on the catheter. A perfusion section is formed into the catheter between these barriers. By way of example of a typical operation, the catheter is advanced through the vasculature of a patient and into the coronary sinus. Advancement continues until the barriers of the catheter are positioned to straddle the ostium of the left atrial vein. As so positioned, a perfusion chamber is established in the coronary sinus between the barriers. Also, the perfusion chamber is positioned for fluid communication with the left atrial vein. Liquid medicament can then be transferred from a source into the perfusion chamber for perfusion of the medicament into tissue of the atrial vein.

Abstract: An introducer is configured to distinguish an introducer provided with a sheath tube whose wall thickness is reduced, from an introducer provided with a sheath tube whose wall thickness is not reduced, and to recognize the relationship between the inner diameter and the outer diameter for the sheath tube in which the wall thickness is reduced. An introducer includes an introducer sheath and a dilator. The introducer further includes a first information piece on at least one of the introducer sheath and the dilator and has an inner diameter dimension of the sheath tube as an index. Furthermore, a second information piece having an outer diameter dimension of the sheath tube as an index is on at least one of the introducer sheath and the dilator.

Abstract: Apparatus are provided for infusion devices and related operating methods. An exemplary device includes a sensing arrangement to provide an output indicative of a characteristic that is influenced by operation of the device, and a control module that is coupled to the sensing arrangement to apply a matched filter corresponding to a condition associated with the operation of the device to the output of the sensing arrangement and detect that condition based on the filtered output. In one example, the device includes a motor coupled to a plunger of a reservoir and operable to displace the plunger, wherein the characteristic is a force opposing displacement of the plunger and the control module detects an occlusion condition in a fluid path from the reservoir based on filtered force measurements.

Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device to deliver fluid to a body of a user involves obtaining measurement values for a physiological condition influenced by the fluid, autonomously operating the infusion device to deliver the fluid based at least in part on the measurement values, and detecting a nonactionable condition based on the measurement values. In response to detecting the nonactionable condition, delivery of the fluid is limited while maintaining autonomous operation of the infusion device. In one exemplary embodiment, the nonactionable condition is a rescue condition indicative of the user having consumed fast-acting carbohydrates, and thus insulin delivery may be automatically limited in response to detecting the rescue carbohydrate consumption.

Abstract: A needle structure for injecting a filler and monitoring a blood backflow situation simultaneously includes a needle, a housing and a partitioning member. The needle includes a needle chamber and a needle opening connected to the needle chamber. The housing includes a housing chamber and a housing opening connected to the housing chamber, and the housing chamber is connected to the needle chamber to form a needle housing chamber. The partitioning member is disposed in the needle housing chamber. The needle housing chamber is separated into a first chamber and a second chamber by the partitioning member. The needle opening is separated into an injection opening and a blood backflow opening by the partitioning member. The first chamber is connected to the injection opening, and the blood backflow opening and the housing opening are connected by the second chamber.

Abstract: An introducer assembly includes a valve having a first end and an opposite second end; a sheath fixedly secured to and extending axially from one of the first and second ends of the valve; a dilator extending through the valve and sheath; and a lock knob rotatable between locked and unlocked positions to releasably axially lock the tool relative to the sheath without causing corresponding rotation of the tool therewith.

Abstract: An injector apparatus is disclosed for use with a container of therapeutic material to deliver a metered dose of therapeutic material therefrom. The apparatus includes a first body portion arranged to be fixed relative to the container and defining a first conduit portion for the delivery of the therapeutic material from the container and a second body slidably connected to the first body and defining a second conduit portion, in fluid communication with the first conduit portion. Relative sliding motion between the first body and second body results in the displacement of one of the conduit portions into the other conduit portion such that the combined volume of the conduit may be decreased.

Abstract: The present invention relates to a drive mechanism for a drug delivery device for dispensing of a dose of a medicament, and to a respective drug delivery device, wherein the drive mechanism comprises: an elongated housing (20) extending in an axial direction (1, 2), a piston rod (160) to operably engage with a piston (14) of a cartridge (12) to displace the piston (14) in axial distal direction (1), a drive wheel (110) axially fixed to the housing (20), engaged with the piston rod (160) and rotatable relative to the housing (20) for driving the piston rod (160) in distal direction (1), a drive sleeve (30) axially displaceable relative to the drive wheel (110) to rotatably engage with the drive wheel (110) in a distal dose dispensing position and to disengage from the drive wheel (110) in a proximal dose setting position, wherein the drive sleeve (30) is rotatably secured to the housing (20) in the proximal dose setting position by means of a ratchet member (32).

Abstract: A neuro-surgery assembly includes a neuro-catheter slidably received over a wire guide. The wire guide includes an inner tube positioned within an elongate hollow tube that includes a pattern of openings at its distal segment to provide an atraumatic tip for reaching sensitive locations in a brain. The wire guide is changeable between a stiff condition in which the inner tube is pressurized and a soft condition in which the inner tube is depressurized. The user may switch between the stiff and soft conditions to negotiate the tortuous pathway to a brain treatment site without a need to swap out to a different wire guide to support advancement of the neuro-catheter.

Abstract: A fluid delivery system is provided and includes a power injector supporting a high pressure syringe. The fluid delivery system further includes a manifold and a low pressure hand-operated syringe. The manifold generally includes a plurality of fluid control valves in series fluid communication. A first fluid control valve of the plurality of fluid control valves has a first port, a second inlet port, and a third port. The third port of the first fluid control valve is in fluid connection with a first port of a second fluid control valve. The low pressure hand-operated syringe is in fluid connection with the first port of the first fluid control valve, and the high pressure syringe is in fluid connection with the second port of the first fluid control valve. The fluid control valves may be multi-position stopcock valves.

Abstract: A medical device accessory comprising an interface configured to connect the medical device accessory with a medical device for administration of a medical treatment using the medical device and the medical device accessory, a plurality of electrical contacts proximate the interface, the electrical contacts comprising a lead electrical contact adapted to receive an voltage from a power source associated with the medical device and one or more identifying electrical contacts, and at least one conductor providing an electrical connection between the lead electrical contact and the one or more identifying electrical contacts. An arrangement of the one or more identifying electrical contacts connected to the lead electrical contact identifies a characteristic of the medical device accessory.

Abstract: Drug delivery system comprising a housing and expelling means with a first rotational member adapted to rotate relative to the housing corresponding to a set and/or expelled dose and comprising a first force transmitting surface, a second rotational member adapted to rotate relative to the housing corresponding to a set and/or expelled dose and comprising a second force transmitting surface. At least portions of the first and second force transmitting surfaces are adapted to engage each other during setting and/or expelling of a dose, and the first rotational member including the force transmitting surface is formed from a polymeric material containing magnetic particles, wherein the polymeric material having been magnetized to provide a magnet producing a magnetic spatial field. Hereby a spatial magnetic field is generated which varies corresponding to the rotational movement of the first rotational member.

Abstract: An injection port assembly including a body having first and second mating structures configured to mate with a first connector for a first fluid pathway and a second connector on a device, respectively. A resilient barrier substantially contained within the body and compressible from a first position in which fluid flow between the first and second connectors is blocked to a more compressed second position in which fluid flow between the first and second connectors is permitted. A hollow cannula can be coupled with the first mating structure and disposed within the resilient barrier, the hollow cannula having a distal end configured to extend through the resilient barrier when the resilient barrier is in the second position, the distal end having lateral slots. The resilient barrier can have first and second annular sealing rings positioned above and below the lateral slots respectively.

Abstract: The present invention is directed to a housing for a drug delivery device. The housing comprises an outer shell with an aperture, an insert received within the aperture and a clamp attached to the outer shell. The insert has at least one recess which is engaged by a lug of the clamp to retain the insert within the aperture of the outer shell. The invention is further directed to a pen-type injector having such a housing.

Abstract: Composite microneedle arrays including microneedles and a film overlaying the microneedles are provided. The film includes a plurality of nano-sized structures fabricated thereon. Devices may be utilized for interacting with a component of the dermal connective tissue. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. Devices may be beneficially utilized for delivery of an agent to a cell or tissue. Devices may be utilized to directly or indirectly alter cell behavior through the interaction of a fabricated nanotopography with the plasma membrane of a cell and/or with an extracellular matrix component.

Abstract: Medical devices that incorporate siRNA are provided. In addition to one or more siRNA constructs, devices include nanostructures fabricated on a surface to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. Microneedles may be incorporated on devices. The pattern including nanostructures may be formed on the surface of the microneedles.

Abstract: Devices for delivering a rheumatoid arthritis drug across a dermal barrier are provided. The devices include microneedles for penetrating the stratum corneum and also include structures fabricated on a surface of the microneedles to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. The pattern of structures on the surface of the microneedles may include nano-sized structures.