Abstract: Needleless connectors are described. An example needleless connector includes a housing and a compressible valve. The housing may define an internal cavity and may include a body section having a first port and one or more internal contact tabs and a base section having a valve mount and a second port. The compressible valve may be disposed within at least a portion of the internal cavity and be movably retained within the housing. The compressible valve may include a flange portion for securing the compressible valve within the housing. A central longitudinal axis of the housing may be defined by a coaxial arrangement of the first and second port. The one or more internal contact tabs may be arranged to contact an outer side surface of the flange portion such that a radial force substantially orthogonal to the central longitudinal axis is provided for securement.

Abstract: The present invention relates to method of manufacturing a fluid guiding assembly for a drug delivery device and to a respective fluid guiding assembly. Said method comprising the steps of: providing a first member having at least one recess in a first surface portion, at least partially filling the recess with a joining component at least partially protruding from the first surface portion of the first member, arranging a second member having a second surface portion adjacent to the first member such that first and second surface portions thereof face towards each other to form an interface area between the first and the second members, wherein the joining component comprises a material different to the material of the first and/or second member wherein at least one channel structure extending along the interface area is formed by at least one deepening of the first member and/or of the second member, selectively providing thermal energy to the joining component to bond together first and second members.

Abstract: A handheld injection device includes a housing and a dose indicator positioned within and axially constrained to the housing and rotatable with respect to the housing during dose setting and during dose dispensing. The dose indicator includes a flexible clicker arm which, only during dispense, is displaced in a first radial direction and, when the device reaches its minimum dose position, in a second, opposite radial direction.

Abstract: The invention refers to a handheld injection device comprising a housing (10; 410), a dose indicator (90; 480) positioned within and axially constrained to the housing (10; 410) and rotatable with respect to the housing (10; 410) during dose setting and during dose dispensing, a gauge element (80; 490), which is at least partly interposed between the housing (10; 410) and the dose indicator (90; 480), wherein the gauge element (80; 490) is axially guided within the housing (10; 410) and in threaded engagement with the dose indicator (90; 480) such that rotation of the dose indicator (90; 480) causes an axial displacement of the gauge element (80; 490). A contrast element having a first marking is provided and at least a region of the gauge element (80; 490) is provided with a second marking, with the first marking and/or the second marking being visible through a first window (12a) or aperture in the housing (10; 410) depending on the axial position of the gauge element (80; 490) within the housing (10; 410).

Abstract: A therapeutic agent injection device including an injection device for delivering a therapeutic agent to a patient having a body, the body having a patient face and a port face opposite the patient face, the port face having an introducer port including an introducer channel and an injection port including an injection channel, the introducer channel being in fluid communication with the injection channel through a cross channel, the injection channel defining an injection axis; a delivery tube for subcutaneous delivery of the therapeutic agent to the patient, the delivery tube projecting from and being generally perpendicular to the patient face, the delivery tube defining an introducer axis and being in fluid communication with the injection port; and a patch, the patch being attached to the patient face and being operable to adhesively attach to the patient; wherein the injection axis is parallel to the introducer axis.

Abstract: This disclosure relates to fluid line sets and related methods. In certain aspects, the fluid line sets include a vial adapter connected to a first end of a fluid line, and a cap removably attached to a second end of the fluid line such that the cap seals the second end of the fluid line. The vial adapter includes a base, a spike extending from a central region of the base, and a sidewall extending from the base and substantially surrounding the spike. The base and the side wall at least partially define a cavity configured to receive a portion of a vial. The cap includes a deformable portion at least partially defining a gas chamber, and the cap is configured so that deformation of the deformable portion causes gas to be forced from the gas chamber to the vial adapter via the fluid line.

Abstract: The combination microarray patch for drug delivery and electrochemotherapy device is a medical device for delivering two separate pharmaceutical preparations to a patient, as well as providing electrostimulation for electroactive pharmaceuticals. A first pharmaceutical preparation is manually delivered into the patient through a first set of drug delivery needles. Similarly, a second pharmaceutical preparation is manually delivered into a patient through a second set of drug delivery needles. A desired electrical potential may then be selectively applied across first and second sets of electrotherapy needles for electroporation to facilitate delivery of the pharmaceutical preparations. The second pharmaceutical preparation may be a conjugate of the first for targeted drug delivery.

Abstract: A convection enhanced delivery device comprises a support member and an elongated microcatheter carried by the support member. The microcatheter projects lengthwise away from the support member. The microcatheter includes a catheter lumen extending in a first direction. A fluid conduit carried by the support member. The fluid conduit includes a conduit lumen that extends in a second direction different than the first direction. The conduit lumen is in fluid communication with the catheter lumen. An inlet port and a connecting port are also carried by the support member. The inlet port is in fluid communication with the fluid conduit. The connecting port is separate from the inlet port and is in fluid communication with the fluid conduit. The connecting port is configured to engage an end portion of an external fluid conduit such that the external fluid conduit projects away from the connecting port and from the support member.

Abstract: The invention relates a safety IV catheter assembly comprising a catheter tube having a distal end and a proximal end; a catheter hub having a distal end and a proximal end; a needle extending through the catheter hub and the catheter tube having opposite proximal and distal ends defining an axial direction A, wherein the proximal end is joined to the needle hub and the distal end forms a needle tip and a change in profile is provided between the proximal and distal ends of the needle; and a tip protector assembly being arranged movably on the needle in-between the catheter hub and needle hub outside the catheter hub in an arrangement engaging with one or more second locking means provided on the catheter hub in its ready position, wherein the first arm is deflected radially outwards by the needle against a restoring force, wherein the tip protector assembly is configured to entrap the needle tip upon withdrawal of the needle from the catheter hub.

Abstract: A novel retinal and optic nerve autologous bone-marrow derived stem cell surgery method is provided. The method generally includes the separation of stem cells from the bone-marrow of a patient, and the reintroduction of the cells to treat various optic nerve and retinal conditions of the eye. Novel needle embodiments which can be used during the stem cell surgery are also described.

Abstract: An apparatus has a first fluid conduit, a second fluid conduit, a connector member, an first tubular member, a second tubular member, and an inner cannula. The connector member has first and second passageways in which the first and second fluid conduits are positioned, respectively. A portion of the second tubular member is positioned within the lumen of the first tubular member. A proximal portion of the inner cannula is fixedly secured within the lumen of the first tubular member. The inner cannula lumen is in fluid communication with the first and second fluid conduits via the lumen of the first tubular member and the lumen of the second tubular member. The inner cannula may be inserted into the subretinal space of a human eye to deliver a leading bleb of fluid and then deliver a therapeutic agent, without having to withdraw the inner cannula from the subretinal space between the acts of delivering the leading bleb delivering the therapeutic agent.

Abstract: A detent mechanism for controlling translation between two components in a longitudinal direction includes a resilient beam on one of the components and a rhomboid ramp member on the other component. The resilient beam is essentially straight when relaxed and has a first beam head and is arranged to interact in a ramped engagement with respectively one of two ramps. Each ramp is on one longitudinal side of the rhomboid ramp member such that application of a translative force between the components in one longitudinal direction with the first beam head engaged to one of the ramps in a first state deflects the resilient beam in one transversal direction and such that application of a translative force between the components in the other longitudinal direction with the first beam head engaged to the other one of the ramps deflects the resilient beam in the other transversal direction.

Abstract: Medical systems are described herein. More particularly, the disclosure relates to medical systems, methods, and kits useful in providing the diameter of a balloon during the performance of a procedure. An exemplary medical system comprises a balloon catheter, an inflation device, and a measuring device having one or more indicia. Each indicium of the one or more indicia has a form that corresponds to the nominal value of a balloon diameter.

Abstract: A total dose of a therapeutic agent to be delivered to a patient by an infusion device over a total period of time is automatically divided into a plurality of unit doses to be delivered to the patient over a plurality of unit periods of time. The infusion device is automatically programmed to deliver one of the unit doses of the therapeutic agent to the patient over its respective unit period of time, after which the one unit dose is delivered, and a determination is made of whether an error occurred in delivering the one unit dose to the patient. Delivery of the total dose of the therapeutic agent to the patient may include iteratively automatically programming the infusion device to deliver successive unit doses upon determining that no error occurred in delivering a previous unit dose to the patient. Accordingly, the risk of improperly dosing the patient with the therapeutic agent in an event of a software or hardware anomaly within the infusion device is prevented or reduced.

Abstract: An apparatus provides feedback regarding the material in which tip of the apparatus is located as the tip is advanced into matter of varying resistances. The apparatus responds to a change in pressure, force, or other parameter such that when the tip reaches matter of a certain resistance, a change in the parameter is sensed. The apparatus provides a driving force to a penetrating medical device, such as a needle, when the apparatus tip encounters material of high resistance. When the apparatus tip encounters a low resistance material, no further driving force is applied to the apparatus. An inner core may be advanced into the low resistance material for deployment of a gas or a liquid as desired.

Abstract: A catheter can efficiently transmit an operator's pushing force to a distal end of the catheter with a reduced risk of getting caught at a curved region of a lumen (e.g., a blood vessel, bile duct, pancreatic duct or the like). The catheter includes a first core wire and a second core wire disposed between an inner tube and an outer tube. The second core wire can move to an optimal position depending on external forces exerted at a curved region of the lumen when the catheter is inserted into the curved region. Therefore, there is a reduced risk that the first core wire and the second core wire will interfere with each other, which would prevent the catheter from bending along the lumen and potentially break one or both of the first core wire and the second core wire.

Abstract: A trigger assembly for an automatic injection device which by its operation releases a biased element of the device for movement. The trigger assembly includes a button pressable by a user, and a lock member. Prior to the button being plunged, a blocking element on the button is abutted by a button-engaging surface of the lock member to prevent lock member rotation, thereby allowing an engagement surface on the lock member to remain in engagement with an engagement surface of the biased element so as to restrain motion of the biased element. When the button is plunged, the blocking surface moves clear of the button-engaging surface to allow the lock member to rotate, during which rotation the engagement surfaces disengage to release the biased element for movement.

Abstract: A convection enhanced delivery device comprises a support member and an elongated microcatheter carried by the support member. The microcatheter projects lengthwise away from the support member. The microcatheter includes a catheter lumen extending in a first direction. A fluid conduit carried by the support member. The fluid conduit includes a conduit lumen that extends in a second direction different than the first direction. The conduit lumen is in fluid communication with the catheter lumen. An inlet port and a connecting port are also carried by the support member. The inlet port is in fluid communication with the fluid conduit. The connecting port is separate from the inlet port and is in fluid communication with the fluid conduit. The connecting port is configured to engage an end portion of an external fluid conduit such that the external fluid conduit projects away from the connecting port and from the support member.

Abstract: A transdermal therapeutic system with a system support, at least one advancing element which is embedded into the system support, and at least one active ingredient reservoir which can be elastically deformed at least in some regions and which is embedded into the advancing element. On the application side of the transdermal therapeutic system, the system support surrounds the advancing element, and the advancing element surrounds the active ingredient reservoir. The advancing element comprises a swelling body which can be expanded by means of a liquid intake. The system support is designed to be rigid at least in some regions. A transdermal therapeutic system is developed which enhances the effect of the advancing element.

Abstract: A system for identifying information regarding a syringe assembly used with a fluid injector includes at least one syringe assembly having a barrel extending from a distal end to an open proximal end, at least one indicator provided on at least a portion of an outer circumferential surface of the barrel, an injector having at least one syringe port adapted to receive the at least one syringe assembly, and at least one sensor provided on or within at least a portion of each syringe port. The at least one indicator may conduct electricity corresponding to information regarding the at least one syringe assembly, which is identified by the at least one sensor.