Patents Examined by Amy C Bonaparte
  • Method for producing phosphoryl imide salt, method for producing nonaqueous electrolyte solution containing said salt, and method for producing nonaqueous secondary battery
    Patent number: 11230564
    Abstract: To provide a method for producing a phosphoryl imide salt represented by the following general formula (1) at a satisfactory yield by cation exchange. The method comprises the step of performing cation exchange by bringing a phosphoryl imide salt represented by the following general formula (2) into contact with a cation exchange resin having M1 n+ or a metal salt represented by the general formula (4) in an organic solvent having a water content of 0.3% by mass or less.
    Type: Grant
    Filed: November 2, 2020
    Date of Patent: January 25, 2022
    Assignee: CENTRAL GLASS CO., LTD.
    Inventors: Mikihiro Takahashi, Takayoshi Morinaka, Masutaka Shinmen, Ryosuke Terada
  • Process for preparing safinamide
    Patent number: 11225457
    Abstract: The present invention is related to a process for preparing safinamide and salts thereof, preferably safinamide methanesulfonate, with high yields and high enantiomeric and chemical purity without the need of using highly pure intermediates. The process of the present invention is suitable for the production of safinamide and its salts, preferably safinamide methanesulfonate, at industrial scale.
    Type: Grant
    Filed: August 5, 2020
    Date of Patent: January 18, 2022
    Assignee: MEDICHEM, S.A.
    Inventors: Yisong Wen, David Font Gimbernat, Ernesto Durán López
  • Process for production of hydrazine hydrate
    Patent number: 11225413
    Abstract: A process for the production of concentrated aqueous solutions of hydrazine hydrate includes preparation of hydrazine hydrate by a ketazine method using 50-70% hydrogen peroxide, recyclable solid acetamide and ammonium acetate activator for ketazine formation, and catalyst-free hydrolysis of ketazine to provide aqueous solutions of hydrazine hydrate in an energy efficient manner.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: January 18, 2022
    Assignees: Council of Scientific & Industrial Research, Gujarat Alkalies and Chemicals Limited
    Inventors: Pradeep Kumar Mamidpelliwar, Ravindranath Kajjam, Radhakrishna Madabhushi, Ashutosh Ugle, Shobha Rajendra Pathak, Vijaya Garikapati Murthy, Thyagarajan Srinivasan, Gannoji Veeraiah, Shyam Sunder Mamilla, Vanka Uma Maheshwara Sarma, Parthasaradhy Yellamraju, Sunil Sinha, Manish Babulal Shah, Nikhilkumar Navinchandra Shah, Shailesh Ashabhai Patel, Gautam Punjabhai Patel
  • Process for the preparation of a mixture of chelating agents, mixture of chelating agents and methods of using them
    Patent number: 11225456
    Abstract: The present invention relates to a process for in situ the preparation of mixtures of chelating agents by catalyzed reactions of diethanolamine derivatives with maleic acid and then with 2-halocarboxylic acid, to mixtures of chelating agents and methods using such chelating agents.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: January 18, 2022
    Assignee: Kemira Oyj
    Inventors: Reijo Aksela, Jonas Konn, Anna-Maija Perander, Anna Haarala, Riitta Ilmoniemi, Hanna Hoffren
  • Rhodamine triplet state complex and preparation and photodynamic therapy (PDT) study thereof
    Patent number: 11214586
    Abstract: Through the use of a rhodamine appended chelate, a versatile strategy has been demonstrated to generate mitochondria-targeting photosensitizers via the incorporation of variety of luminescent transition metal systems. The generation of triplet excited state of rhodamine moiety endows the complexes with mitochondria-targeting photosensitizing ability to form singlet oxygen (1O2) for use as photodynamic therapy (PDT) agent. The combination of rhodamine organic dye and luminescent transition metal centers in such hybrid systems exhibits the synergistic merits, including low dark cytotoxicity, selective tumor cell uptake, high molar absorptivity for low-energy excitation in the visible region, and high photostability.
    Type: Grant
    Filed: August 16, 2018
    Date of Patent: January 4, 2022
    Assignees: SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY, SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES
    Inventors: Keith Man Chung Wong, Chuangjun Liu, Ping Gong, Lihua Zhou, Lintao Cai
  • Acrylic acid purification via dividing wall columns
    Patent number: 11214534
    Abstract: The present disclosure relates to a process for producing high-purity acrylic acid using a dividing wall distillation column and in some instances using water as an entrainer and azeotroping agent. This disclosure provides a process for separating acrylic acid from recovered feed streams which comprise saturated organic acids including propionic acid. The resulting acrylic acid product is of sufficient purity to produce acrylate esters and high molecular weight acrylic acid polymers.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: January 4, 2022
    Assignee: Eastman Chemical Company
    Inventors: Craig Alan Hoyme, Robert Scott Huss, Joseph Jerome Puhr
  • Substituted benzamides and methods of use thereof
    Patent number: 11203572
    Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, ring B, R1, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
    Type: Grant
    Filed: September 3, 2020
    Date of Patent: December 21, 2021
    Assignees: GENENTECH, INC., XENON PHARMACEUTICALS, INC
    Inventors: Sultan Chowdhury, Christoph Martin Dehnhardt, Thilo Focken, Michael Edward Grimwood, Ivan William Hemeon, Steven McKerrall, Daniel Sutherlin
  • Hydrogenation of aromatic compounds
    Patent number: 11203566
    Abstract: Process for hydrogenating aromatic compounds over a solid catalyst in the presence of a hydrogen-containing gas comprising a first reactor operated in loop mode, a second reactor operated in straight pass, at least part of the output of the first reactor is supplied to the second reactor, characterized in that the first reactor is configured as a trickle bed reactor and is operated in trickle bed mode and the second reactor is operated such that the catalyst present therein is partially flooded.
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: December 21, 2021
    Assignee: BASF SE
    Inventor: Frank Poplow
  • Methods of synthesis of (1R,2R,5R)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein
    Patent number: 11192847
    Abstract: Provided herein are methods and intermediates for making (1R,2R,5R)-5-amino-2-methylcyclohexanol hydrochloride, which are useful for the preparation of compounds useful for the treatment of a disease, disorder, or condition associated with the JNK pathway.
    Type: Grant
    Filed: August 13, 2020
    Date of Patent: December 7, 2021
    Assignee: Celgene Corporation
    Inventors: Terrence Joseph Connolly, Hon-Wah Man
  • Twin tail amine compounds and their zwitterionic derivatives
    Patent number: 11186538
    Abstract: A compound of general formula (I) or (II), wherein Rn and Rm independently represent a C3-C27 aliphatic group, R1 to R4, which may be the same or different at each occurrence, represent hydrogen or a C1-C8 alkyl group, X1 and X2, which may be the same or different at each occurrence, represent a linear or branched divalent hydrocarbon radical with 1 to 24 carbon atoms which can be optionally substituted and/or interrupted by one or more heteroatoms or heteroatom containing groups, and R5 and R6, which may be the same or different at each occurrence, represent a group selected from —O?, -Alk-CH(OH)—CH2—SO3— and -Alk-CO2— wherein Alk represents an alkylene group.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: November 30, 2021
    Assignee: RHODIA OPERATIONS
    Inventors: Olivier Back, Roberto Company, Hong Liu, Rémy Leroy, Philippe Marion
  • Method for producing methionine
    Patent number: 11180447
    Abstract: An object of the present invention to provide a method for producing methionine with consideration given to the environment. The production method of the present invention comprises a removal step of blowing an inert gas into a liquid containing 5-(2-methylmercaptoethyl)hydantoin and thereby diffusing ammonia remaining in the liquid to obtain an emission gas containing the ammonia, and a recovery step of bringing the emission gas into contact with a washing liquid to recover ammonia contained in the emission gas.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: November 23, 2021
    Assignee: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Noriyuki Shimada, Takao Mizuno, Daisuke Yamashita
  • Method of reducing impurities in a catalyst for producing terephthalic acid
    Patent number: 11180439
    Abstract: A method of reducing impurities in a catalyst for the production of purified terephthalic acid includes forming purified terephthalic acid by hydrogenating crude terephthalic acid with a catalyst in a reactor; separating the purified terephthalic acid from the catalyst and reactivating the catalyst by washing with a caustic solution; and flushing the catalyst contaminated with impurities with a non-caustic liquid at a flushing temperature of greater than or equal to 50° C.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: November 23, 2021
    Assignee: SABIC GLOBAL TECHNOLOGIES B.V.
    Inventors: Syed Azhar Hashmi, Sankaran B. Nedumbamana, Paresh Bhagvanbhai Rasadiya
  • Cathepsin inhibitors
    Patent number: 11174224
    Abstract: This invention relates to compounds that are useful as inhibitors, in particular as inhibitors of Cathepsin K (CatK), and to a method of inhibiting cathepsin activity, comprising administering a compound or formulation comprising a compound according to the invention.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: November 16, 2021
    Assignee: ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LUMC)
    Inventors: Huib Ovaa, Maria Wilhelmina Elisabeth Mons, Stan Van Boeckel
  • Aromatic amine compound, curing agent for epoxy compound, curable composition, cured product, method for producing cured product, and method for producing aromatic amine compound
    Patent number: 11174221
    Abstract: An aromatic amine compound capable of satisfactorily forming a cured product having exceptional alkali resistance by reaction with an epoxy compound; a curing agent for an epoxy compound, the curing agent including the aromatic amine compound; a curable composition including the curing agent for an epoxy compound; a cured product of the curable composition; a method for producing the cured product; and a method for producing the abovementioned aromatic amine compound. The aromatic amine compound has a structure such that a specific position in a central skeleton comprising a fused ring such as a fluorene ring is substituted with a side-chain group including two aromatic groups linked by a flexible bond such as an amide bond, at least one amino group is bonded to the end of the side-chain group, and the structure has no hydroxyl groups.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: November 16, 2021
    Assignee: Tokyo Ohka Kogyo Co., Ltd.
    Inventors: Jiro Hikida, Dai Shiota
  • Chemoselective thiol-conjugation with alkene or alkyne-phosphonamidates
    Patent number: 11161873
    Abstract: Disclosed are novel conjugates and processes for the preparation thereof. A process tor the preparation of alkene- or alkyne-phosphonamidates comprises the steps of (I) reacting a compound of formula (III), with an azide of formula (IV), to prepare a compound of formula (V), reacting a compound of formula (V) with a thiol-containing molecule of formula (VI), resulting in a compound of formula (VII).
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: November 2, 2021
    Assignees: FORSCHUNGSVERBUND BERLIN E.V., LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN
    Inventors: Christian Hackenberger, Marc André Kasper, Maria Glanz, Tom Sauer, Dominik Schumacher, Jonas Helma-Smets, Heinrich Leonhardt, Andreas Stengl
  • Cyclic process for producing taurine from monoethanolamine
    Patent number: 11161808
    Abstract: There is disclosed a cyclic process for producing taurine from monoethanolamine comprising the steps of: (a) reacting monoethanolamine with ammonium sulfate in the recycling mother liquor to yield monoethanolamine sulfate; (b) reacting the monoethanolamine sulfate with sulfuric acid to form 2-aminoethyl hydrogen sulfate ester; (c) subjecting the 2-aminoethyl hydrogen sulfate ester to a sulfonation reaction with ammonium sulfite to yield taurine and ammonium sulfate; (d) separating the taurine and the ammonium sulfate by means of solid-liquid separation; (e) removing the excess ammonium sulfite from the mother liquor to obtain an aqueous solution comprised of ammonium sulfate and (f) returning the aqueous solution to step (a) to complete the cyclic process.
    Type: Grant
    Filed: September 9, 2020
    Date of Patent: November 2, 2021
    Assignee: Vitaworks IP, LLC
    Inventor: Songzhou Hu
  • Pleuromulin acitretin ester with antibacterial activity and a method of preparing the same
    Patent number: 11155514
    Abstract: A compound with anti-drug resistant bacteria activity having the following formula (I) is disclosed. A method of preparing the compound of formula (I) is also disclosed.
    Type: Grant
    Filed: December 19, 2020
    Date of Patent: October 26, 2021
    Assignee: SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Bin Tian, Juan Li, Nan Hui, Guaiping Qiao, Liang Xin, Jingyi Li, Dan Yang, Han Li, Yanjun Li, Liang Qi, Wenbo Yao, Chengyuan Liang
  • Magnesium citrate glycinate co-salt
    Patent number: 11148990
    Abstract: A magnesium citrate glycinate co-salt has a formula of Mg2C8H9NO9—XH2O and a suggested structure of: The magnesium citrate glycinate co-salt has an apparent density of 1740 kg/m3 and is compressible in a range of compression pressures from approximately 50 MPa to approximately 150 MPa. The magnesium citrate glycinate co-salt is formed by combining citric acid and glycine in a 1:1 molar ratio to form an aqueous reaction mixture and neutralizing the aqueous reaction mixture with a magnesium source having a magnesium:ligand ratio of 1:1.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: October 19, 2021
    Assignee: Jost Chemical Co.
    Inventors: Joseph R. Hardimon, Kasey L. Morris
  • Processes for preparation of 4-aminoindane compounds and related aminoindane amides
    Patent number: 11148995
    Abstract: A process for preparation of 4-aminoindane compounds of a first formula, salts and enantiomers thereof including: a) hydrogenating a 1,2-dihydroquinoline of a second formula to give a corresponding tetrahydroquinoline of a third formula; b) acylating the tetrahydroquinoline of the third formula with a carboxylic acid derivative of a fourth formula to obtain a corresponding acyl derivative compound of a fifth formula; c) rearranging the acyl derivative compound of the fifth formula under acidic conditions so as to give an acyl indane compound of a sixth formula or an addition salt thereof; and d) hydrolysing the acyl group of the acyl indane compound of the sixth formula so as to obtain the 4-aminoindane derivatives of the first formula.
    Type: Grant
    Filed: March 31, 2020
    Date of Patent: October 19, 2021
    Assignee: STICHTING I-F PRODUCT COLLABORATION
    Inventors: Paolo Bellandi, Giampaolo Zanardi, Ravindra Vitthal Datar, Chockalingam Devarajan, Swamynathan Murali, Narayana Swamy
  • Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives
    Patent number: 11136290
    Abstract: Provided is a compound of Formula (I): wherein the variable groups are defined herein.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: October 5, 2021
    Assignee: The Liver Company Inc.
    Inventors: Julie Farand, Joshua A. Kaplan, Gregory Notte, Casey Lockwood Olen, Michael Sangi, David Sperandio