Abstract: The present disclosure relates generally to processes for recovering tricyanohexane (TCH) via purification of by-product or co-product streams of adiponitrile production. In particular, the present disclosure relates to a process for purifying tricyanohexane (TCH), the process having the steps of (a) separating an adiponitrile process stream comprising adiponitrile and TCH to form a first overhead lights stream comprising low-boiling components and high-boiling components and a first bottoms heavies stream comprising high-boiling components and solid impurities; and (b) separating the first overhead lights stream in a distillation column to form a second overhead lights stream comprising low-boiling components, a second bottoms heavies stream comprising high-boiling components, and a TCH stream comprising TCH and less than 10 wt. % impurities; wherein the distillation column is a low pressure distillation column.
Abstract: Compositions include ether ester compounds derived from neo-alcohols, lubricating oil base stocks containing such ester compounds, and lubricating oil compositions containing such ester compounds. Methods can include making and formulating compositions containing ether ester compounds derived from neo-alcohols.
Type:
Grant
Filed:
May 12, 2020
Date of Patent:
January 10, 2023
Assignee:
EXXONMOBIL RESEARCH AND ENGINEERING COMPANY
Inventors:
Abhimanyu O. Patil, Satish Bodige, Kyle G. Lewis
Abstract: The disclosure relates to substituted fused heteroaromatic tricyclic compounds and the use thereof. Specifically, the disclosure provides compounds of the following Formula I: or a pharmaceutically acceptable salt or prodrug thereof, wherein A1-A3, B1-B3, D1-D4 and R1-R2 are defined herein. Compounds having Formula I are ATM kinase inhibitors. Therefore, compounds of the disclosure may be used to treat clinical conditions caused by DDR functional defects, such as cancer.
Type:
Grant
Filed:
February 26, 2018
Date of Patent:
January 10, 2023
Assignee:
IMPACT THERAPEUTICS (SHANGHAI), INC
Inventors:
Suixiong Cai, Ye Edward Tian, Xiaozhu Wang
Abstract: The present invention includes methods for making and isolating N-acetylcysteine amide, (2R,2R?)-3,3?-disulfanediyl bis(2-acetamidopropanamide, diNACA), intermediates and derivatives thereof comprising: contacting cystine with an alcohol and a chlorinating reagent to form an organic solution containing L-cystine dimethylester dihydrochloride; combining dried or undried L-cystine dimethylester dihydrochloride with a triethylamine, an acetic anhydride, and an acetonitrile to form a di-N-acetylcystine dimethylester; mixing dried di-N-acetylcystine dimethylester with ammonium hydroxide to form a di-N-acetylcystine amide (diNACA); and separating dried di-N-acetylcystine dimethylester into N-acetylcysteine amide with dithiothreitol, triethylamine and an alcohol.
Type:
Grant
Filed:
July 2, 2021
Date of Patent:
January 10, 2023
Assignee:
NACUITY PHARMACEUTICALS, INC.
Inventors:
G. Michael Wall, Douglas G. Johnson, Anja Rubenstein, Rodney Tucker, Josh Bolger
Abstract: The present invention relates to novel uses of stable inorganic peroxoacids as catalysts in the preparation of alkanesulfonic acids from alkanes and sulfur trioxide, methods for the production of alkanesulfonic acids employing said catalysts as well as reaction mixtures comprising said catalysts. The invention particularly relates to the production of methanesulfonic acid from methane and sulfur trioxide employing stable inorganic peroxoacids as catalysts.
Abstract: A method for preparing a dicyanoalkane may omit a filtration for a catalyst after a cyanation reaction can by carrying out the cyanation reaction in a state in which precipitation of a metal catalyst is suppressed. A method for preparing a dicyanoalkane may involve cyanating one or more aliphatic dicarboxylic acids and/or salt(s) thereof with an ammonia source in the presence of a predetermined compound and a catalyst, wherein, in the cyanation, the amount of the predetermined compound is maintained at a predetermined amount or more with respect to the catalyst.
Abstract: A process for synthesis of urea from CO2 and NH3 wherein a steam flow (13) produced in the condenser (3) of a high-pressure synthesis loop is compressed to raise its pressure and temperature before using the steam as a heat source for a downstream step of the process.
Abstract: This invention is directed to compositions, methods and kits that can be used for the treatment or amelioration of pain and fever.
Type:
Grant
Filed:
May 17, 2021
Date of Patent:
December 20, 2022
Assignees:
The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, University of Alcala de Henares, South Rampart Pharma, LLC
Inventors:
Nicolas Bazan, Hernan Bazan, Julio Alvarez-Builla Gomez, Dennis Paul, Carolina Burgos Garcia
Abstract: A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.
Type:
Grant
Filed:
April 24, 2021
Date of Patent:
December 6, 2022
Assignee:
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY
Inventors:
Qianqian Zhao, Jie Zhang, Liang Xin, Jingyi Li, Ruina Bian, Yuqing Zhao, Dan Yang, Han Li, Bin Tian, Yongbo Wang, Chengyuan Liang
Abstract: Provided is a process for the preparation of certain 1,4-bicyclo[2.2.2]octane derivatives. The new synthetic procedure involves treating 1,4-dimethylene cyclohexane with an oxidizing agent in the presence of a transition metal catalyst to afford an oxo-substituted bicyclo[2.2.2]octane species. This intermediate structure can then be further derivatized. The processes of this disclosure thus affords a novel and simplified means for the commercial production of a wide variety of bicyclo[2.2.2]octane derivatives.
Type:
Grant
Filed:
October 10, 2018
Date of Patent:
December 6, 2022
Assignee:
Eastman Chemical Company
Inventors:
Yue Rachel Hu, Robert Thomas Hembre, Gerald Charles Tustin, Zhufang Liu, Steven J. Adams
Abstract: The present invention provides a process for preparing a compound of the following general formula (2): wherein R1 represents a monovalent hydrocarbon group having 1 to 10 carbon atoms, and R3 represents a hydrogen atom or a methyl group, the process comprising: subjecting a compound of the following general formula (1): wherein R1 and R2 represent, independently of each other, a monovalent hydrocarbon group having 1 to 10 carbon atoms, R3 represents a hydrogen atom or a methyl group, and the wavy bond represents an E-configuration, a Z-configuration, or a mixture thereof, to a Dieckmann condensation in the presence of base to form the compound (2).
Abstract: The presently claimed invention relates to a color developer, a process for its manufacture and its use as a component in heat sensitive recording material. The heat sensitive recording material is useful for thermographic printing.
Type:
Grant
Filed:
March 1, 2019
Date of Patent:
November 29, 2022
Assignee:
Solenis Technologies, L.P.
Inventors:
Leonhard Feiler, Frank Bachmann, Prachin Kolambkar, Vilas Wakhare, Priti Kulkarni, Robert Montgomery O'Neil
Abstract: A process for preparing an aromatic isocyanate by direct carbonylation of a nitro aromatic compound by reacting the nitro aromatic compound with carbon monoxide in the presence of a catalyst, characterized in that the catalyst contains a multi metallic material comprising one or more binary intermetallic phases of the general formula AxBy wherein: A is one or more element selected from Ni, Ru, Rh, Pd, Ir, Pt and Ag, B is one or more element selected from Sn, Sb, Pb, Zn, Ga, In, Ge and As, x is in the range 0.1-10, y in is in the range 0.1-10.
Type:
Grant
Filed:
April 4, 2018
Date of Patent:
November 29, 2022
Inventors:
Sven Titlbach, Andreas Kuschel, Carlos Lizandara, Stephan A Schunk, Joerg Rother, Juergen Bechtel, Nedko Stefanov Drebov, Stefan Maixner, Matthias Hinrichs, Mohamed Halabi, Imke Britta Mueller, Michaela Fenyn
Abstract: Methods for syntheses of organic acids from ?-keto acids, including methods for syntheses of isotopically enriched organic acids from ?-keto acids are disclosed. The isotopically enriched organic acids are useful, for example, in metabolic flux analyses.
Type:
Grant
Filed:
January 17, 2020
Date of Patent:
November 22, 2022
Assignee:
Furman University
Inventors:
Gregory Gardner Springsteen, Robert Trent Stubbs
Abstract: There is provided a process and an apparatus for urea production in which preheating of raw material ammonia or heating in a medium-pressure decomposition step can be performed at a relatively low pressure while preventing decrease in an overall heat transfer coefficient. A process for urea production includes: a synthesis step of generating a urea synthesis solution; a high-pressure decomposition step of heating the urea synthesis solution to separate a gaseous mixture containing ammonia and carbon dioxide from the urea synthesis solution; a condensation step of condensing the gaseous mixture; a medium-low-pressure steam generation step of reducing a pressure of medium-pressure steam condensate obtained in the high-pressure decomposition step to a medium-low pressure to generate medium-low-pressure steam and medium-low-pressure steam condensate; and one or both of a medium-pressure decomposition step and an ammonia preheating step.
Abstract: The present invention relates to the use of a stabilizing composition comprising at least one N-oxyl compound and at least one polymerization inhibitor other than an N-oxyl compound, for inhibiting transesterification catalyst degradation in a process for the synthesis of aminoalkyl (meth)acrylates. Preferably, the transesterification catalyst is a titanium organometallic compound and the stabilising composition comprises at least one N-oxyl derivative and at least one polymerization inhibitor chosen from phenolic compounds and phenothiazine compounds in a weight ratio of between 1 and 10, preferably between 4 and 10, limits inclusive.
Abstract: The present invention is directed towards a process for manufacturing a complexing agent, said process comprising the steps of (a) Providing a nitrile according to general formula (I a) or (I b) With M being selected from alkali metal and hydrogen and combinations thereof, (b) Saponification with a total alkali amount of 2.5 to 2.9 mol of alkali metal hydroxide per mole of nitrile according to general formula (I a) or (I b), respectively, and a pH value in the range of from 9.5 to 11.5 at the end of step (b), (c) Adding an amount of alkali metal hydroxide so that the total alkali content is 2.9 to 3.15 moles per mole nitrile according to general formula (I a) or (I b), respectively, and (d) Allowing further conversion.
Type:
Grant
Filed:
June 19, 2018
Date of Patent:
November 1, 2022
Assignee:
BASF SE
Inventors:
Thomas Schmidt, Armin Stamm, Marta Reinoso Garcia, Verena Mormul, Michael Klemens Mueller, Frank Jaekel, Jeremy T Manning
Abstract: The present invention relates to a method of producing a compound of formula (I) or a salt of a compound of formula (I). The invention also relates to a compound of formula (I) or a salt of a compound of formula (I) for use in a therapeutic method to achieve one or more therapeutic effects as well as for use in the treatment and/or prevention of certain diseases. Furthermore, the invention provides a pharmaceutical composition comprising one or more compound(s) of formula (I) or salt(s) of compound(s) of formula (I).
Type:
Grant
Filed:
June 28, 2018
Date of Patent:
November 1, 2022
Assignee:
SYMRISE AG
Inventors:
Bernd Fiebich, Matthias Winkler, Marcus Rudolf Götz, Oskar Koch