Abstract: Injectable formulations comprising ethanol, sesame oil, and an Immune Response Modifier compound are disclosed. Methods of making the formulations and methods of using the formulations for treatment of a disease in a subject, e.g., neoplastic disease, comprising injecting the formulations into a subject hi need of treatment, are also provided.
Type:
Grant
Filed:
October 30, 2014
Date of Patent:
June 1, 2021
Assignee:
3M INNOVATIVE PROPERTIES COMPANY
Inventors:
Joseph M. Beaurline, James M. Elvecrog, John P. Vasilakos, John Thomas Capecchi, Karen Elizabeth Johnson
Abstract: Embodiments of the invention include plant stem cell products and treatment methods using the products. In some embodiments, the products may include extracts of plant stem cells, such as apple stem cells, and an aerosolizing device configured to create an aerosol from the plant stem cell products and to deliver the aerosol to the lung via inhalation. Treatment methods include aerosol inhalation of the plant stem cell products.
Type:
Grant
Filed:
April 18, 2019
Date of Patent:
April 27, 2021
Inventors:
Maryam Rahimi, Steven Phillip Gallagher
Abstract: Bee venom nanoparticles and methods of synthesizing bee venom nanoparticles are provided. The bee venom nanoparticles may be synthesized by drying bee venom, suspending the dried bee venom in a solvent to form a first bee venom solution, spraying the first bee venom solution into boiling water under ultrasonic conditions to form a bee venom solution including the bee venom nanoparticles, stirring the bee venom solution including the bee venom nanoparticles, and freeze-drying the bee venom solution. The resulting nanoparticles may be used in pharmaceutical compositions, and may be useful for their antimicrobial activities.
Type:
Grant
Filed:
February 25, 2020
Date of Patent:
April 20, 2021
Assignee:
KING SAUD UNIVERSITY
Inventors:
Reem Atta Alajmi, Nadin Mohamed Moubayed, Manal Ahmed Gasmelseed Awad, Hany Mohamed Yehia, Manal Fawzy Elkhadragy, Ibrahim Abdullah Barakat, Faten Nasser Alsaqabi, Amany Zein Elabedein Mahmoud Elshahidy
Abstract: Provided are methods of making an extract of fruit of the Solanaceae family wherein fruit is processed to optimise the platelet aggregation inhibiting activity of the extract. The methods involve preparing a start mix of homogenised fruit; separating a water soluble fraction from fruit solids; filtration of the water soluble fraction; and concentration of active agents in the filtration permeate. The invention also provides fruit extracts manufactured by such methods, and also fruit extracts containing glycosylated phenolic acid or a phenolic ester, or derivatives thereof, a glycosylated flavonoid; and a nucleoside. The extracts of the invention are useful as medicaments for the treatment or prevention of a medical condition characterised by inappropriate platelet aggregation. In particular, the medicaments may be of use in maintaining heart health by reducing platelet aggregation; benefiting the circulation, and/or normalizing or otherwise benefiting blood flow.
Abstract: Herbo-mineral formulation for prevention and treatment of Renal disorders are disclosed herein. The formulation includes combination of herb and mineral elements for treating Renal disorders. Renal disorders include any condition associated with Kidney function such as Chronic renal failure.
Abstract: The present disclosure relates, according to some embodiments, to methods and systems for purifying proteins, carbohydrate rich products, and polysaccharide products from a microcrop (e.g., photosynthetic aquatic species) and compositions thereof. For example, the present disclosure relates, in some embodiments to methods and systems for extracting proteins, dry biocrude, carbohydrate-rich meal, and polysaccharide products from Lemna.
Abstract: Oral capsules have been dismissed as a dosage form for delivery high dosages of krill phospholipids, but by purifying these to high levels it is indeed possible to use this dosage form to deliver, for example, 700 mg or more phospholipids per capsule.
Type:
Grant
Filed:
February 12, 2015
Date of Patent:
March 30, 2021
Assignee:
Aker BioMarine Antarctic AS
Inventors:
Stefan Hupfeld, Tove Jule Evjen, Finn Myhren, Håvard Thøgersen
Abstract: An herbal composition, comprising a therapeutically effective amount of an extract of Terminalia chebula; a therapeutically effective amount of an extract of Curcuma longa; and a therapeutically effective amount of a non-acidic, water-immiscible organic solvent extract of a Boswellia serrata resin.
Abstract: The present invention relates to Nelumbo nucifera callus having an increased content of gallic acid or an extract thereof and to a method for preparing the same. The Nelumbo nucifera callus extract according to the present invention has an excellent whitening effect by containing a large amount of gallic acid, and thus can be advantageously used as a cosmetic composition.
Type:
Grant
Filed:
March 30, 2017
Date of Patent:
March 16, 2021
Assignees:
Celltrion Inc., BIO-FD&C Co., Ltd.
Inventors:
Yeon Sook Kim, Jung Yeon Kim, Jae Hun Kim, Hyeong Mi Kim, Jung Soo Bae, Jung Yun Kim, Ju Yeon Kim, Joo Hyuck Lim, Seung Ki Lee, Sung Ho Moon, Shin Jae Chang, Sang Hyun Moh, Jeong Hun Lee, Hyo Hyun Seo, Ji Hong Moh, Soo Yun Kim, Jeong Gon Park
Abstract: The invention relates to Boswellia frereana and particularly an extract of same for treating a range of inflammatory disorder or conditions selected from the group comprising: inflammatory bowel disease (IBD), all forms of muscular dystrophy especially Duchenne muscular dystrophy, sepsis, sepsis syndrome, osteoporosis, ischemic injury, graft vs. host disease, reperfusion injury, asthma, diabetes, cancer, myelogenous and other leukemias, psoriasis and cachexia, Alzheimer's Disease, demyelinating neurological disorders including multiple sclerosis, acetylcholinesterase mediated disorders, retinal disorders, neurological, retinal, and muscular disorders.
Type:
Grant
Filed:
August 3, 2016
Date of Patent:
March 9, 2021
Assignee:
COMPTON DEVELOPMENTS LTD.
Inventors:
Emma Jane Blain, Victor Collin Duance, Ahmed Yasine Ali, Ifor Delme Bowen
Abstract: A novel treatment for topical inflammatory conditions such as acne, eczema, shingles, insect bites, and hives is provided, consisting of the application of a herbal cream or ointment which incorporates grounded PawPaw Seeds in a granular form. The cream preferably contains one or more thickeners, a bio-adhesive agent such as petroleum jelly such that the cream can stick to the area to be treated.
Abstract: An ocular covering fabricated from at least one amniotic membrane, at least one chorionic membrane, or at least one amniotic membrane and at least one chorionic membrane obtained from human birth tissue is provided. Methods of preparing the one or more membranes to form an ocular covering are provided. Methods of treating a disease, condition, or surgical site of the eye and surrounding tissue are also provided.
Abstract: Disclosed is a beverage and a method of administering the beverage. The beverage is free of phosphoric acid and instead contains at least 0.3% by weight/volume of gluconic acid, is low in minerals, specifically contains less than 250 mg/liter of minerals, is low in sugar, specifically contains at most 2.5% by weight/volume of sugar. These sugars comprise at least 10% weight/weight galactose and in addition a proportion of isomaltulose and/or tagatose The beverage has a glycemic index of at most 35 (GI<35).
Abstract: A bone implant comprising cancellous bone that is essentially free of blood cells, and which has been treated with at least one loosening agent, such as collagenase or a digestive enzyme, for a time and at a concentration to loosen the osteogenic cells in the cancellous bone matrix. The osteogenic cells in the matrix are viable cells. The treatment of the cancellous bone with at least one loosening agent enables the osteogenic cells to be more available for carrying out their osteogenic function and to provide for an increased rate of bone formation. Such implant also may include demineralized bone, such as demineralized cortical bone, which enhances the bone regenerative capacity of the cancellous bone.
Type:
Grant
Filed:
June 14, 2017
Date of Patent:
January 26, 2021
Assignee:
NuVasive, Inc.
Inventors:
Michelle LeRoux Williams, Charles Randal Mills, Rodney Monroy, Robert A. Zambon, Dayna Buskirk, Earl Fender
Abstract: A pharmaceutical composition includes an alcohol-soluble, water insoluble, extract of Radix Glycyrrhizae; and wolfberry. A weight ration of the extract and wolfberry is 0.01˜5:15˜25. The composition is useful for controlling blood glucose and blood lipids, and for weight control. Health food products containing the recited combination are also provided.
Abstract: Embodiments of the invention generally relate to supplements for treating fibromyalgia and symptoms associated with fibromyalgia, wherein the nutritional supplement is administered for at least one of following: fatigue, chronic pain, morning stiffness, headaches, and problems with thinking and memory.
Abstract: The present invention generally relates to compositions and methods related to controlling arthropods. Embodiments of the invention include compositions for controlling an arthropod, which can include one or more plant essential oils and methods for using these compositions. The plant essential oils, when combined, can have a synergistic effect. Embodiments of the invention relate to compositions and methods related to controlling lice.
Abstract: Cactus pear (Opuntia) extract compositions, their methods of preparation, and their uses in products are provided. The Opuntia extract compositions are a mixture of an extract prepared by extraction of Opuntia fruit/fruit parts, combined with an extract prepared by extraction of Opuntia cladodes/cladode parts. The resulting Opuntia extract compositions exhibit improved therapeutic characteristics as compared with known Opuntia fruit juices or extracts, including increased hypoglycemic effects.
Type:
Grant
Filed:
November 6, 2008
Date of Patent:
December 8, 2020
Assignee:
FINZELBERG GMBH & CO. KG
Inventors:
Ivo Pischel, Bjoern Feistel, Bernd Walbroel