Patents Examined by Anand U Desai
  • Composition and methods for preventing or reducing the incidence of transient ischemic attacks
    Patent number: 11160802
    Abstract: A composition and method for preventing or reducing the incidence of a transient ischemic attack in a subject at risk for developing a stroke comprises orally administering to the subject a prophylactically effective amount of a pharmaceutical composition comprising an ASIC1a inhibitor capable of penetrating the blood-brain barrier. Preferred ASIC1a inhibitors for use in the disclosed methods include amiloride and amiloride analogs.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: November 2, 2021
    Assignee: MOREHOUSE SCHOOL OF MEDICINE
    Inventors: Zhigang Xiong, Roger P. Simon
  • Non-antibody high-affinity-based sample preparation, sorbent, devices and methods
    Patent number: 11155575
    Abstract: In various aspects, the present disclosure pertains to sorbents for isolating at least one target protein from a liquid sample, the sorbents comprising a solid support comprising attached at least one attached high affinity reagent with an affinity for the at least one target protein. Other aspects of the present disclosure include kit that contain such sorbents and methods of treating samples using the same.
    Type: Grant
    Filed: March 21, 2019
    Date of Patent: October 26, 2021
    Assignee: Waters Technologies Corporation
    Inventors: Laks Iyer, Beatrice W. Muriithi
  • Process for preparing sphingolipids
    Patent number: 11155842
    Abstract: The invention provides a process for preparing sphingolipids, compositions comprising sphingolipids and further components, and for the use of the compositions.
    Type: Grant
    Filed: March 18, 2019
    Date of Patent: October 26, 2021
    Assignee: Evonik Operations GmbH
    Inventors: Marrit Friederike Eckstein, Monica Desiree van Logchem, Hans Henning Wenk, Annika Schrader, Ursula Maczkiewitz, Claudia Hierath, Sunay Karacocuk, Andreas Seifert
  • Polypeptides having RNase activity
    Patent number: 11149233
    Abstract: The present invention relates to polypeptides having RNase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: October 19, 2021
    Assignee: Novozymes A/S
    Inventors: Fabian Barrientos, Morten Gjermansen, Klaus Gori, Henriette Draborg, Mary Ann Stringer, Dorotea Raventos Segura, Marc Dominique Morant
  • CRISPR-Cas systems and methods for altering expression of gene products, structural information and inducible modular Cas enzymes
    Patent number: 11149259
    Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends the engineering of optimized modular CRISPR-Cas enzyme systems.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: October 19, 2021
    Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology
    Inventors: Feng Zhang, Bernd Zetsche
  • Insect toxin delivery mediated by a densovirus coat protein
    Patent number: 11140902
    Abstract: A coat protein of Junonia coenia densovirus (JcDNV) is used to deliver attached peptide insect toxin across the gut epithelium of a fall armyworm, Spodoptera frugiperda. A fusion protein comprising VP4 attached to an insect toxin via a peptide linker is developed. A composition comprising a JcDNV coat protein attached to an insect toxin via a peptide linker can be used for insect pest control.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: October 12, 2021
    Assignees: University of Florida Research Foundation, Inc., Iowa State University Research Foundation, Inc.
    Inventors: Bryony C. Bonning, Mariah Kemmerer
  • Protein composition, method for producing same and method for improving heat stability
    Patent number: 11142553
    Abstract: The present invention relates to a protein composition formed of dry matter of a dispersion in which a protein is dispersed in a stabilizer solution, in which the stabilizer includes at least one type selected from the group consisting of a catechol-based stabilizer, 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, 2,6-di-tert-butyl-p-cresol, 2-tert-butyl-4-methoxyphenol, and 6,6?-di-tert-butyl-4,4?-butylidenedi-m-cresol.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: October 12, 2021
    Assignees: Spiber Inc., Kojima Industries Corporation
    Inventors: Toshiaki Taniike, Anh Thi Ngoc Dao, Koyuru Nakayama, Junichi Shimokata, Kengo Takeuchi, Abhijit Ravikiran Muley, Sunita Darbe
  • Compositions comprising digestive enzymes
    Patent number: 11142754
    Abstract: Provided herein are compositions with enhanced protein specific activity, protein combinations and methods for the preparation thereof.
    Type: Grant
    Filed: March 2, 2021
    Date of Patent: October 12, 2021
    Assignee: Clara Foods Co.
    Inventors: Halle Redfearn, Harshal Kshirsagar, Kritika Mahadevan, Alexandre Chapeaux, Wesley Rutherford-Jenkins, Joel Andrew Kreps, Isha Joshi
  • Concentrated aqueous silk fibroin solution and use thereof
    Patent number: 11129921
    Abstract: The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides for the use of these solutions in production of materials, e.g., fibers, films, foams, meshes, scaffolds and hydrogels.
    Type: Grant
    Filed: May 8, 2019
    Date of Patent: September 28, 2021
    Assignee: Trustees of Tufts College
    Inventors: David L. Kaplan, Ung-Jin Kim, Jaehyung Park, Hyoung-Joon Jin
  • Cas variants for gene editing
    Patent number: 11124782
    Abstract: Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. In some embodiments, fusion proteins of Cas9 and nucleic acid editing enzymes or enzyme domains, e.g., deaminase domains, are provided. In some embodiments, methods for targeted nucleic acid editing are provided. In some embodiments, reagents and kits for the generation of targeted nucleic acid editing proteins, e.g., fusion proteins of Cas9 and nucleic acid editing enzymes or domains, are provided.
    Type: Grant
    Filed: April 3, 2019
    Date of Patent: September 21, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: David R. Liu, Alexis Christine Komor
  • Dynamic bio-nanoparticle platforms
    Patent number: 11096901
    Abstract: The invention in suitable embodiments is directed to dynamic bio-nanoparticle elements and bio-nanoparticle platforms employing such bio-nanoparticle elements. In one aspect, one or more elements of one or more types, formed from isolated, synthetic and or recombinant amino acid residues comprising in whole or in part one or more types of Clathrin and or Coatomer I/II proteins of one or more isoforms, execute one or more functions and or effect one or more ends, in vivo and or in vitro.
    Type: Grant
    Filed: March 19, 2013
    Date of Patent: August 24, 2021
    Assignee: METAQOR LLC
    Inventors: Franco Vitaliano, Gordana Dragan Vitaliano
  • Processes for preparing glycoprotein-drug conjugates
    Patent number: 11085062
    Abstract: A process for modifying glycoproteins is provided. The invention also provides a process for producing glycoprotein-payload conjugates, as well as the conjugates produced thereby.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: August 10, 2021
    Assignee: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
    Inventors: Shih-Chong Tsai, Chun-Chung Lee, Meng-Sheng Lee, Ching-Yao Chen, Shih-Hsien Chuang, Yi-Jen Chen, Win-Yin Wei
  • Lysine decarboxylases having modifications at titratable amino acids
    Patent number: 11078473
    Abstract: The invention provides CadA polypeptides with mutations that increase activity in alkaline pH compared to the wild-type lysine decarboxylase. The invention also provides methods of generating such mutant polypeptides, microorganisms genetically modified to overexpress the mutant polypeptides, and methods of generating such microorganisms.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: August 3, 2021
    Assignees: CATHAY BIOTECH INC., CIBT AMERICA INC.
    Inventors: Howard Chou, Ling Chen, Wenqiang Lu, Xiucai Liu
  • Compositions and methods for making terpenoid indole alkaloids
    Patent number: 11072613
    Abstract: Methods that may be used for the manufacture of a class of chemical compounds known as terpenoid indole alkaloids, including tabersonine and catharanthine are provided. Compositions useful for the synthesis of terpenoid indole alkaloids, including tabersonine and catharanthine are also provided. The provided compounds are useful in the manufacture of chemotherapeutic agents.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: July 27, 2021
    Assignee: Willow Biosciences, Inc.
    Inventors: Vincenzo De Luca, Yang Qu
  • Process for enzymatic hydrolysis of lignocellulosic material and fermentation of sugars
    Patent number: 11060117
    Abstract: The invention relates to an integrated process for alcohol production from lignocellulosic material.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: July 13, 2021
    Assignee: DSM IP ASSETS B.V.
    Inventor: Johannes Petrus Smits
  • Apolipoprotein nanodiscs with telodendrimer
    Patent number: 11053322
    Abstract: The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R)n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a polyethylene glycol) polymer; each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: July 6, 2021
    Assignee: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC
    Inventors: Juntao Luo, Wei He, Kit S. Lam, Paul Henderson, Matthew A. Coleman
  • Method of producing lipid
    Patent number: 11053523
    Abstract: A method of producing lipids, containing the steps of: culturing an alga belonging to the genus Nannochloropsis; and producing fatty acids or lipids containing the same as components; wherein expressions of genes encoding a ?12-desaturase and a ?6-desaturase are enhanced in the alga; and a transformant of an alga belonging to the genus Nannochloropsis, wherein expressions of genes encoding a ?12-desaturease and a ?6-desaturease are enhanced.
    Type: Grant
    Filed: August 28, 2017
    Date of Patent: July 6, 2021
    Assignee: Kao Corporation
    Inventor: Tatsuro Ozaki
  • Host cell modified to produce lactams
    Patent number: 11046981
    Abstract: The present invention provides for a genetically modified host cell capable of producing a lactam comprising a 2-pyrrolidone synthase, or an enzymatically active fragment thereof, heterologous to the host cell.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: June 29, 2021
    Assignee: The Regents of the University of California
    Inventors: Jingwei Zhang, Jay D. Keasling
  • Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
    Patent number: 11046936
    Abstract: The present application provides engineered polypeptides having imine or oxime reductase activity, polynucleotides encoding the engineered polypeptides, host cells capable of expressing the engineered polypeptides, and methods of using these engineered polypeptides with a range of ketone amine substrate compounds to prepare secondary and tertiary amine product compounds.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: June 29, 2021
    Assignee: Codexis, Inc.
    Inventors: Margie Tabuga Borra-Garske, Oscar Alvizo, Melissa Ann Mayo, Stephan Jenne, Auric Anthony Sowell-Kantz, Carmela Molinaro
  • Auxotrophic strains of bacterium
    Patent number: 11041217
    Abstract: The present disclosure provides recombinant Staphylococcus bacterium (e.g. S. epidermidis) that are dependent on D-alanine for growth. In one aspect, the disclosure features a recombinant Staphylococcus bacterium comprising two inactivated alanine racemase genes (?alr1?alr2); and an inactivated D-alanine aminotransferase (dat) gene. In another aspect, the disclosure features a method of making the recombinant Staphylococcus bacterium.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: June 22, 2021
    Assignee: Azitra Inc
    Inventors: Travis Michael Whitfill, Ming-De Deng, David Richard Dodds, Alexander Tikhonov