Abstract: Disclosed is a method for preparing dispersion gradients and an SPR injection method for determining full kinetics and affinity analysis in the presence of a competitor molecule. The SPR injection provides a dispersion gradient of two or more samples to a SPR flow cell and detector.

Abstract: The present disclosure relates to a method for characterizing and identifying a bioparticle. The method comprises introducing the sample to a substrate having a surface comprising a plurality of binding sites whereon bioparticles can be bound, determining, for at least one temperature, data representative for the interface thermal resistance of the surface of the substrate sufficiently long to include the detachment process of the bioparticles, and deriving, for the at least one temperature, a bioparticle retention time and/or detachment rate from the data representative for the interface thermal resistance data. The present disclosure also relates to a bio-sensing device suitable for the detection and/or characterization of target bioparticles.

Abstract: A Sampler and process for collecting, growing, inoculating and evaluating microbes in-situ. The Sampler may be loaded with an active or inert media to assist with the collection of microbes. It is closed and lowered to a desired depth. Sampler is opened to initiate sampling. Materials are added to the sampler to stimulate growth or change the environment. To collect and grow in situ microbes, the sampler is left open for a period of time, a trigger closes and seals the sampler capturing contents specific to that location. The sampler is lifted preserving the in-situ conditions from the collection location. The contents of the sampler can be interrogated through sealed ports at the field site or at a remote location. The sampler can also be utilized as a biologic reactor allowing researchers to connect laboratory equipment to analyze, modify, or cultivate the collected sample.

Abstract: Methods and compositions for the detection and quantitative measurement of biomarkers and other target analytes by determining impedance in bodily fluid samples and/or environmental samples using compositions comprising a base substrate with electrodes, a nanoporous membrane placed on top of the nanoporous membrane, O-rings placed on top of the nanoporous membrane and a manifold placed on top of the O-rings. Such a composition may be placed in a testing platform to ensure the application of constant, repeatable pressure to the composition.

Abstract: Provided is an amine group-derivatized composition including a Boc compound for liquid chromatography-mass spectrometry (LC-MS) analysis, and when the amine group-derivatized composition is used in analysis using reverse-phase LC-MS, it is possible to effectively analyze compounds including an amine group and an amino acid at a low cost in a short time.

Abstract: An optical sensing system for sensing hydrogen in a fluid comprising a first optical sensor comprising a first optical fiber, wherein an end portion of the first optical fiber is coated with a first hydrogen-sensitive multilayer on an end surface perpendicular to a longitudinal axis of the first optical fiber, the first multilayer being adapted to change its optical properties dependent on a hydrogen partial pressure in the fluid and dependent on a temperature of the fluid, with a known first characteristic; a second optical sensor comprising a second optical fiber, wherein an end portion of the second optical fiber is coated with a second hydrogen-sensitive multilayer on an end surface perpendicular to the longitudinal axis of the second optical fiber, the second multilayer being adapted to change its optical properties dependent on the hydrogen partial pressure in the fluid and dependent on a temperature of the fluid, with a known second characteristic which is different from the first characteristic; at le

Abstract: An exhaust purification system includes a NOx-occlusion-reduction-type catalyst that occludes NOx in exhaust in a lean state and reduces and purifies the occluded NOx in exhaust in a rich state, and a NOx purge rich control unit that executes NOx purge of reducing and purifying the occluded NOx by putting the exhaust into the rich state by fuel injection control, where a catalyst temperature of the NOx-occlusion-reduction-type catalyst is equal to or higher than a catalyst temperature threshold value and a NOx occlusion amount of the NOx-occlusion-reduction-type catalyst is equal to or higher than an NOx occlusion amount threshold value, and executes the NOx purge when the catalyst temperature is lower than a catalyst temperature threshold value.

Abstract: An elemental analysis system includes a reactor having at least one reduction reaction zone including a metal zeolite that can reduce nitrogen oxides (NOx) to molecular nitrogen (N2) by selective catalytic reduction. Correspondingly, a method of elemental analysis includes providing a reactor having at least one reduction reaction zone including a metal zeolite and reducing nitrogen oxides (NOx) to molecular nitrogen (N2) by selective catalytic reaction on the metal zeolite.

Abstract: A pre-analysis treatment method includes: a first retaining step of supplying, to a solid phase, each predetermined amount of the sample and a first solvent, and allowing a component at low concentration to be retained in the solid phase; a first washing step of supplying the first solvent to the solid phase and removing a component at high concentration from the solid phase; a second retaining step of supplying the sample in a smaller amount than the predetermined amount supplied in the first retaining step, and a second solvent to the solid phase, and allowing the component at high concentration to be retained in the solid phase; and an elution step of simultaneously extruding the components retained in the solid phase with an extrusion solvent.

Abstract: A computer system including a processor executing processor-executable code stored in a non-transitory processor-readable medium, causing the processor to receive a signal via an input port, including data indicative of an amount of a combustion product produced by a sample of drill cuttings subjected to oxidation at a constant temperature (1000° C. or 650° C. 100° C.) as a function of time and process the data according to a predetermined logic to: locate a peak in the amount of the combustion product produced at a set of instants in time; correlate the set of instants in time with the presence in the sample of an organic carbon from a contaminant or light volatile carbon molecules, organic carbon, and inorganic carbon; calculate at least one of an amount of contaminant, a total amount of organic carbon, and a total amount of inorganic carbon; and output a signal indicative of the calculated amount.

Abstract: A sample testing system includes a test receptacle support structure, an optical element positioned for transmitting electromagnetic radiation emitted or reflected by a sample disposed in a test receptacle supported by the test receptacle support structure, a cleaning member, and an automated transport arm configured to (i) detachably couple the cleaning member, (ii) move the detachably-coupled cleaning member into a position proximate to and/or contacting the optical element, and (iii) decouple the cleaning member.

Abstract: Disclosed is a microsensor package. Particularly, disclosed is a microsensor package, in which a sensing chip is packaged by using PCBs stacked on top of one another, whereby the thickness of the package slim can be kept slim, and at the same time, it can be manufactured at a low cost and can be easily manufactured.

Abstract: The subject invention concerns metal or metalloid oxide-based sol-gel hybrid sorbent and methods of synthesis. In one embodiment, the sorbent is a ZrO2 polypropylene oxide based sol-gel. The subject invention also concerns a hollow tube or capillary internally coated with a sorbent of the invention. Sorbent coated tubes and capillaries of the invention can be used in extraction and/or enrichment of samples to be analyzed for catecholamines and related compounds.

Abstract: An oxygen sensor has an oxygen sensitive fluorescent material including an oxygen sensitive dye and an oxygen insensitive dye, the oxygen sensitive dye and an oxygen insensitive dye being fluorophores; and a large diameter optical fiber. The large diameter optical fiber includes a first end and a second end. The large diameter optical fiber is configured to transit photons and transmit emissions from one or more of the fluorophores upon excitation thereof. The oxygen sensitive fluorescent material is located on the first end of the large diameter optical fiber.

Abstract: Methods of identification of at least one most likely elemental composition of at least one species of molecules contained in a sample and/or originated from a sample by at least one ionisation process are provided. The method includes measuring a mass spectrum of the sample and may include reducing the measured mass spectrum to a neutral mass spectrum. The method further includes determining for a peak of interest a set of candidate species of molecules which have an expected peak with a peak position within a peak position tolerance range in the corresponding measured mass spectrum or neutral mass spectrum. An identification mass spectrum is identified for each candidate species and a range of peak positions is determined of all peaks of the identification mass spectrum. Two subscores of candidate species are determined by comparing the identification spectra with the measured or neutral mass spectrum and final scores are calculated from the subscores.

Abstract: An assay to determine anticoagulants in a blood or blood plasma sample, wherein the assay comprises analyses with at least two wet chemistry prothrombine time (PT) methods. The assay comprises measuring PT in a first reaction mixture with a first PT method and measuring PT in a second reaction mixture with a second PT method, wherein the concentration of blood or blood plasma in the second reaction mixture differs from the concentration of blood or blood plasma in the first reaction mixture. The PT methods are calibrated to give the same or approximately the same PT results for reference samples which lack anticoagulants of interest for the assay. Further, calculating a difference in PT from the measurements, wherein if the difference in PT is 1) significant, this is indicative of a presence of anticoagulants in the sample, or 2) non-significant, this is indicative of an absence of anti-coagulants above detectable level in the sample.

Abstract: A method and system is provided for mass spectrometry for identification of a specific elemental formula for an unknown compound which includes but is not limited to a metabolite. The method includes calculating a natural abundance probability (NAP) of a given isotopologue for isotopes of non-labelling elements of an unknown compound. Molecular fragments for a subset of isotopes identified using the NAP are created and sorted into a requisite cache data structure to be subsequently searched. Peaks from raw spectrum data from mass spectrometry for an unknown compound. Sample-specific peaks of the unknown compound from various spectral artifacts in ultra-high resolution Fourier transform mass spectra are separated. A set of possible isotope-resolved molecular formula (IMF) are created by iteratively searching the molecular fragment caches and combining with additional isotopes and then statistically filtering the results based on NAP and mass-to-charge (m/2) matching probabilities.

Abstract: A molecular sensor includes a substrate defining a substrate plane, and a plurality of pairs of electrode sheets above or below the substrate at an angle to the substrate plane. The molecular sensor further includes a plurality of inner dielectric sheets between each electrode sheet in each pair of electrode sheets of the plurality of pairs, and an outer dielectric sheet between each pair of electrode sheets of the plurality of pairs.

Abstract: Methods and systems for detecting a particle defect on a wafer surface, transforming the particle to a spectroscopically active state, and identifying a material composition of the activated particle by a spectroscopic technique are described herein. Particle defects are transformed by chemical treatment, thermal treatment, photochemical treatment, or a combination thereof, such that an activated particle exhibits atomic vibrational bands that can be observed spectroscopically. In one embodiment, a surface inspection system detects the presence of a particle defect on a wafer surface, activates observable Raman bands in one or more of the detected particles, and identifies the material composition of the activated particle by a spectroscopic technique.

Abstract: A sensor for determining an air ratio of a fuel gas/air mixture, wherein a housing is formed, which delimitates a measuring space. The housing has on one side a diffusion passage for coupling with a fuel gas/air mixture flow, wherein the diffusion passage is formed by a gas-permeable separating agent. An electrically operated excitation element is arranged for energy supply into the measuring space in order to induce a chemical reaction of a fuel gas/air mixture in the measuring space. At least one optical detection device is directed into the measuring space with its detection area, wherein the at least one optical detection device detects the intensity of radiation from the reaction position in at least a first wavelength range and produces a signal being allocated to the detected intensity, from which the air ratio is inferable.