Abstract: A microscope includes a wide-field illuminator configured to illuminate at least one selected region of a sample, and a beam splitter configured to generate a first detection beam path and a second detection beam path. A camera detector is arranged within the first detection beam path and is configured to record images of the selected region of the sample. A point detector is arranged within the second detection beam path and is configured to acquire a predetermined subregion of the sample lying within the selected region. A detection objective, which is arranged within the first and second detection beam paths on an object side of the beam splitter. The detection objective is a common detection objective for the camera detector and the point detector.

Abstract: An article including a substrate having at least one main surface coated with a layer A having a refractive index lower than or equal to 1.50, said layer A being obtained by deposition of activated species issued from at least one compound C in gaseous form, containing in its structure at least one Si-fluoroalkyl group, at least one carbon atom, at least one hydrogen atom and optionally at least one nitrogen atom and/or at least one oxygen atom, the deposition of said layer A being carried out by applying a bombardment with an ion beam to layer A while layer A is being formed, and said layer A being formed in the absence of inorganic precursor compounds. Application to the preparation of interferential coatings.

Abstract: Embodiments disclose an optical material having a visual confirmation effect due to higher directivity of light reflection than a conventional optical material. Embodiments can include a laminate having a multilayer laminated film in which 11 or more layers of different thermoplastic resins are alternately laminated. With respect to light in a wavelength range of 400 to 700 nm and that is perpendicularly incident on an outer surface of the multilayer laminated film, the laminate has an average transmittance in the above wavelength range of 50% or more. When average reflectances in a wavelength range of 400 to 700 nm with respect to S-wave light in the wavelength range, incident at angles of 20° and 70° with respect to the normal line of the outer surface of the film at azimuths ?n (n: 1 to 5), are given as Rs20(?n) and Rs70(?n), respectively, the laminate satisfies, at least one azimuth ?n:Rs70(?n)?Rs20(?n)?50(%).

Abstract: An apparatus for detecting movements of a sample with respect to an objective includes imaging optics which include the objective, which have an image plane and which are configured to image light from at least one reference object that is connected to the sample arranged in front of the objective into reference object images in the image plane. The apparatus further includes a camera which is arranged in the image plane of the imaging optics and which is configured to record the reference object images at consecutive points in time, and an optical device arranged between the objective and the camera in a plane that is Fourier-conjugated with respect to the image plane. The optical device is configured to mask out low spatial frequencies of reference object images which the imaging optics image into the image plane.

Abstract: Holographic and diffractive optical encoding techniques for forming reflection or transmission holograms. The encoding device includes a substrate having an interference pattern that can propagate light along a light propagation path from one side of the substrate to another side of the substrate. Furthermore, an optical element may be used to propagate light according to a four-dimensional light field coordinate system.

Abstract: An imaging system includes a first finite conjugate objective at a frontal end of the system and a second finite conjugate objective at a distal end of the system. The system also includes a beam splitting or merging element positioned between the first finite conjugate objective and the second finite conjugate objective. The system also includes an excitation unit configured to direct an excitation beam into a sample positioned in front of the first finite conjugate objective. The excitation beam is in the form of an excitation plane. The system also includes an image sensor positioned facing the second finite conjugate objective. The image sensor lies in a conjugate plane of an excitation beam illumination plane at the frontal end of the system.

Abstract: Compact folded camera modules having auto-focus (AF) and optical image stabilization (OIS) capabilities and multi-aperture cameras including such modules. In an embodiment, a folded camera module includes an optical path folding element (OPFE) for folding light from a first optical path with a first optical axis to a second optical path with a second optical axis perpendicular to the first optical axis, an image sensor and a lens module carrying a lens with a symmetry axis parallel to the second optical axis. The lens module can be actuated to move in first and second orthogonal directions in a plane perpendicular to the first optical axis, the movement in the first direction being for auto-focus and the movement in the second direction being for OIS. The OPFE can be actuated to tilt for OIS.

Abstract: An adapter configured to be optically coupled to a plurality of microscopes and including a) a first microscope interface configured to optically couple a first microscope to an optical element in optical communication with an optical probe; b) a second microscope interface configured to optically couple a second microscope to the optical element in optical communication with the optical probe; and c) an optical arrangement configured to direct light collected from a sample with the aid of the optical probe to (1) the first microscope and second microscope simultaneously, or (2) the first microscope or second microscope selectively.

Abstract: In some implementations, an optical interference filter includes a substrate; and a set of layers that are disposed on the substrate, wherein the set of layers includes: a first subset of layers; and a second subset of layers; wherein: each of the first subset of layers includes an aluminum nitride (AlN) material, a stress of each of the first subset of layers is between ?1000 and 800 megapascals, the first subset of layers has a first refractive index with a first value, each of the second subset of layers includes at least one other material, the second subset of layers has a second refractive index with a second value that is different than the first value, and the optical interference filter has an effective refractive index greater than or equal to 95% of a highest value of the first value and the second value.

Abstract: Devices, systems and methods are described that can be used to develop confocal microscopes with high lateral resolution. One example confocal microscope includes a first dispersion element that receives a light beam and to produce illumination beams with different spectral components, and an objective that receives reflected light upon reflection of the illumination beams from a target. The confocal microscope further includes a second dispersion element that receives the reflected light after propagation through in the objective lens, and a third dispersion element that receives the dispersed light associated with the second dispersion element and provides an output light to a camera lens for focusing onto a detector. The second and the third dispersion elements are positioned such that each point on the detector is conjugate to a corresponding single point on the target. Some applications of the disclosed confocal microscopes include skin disease diagnosis and imaging of freshly-excised tissues.

Abstract: An apparatus for light-beam scanning microscopy includes a microscope objective and a movement system for moving an excitation light beam. The movement system for moving the excitation light beam includes a first focusing optical component suitable for focusing the excitation light beam in an intermediate focal plane, another focusing optical component suitable for forming an image of the intermediate focal in a focal plane of the microscope objective and a single scanning mirror arranged between the first optical component and the intermediate focal plane, the scanning mirror being mounted on a stage, the orientation of which can be adjusted, so as to move the image of the focusing point in two transverse directions in the object focal plane or in the image focal plane of the microscope objective.

Abstract: A microscope system may comprise a plurality of microscope modules, a cassette for holding a plurality of slides, a slide loader configured to move the plurality of slides between the cassette and the plurality of microscope modules, and a processor coupled to the slide loader. The processor may be configured with instructions which, when executed, cause the slide loader to move a slide into or from a selected microscope module among the plurality of microscope modules. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: A light microscope has a light source for illuminating a specimen, a photon-counting detector array with a plurality of photon-counting detector elements for measuring detection light coming from the specimen, wherein the photon-counting detector elements are configured to output respective measured photon count rates, and a control device for controlling the photon-counting detector array. The control device is configured to individually influence the measurable photon count rates which are simultaneously measurable with different photon-counting detector elements and/or which are consecutively measurable with the same photon-counting detector element. Furthermore, in an imaging method the measurable photon count rates of photon-counting detector elements are individually influenced to increase the signal-to-noise ratio for the photon-counting detector array.

Abstract: A method for high-resolution imaging includes illuminating a target region of a specimen by first and second illumination light beams during respective holding durations to transfer respective subsets of fluorophores from a first into a second state. The fluorophores emit fluorescence photons upon transition from the second back into the first state, which are used to produce respective raw images. The illumination light beams have different power and/or beam profiles. A high-resolution image is produced from the raw images. The respective holding durations are shorter than a lifetime of a third state of the fluorophores, into which a third subset of the fluorophores is transferred by the illumination of the target region by the first and/or second illumination light beam, and the lifetime of the third state is longer by a factor of at least 2 than a lifetime of the second state.

Abstract: Disclosed is an electronic device. An electronic device according to various embodiments includes: a housing; a first glass plate attached to the housing and forming a portion of an external surface of the electronic device, wherein the first glass plate includes a flat portion, a curved portion extending from an edge of the flat portion, a first surface facing outwardly from the electronic device, and a second surface facing inwardly towards the electronic device; and a coating layer formed on the first surface of the first glass plate, wherein the coating layer includes a first layer having a first refractive index and containing at least one first material, and includes a second layer disposed further from the first surface than the first layer, containing at least one second material, and having a second refractive index different from the first refractive index.

Abstract: A microscope includes: an optical system including an immersion objective for an immersion medium of a predetermined refractive index; an aperture stop; and a processor for setting an immersion-free imaging mode in which the optical system is operated without immersion medium. The processor controls the aperture stop in the immersion-free imaging mode to set a numerical aperture of the immersion objective to a reduced value which is lower than a nominal value of the numerical aperture, the numerical aperture being equal to the nominal value when the optical system is operated using the immersion medium without reducing the numerical aperture by the aperture stop. The processor controls the optical system in accordance with the reduced value of the numerical aperture in the immersion-free imaging mode to generate at least one image representing the overview image of the sample.

Abstract: A system for photonic computing, preferably including an input module, computation module, and/or control module, wherein the computation module preferably includes one or more filter banks and/or detectors. A photonic filter bank system, preferably including two waveguides and a plurality of optical filters optically coupled to one or more of the waveguides. A method for photonic computing, preferably including controlling a computation module, controlling an input module, and/or receiving outputs from the computation module.

Abstract: A dielectric film is provided on a transparent substrate. The dielectric film has at least one low refractive index layer. An uppermost layer of the dielectric film contains SiO2 and has a film density of 92% or more. The uppermost layer contains an element having an electronegativity smaller than Si.

Abstract: A illumination arrangement for a microscope for illuminating a sample with a light sheet includes an illumination input configured to feed an illumination beam along an optical axis of the illumination arrangement and an illumination output which faces a sample side and is configured to output the illumination beam to the sample side. A focusing optical system is provided with a set depth of focus. At least one optical modification element is configured to geometrically modify the illumination beam. Different rays of the illumination beam intersect the optical axis within an axis intersection region at the illumination output. The axis intersection region extends over at least the depth of focus of the focusing optical system along the optical axis.

Abstract: Aligning a sample carrier of a microscope includes: capturing an overview image in which the sample carrier and/or a sample carrier environment is at least partially visible; evaluating the overview image with a machine learning model of a computer program, which performs an object localization in the overview image with respect to at least one predefined object; evaluating whether the sample carrier is centred in the overview image with the computer program based on the object localization; if the sample carrier is evaluated as not centred in the overview image: determining a centring movement based on the object location with the computer program, the centring movement indicating a sample stage movement for moving the sample carrier towards an image centre of the overview image; performing a sample stage adjustment based on the centring movement; and capturing a centred overview image after the sample stage adjustment has been performed.