Patents Examined by Arnold Turk
  • Patent number: 4555819
    Abstract: A holder comprising a sealed container provided to receive a water-soluble active, solid composition and to protect it against the direct erosion by water susceptible to penetrate in the container. The holder including a basin having a predetermined volume arranged at the upper portion of said container and having at least one hole in the bottom thereof, a discharge device for discharging in a water closet (WC) bowl and consisting of two siphon-type systems and of an appropriate hooking system to hook the holder under an edge of a WC bowl.
    Type: Grant
    Filed: April 20, 1984
    Date of Patent: December 3, 1985
    Assignee: Reckitt & Colman S.A.
    Inventors: Richard Weiss, Hubert Delagneau
  • Patent number: 4555383
    Abstract: A gas chromatograph system is provided with an improved electrolytic conductivity cell (16) for detecting a selected material species in a fluid stream from conventional gas chromatograph (10, 12) having both gas and liquid phases. Planar electrodes (80, 82) are spaced by an insulator (84) and define borehole diameters (88, 90, 92) which enhance the generated signal-to-noise ratio by providing a short fluid transit time within the conductivity detecting volume compared with the effective time of the chromatographic event of interest. A pneumatic damper (108) may be further included to reduce generated system signal noise.
    Type: Grant
    Filed: March 2, 1984
    Date of Patent: November 26, 1985
    Assignee: O. I. Corporation
    Inventor: Randall C. Hall
  • Patent number: 4554254
    Abstract: A novel, inexpensive, highly sensitive and quantitative assay for measuring protein in solution based on the capacity of protein to bind silver is described. In this procedure, protein samples are first treated with glutaraldehyde and then exposed to ammoniacal silver. After a specified time, the reaction is terminated by the addition of sodium thiosulfate and the optical density measured at 420 nm. The useful range of the assay for the majority of standard proteins tested lies between 15 and 2000 ng. This represents a 100-fold increase in sensitivity over the Coomassie Brilliant Blue dye binding procedure. There is little or no interference from carbohydrates, non-ionic detergents or ethanol. Pretreatment of protein samples with Bio-Gel P-2 to remove salts, thiol agents, EDTA and SDS, makes this procedure compatible with most commonly used buffers.
    Type: Grant
    Filed: December 17, 1984
    Date of Patent: November 19, 1985
    Inventor: Gerald Krystal
  • Patent number: 4554133
    Abstract: A highly sensitive test tube according to the invention increases the sensitivity of detection of a component in a gas substantially and thus enlarges the area of use of the test tube. It possesses a reagent strip impregnated according to the gas to be detected, which strip is held by a granular fill material between holding elements. The test gas, conveyed by a pump through the test tube, from which test gas the gas to be detected is removed at the reagent strip, is continually moved through the granular fill material and thoroughly mixed, so that the actual continually decreasing concentration of the gas component is available at the reagent strip. Upon complete removal of this gas component by reaction with the reagent strip, the concentration can then be read at the reagent strip. The narrow reagent strip, which takes up the entire gas component, evidences even small admixtures.
    Type: Grant
    Filed: September 28, 1983
    Date of Patent: November 19, 1985
    Assignee: Dragerwerk A.G.
    Inventor: Kurt Leichnitz
  • Patent number: 4552848
    Abstract: A method for determining macromolecules in polyacrylamide gels comprises forming a latent stain image by nucleating the gel with a palladium tetramine salt and developing the latent stain image by treating the gel with a physical developing solution comprising dimethylamine borane and a member selected from the group consisting of a transition metal salt and a tetrazolium salt.
    Type: Grant
    Filed: May 16, 1983
    Date of Patent: November 12, 1985
    Assignee: Eastman Kodak Company
    Inventors: Joseph S. Yudelson, Thomas M. Johnson
  • Patent number: 4551307
    Abstract: There is disclosed an analytical element comprising a light-transmissive and liquid-impermeable support and at least one developing layer of a fibrous structure containing at least one kind of interactive composition reactive with a component in a liquid sample, characterized in that the fiber constituting the developing layer of a fibrous structure and the interactive composition are bonded to each other by a compound having a reactive group. A quantitative analysis of a specific component in a liquid sample can effectively be carried out by using the analytical element according to this invention.
    Type: Grant
    Filed: May 25, 1982
    Date of Patent: November 5, 1985
    Assignee: Konishiroku Photo Industry Co., Ltd.
    Inventors: Mikio Koyama, Shozo Kikugawa, Kenichiro Okaniwa
  • Patent number: 4551434
    Abstract: Titanium alloy test samples including welded samples of such alloys are tested for recognizing textural or structural faults or flaws in the form of segregations or liquations. To make these flaws visible by increasing the contrast between a flaw and the background, an etching method including two etching steps is used, which achieves especially marked contrasts. The method is based on the selective solution removal of a phase, a grain, or of an impurity of an alloy type. An especially good visual recognition of segregations, liquations or inhomogeneities of welded test samples is made possible by the resulting matte gray surface against which lustrous flaws are clearly visible.
    Type: Grant
    Filed: February 22, 1984
    Date of Patent: November 5, 1985
    Assignee: MTU Motoren-und Turbinen-Union Muenchen GmbH
    Inventor: Martin Thoma
  • Patent number: 4551306
    Abstract: Edges of reagent matrix are sealed such that liquid present in the reagent matrix material is retained therein and prevented from running over into another reagent matrix area present on the same reagent test device.
    Type: Grant
    Filed: May 20, 1983
    Date of Patent: November 5, 1985
    Assignee: Miles Laboratories, Inc.
    Inventors: Dale W. Bouwman, Harold K. Clayborn
  • Patent number: 4551308
    Abstract: A sample of blood is divided into a plurality of isolated test chambers. The blood is mixed with additive reagent having previously been measured into each test chamber. A clot detector and analyzer system determines the time required for the blood-reagent mixture in each chamber to form a clot. In a first mode of analyzer system operation there is recorded the time required for a selected number of clots to be detected. A second mode of operation identifies those chambers in which clots have been detected within a specified time interval.
    Type: Grant
    Filed: December 23, 1983
    Date of Patent: November 5, 1985
    Assignee: International Technidyne Corp.
    Inventor: Michael D. Mintz
  • Patent number: 4551425
    Abstract: A pyroelectric substrate is provided with a heater and at least one set of electrodes for sensing charge redistributions due to changes in the substrate temperature. In a preferred embodiment, there are two interdigitated electrodes, one coated with an absorber/desorber material. The heater pulsatingly raises the temperature of the substrate past the desorption temperature of a fluid of interest. If the fluid was exposed to the absorber/desorber material prior to heating, a portion of the fluid will have been absorbed. When the substrate reaches the desorption temperature, additional heat pulses will not increase the substrate temperature significantly until the fluid has desorbed. Thus, heat used in changing state does not raise the substrate temperature and, lacking a temperature change, reduces the charge redistribution sensed by the electrode coated with the material.
    Type: Grant
    Filed: September 28, 1982
    Date of Patent: November 5, 1985
    Assignee: Trustees of the University of Pennsylvania
    Inventor: Jay N. Zemel
  • Patent number: 4550083
    Abstract: A Karl Fischer reagent useful in the determination of water, comprises sulfur dioxide, iodine and a salt which is a system compatible addition compound of a nitrogen-containing organic base having a pK.sub.b <10 with a weak aromatic carboxylic acid having a pK.sub.a >2.
    Type: Grant
    Filed: February 14, 1983
    Date of Patent: October 29, 1985
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Wolfgang Fischer, Georg Seitz, Karl-Dieter Krenn
  • Patent number: 4550085
    Abstract: Histamine is detected or determined selectively in a sample by causing the sample to contact glass microfibers in such a quantitative proportion as will permit the histamine present to bind to the fibers. The amount of bound histamine may be determined by competitive determination in the presence of labelled histamine on the basis of a standard curve, or may be determined directly by conventional coupling reactions.The method is simple and particularly useful for allergy diagnostics because it exhibits good correlation with known fluorometric methods.
    Type: Grant
    Filed: September 8, 1981
    Date of Patent: October 29, 1985
    Inventors: Per S. Skov, Svend Norn, Bent Weeke
  • Patent number: 4549952
    Abstract: A capillary transport device is disclosed, suitable for use as an ion bridge for potentiometric test elements. Such device has an internal capillary transport passage, and two access apertures for separate access of two different liquids to two spaced-apart regions of the passage. To control the liquid flow rate within the passage, there is disposed on at least a portion of at least one of the surfaces of the passage between the two regions, means for (a) increasing the viscosity of the liquid while it is flowing past at least one surface, and (b) at the same time maintaining such flow continuous within the passage.
    Type: Grant
    Filed: October 3, 1983
    Date of Patent: October 29, 1985
    Assignee: Eastman Kodak Company
    Inventor: Richard L. Columbus
  • Patent number: 4548905
    Abstract: A reagent composition, dry analytical element and a method of using same to determine total bilirubin in aqueous liquids are disclosed. The reagent composition comprises a diazonium salt, or reagents capable of producing a diazonium salt when contacted with water, and 3,3-dimethylglutaric acid or a salt thereof present in an amount effective to buffer the composition at a pH of about 3.5 or less when the composition is contacted with a 2 .mu.L sample of pooled human serum. The composition and elements described herein provide a means to eliminate the effect of an undetermined interferent which is either preformed or formed in situ in diazo-based total bilirubin determinations of biological fluids (e.g. uremic serum).
    Type: Grant
    Filed: April 9, 1984
    Date of Patent: October 22, 1985
    Assignee: Eastman Kodak Company
    Inventor: Tai-Wing Wu
  • Patent number: 4548907
    Abstract: A fluorescence-based optical sensor includes a membrane immobilized fluorophor secured to one end of a bifurcated fiber optic channel for exposure to the sample to be analyzed. The fiber optic channel also has an input end coupled to a radiation source arranged to supply radiation at two different wavelengths and an output end coupled to a bandwidth limited photosensor. The radiation source alternately excites the fluorophor at a first wavelength that excites an acid form of the fluorophor and at a second wavelength that excites a base form of the fluorophor, and a ratio of the resulting fluorescence intensities is taken as a measure of a characteristic of the sample being analyzed.
    Type: Grant
    Filed: September 14, 1983
    Date of Patent: October 22, 1985
    Assignee: Allied Corporation
    Inventors: William R. Seitz, Zhang Zhujun
  • Patent number: 4548903
    Abstract: A method for revealing the microstructure of metal alloys which comprises the steps of polishing the sample, chemically etching the polished metal surface, thermally etching the chemically etched surface and quenching the thermally etched sample. This method allows observation of deformed and recrystallized grains on the same polished surface and provides the opportunity to correlate recrystallized grains to their nucleation sites.
    Type: Grant
    Filed: March 30, 1984
    Date of Patent: October 22, 1985
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: Isaac Weiss, Francis H. Froes, Daniel Eylon
  • Patent number: 4548906
    Abstract: An integral multilayer analytical element for the analysis of ammonia or an ammonia forming substrate in a liquid sample is disclosed. The element comprises a transparent support on which an indicator layer for ammonia, a liquid blocking layer, a reagent layer incorporated with a reagent which may react with the substrate to form ammonia, and a spreading layer, are integrally superposed in this order. The improvement is that the liquid blocking layer is made of a porous material which is permeable to ammonia but substantially impermeable to liquids.
    Type: Grant
    Filed: May 11, 1984
    Date of Patent: October 22, 1985
    Assignee: Fuji Shashin Film Kabushiki Kaisha
    Inventors: Nobuyoshi Sekikawa, Harumi Katsuyama, Asaji Kondo
  • Patent number: 4547460
    Abstract: A multizone analytical element for the determination of an analyte in an aqueous liquid comprises a registration zone and a porous spreading zone to receive and transport the aqueous liquid. The spreading zone contains a nonpolymeric quaternary ammonium compound represented by either of the structures: ##STR1## wherein represents a single or double bond; R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently alkyl; aryl; cycloalkyl; or alkaryl; provided that R.sub.1, R.sub.2, R.sub.3 and R.sub.4 together comprise at least 12 carbon atoms; or R.sub.1 and R.sub.2 taken together with the nitrogen atom, form a quaternary 5- to 16-membered heterocyclic ring; or R.sub.1, R.sub.2 and R.sub.3 taken together with the nitrogen atom, form a quaternary 5- to 16-membered heterocyclic ring; and X.sup.- is a monovalent anion.
    Type: Grant
    Filed: April 16, 1984
    Date of Patent: October 15, 1985
    Assignee: Eastman Kodak Company
    Inventor: Jon N. Eikenberry
  • Patent number: 4547465
    Abstract: A dry element capable of use for the analysis or transport of liquids comprises an isotropically porous zone which comprises a blush polymer having dispersed therein a particulate material and a nonpolymeric heterocyclic, aliphatic or carbocyclic quaternary ammonium compound comprising at least 12 carbon atoms therein. This compound is present in the porous zone in an amount of at least about 2 weight percent, based on the dry weight of the blush polymer. The porous zone of this element has improved cohesive strength which improves its resistance to abrasion. The element can be used to determine an analyte in an aqueous liquid, such as biological fluids.
    Type: Grant
    Filed: April 16, 1984
    Date of Patent: October 15, 1985
    Assignee: Eastman Kodak Company
    Inventor: Jon N. Eikenberry
  • Patent number: 4546088
    Abstract: A process and an apparatus for flow extraction whereby a substance dissolved in a first solvent is extracted over to a second solvent which is insoluble in the first. The two solvents are brought together via two legs in a T-tube, and the mixture exits through the third leg, the cross-sectional areas of the legs being dimensioned to produce segmented flow with alternating plugs of the second and first solvents. The ratio between the cross-sectional areas of the tube legs for the first and second solvents is 2-8:1, preferably 4:1. Between the first and third legs carrying the confluent flows, the ratio between the cross-sectional areas thereof is reduced to 0.7-1.2:1, preferably 1:1, at a distance from the juncture which is 1-3 times the inner diameter of the third leg. The confluent flow is led through a spiral hose, producing a powerful extraction due to the counter-current turbulence.
    Type: Grant
    Filed: April 4, 1983
    Date of Patent: October 8, 1985
    Assignee: Bifok AB
    Inventors: Bo I. Karlberg, Sidsel Thelander