Patents Examined by Ba K. Trinh
  • Patent number: 6872842
    Abstract: Taxane derivatives having a 3? butenyl substituted C13 side chain.
    Type: Grant
    Filed: March 29, 2002
    Date of Patent: March 29, 2005
    Assignee: Florida State University
    Inventors: Robert A. Holton, Ki-byung Chai, Hossain Nadizadeh
  • Patent number: 6869973
    Abstract: The present invention describes novel nitrosated and/or nitrosylated taxanes, and novel compositions comprising at least one nitrosated and/or nitrosylated taxane, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The present invention also provides novel compositions comprising at least one taxane and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The compounds and compositions of the present invention can also be bound to a matrix.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: March 22, 2005
    Assignee: NitroMed, Inc.
    Inventors: David S. Garvey, L. Gordon Letts, Chia-En Lin, Stewart K. Richardson, Tiansheng Wang
  • Patent number: 6870061
    Abstract: A continuous and scalable process for producing glycidyl nitrate, or glyn, from glycerin, nitric acid, and caustic wherein the process includes the reaction of glycerin and nitric acid to form dinitroglycerin and the reaction of dinitroglycerin with caustic, such as sodium hydroxide, system for producing the inventive material is also disclosed. The vessel, a second reaction vessel, and a separation apparatus.
    Type: Grant
    Filed: January 10, 2003
    Date of Patent: March 22, 2005
    Assignee: Alliant Techsystems Inc.
    Inventors: Thomas K. Highsmith, Harold E. Johnston
  • Patent number: 6864379
    Abstract: Methods for manufacture of citalopram through stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans are disclosed.
    Type: Grant
    Filed: September 10, 2002
    Date of Patent: March 8, 2005
    Assignee: H. Lundbeck A/S
    Inventors: Hans Petersen, Haleh Ahmadian
  • Patent number: 6864282
    Abstract: 9,11-Cycloendoperoxide derivatives of biologically active prostaglandin analogs, and particularly of the ocular hypotensive drugs Bimatoprost, Latanaprost, Unoprostone, Travoprost and prostaglandin H2 1-ethanolamide or of structurally closely related analogs, are pro-drugs which hydrolyze under physiological conditions to provide prostaglandin analogues that are capable of providing sustained ocular and other in vivo concentrations of the respective drugs. The compounds of the invention have the formula shown below where the variables have the meaning defined in the specification.
    Type: Grant
    Filed: August 5, 2002
    Date of Patent: March 8, 2005
    Assignee: Allergan, Inc.
    Inventors: Kah-Hiing John Ling, Wu Yang, Jinsong Ni, Haiqing Yuan, Diane D. S. Tang-Liu
  • Patent number: 6861501
    Abstract: A process is provided in which at least one multi-functional alcohol having a hydroxyl functionality of at least two serves as a polymerization initiator. The multi-functional alcohol initiator is optionally, although preferably, reacted with a catalyst to form a catalyst-initiator complex, which is then used in the polymerization of glycidyl nitrate. The resulting poly(glycidyl nitrate) has a functionality substantially equivalent in number to the hydroxyl functionality of the multi-functional alcohol initiator. The poly(glycidyl nitrate) is cross-linked with at least one aromatic polyisocyanate having at least one aromatic ring and, on average, more than two isocyanate moieties bonded directly to the aromatic ring.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: March 1, 2005
    Assignee: Alliant Techsystems Inc.
    Inventors: Andrew J. Sanderson, Laura J. Martins, Michael A. Dewey
  • Patent number: 6861537
    Abstract: The synthesis of taxol and other tricyclic and tetracyclic taxanes.
    Type: Grant
    Filed: July 12, 2002
    Date of Patent: March 1, 2005
    Assignee: Florida State University
    Inventors: Robert A. Holton, Carmen Somoza, Hyeong Baik Kim, Mitsuru Shindo, Ronald J. Biediger, P. Douglas Boatman, Chase Smith, Feng Liang, Krishna Murthi
  • Patent number: 6861446
    Abstract: Taxanes having a heterosubstituted acetate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: November 24, 2003
    Date of Patent: March 1, 2005
    Assignee: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • Patent number: 6861538
    Abstract: The object of the present invention is to provide a novel method for effectively producing a cyclic lactic acid oligomer, and a cyclic lactic acid oligomer produced by the method.
    Type: Grant
    Filed: September 20, 2000
    Date of Patent: March 1, 2005
    Assignee: Amato Pharmaceutical Products, Ltd.
    Inventors: Mikio Watanabe, Jiro Takano, Yoshimi Ishihara, Masahiro Murakami
  • Patent number: 6858632
    Abstract: Novel derivatives of isosorbide mononitrate and its pharmaceutically acceptable salts, which have vasodilating activity with a reduced effect of tolerance, of the general formula (I) in which A and B independently represent any of the groups —ONO2 and —Z—CO—R, wherein Z is an oxygen atom or sulphur atom and R is an alkyl C1-C4 group, an aryl group or an aralkyl group, eventually substituted, or the group in which R1 is hydrogen, or an alkyl C1-C4 group, an aryl group or an aralkyl group, eventually substituted, with the proviso that one of A or B is always —ONO2, but never both of them at the same time, when Z is an sulphur atom R is an alkyl C1-C4 group, an aryl group or an aralkyl group, eventually substituted, and when Z is an oxygen atom R is the group
    Type: Grant
    Filed: April 28, 2003
    Date of Patent: February 22, 2005
    Assignee: Lacer, S.A.
    Inventors: Jose Repolles Moliner, Francisco Pubill Coy, Lydia Cabeza Llorente, Marcel.li Carbo Banus, Cristina Negrie Rofes, Juan Antonio Cerda Riudavets, Alicia Ferrer Siso, Marek W. Radomski, Eduardo Perez-Rasilla, Juan Martinez Bonnin
  • Patent number: 6858743
    Abstract: The invention relates to a method for the production of 2-coumarone or substituted 2-coumarones, whereby cyclohexanone or substituted cyclohexanone is reacted with a carboxyl-containing acylating agent a) to give methyl 2-(2-oxo-cyclohexyl)-2-hydroxyacetate or substituted methyl 2-(2-oxo-cyclohexyl)-2-hydroxyacetates, which are either a1) directly converted to 2-coumarone or substituted 2-coumarones by means of catalytic gas-phase dehydrogenation, or a2) dehydrated by means of azeotropic distillation under basic conditions, or by use of a strong acid, or a strongly acidic ion exchanger to a mixture of methyl 2-oxocyclohexylidenacetate and the enol-lactone of the 2-oxocyclohexylidenacetic acid, or a mixture of substituted methyl 2-oxocyclohexylidenacetate and the enol-lactone of the substituted 2-oxocyclohexylidenacetic acid, which is finally converted in turn by catalytic gas-phase dehydrogenation to 2-coumarone, or substituted 2-coumarones, or b) are directly converted under acidic or basic conditions into a
    Type: Grant
    Filed: May 9, 2001
    Date of Patent: February 22, 2005
    Assignee: DSM Fine Chemicals Austria NFG GmbH & Co, KG
    Inventors: Michael Stanek, Peter Hildebrand, Curt Zimmermann, Marianne Castelijns
  • Patent number: 6855835
    Abstract: Allomorph of Z isomer of N-[2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio]ethyl]-N?-methyl-2-nitro-1,1-ethenediamine hydrochloride, with two carbon atoms linked by a rigid ethylenic bond, marked by an asterisk (*), characterized by the following structural formula: wherein -Fur- represents a furane ring.
    Type: Grant
    Filed: August 29, 2002
    Date of Patent: February 15, 2005
    Assignee: Pharmexcel SRL
    Inventor: Paolo Alberto Veronesi
  • Patent number: 6852868
    Abstract: Processes are disclosed for the preparation of 2-methylfuran and 2-methyltetrahydrofuran. The continuous vapor-phase processes are commercially viable and efficient because they permit the preparation of 2-methylfuran and 2-methyltetrahydrofuran using commercially-available catalysts, namely, a reduced copper-based catalyst consisting essentially of cupric oxide, chromium (III) oxide, manganese oxide and barium chromate and a reduced nickel-based catalyst consisting essentially of nickel, nickel (II) oxide, aluminum oxide and silica. An apparatus comprising two inline hydrogenators is used for preparing the 2-methylfuran or 2-methyltetrahydrofuran.
    Type: Grant
    Filed: August 21, 2002
    Date of Patent: February 8, 2005
    Assignee: Pure Energy Corporation
    Inventor: Irshad Ahmed
  • Patent number: 6849750
    Abstract: Disclosed are intermediates and processes for preparing epoxides of the formula: where R and PROT are defined herein. These epoxides are useful as intermediates in the production of biologically active compounds, i.e., in the production of pharmaceutical agents.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: February 1, 2005
    Assignee: Pharmacia & UpJohn Company LLC
    Inventor: Michael R. Reeder
  • Patent number: 6846937
    Abstract: A method for removing acyl-groups appended by an ester linkage to the 2?-hydroxyl group present in paclitaxel-related molecules comprising treatment with alcohol under non-acidic conditions.
    Type: Grant
    Filed: September 27, 2002
    Date of Patent: January 25, 2005
    Assignee: The University of Toledo
    Inventors: Paul W. Erhardt, Wieslaw A. Klis, Jeffery G. Sarver
  • Patent number: 6844451
    Abstract: A method of isolating terpene trilactones from Ginkgo biloba plant material or extract comprising the steps of suspending the plant material or extract in either water or an aqueous solution of an oxidation reagent; extracting the terpene trilactones using an acceptable extraction agent; separating the organic layer from the aqueous layer; washing the organic layer with an acceptable aqueous salt or hydroxide solution, which may be an alkaline solution; and drying the organic layer to form a dried extract containing terpene trilactones. Further purification by treatment with or filtration over activated charcoal, by treatment with or filtration over alumina and by recrystallization with an acceptable solvent or solvent mixture leads to extracts with a content of terpene trilactones higher than 50%. Unwanted levels of ginkgolic acids are reduced to acceptable levels by reversed phase chromatography.
    Type: Grant
    Filed: July 7, 2003
    Date of Patent: January 18, 2005
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Dirk Lichtblau, Nina Berova, John Berger, Koji Nakanishi
  • Patent number: 6841571
    Abstract: Disclosed are cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (Ia) and (Ib) where R2, R3, R4, R6, R8 and Y are defined herein. The compounds are useful for treating autoimmune and other diseases.
    Type: Grant
    Filed: October 24, 2002
    Date of Patent: January 11, 2005
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Younes Bekkali, Denice Mary Spero, Sanxing Sun, Yancey David Ward
  • Patent number: 6838571
    Abstract: Process for manufacturing oxirane by reaction of an olefin with a peroxide compound in the presence of a catalyst and a solvent in at least two reactors arranged in series, each of which contains a portion of catalyst, according to which the peroxide compound is introduced only into the first reactor, the subsequent reactor(s) not being fed with fresh peroxide compound, but only with the peroxide compound which is present in the medium obtained from the preceding reactor and which was not consumed in this preceding reactor.
    Type: Grant
    Filed: August 29, 2003
    Date of Patent: January 4, 2005
    Assignee: Solvay (Societe Anonyme)
    Inventor: Dominique Balthasart
  • Patent number: 6835849
    Abstract: The invention relates to the synthesis of alkenoate esters from a corresponding lactone and an alcohol in the presence of a basic catalyst. More specifically, this invention relates to the synthesis of methyl-4-pentenoate ester from 5-methyl butyrolactone and methanol.
    Type: Grant
    Filed: July 11, 2003
    Date of Patent: December 28, 2004
    Assignee: E. I. du Pont de Nemours and Company
    Inventor: Leo Ernest Manzer
  • Patent number: 6835746
    Abstract: Pharmaceutical compositions, methods of administration, and methods of treatment of cancer with new generation taxoids, of formulas (I) and (II), and derivatives thereof, are described:
    Type: Grant
    Filed: December 30, 2002
    Date of Patent: December 28, 2004
    Assignee: The Research Foundation of State University of New York
    Inventor: Iwao Ojima