Patents Examined by Ba K. Trinh
  • Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
    Patent number: 6727369
    Abstract: Process for the preparation of a derivative or analog of baccatin III or 10-desacetyl baccatin III having a C2 substituent other than benzoate and/or a C4 substituent other than acetate in which the C2 benzoate substituent and/or the C4 acetate substituent of a derivative of baccatin III or 10-desacetyl baccatin III is/are selectively reduced to the corresponding hydroxy group(s) and converted to R7COO— and/or R8COO—, respectively, wherein R7 and R8 are independently H, C1-C6 alkyl, C2-C6 alkenyl, C2-C8 alkynyl, moncyclic aryl, or monocyclic heteroaryl.
    Type: Grant
    Filed: April 14, 1995
    Date of Patent: April 27, 2004
    Assignee: Florida State University
    Inventors: Robert A. Holton, Seokchan Kim, Yukio Suzuki
  • Cyclic organo-oxide storage vent scrubbing
    Patent number: 6727389
    Abstract: A method for processing at least one cyclic organo-oxide using a closed loop scrubber/holding tank system that contains at least one amine, and circulating the amine through the closed loop while admitting the cyclic organo-oxide to the closed loop.
    Type: Grant
    Filed: April 16, 2003
    Date of Patent: April 27, 2004
    Assignee: Equistar Chemicals, LP
    Inventor: Krishnan Viswanathan
  • Method for producing oxirane
    Patent number: 6723861
    Abstract: Process for manufacturing oxirane by reaction of an olefin with a peroxide compound in the presence of a catalyst and a solvent in at least two reactors arranged in series, each of which contains a portion of the catalyst, according to which two epoxidation reactions are carried out in series including intermediate distillation, to minimize the formation of by-products.
    Type: Grant
    Filed: December 19, 2002
    Date of Patent: April 20, 2004
    Assignee: Solvay (Societe Anonyme)
    Inventor: Dominique Balthasart
  • Glucopyranoside benzothiophenes
    Patent number: 6723739
    Abstract: A compound of the formula or a pharmaceutically acceptable salt or solvate thereof. Also provided by the invention are methods of use of the above compounds, and processes for the preparation thereof.
    Type: Grant
    Filed: March 15, 1995
    Date of Patent: April 20, 2004
    Assignee: Eli Lilly and Company
    Inventors: Jeffrey A. Dodge, Charles A. Frolik, Terry D. Lindstrom, Charles W. Lugar, III
  • Process for the epoxidation of olefins
    Patent number: 6720436
    Abstract: A process for the catalytic epoxidation of olefins in at least one reaction stage comprising: (a) reacting the olefin with hydrogen peroxide in an organic, water-miscible solvent in the presence of a titanium silicalite catalyst in a reactor while continuously feeding an inert gas stream into the reactor, (b) continuously removing an exit gas stream containing olefin oxide, unreacted olefin, oxygen and inert gas from the reactor, (c) bringing the exit gas stream into contact in an absorption unit with the same solvent as used in the reaction stage, (d) removing a solvent stream loaded with olefin and olefin oxide from the absorption unit and (e) discharging an gas stream containing oxygen and the inert gas from the absorption unit.
    Type: Grant
    Filed: March 7, 2003
    Date of Patent: April 13, 2004
    Assignees: Degussa AG, Uhde GmbH
    Inventors: Willi Hofen, Georg Thiele, Thomas Haas, Wolfgang Wöll, Percy Kampeis, Bärbel Kolbe
  • Oxirane production method
    Patent number: 6720435
    Abstract: Process for manufacturing an oxirane in a reactor containing a liquid reaction medium, according to which an olefin is reacted, in a liquid reaction medium, with a peroxide compound in the presence of a solvent and in the presence of a solid catalyst which is used in the form of particles, at least some of which are in fluidized form in the reactor.
    Type: Grant
    Filed: December 27, 2002
    Date of Patent: April 13, 2004
    Assignee: Solvay
    Inventors: Dominique Balthasart, Michel Strebelle, Jean-Pierre Catinat
  • Process for operating the epoxidation of ethylene
    Patent number: 6717001
    Abstract: A process for the vapor phase oxidation of ethylene to ethylene oxide, which process involves reacting a reaction mixture having ethylene and oxygen in the presence of a supported highly selective silver-based catalyst by: operating at an initial operation phase wherein fresh catalyst is used, and operating at a further operation phase when a cumulative ethylene oxide production exceeds 0.01 kT ethylene oxide per m3 of catalyst, wherein in said further operation phase the concentration of ethylene in the reaction mixture is increased; and a method of using ethylene oxide into the 1.2-ethanediol or the 1,2-ethanediol ether wherein the ethylene oxide has been obtained by the process for the production of ethylene oxide.
    Type: Grant
    Filed: December 6, 2002
    Date of Patent: April 6, 2004
    Assignee: Shell Oil Company
    Inventors: Wayne Errol Evans, Peter Ingraham Chipman
  • Total synthesis of antitumor acylfulvenes
    Patent number: 6717017
    Abstract: The present invention provides a method of synthesizing compounds of formula (I) or (II): wherein R1 is hydrogen, R′ is (C1-C4)alkyl and X is a hydroxyl protecting group.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: April 6, 2004
    Assignee: The Regents of the University of California
    Inventor: Trevor C. McMorris
  • Tetraphosphonate bicyclic trisanhydrides
    Patent number: 6713623
    Abstract: Disclosed are novel bicyclic tris(anhydride)s useful as intermediates in the synthesis of biologically active compounds, and the compounds which may be synthesized from such intermediates.
    Type: Grant
    Filed: November 13, 2001
    Date of Patent: March 30, 2004
    Assignee: Pharmasset, Ltd.
    Inventors: Krzysztof W. Pankiewicz, Krystyna Lesiak, Kyoichi A. Watanabe
  • Process for preparing crystalline microporous and mesoporous metal silicates, products obtainable by said process and their use
    Patent number: 6710193
    Abstract: Microporous and mesoporous metal silicates are prepared by the hydrothermal reaction of a silicon and metal source in the presence of a template. The choice of raw materials influences the purity and hence the catalytic activity of the products. A pyrogenic mixed oxide is used as the silicon and metal source. Prepared products have the composition (SiO2)1-x(AmOn)x, where A is Ti, Al, B, V or Zr and x is 0.005 to 0.1. Shaped objects of the microporous and mesoporous metal silicates are obtained directly by using a shaped object of the pyrogenic mixed oxide. The products obtained are used as oxidation catalysts.
    Type: Grant
    Filed: August 17, 2001
    Date of Patent: March 23, 2004
    Assignee: Degussa AG
    Inventors: Steffen Hasenzahl, Helmut Mangold, Eckehart Roland, Mario Scholz, Georg Thiele
  • Epoxidation process
    Patent number: 6710194
    Abstract: Propylene oxide is produced by liquid phase reaction of propylene oxygen and hydrogen in contact with a solid epoxidation catalyst at elevated temperature and pressure, the reaction conditions being regulated to provide a weight ratio of dissolved oxygen to dissolved hydrogen in the liquid reaction mixture of at least 16.
    Type: Grant
    Filed: January 23, 2003
    Date of Patent: March 23, 2004
    Assignee: ARCO Chemical Technology, L.P.
    Inventors: Robert N. Cochran, Prakash G. Balan, Mark A. Liepa, Bernard Cooker
  • 9&bgr;-hydroxytetracyclic taxanes
    Patent number: 6710191
    Abstract: Process for the preparation of a derivative or analog of baccatin III or 10-desacetyl baccatin III having a C9 substituent other than keto in which the C9 keto substituent of taxol, a taxol analog, baccatin III or 10-desacetyl baccatin III is selectively reduced to the corresponding hydroxy group.
    Type: Grant
    Filed: July 30, 2002
    Date of Patent: March 23, 2004
    Assignee: Florida State University
    Inventors: Robert A. Holton, Carmen Somoza, Yukio Suzuki, Mitsuru Shindo
  • Process for selective derivatization of taxanes
    Patent number: 6706896
    Abstract: Processes for the preparation of taxol and other taxanes through selective derivatization of the C(7) and C(10) hydroxyl groups of 10-DAB, particularly a novel process using a new strategy in which the C(10) hydroxyl group is protected or derivatized prior to the C(7) hydroxyl group; and the provision of C(7) and C(10) derivatized 10-DAB compounds.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: March 16, 2004
    Assignee: Florida State University
    Inventors: Robert A. Holton, Zhuming Zhang, Paul A. Clarke
  • Process for preparing organic hydroperoxide containing product
    Patent number: 6700005
    Abstract: Process for preparing alkylaryl hydroperoxide containing product, which process comprises: (a) oxidation of an alkylaryl compound to obtain reaction product containing alkylaryl hydroperoxide, (b) contacting with water at least part of the alkylaryl hydroperoxide containing reaction product obtained in step (a) which reaction product contains less than 0.05% wt of sodium, (c) separating the product of step (b) into a hydrocarbonaceous phase containing alkylaryl hydroperoxide and an aqueous phase, (d) optionally repeating process steps (b) and (c) one or more times, (e) contacting at least part of the hydrocarbonaceous phase containing alkylaryl hydroperoxide obtained in step (c) or (d) with olefin and catalyst to obtain alkylaryl hydroxide and oxirane compound, and (f) separating at least part of the oxirane compound from the alkylaryl hydroxide.
    Type: Grant
    Filed: February 6, 2003
    Date of Patent: March 2, 2004
    Assignee: Shell Oil Company
    Inventors: Antoon Paul Michael Kremers, Eduardus Petrus Simon Schouten, Cornelis Willem Adriaan Schram
  • Hydrolytic kinetic resolution of epoxides
    Patent number: 6693206
    Abstract: The present invention provides a process for the preparation of an enantiomerically enriched non-racemic chiral diol and an enantiomerically enriched non-racemic chiral epoxy compound by a hydrolytic kinetic resolution reaction. The process includes the step of contacting oxygen and mixture including a racemic chiral epoxy compound, a non-racemic Co(II) complex catalyst, an aromatic carboxylic acid and water, at a temperature and length of time sufficient to produce a mixture of said non-racemic chiral diol and said non-racemic chiral epoxy compound. The present invention also provides a process for the preparation of an enantiomerically enriched non-racemic chiral diol and an enantiomerically enriched non-racemic chiral epoxy compound by a hydrolytic kinetic resolution reaction.
    Type: Grant
    Filed: August 22, 2002
    Date of Patent: February 17, 2004
    Assignee: Rhodia Chirex, Inc.
    Inventors: Yi Liu, Marcello DiMare, Salvatore Anthony Marchese, Eric N. Jacobsen, Serge Jasmin
  • Method for purification of cyclic ester
    Patent number: 6693204
    Abstract: A method of refining a crystal of a crude cyclic ester comprises the steps of supplying the crude cyclic ester to a vertically extending cylindrical refiner (1) from an inlet (3) provided at a lower part of the refiner (1), agitating the crude cyclic ester by an agitator provided in the refiner (1) to make the crude cyclic ester flow upwardly, refining the crystals of the crude cyclic ester by counterflow-contact between the upflowing crude cyclic ester and a downflowing melted liquid containing a refined crystal component, and taking out refined crystals of the crude cyclic ester from an outlet (4) provided at an upper part of the refiner (1).
    Type: Grant
    Filed: September 30, 2002
    Date of Patent: February 17, 2004
    Assignee: Kureha Kagaku Kogyo K.K.
    Inventors: Tetsuo Ejiri, Kazuyuki Yamane, Kentaro Otawara
  • Process for preparing piperonal
    Patent number: 6686482
    Abstract: The present invention is to provide a process for producing piperonal which comprises continuous three steps of: (A) an addition reaction step wherein 1,2-methylenedioxybenzene and glyoxylic acid are reacted to form 3,4-methylenedioxymandelic acid in the presence of a strong acid, (B) an extraction step wherein an organic solvent is then added to a reaction mixture and the mixture is neutralized with a base to extract 3,4-methylenedioxymandelic acid in an organic solvent layer, and separating the organic solvent layer and an aqueous layer, and (C) an oxidation reaction step wherein the aqueous layer is removed and the organic solvent layer is concentrated, and then, nitric acid is added to a concentrate, and the 3,4-methylenedioxymandelic acid and nitric acid are reacted to form piperonal.
    Type: Grant
    Filed: July 30, 2002
    Date of Patent: February 3, 2004
    Assignee: Ube Industries, Ltd.
    Inventors: Katsumasa Harada, Masashi Shirai, Koji Shiba, Toshio Furuya
  • Catalytic asymmetric epoxidation
    Patent number: 6686483
    Abstract: The present invention provides a variety of methods that are based on stereoselective epoxidation of an olefin by an epoxidizing agent derived from a reaction between an oxidizing agent and a chiral ketone. For example, present invention provides methods for producing an epoxide from an olefin, for increasing a relative concentration of at least one stereoisomer of an olefin, and for stereoselectively producing an &agr;-acyloxy carbonyl compound. Preferably, the chiral ketone is of the formula: or a derivative thereof which is capable of converting to the chiral ketone of Formula I under the reaction conditions, where a, b, n, X, R1, R2, R3, R4, R5 and R6 are those defined herein.
    Type: Grant
    Filed: January 7, 2002
    Date of Patent: February 3, 2004
    Assignee: Colorado State University Research Foundation
    Inventor: Yian Shi
  • Condensation derivatives of thiocolchicine and baccatin as antitumor agents
    Patent number: 6683109
    Abstract: N-deacetyl-thiocolchicine and 10-deacetyl-baccatin III derivatives of formula (I) wherein R and n have the meanings specified in the disclosure, are valuable antitumoral drugs.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: January 27, 2004
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Alessandro Pontiroli
  • Process for the preparation of metal alkoxides
    Patent number: 6683196
    Abstract: A process for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted isoserine esters in which a metal alkoxide is reacted with a &bgr;-lactam.
    Type: Grant
    Filed: November 6, 2002
    Date of Patent: January 27, 2004
    Assignee: Florida State University
    Inventor: Robert A. Holton