Abstract: A process is described for the preparation of mono (2-ammonium-2-hydroxymethyl-1,3-propanediol) (2R,cis)-1,2-epoxypropyl-phosphonate with improved characteristics of stability, of processing for the preparation of pharmaceutical forms and of stability of the pharmaceutical forms that contain it.

Abstract: Antiviral new peptides of the formula ##STR1## in which R.sup.3 denotes straight-chain or branched alkyl having up to 8 carbon atoms ordenotes aryl having 6 to 10 carbon atoms or tolyl, andR.sup.4 denotes straight-chain or branched alkyl having up to 8 carbon atoms,and physiologically acceptable salts thereof.

Abstract: The invention provides a process for the preparation of 5,6-dihydro-2H-pyran derivatives, wherein an aldehyde of formula I: ##STR1## wherein R.sub.1 represents an alkyl, cycloalkyl, aralkyl, alkaryl or aryl group having at most 15 carbon atoms and a diene of formula II: ##STR2## wherein R.sub.2 and R.sub.3 represents a hydrogen atom or an alkyl group having 1-6 carbon atoms are reacted in a Diels-Alder-type reaction under the influence of an inorganic Lewis acid catalyst, producing a compound of formula III wherein R.sub.1 -R.sub.3 have the meaning given above. ##STR3## Preferably R.sub.1 represents a 1-6 carbon atom alkyl group, a phenyl group or an o-, m- or p-tolyl group. Isoprene or 2-methyl-1,3-pentadiene is preferably used as the diene. The preferred catalyst is AlCl.sub.3 or SnCl.sub.4 and an organic nitro compound may be used as the co-catalyst.

Abstract: Derivatives of pravastatin are provided which are useful in inhibiting cholesterol biosynthesis and in preparing radiolabeled compounds useful in the radioimmunoassay (RIA) of pravastatin and derivatives thereof. The pravastatin derivatives have the structure ##STR1## wherein R is hydroxy, lower alkylamine, arylamine, arylalkylamine or heterocyclic alkylamine such as histamine, tyramine, O-benzyltyramine, methyl tyrosinate as well as iodinated derivatives thereof.

Abstract: The compound of the formula: ##STR1## in which X, Y and Z are, independently, hydrogen, halogen, hydroxy, nitro, cyano, carboxyl, trifluoromethyl, phenyl, amino, alkylamino, dialkylamino, alkyl or alkoxy; R.sub.1 is alkyl, hydroxyalkyl, alkenyl, cycloalkyl, phenyl, benzyl, phenylethyl or substituted phenyl, benzyl or phenylethyl, alkoxy, halogen, cyano, trifluoromethyl, amino, alkylamino, dialkylamino, nitro, phenyl, benzyl or phenethyl or R.sub.1 is thienyl, imidazolyl, thiazolyl, pyridinyl, pyrimidinyl, pyrazinyl or benzamidazolyl; R.sub.2 is hydrogen, alkyl, cycloalkyl, phenyl, benzyl or substituted phenyl or benzyl, alkoxy, hologen, cyano, trifluoromethyl amino, nitro, alkylamino or dialkylamino; or a pharmaceutically acceptable salt thereof, are useful as ACAT inhibitors.

Abstract: The invention relates to new thio-alkanones of the formula ##STR1## in which X represents an oxygen or sulphur atom,R.sub.1 represents hydrogen or a C.sub.1 -C.sub.2 -alkyl group and the broken lines represent a single bond or no bond,to a process for their preparation and their use as flavorings.

Abstract: The present invention provides compounds which upon thermolyis, hydrolysis or both, release an odorant molecule. They find utility, for example, in tobacco, in tobacco paper, and as additives to food, beverages or gum. These compounds are dicarboalkoxy dioxolane derivatives having the following formula: ##STR1## wherein R.sup.1 and R.sup.2 are, independently, --CO.sub.2 R.sup.3 wherein R.sup.3 is --H.sub.3 or lower alkyl, provided that in at least one of R.sup.1 and R.sup.2, R.sub.4 is lower alkyl; wherein Z is a direct bond, or --CH.dbd.C(R.sup.4)--; where R.sup.4 is an alkyl group; and Y is, when Z is a direct bond, ##STR2## where R.sup.5 is lower alkyl; and Y, when Z is --CH.dbd.C(R.sup.4)--, ##STR3## where R.sup.6 is H, lower alkyl or OR.sup.7, where R.sup.7 is H or lower alkyl.

Abstract: A new carbazate represented by the formula ##STR1## is found to be antifungal and especially useful in the treatment of mycotic infections caused by the Cryptococcus species.

Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein the dotted lines represent a possible endo or exo double bond, R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, alkenyl and alkynyl of 2 to 8 carbon atoms, aryl of 6 to 14 carbon atoms, aralkyl of 7 to 18 carbon atoms and ##STR2## R'.sub.2 is alkyl of 1 to 8 carbon atoms or aryl of 6 to 14 carbon atoms, X is --O-- or --NR--, R is selected from the group consisting of --OH, hydrogen, ##STR3## and --COOR', R' is hydrogen or alkyl of 1 to 8 carbon atoms, Y is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms and alkenyl and alkynyl of 2 to 8 carbon atoms, all optionally substituted with at least one halogen or --OH, with the proviso that if Y is --OH, X is not --NH-- and their non-toxic, pharmaceutically acceptable addition salts of acids or bases having antibacterial and immunological properties.

Abstract: An isochromane derivative having the general formula I ##STR1## in which each of R.sub.1, R.sub.2, and R.sub.3 is one to four substituents independently selected from hydrogen, hydroxy, alkyl (1-4 C), alkoxy (1-4 C), halogen, or CF.sub.3, or represents a methylenedioxy group;R.sub.4 is selected from hydrogen or alkyl (1-4 C);Alk is an alkylene group with 1-4 carbon atoms;Alk' is an alkylene group with 2-4 carbon atoms, when R.sub.5 is selected from hydrogen or alkyl (1-4 C) and X is O or S; orAlk' is an alkylene group with 1-4 carbon atoms or a bond, when R.sub.5 is an alkyl (1-4 C) group and X is CH.sub.2 or a bond;or a pharmaceutically acceptable salt thereof.

Abstract: A 21-carbon aliphatic branched chain dicarboxylic acid and a 21-carbon lactone are produced by reacting fatty acid (which contains linoleic acid) with acrylic acid via iodine catalysis, and subsequently removing from the low monomer reaction product the resulting C-21 lactone via solvent extraction with acetonitrile and hexane or heptane. The reaction products are distilled to yield dicarboxylic acid and lactone of high purity.

Abstract: A process for producing high purity .alpha.-zeranol from a zeralenone containing surface fermentation product is described. One feature of the process entails fractional crystallization from an aqueous acetonitrile solvent of high purity .alpha.-zeranol from a solution containing a mixture of 50 to 60 parts by weight .alpha.-zeranol and 40 to 50 parts by weight .beta.-zeranol.

Abstract: Combatting fungi and bacteria with aminomethylheterocyclic compounds of the formula ##STR1## in which R.sup.1 represents hydrogen, alkyl, alkenyl, in each case optionally substituted tetrahydronaphthyl, decahydronaphthyl, cycloalkyl or cycloalkenyl, furthermore alkyl which is substituted by cycloalkyl, cycloalkenyl, cycloalkyloxy or cycloalkylthio, where the cyclic radicals may optionally be substituted, furthermore optionally substituted aryl, in addition alkyl which is substituted by aryl, aryloxy, arylthio, arylsulphinyl or arylsulphonyl, or alkenyl which is substituted by aryl, where the aryl radicals may in each case optionally be substituted;R.sup.2 represents hydrogen or methyl,R.sup.

Abstract: A 13 or 14 member macrocyclic compound having the following ring nucleus: ##STR1## wherein: n=0 or 1;m=0 or 1;n+m>0;X.sub.1, X.sub.2, Z.sub.1 and Z.sub.2 independently represent H.sub.2 or O;Y.sub.1, Y.sub.2, Y.sub.3 and Y.sub.4 independently represent H, lower alkyl or CH.sub.2 COOH;L.sub.1 and L.sub.2 independently represent side chains of alpha amino acids, except that L.sub.1 and L.sub.2 do not both represent H; andR.sub.1 and R.sub.2 independently represent H or OH forms stable complexes with transition metal ions that may be used as catalysts for oxidizing alkenes to epoxides with oxidizing agents.

Abstract: A process for oxidizing fluorinated olefins to the corresponding epoxides by reacting a fluoroolefin with oxygen in a concentration, in the reaction mixture, ranging from 1 to 60% by volume, at a temperature up to 250.degree. C. and in the presence of a catalyst consisting of porous silicon dioxide in a crystalline form, with a high purity degree and carrying metal oxides of the first transition series, or copper oxides or lanthanide oxides or mixtures thereof.

Abstract: A process for producing gamma-butyrolactone by catalytic hydrogenation of maleic anyhydride in the liquid phase with hydrogen, at a high temperature and under pressure, in the presence of a catalyst comprising nickel and palladium deposited on a support, wherein said support is a silica based support having a very high specific surface area , the value of which may range from 50 m.sup.2 /g, preferably from about 100 m.sup.2 /g to about 800 m.sup.2 /g and more.Very high conversion rates of 90-98 mole % and excellent selectivities to gamma-butyrolactone of 95 to 97 mole % are achieved by the process.

Abstract: Disclosed is a novel process for the preparation of epoxyalkanes and epoxycycloalkanes which comprises hydrogenating .gamma.,.delta.-epoxyalkenes or .gamma.,.delta.-epoxycycloalkenes in the presence of a rhodium catalyst. The process is especially useful for the preparation of 1,2-epoxybutane from 3,4-epoxy-1-butene.

Abstract: New amino acid esters, a process for their preparation, medicaments containing them, and the use thereof The invention relates to amino acid esters of the formula I ##STR1## in which n is 1 or 2, R, R.sup.1, R.sup.2 and R.sup.3 denote hydrogen or a defined radical, R.sup.4 together with R.sup.5 and the atoms carrying them form a heterocyclic ring system, to a process for their preparation, to agents containing them, and to the use thereof.

Abstract: New furanone compounds have anti-inflammatory, immunosuppresive and anti-proliferative activity and are useful in treating psoriasis and modifying calcium homeostasis. A compound of the invention is 4-[3,6-dihydro-6-hydroxy-5-(3-phenylpropyl)-2H-pyran-2-yl]-5-hydroxy-2-(5H )-furanone.

Abstract: A process for preparing alpha-(alkylphenyl)-4-(hydroxy diphenylmethyl)-1-piperidine butanols of formula (I) ##STR1## in which R is a C.sub.1 -C.sub.5 alkyl, by reacting an isonipecotate of formula (II): ##STR2## in which R' is a C.sub.1 -C.sub.5 alkyl or benzyl, with 1-(alkylphenyl)-4-chlorobutanol to obtain the compound (IV) directly ##STR3## and reacting (IV) with phenylmagnesium halide (V) to obtain (I).