Abstract: A gas-assisted continuous process for the rapid conversion of oligomers of alpha-hydroxycarboxylic acids, esters or salts thereof to cyclic esters in high yields and high states of purity.
Abstract: Described is a process for the preparation of compositions of matter containing unsaturated lactones defined according to the generic structure: ##STR1## wherein R represents C.sub.6 alkyl or alkenyl; and X represents C.sub.2, C.sub.4 or C.sub.6 alkylene or alkenylene; with the provisos that R is C.sub.6 alkyl when X is alkenylene and R is C.sub.6 alkenyl when X is alkylene by means of the sequential steps of (i) fermentation of castor oil or ricinoleic acid using a microorganism selected from the group consisting of:Candida petrophilum, ATCC 20226;Candida oleophila, ATCC 20177;Candida sp., ATCC 20504; andCandida sake, ATCC 28137whereby gamma hydroxydecanoic acid and a mixture of other acids defined according to the generic structure: ##STR2## is formed wherein Y represents an oxo-saturated, oxo-unsaturated or di-unsaturated C.sub.9, C.sub.11 or C.sub.
Type:
Grant
Filed:
June 29, 1990
Date of Patent:
June 11, 1991
Assignee:
International Flavors & Fragrances Inc.
Inventors:
Mohamad I. Farbood, James A. Morris, Mark A. Sprecker, Lynda J. Bienkowski, Kevin P. Miller, Manfred H. Vock, Myrna L. Hagedorn
Abstract: Disclosed are .alpha.-(.omega.-Cyanoalkanoyl)-.gamma.-butyrolactone represented by the formula: ##STR1## wherein n represents an integer of 7 to 11, and a method for producing the same, which comprises reacting .omega.-cyano fatty acid ester represented by the formula:NC--(CH.sub.2).sub.n --COOR (II)wherein R represents an alkyl group having 1 to 4 carbon atoms and n has the same meaning as in the above, with .gamma.-butyrolactone in the presence of alkali metal alcoholate represented by the formula:R'OM (III)wherein R' represents an alkyl group having 1 to 4 carbon atoms and M represents an alkali metal.
Abstract: A method for producing a lactone by hydrogenating a dicarboxylic acid, a dicarboxylic acid anhydride and/or a dicarboxylic acid ester in the presence of a catalyst, wherein said catalyst is a ruthenium catalyst comprising (1) ruthenium, (2) an organic phosphine and (3) a conjugate base of an acid having a pKa of less than 2.
Abstract: The present invention relates to novel derivatives of LL-F28249 compounds wherein the 23-hydroxy group is eliminated to introduce a double bond at the 23,24 position. These resulting derivatives are .DELTA..sup.23 -LL-F28249 compounds. These LL-F28249 precursor compounds preferably are derived via a controlled microbiological fermentation of Streptomyces cyaneogriseus subsp. noncyanogenus having deposit accession number NRRL 15773. The novel derivatives of the present invention possess activity as anthelmintic, ectoparasitic, insecticidal, acaricidal and nematicidal agents. They also are useful in areas of human and animal health and in agricultural crops.
Abstract: Novel (6,11-dihydro-11-oxodibenz[b,e]oxepinyl)pentanoic acids and derivatives thereof, intermediates and processes for the preparation thereof, and methods for suppressing arthritis-like inflammation utilizing compounds or compositions thereof are disclosed.
Abstract: .beta.-Lactones are synthesized from a thiol ester and a ketone by a method which efficiently produces .beta.-lactones in high yields. The method involves combining the thiol ester, a ketone or aldehyde, a base, and an organic solvent at subambient temperatures. The thiol ester and ketone form an adduct, which upon warming, spontaneously cyclizes to yield a .beta.-lactone. .beta.-Lactones formed by this method are then decarboxylated, generally by warming in the presence of an adsorbent in an organic solvent, to stereospecifically form the corresponding alkenes.
Abstract: Fungicidal hydroxyalkyl-triazdyl derivatives of the formula ##STR1## in which R represents a radical of the formula --CH.sub.2 --CH(CH.sub.3).sub.2, --(CH.sub.2).sub.4 --CH.sub.3, --(CH.sub.2).sub.5 --CH.sub.3, --(CH.sub.2).sub.6 --CH.sub.3, ##STR2## Z represents halogen, alkyl with 1 to 4 carbon atoms, halogenoalkyl with 1 or 2 carbon atoms and 1 to 5 halogen atoms, halogenoalkoxy with 1 or 2 carbon atoms and 1 to 5 halogen atoms, halogenoalkylthio with 1 or 2 carbon atoms and 1 to 5 halogen atoms, phenyl or alkoximinimethyl with 1 to 4 carbon atoms in the alkoxy group andm represents the numbers 0, 1, 2 or 3,and addition products thereof with acids and metal salts. Intermediates of the formulas ##STR3## are also new.
Type:
Grant
Filed:
August 17, 1989
Date of Patent:
March 12, 1991
Assignee:
Bayer Aktiengesellschaft
Inventors:
Graham Holmwood, Udo Kraatz, Karl H. Buchel, Wilhelm Brandes, Stefan Dutzmann, Paul Reinecke
Abstract: A process for the manufacture of 6-aliphatic C.sub.2-20 -carboxylic acid esters of ascorbic acid by esterifying the ascorbic acid with an aliphatic C.sub.2-20 -carboxylic acid halide in the presence of a N,N-dialkyl-alkanecarboxylic acid amide, of a cyclic amide of the 1-methyl-2-pyrrolidone type, of a tetraalkylcarbamide such as tetramethylurea, of a cyclic carbamide of the 1,3-dimethyl-2-imidazolidinone type or of a phosphoric acid triamide of the hexamethylphosphoric acid triamide type. The 6-ascorbyl linolate which can be manufactured in this manner is novel and is likewise an object of the present invention. The thus-manufacturable 6-aliphatic C.sub.2-20 -carboxylic acid esters of ascorbic acid are important alternative application forms of L-ascorbic acid (vitamin C).
Abstract: A novel method for preparing an epoxy compound is disclosed which comprises the step of reacting an olefin compound having 4 to 16 carbon atoms with an organic hydroperoxide in an inactive solvent in the presence of a molybdenum compound and at least one metal halide selected from the group consisting of halides of alkali metals and alkaline earth metals, in order to form the corresponding epoxy compound. Typical examples of the aforesaid metal halide include sodium chloride, potassium iodide, sodium bromide and barium chloride. According to the present invention, the epoxy compound having 4 to 16 carbon atoms can be prepared in an extremely high yield.
Abstract: A series of novel polypeptide derivatives, containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues, which are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin. Particularly valuable precursors for many of these compounds are certain other 5-amino-2,5-disubstituted-4-hydroxypentanoic acid derivatives.
Type:
Grant
Filed:
March 22, 1990
Date of Patent:
February 12, 1991
Assignee:
Pfizer Inc.
Inventors:
Edward F. Kleinman, Robert L. Rosati, Jasjit S. Bindra
Abstract: Tertiary butyl hydroperoxide and tertiary butyl alcohol are recovered from the reaction product formed by reacting excess propylene with tertiary butyl hydroperoxide in solution in tertiary butyl alcohol in the presence of a soluble molybdenum catalyst, by fractionating the reaction produce to provide distillate propylene, propylene oxide, and tertiary butyl alcohol fractions and a heavy distillation fraction comprising tertiary butyl hydroperoxide, tertiary butyl alcohol and impurities, including dissolved molybdenum catalyst, the tertiary butyl hydroperoxide and tertiary butyl alcohol being recovered from the heavy distillation fraction by vacuum evaporation under evaporation conditions including a temperature of about 25.degree. to about 160.degree. C. and a pressure of about 2 to about 200 mm Hg. in order to provide a lighter condensate fraction comprising about 60 to about 95 wt. % of the heavy distillation fraction and containing from about 70 to about 95 wt.
Type:
Grant
Filed:
August 31, 1989
Date of Patent:
February 12, 1991
Assignee:
Texaco Chemical Company
Inventors:
Edward T. Marquis, Kenneth P. Keating, John R. Sanderson, Robert A. Meyer
Abstract: Present invention relates to the production of propylene oxide by reaction of propylene with a C.sub.4 or higher hydroperoxide wherein at least a portion of the propylene is derived from the hydroperoxide moiety.
Type:
Grant
Filed:
July 28, 1989
Date of Patent:
January 29, 1991
Assignee:
Arco Chemical Technology, Inc.
Inventors:
Morris Gelb, David W. Leyshon, John A. Sofranko, C. Andrew Jones
Abstract: Fermentation of a nutrient medium by a Hypomycetes fungus of the genus Memnoniella or Stachybotrys yields a product with a major component of structural formula I: ##STR1## which is an inositol monophosphate phosphatase inhibitor and thereby useful in the treatment of manic depression.
Type:
Grant
Filed:
September 14, 1989
Date of Patent:
January 1, 1991
Assignee:
Merck & Co., Inc.
Inventors:
Robert A. Giocobbe, Leeyuan Huang, Yu L. Kong, Yiu-Kuen T. Lam, Sagrario M. Del Val, Carol F. Wichmann, Deborah L. Zink
Abstract: Tetrahydropyridones which in one of their tautomeric forms conform to the general formula (I) ##STR1## where R.sup.1 and R.sup.2 are each independently of the other C.sub.1 -C.sub.12 -alkyl, which may be oxygen-interrupted, C.sub.5 -C.sub.6 -cycloalkyl or C.sub.7 -C.sub.12 -phenylalkyl where the phenyl is unsubstituted or monosubstituted, disubstituted or trisubstitued by C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, fluorine, chlorine or bromine, or ##STR2## is a from 5- to 12-membered cycloaliphatic ring which may be monosubstituted, disubstituted, trisubstituted or tetrasubstituted by C.sub.1 -C.sub.4 -alkyl, andR.sup.3 is hydrogen, substituted or unsubstituted alkyl or phenyl alkyl or alkanoyl, are effective stabilizers for plastics and coatings.
Type:
Grant
Filed:
November 30, 1989
Date of Patent:
January 1, 1991
Assignee:
BASF Aktiengesellschaft
Inventors:
Alexander Aumueller, Peter Neumann, Hubert Trauth
Abstract: Compound of the formula (I) ##STR1## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each alkyl or R.sup.1 and R.sup.2 or R.sup.3 and R.sup.4 are together tetra- or pentamethylene and R.sup.5 is hydrogen, alkanoyl, alkyl, cyanoalkyl, hydroxyalkyl, aminoalkyl or phenylalkyl, in which the phenyl nucleus may be substituted by C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy or halogen, and the acid addition salts and hydrates of these compounds are useful stabilizers for organic materials, in particular plastics.
Type:
Grant
Filed:
November 20, 1989
Date of Patent:
December 25, 1990
Assignee:
BASF Aktiengesellschaft
Inventors:
Alexander Aumueller, Peter Neumann, Hubert Trauth
Abstract: The present invention relates to conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule chosen from antibodies, fragments of antibodies, proteins such as peptide hormones or human proteins, and peptide ligands. It also relates to the activated ionophores.These conjugates are suitable as immunotoxin potentiators.
Abstract: A method for the catalytic epoxidation of olefins with hydrogen peroxide in the presence of rhenium-oxo-complexes or of a binuclear compound of the type .mu.-oxobis [porphyrinato-oxo-rhenium(V)] with octaethyl porphyrin or 5,10,15,20-tetraphenyl porphyrin or 5,10,15,20-tetra(4-pyridyl)-porphyrin as ligands.
Type:
Grant
Filed:
September 21, 1988
Date of Patent:
November 27, 1990
Assignee:
Degussa Aktiengesellschaft
Inventors:
Johann Buchler, Manfred Schmidt, Guenter Prescher
Abstract: The present invention provides a process for preparing lactone intermediates to 2',2'-difluoronucleosides whereby reversion back to the lactone's open chain precursor is minimized and the desired erythro enantiomer can be selectively isolated from an enantiomeric mixture of erythro and threo lactones in crystalline form. Also provided is a process for producing 2'-deoxy-2',2'-difluoronucleosides in about a 1:1 .alpha./.beta. anomeric ratio, and processes for selectively isolating .beta.-2'-deoxy-2',2'-difluorocytidine, or an organic or inorganic acid addition salt thereof, from the 1:1 .alpha./.beta. mixture.
Type:
Grant
Filed:
December 4, 1989
Date of Patent:
October 23, 1990
Assignee:
Eli Lilly and Company
Inventors:
Ta-Sen Chou, Perry C. Heath, Lawrence E. Patterson
Abstract: Novel N-(3-hydroxy-4-piperidinyl)benzamides and derivatives thereof, said compounds being useful as stimulators of the motility of the gastro-intestinal system.