Abstract: A practical, selective process for preparing oxetanes is disclosed. A 1,3-glycol monosulfate salt is prepared by sulfation and neutralization of the corresponding 1,3-glycol. The neutral monosulfate salt is then reacted with a strong base, resulting in efficient ring closure to the oxetane.
Type:
Grant
Filed:
August 6, 1990
Date of Patent:
January 14, 1992
Assignee:
Arco Chemical Technology, Inc.
Inventors:
Roger A. Grey, Lawrence J. Karas, H. Dean Moore, Jr.
Abstract: The present invention relates to the epoxidation of olefinic compounds by reaction with an organic hydroperoxide in the presence of a solid, heterogeneous catalyst comprised of molybdenum oxide finely dispersed in silica or of both molybdenum oxide and titanium oxide finely dispersed in silica.
Abstract: Disclosed is a novel process for the preparation of epoxyalkanes and epoxycycloalkanes which comprises hydrogenating .gamma.,.delta.-epoxyalkenes or .gamma.,.delta.-epoxycycloalkenes in the presence of a rhodium catalyst. The process is especially useful for the preparation of 1,2-epoxybutane from 3,4-epoxy-1-butene.
Abstract: Esters of the general formula I ##STR1## where A is hydrogen, alkyl, cycloalkyl, cycloalkenyl, naphthyl, biphenyl, hetaryl or phenyl, these radicals being substituted or unsubstituted, and X is CH or N, and fungicides containing these esters.
Abstract: An antibiotic compound of the formula: ##STR1## is an antiparasitic agent active against insect pests, acari, free living nematodes and endo- and ectoparasites. It is prepared by fermentation using the microorganism Streptomyces griseochromogenes ATCC 53928.
Type:
Grant
Filed:
July 25, 1990
Date of Patent:
December 17, 1991
Assignee:
Pfizer Inc.
Inventors:
Yasuhiro Kojima, Hiroshi Maeda, Satoshi Nishiyama, David A. Perry
Abstract: Compounds of the formula ##STR1## wherein: R.sub.1 is cyano or nitro;R.sub.2 and R.sub.3 are independently hydrogen or lower alkyl; andR.sub.4 is alkyl; alkenyl; optionally substituted phenyl or phenyl lower alkyl; --(CH.sub.2).sub.m OR.sub.2 or --(CH.sub.2).sub.m N(R.sub.2).sub.2 ; wherein m is an integer of 1-5 and R.sub.2 is as defined above;or a pharmaceutically acceptable ester thereof; are smooth muscle relaxants, particularly useful in the treatment of hypertension.
Abstract: The invention relates to an improved process for producing alkenylated aromatic amines which involves the catalytic reaction of an aromatic amine with a diene. The improvement resides in using a solvent in which the aromatic amine and diene are soluble in the proportions present in the reaction but inert to the reaction.
Type:
Grant
Filed:
December 21, 1987
Date of Patent:
December 10, 1991
Assignee:
Air Products and Chemicals, Inc.
Inventors:
William F. Burgoyne, Jr., Dale D. Dixon
Abstract: A process for preparing an optically active alcohol is disclosed, which comprises asymmetrically hydrogenating a carbonyl compound in the presence of a ruthenium-optically active phosphine complex as a catalyst. The resulting alcohol has high optical purity.
Abstract: Compound of formulae (I) and (II) are HMG-CoA synthase inhibitors and exhibit antifungal activity.
Type:
Grant
Filed:
July 31, 1989
Date of Patent:
November 12, 1991
Assignee:
Merck & Co., Inc.
Inventors:
George M. Garrity, Robert Giacobbe, Michael D. Greenspan, Otto D. Hensens, Henry Joshua, Maria T. D. Matas, Isabel Martin, James A. Milligan, Sagrario M. del Val, Walter Rozdilsky, Janet C. Onishi, Jerrold M. Liesch
Abstract: Perfluoropolyethers having fluorinated epoxy groups positioned along their perfluoropolyether chain, and free from peroxidic oxygen, are obtained using a low-temperture oxidation process, in the liquid phase, with molecular oxygen and in the presence of U.V. light, of a mixture of a perfluorinated monoolefin and a perfluorinated conjugated diene, and of the subsequent photochemical decomposition of the peroxy groups contained in the photoxidation product, carried out by treating the peroxy-groups-containing product with U.V. light at a temperature within the range of from 0.degree. C. to 160.degree. C. Derivatives of said epoxy containing perfluoropolyethers in which the epoxy groups have been turned into functional groups.
Type:
Grant
Filed:
July 30, 1990
Date of Patent:
October 22, 1991
Assignee:
Ausimont S.p.A.
Inventors:
Giuseppe Marchionni, Ugo De Patto, Ezio Strepparola, Gian Tommaso Viola
Abstract: A fluorogenic substrate for tryptophanase useful for identifying an unknown microorganism is a fluorescent dye linked to an amino acid by a carbamate or thiocarbamate group. In preferred substrates, the dye is fluorescein or 7-amino-4-methyl coumarin and the amino acid linked thereto is cysteine, threonine or serine.
Abstract: A process for producing a lactone by reacting in a hydrogenation reaction zone a dicarboxylic acid, a dicarboxylic acid anhydride and/or a dicarboxylic acid ester with hydrogen in a liquid phase using a solvent in the presence of a catalyst comprising ruthenium and an organic phosphine, which process comprises the following steps (1) to (6):(1) a first step of recovering the liquid phase from the hydrogenation reaction zone,(2) a second step of distilling the liquid phase in a first distillation column to obtain a first distillate and a first residue,(3) a third step of recycling the first residue to the hydrogenation reaction zone,(4) a fourth step of distilling a part of the first residue in a second distillation column to obtain a second distillate and a second residue,(5) a fifth step of recycling the second distillate to the hydrogenation reaction zone or the first distillation column, and(6) a sixth step of recovering a lactone from the first distillate.
Abstract: A continuous, gas-assisted atmospheric process for preparing cyclic esters of alpha-hydroxycarboxylic acids, such as lactide, which comprises feeding the reactants into a reactor having means for introducing an inert gas at the operating temperature, forming a reaction mass having cyclic esters in the reactor, passing a flow of said inert gas through said reactor whereby cyclic esters are swept from the reaction mass into a gaseous product stream, and recovering the cyclic esters therefrom.
Abstract: Substituted hydroxylamines of the formula ##STR1## in which R.sup.1 stands for an aromatic or heterocyclic radical,are especially useful in the treatment of hyperlipoproteinaemia, lipoproteinaemia and atherosclerosis.
Type:
Grant
Filed:
March 8, 1990
Date of Patent:
July 16, 1991
Assignee:
Bayer Aktiengesellschaft
Inventors:
Walter Hubsch, Rolf Angerbauer, Peter Fey, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt
Abstract: This invention relates to 4-substituted-5-hydroxy-2(5H)-furanones, to the process for their preparation, to pharmaceutical compositions containing said 4-substituted-5-hydroxy-2(5H)-furanones and to the use of said 4-substituted-5-hydroxy-2(5H)-furanones for modifying the balance between bone production and bone resorption in a host animal, including man.
Type:
Grant
Filed:
February 23, 1990
Date of Patent:
June 25, 1991
Assignee:
American Home Products Corporation
Inventors:
Marshall A. Hayward, Joseph P. Sabatucci, Ivo L. Jirkovsky, Yvon Lefebvre
Abstract: Pharmaceutical compounds and compositions which may be represented by the following structural formula: ##STR1## wherein NR'" is selected from amino, (C.sub.1 -C.sub.6) alkylamino, dialkylamino or trialkylamino, pyrrolidino or piperidino. The compounds and compositions are useful in treating central cholinergic dysfunction in mammals.
Type:
Grant
Filed:
February 2, 1990
Date of Patent:
June 18, 1991
Assignee:
American Cyanamid Company
Inventors:
Eugene J. Trybulski, Herbert J. Brabander
Abstract: This invention relates to a gas-assisted vaporization process for purifying cyclic esters such as glycolide, lactides and mixtures thereof which enables the cyclic ester to be rapidly separated from its impurities as a vapor component of a gas stream. The process includes a solvent-scrubbing step for recovering the cyclic ester from the gas stream.