Patents Examined by Ba K. Trinh
  • Patent number: 5081265
    Abstract: Fungicidal dioxolanes of the formula ##STR1## in which R.sup.1 represents optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkinyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aryloxy, optionally substituted arylthio, optionally substituted arylsulphinyl, optionally substituted arylsulphonyl, optionally substituted arylalkyl, optionally substituted aryloxyalkyl, optionally substituted arylthioalkyl, optionally substituted arylsulphinylalkyl, optionally substituted arylsulphonylalkyl, optionally substituted aralkyloxyalkyl, optionally substituted aralkylthioalkyl, optionally substituted aralkylsulphinylalkyl or optionally substituted aralkylsulphonylalkyl,R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 independently of one another represent hydrogen, alkyl or cycloalkyl, orR.sup.3 and R.sup.4 together represent divalent alkanediyl and/orR.sup.5 and R.sup.
    Type: Grant
    Filed: September 14, 1990
    Date of Patent: January 14, 1992
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hans-Ludwig Elbe, Eckart Kranz, Wilhelm Brandes, Stefan Dutzmann, Gerd Hanssler
  • Patent number: 5081268
    Abstract: A practical, selective process for preparing oxetanes is disclosed. A 1,3-glycol monosulfate salt is prepared by sulfation and neutralization of the corresponding 1,3-glycol. The neutral monosulfate salt is then reacted with a strong base, resulting in efficient ring closure to the oxetane.
    Type: Grant
    Filed: August 6, 1990
    Date of Patent: January 14, 1992
    Assignee: Arco Chemical Technology, Inc.
    Inventors: Roger A. Grey, Lawrence J. Karas, H. Dean Moore, Jr.
  • Patent number: 5081267
    Abstract: The present invention relates to the epoxidation of olefinic compounds by reaction with an organic hydroperoxide in the presence of a solid, heterogeneous catalyst comprised of molybdenum oxide finely dispersed in silica or of both molybdenum oxide and titanium oxide finely dispersed in silica.
    Type: Grant
    Filed: September 13, 1990
    Date of Patent: January 14, 1992
    Assignee: Arco Chemical Technology, Inc.
    Inventors: M. Rameswaran, Robert N. Cochran
  • Patent number: 5077418
    Abstract: Disclosed is a novel process for the preparation of epoxyalkanes and epoxycycloalkanes which comprises hydrogenating .gamma.,.delta.-epoxyalkenes or .gamma.,.delta.-epoxycycloalkenes in the presence of a rhodium catalyst. The process is especially useful for the preparation of 1,2-epoxybutane from 3,4-epoxy-1-butene.
    Type: Grant
    Filed: May 3, 1990
    Date of Patent: December 31, 1991
    Assignee: Eastman Kodak Company
    Inventor: Stephen N. Falling
  • Patent number: 5077303
    Abstract: Esters of the general formula I ##STR1## where A is hydrogen, alkyl, cycloalkyl, cycloalkenyl, naphthyl, biphenyl, hetaryl or phenyl, these radicals being substituted or unsubstituted, and X is CH or N, and fungicides containing these esters.
    Type: Grant
    Filed: March 22, 1990
    Date of Patent: December 31, 1991
    Assignee: BASF Aktiengesellschaft
    Inventors: Rainer Seele, Franz Schuetz, Horst Wingert, Hubert Sauter, Eberhard Ammermann, Gisela Lorenz
  • Patent number: 5073567
    Abstract: An antibiotic compound of the formula: ##STR1## is an antiparasitic agent active against insect pests, acari, free living nematodes and endo- and ectoparasites. It is prepared by fermentation using the microorganism Streptomyces griseochromogenes ATCC 53928.
    Type: Grant
    Filed: July 25, 1990
    Date of Patent: December 17, 1991
    Assignee: Pfizer Inc.
    Inventors: Yasuhiro Kojima, Hiroshi Maeda, Satoshi Nishiyama, David A. Perry
  • Patent number: 5072006
    Abstract: Compounds of the formula ##STR1## wherein: R.sub.1 is cyano or nitro;R.sub.2 and R.sub.3 are independently hydrogen or lower alkyl; andR.sub.4 is alkyl; alkenyl; optionally substituted phenyl or phenyl lower alkyl; --(CH.sub.2).sub.m OR.sub.2 or --(CH.sub.2).sub.m N(R.sub.2).sub.2 ; wherein m is an integer of 1-5 and R.sub.2 is as defined above;or a pharmaceutically acceptable ester thereof; are smooth muscle relaxants, particularly useful in the treatment of hypertension.
    Type: Grant
    Filed: December 19, 1990
    Date of Patent: December 10, 1991
    Assignee: Recherche Syntex France S.A.
    Inventors: Gilles Genain, Henri Pinhas
  • Patent number: 5072045
    Abstract: The invention relates to an improved process for producing alkenylated aromatic amines which involves the catalytic reaction of an aromatic amine with a diene. The improvement resides in using a solvent in which the aromatic amine and diene are soluble in the proportions present in the reaction but inert to the reaction.
    Type: Grant
    Filed: December 21, 1987
    Date of Patent: December 10, 1991
    Assignee: Air Products and Chemicals, Inc.
    Inventors: William F. Burgoyne, Jr., Dale D. Dixon
  • Patent number: 5066815
    Abstract: A process for preparing an optically active alcohol is disclosed, which comprises asymmetrically hydrogenating a carbonyl compound in the presence of a ruthenium-optically active phosphine complex as a catalyst. The resulting alcohol has high optical purity.
    Type: Grant
    Filed: May 8, 1990
    Date of Patent: November 19, 1991
    Assignee: Takasago International Corporation
    Inventors: Noboru Sayo, Hidenori Kumobayashi, Susumo Akutagawa, Ryoji Noyori, Hidemasa Takaya
  • Patent number: 5064856
    Abstract: Compound of formulae (I) and (II) are HMG-CoA synthase inhibitors and exhibit antifungal activity.
    Type: Grant
    Filed: July 31, 1989
    Date of Patent: November 12, 1991
    Assignee: Merck & Co., Inc.
    Inventors: George M. Garrity, Robert Giacobbe, Michael D. Greenspan, Otto D. Hensens, Henry Joshua, Maria T. D. Matas, Isabel Martin, James A. Milligan, Sagrario M. del Val, Walter Rozdilsky, Janet C. Onishi, Jerrold M. Liesch
  • Patent number: 5059700
    Abstract: Perfluoropolyethers having fluorinated epoxy groups positioned along their perfluoropolyether chain, and free from peroxidic oxygen, are obtained using a low-temperture oxidation process, in the liquid phase, with molecular oxygen and in the presence of U.V. light, of a mixture of a perfluorinated monoolefin and a perfluorinated conjugated diene, and of the subsequent photochemical decomposition of the peroxy groups contained in the photoxidation product, carried out by treating the peroxy-groups-containing product with U.V. light at a temperature within the range of from 0.degree. C. to 160.degree. C. Derivatives of said epoxy containing perfluoropolyethers in which the epoxy groups have been turned into functional groups.
    Type: Grant
    Filed: July 30, 1990
    Date of Patent: October 22, 1991
    Assignee: Ausimont S.p.A.
    Inventors: Giuseppe Marchionni, Ugo De Patto, Ezio Strepparola, Gian Tommaso Viola
  • Patent number: 5055594
    Abstract: A fluorogenic substrate for tryptophanase useful for identifying an unknown microorganism is a fluorescent dye linked to an amino acid by a carbamate or thiocarbamate group. In preferred substrates, the dye is fluorescein or 7-amino-4-methyl coumarin and the amino acid linked thereto is cysteine, threonine or serine.
    Type: Grant
    Filed: July 19, 1990
    Date of Patent: October 8, 1991
    Assignee: Becton, Dickinson and Company
    Inventor: Patrick D. Mize
  • Patent number: 5051512
    Abstract: Described herein is a process for preparation of substituted piperidine dicarbothioate compounds.
    Type: Grant
    Filed: March 19, 1990
    Date of Patent: September 24, 1991
    Assignee: Monsanto Company
    Inventors: Sherrol L. Baysdon, Mitchell J. Pulwer, Helen L. Janoski
  • Patent number: 5047561
    Abstract: A process for producing a lactone by reacting in a hydrogenation reaction zone a dicarboxylic acid, a dicarboxylic acid anhydride and/or a dicarboxylic acid ester with hydrogen in a liquid phase using a solvent in the presence of a catalyst comprising ruthenium and an organic phosphine, which process comprises the following steps (1) to (6):(1) a first step of recovering the liquid phase from the hydrogenation reaction zone,(2) a second step of distilling the liquid phase in a first distillation column to obtain a first distillate and a first residue,(3) a third step of recycling the first residue to the hydrogenation reaction zone,(4) a fourth step of distilling a part of the first residue in a second distillation column to obtain a second distillate and a second residue,(5) a fifth step of recycling the second distillate to the hydrogenation reaction zone or the first distillation column, and(6) a sixth step of recovering a lactone from the first distillate.
    Type: Grant
    Filed: September 14, 1990
    Date of Patent: September 10, 1991
    Assignee: Mitsubishi Kasei Corporation
    Inventors: Chihiro Miyazawa, Kazunari Takahashi, Hiroshi Kameo, Shinji Isogai, Masayuki Otake
  • Patent number: 5043458
    Abstract: A continuous, gas-assisted atmospheric process for preparing cyclic esters of alpha-hydroxycarboxylic acids, such as lactide, which comprises feeding the reactants into a reactor having means for introducing an inert gas at the operating temperature, forming a reaction mass having cyclic esters in the reactor, passing a flow of said inert gas through said reactor whereby cyclic esters are swept from the reaction mass into a gaseous product stream, and recovering the cyclic esters therefrom.
    Type: Grant
    Filed: May 3, 1990
    Date of Patent: August 27, 1991
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Kamlesh K. Bhatia
  • Patent number: 5041563
    Abstract: A process for the manufacture of ascorbic acid from 2-ketogulonic acid esters (KGAE) utilizing amine salts of the latter is disclosed.
    Type: Grant
    Filed: May 22, 1990
    Date of Patent: August 20, 1991
    Assignee: Hoffman-La Roche Inc.
    Inventors: Peter Fahrni, Theodor Siegfried
  • Patent number: 5032590
    Abstract: Substituted hydroxylamines of the formula ##STR1## in which R.sup.1 stands for an aromatic or heterocyclic radical,are especially useful in the treatment of hyperlipoproteinaemia, lipoproteinaemia and atherosclerosis.
    Type: Grant
    Filed: March 8, 1990
    Date of Patent: July 16, 1991
    Assignee: Bayer Aktiengesellschaft
    Inventors: Walter Hubsch, Rolf Angerbauer, Peter Fey, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt
  • Patent number: 5026725
    Abstract: This invention relates to 4-substituted-5-hydroxy-2(5H)-furanones, to the process for their preparation, to pharmaceutical compositions containing said 4-substituted-5-hydroxy-2(5H)-furanones and to the use of said 4-substituted-5-hydroxy-2(5H)-furanones for modifying the balance between bone production and bone resorption in a host animal, including man.
    Type: Grant
    Filed: February 23, 1990
    Date of Patent: June 25, 1991
    Assignee: American Home Products Corporation
    Inventors: Marshall A. Hayward, Joseph P. Sabatucci, Ivo L. Jirkovsky, Yvon Lefebvre
  • Patent number: 5025099
    Abstract: Pharmaceutical compounds and compositions which may be represented by the following structural formula: ##STR1## wherein NR'" is selected from amino, (C.sub.1 -C.sub.6) alkylamino, dialkylamino or trialkylamino, pyrrolidino or piperidino. The compounds and compositions are useful in treating central cholinergic dysfunction in mammals.
    Type: Grant
    Filed: February 2, 1990
    Date of Patent: June 18, 1991
    Assignee: American Cyanamid Company
    Inventors: Eugene J. Trybulski, Herbert J. Brabander
  • Patent number: 5023350
    Abstract: This invention relates to a gas-assisted vaporization process for purifying cyclic esters such as glycolide, lactides and mixtures thereof which enables the cyclic ester to be rapidly separated from its impurities as a vapor component of a gas stream. The process includes a solvent-scrubbing step for recovering the cyclic ester from the gas stream.
    Type: Grant
    Filed: May 24, 1990
    Date of Patent: June 11, 1991
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Kamlesh K. Bhatia