Patents Examined by Blaine G Doletski
  • Amphiphilic biphenyl compounds derived from alpha olefins or vinylidene alpha olefin dimers
    Patent number: 11168053
    Abstract: Compositions comprising a sulfonated reaction product or a salt thereof may be prepared from a biphenyl compound that has been alkylated with an olefin of formula R1R2CCH2, wherein R1 is a C6-C24 hydrocarbyl group, and R2 is H or a C6-C24 hydrocarbyl group. Methods for sulfonating an alkylated biphenyl compound prepared from a biphenyl compound that has been alkylated with an olefin of formula R1R2CCH2, wherein R1 is a C6-C24 hydrocarbyl group, and R2 is H or a C6-C24 hydrocarbyl group may comprise contacting the alkylated biphenyl compound with a sulfonating reagent; forming a sulfonated reaction product; and converting the sulfonated reaction product into a sulfonate salt.
    Type: Grant
    Filed: August 18, 2020
    Date of Patent: November 9, 2021
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Abhimanyu O. Patil, Satish Bodige, Arben Jusufi, Shane Deighton, Kanmi Mao, Alan A. Galuska
  • Alkoxylation of hydroxy acids
    Patent number: 11168048
    Abstract: Alkoxylated hydroxycarboxylic acids according to a formula I? are provided herein, as well as uses thereof and a process for production thereof. Compound 2-[2-(2-hydroxyethoxy)ethoxy]propanoic acid being exclude.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: November 9, 2021
    Assignee: BASF SE
    Inventors: Sophia Ebert, Roman Benedikt Raether
  • Process for oxidative esterification of aldehydes to carboxylic acid esters
    Patent number: 11124471
    Abstract: The present invention relates to a novel process for performing a heterogeneously catalyzed reaction for oxidative esterification of aldehydes to give carboxylic esters. Against this background, it has been possible by the present process according to the invention to perform such processes for longer periods without disruption, with constant or even increased activities and selectivities. This gives rise to the possibility of performing such processes in a very simple, economically viable and environmentally benign manner.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: September 21, 2021
    Assignee: Roehm GmbH
    Inventors: Alexander Lygin, Steffen Krill, Belaid Ait Aissa, Florian Zschunke
  • Pleuromutilin hippuric acid ester with antibacterial activity and a method of preparing the same
    Patent number: 11117859
    Abstract: A compound with anti-drug resistant bacteria activity having the following formula (I) is disclosed. The methods of preparing the compound of formula (I) are also disclosed.
    Type: Grant
    Filed: February 12, 2021
    Date of Patent: September 14, 2021
    Assignee: SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Dan Yang, Jingyi Li, Liang Xin, Qianqian Zhao, Liang Qi, Bin Tian, Jian Zha, Wenbo Yao, Gennian Mao, Han Li, Chunyang Shi, Yongbo Wang, Jingwen Xu
  • Methods for the preparation of deoxycholic acid, and intermediates useful in the preparation of deoxycholic acid
    Patent number: 11117925
    Abstract: The present invention relates to new and improved processes for the preparation of deoxycholic acid (DCA) and pharmaceutically acceptable salts thereof, as well as to novel intermediates useful for the preparation of DCA and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: September 14, 2021
    Assignee: BIONICE, S.L.U.
    Inventors: Antonio Lorente Bonde-Larsen, Ignacio Herraiz Sierra, Yolanda Fernandez Sainz, Jose Luis Barredo Fuente, Alfonso Perez Encabo, Jose Angel Turiel Hernandez
  • Method for preparing acrylic acid and methyl acrylate
    Patent number: 11111200
    Abstract: The present invention provides a method for preparing acrylic acid and methyl acrylate. The method comprises passing the feed gas containing dimethoxymethane and carbon monoxide through a solid acid catalyst to generate acrylic acid and methyl acrylate with a high conversion rate and selectivity at a reaction temperature in a range from 180 to 400 and a reaction pressure in a range from 0.1 MPa to 15.0 MPa, the mass space velocity of dimethoxymethane in the feed gas is in a range from 0.05 h?1 to 10.0 h?1, and the volume percentage of dimethoxymethane in the feed gas is in a range from 0.1% to 95%.
    Type: Grant
    Filed: November 25, 2016
    Date of Patent: September 7, 2021
    Assignee: Dalian Institute of Chemical Physics, Chinese Academy of Sciences
    Inventors: Lei Shi, Zongmin Liu, Youming In, Wenliang Zhu, Yong Liu, Hongchao Liu
  • Oxidized disulfide oil solvent compositions
    Patent number: 11111212
    Abstract: Oxidized disulfide oil (ODSO) solvent compositions are derived from by-product disulfide oil (DSO) compounds produced as by-products from the generalized mercaptan oxidation (MEROX) processing of a refinery feedstock. The oxidized disulfide oil (ODSO) solvent compositions comprise at least a primary oxidized disulfide oil (ODSO) compound selected from either water soluble or water insoluble oxidized disulfide oil (ODSO) compounds and in some embodiments at least 0.1 ppmw of a secondary oxidized disulfide oil (ODSO) compound that is a water soluble oxidized disulfide oil (ODSO) compound.
    Type: Grant
    Filed: August 17, 2020
    Date of Patent: September 7, 2021
    Assignee: Saudi Arabian Oil Company
    Inventors: Omer Refa Koseoglu, Robert Peter Hodgkins, Adnan Al-Hajji, Hendrik Muller, Nadrah Al-Awani, Frederick Marie Adam, Qasim Saleem
  • Triarylmethane leuco compounds and compositions comprising the same
    Patent number: 11104806
    Abstract: A method of making a triarylmethane leuco compound comprises reacting an aromatic aldehyde compound, a first oxyalkylenated aryl compound, and a second oxyalkylenated aryl compound in a condensation reaction in the presence of an acidic catalyst to produce the triarylmethane leuco compound. The first oxyalkylenated aryl compound is oxyalkylenated with ethylene oxide. The second oxyalkylenated aryl compound is oxyalkylenated with propylene oxide or with both ethylene oxide and propylene oxide.
    Type: Grant
    Filed: October 11, 2018
    Date of Patent: August 31, 2021
    Assignee: Milliken & Company
    Inventors: Dominick J. Valenti, Haihu Qin, Sanjeev K. Dey
  • Hydroxylated quinone antipolymerants and methods of using
    Patent number: 11104626
    Abstract: Described are methods and compositions for inhibiting polymerization of a monomer (e.g., styrene) composition using a hydroxylated quinone antipolymerant. The hydroxylated quinone antipolymerant can be used with little or no nitroxyl group containing antipolymerant yet still provide excellent antipolymerant activity in a monomer-containing composition.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: August 31, 2021
    Assignee: Ecolab USA Inc.
    Inventors: Jonathan Masere, Russell P. Watson, Ashish Dhawan
  • Process for the preparation of treprostinil
    Patent number: 11098001
    Abstract: Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anhydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: August 24, 2021
    Assignee: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.
    Inventors: Imre Juhász, Irén Hortobágyi, Tamás Altsach, István Lászlófi, Ágnes Nagyné Borkó, Imre Rozsumberszki, Gábor Havasi, Zsuzsanna Kardos, Péter Buzder-Lantos
  • Method for removing monohydric alcohol from esterification and method for preparing ester composition comprising same
    Patent number: 11091422
    Abstract: Provided is a monohydric alcohol removal method in esterification, the method including a step of reacting a carbonyl-based compound having one or more functional groups selected from the group consisting of carboxyl, ester, and acid anhydride groups with a monohydric alcohol in an esterification reactor including a liquid phase outlet line connected to a liquid phase section in the reactor, and a step of separating in a gas-liquid separation column to remove the monohydric alcohol, wherein the inflow of a liquid phase stream into the gas-liquid separation column starts at the time point between 10% and 70% of the total time required for the gas-liquid separation.
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: August 17, 2021
    Assignee: LG CHEM, LTD.
    Inventors: Ha Na Lee, Sung Kyu Lee, Joon Ho Shin, Hyoung Jun
  • Catalyst, acrylic acid production method, and catalyst production method
    Patent number: 11084029
    Abstract: An object of the present invention is to provide a catalyst ensuring that in the case of causing gas-phase catalytic oxidation of an unsaturated aldehyde and an oxygen-containing gas with use of the catalyst to produce a corresponding unsaturated carboxylic acid, the pressure loss can be kept low and an unsaturated carboxylic acid can be produced with high selectivity. The present invention relates to a ring-shaped or columnar catalyst, which is used at the time of producing a corresponding unsaturated carboxylic acid by causing gas-phase catalytic oxidation of an unsaturated aldehyde and an oxygen-containing gas, wherein the outer peripheral edge part is inclined relative to the center line.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: August 10, 2021
    Assignee: Mitsubishi Chemical Corporation
    Inventors: Kazuharu Tazawa, Yoshimune Abe, Mitsunobu Ito
  • Methods and intermediates for the preparation bile acid derivatives
    Patent number: 11072631
    Abstract: The present invention relates to methods and novel intermediates useful in the preparation of a compound of formula (A) or a pharmaceutically acceptable salt thereof, comprising converting the aldehyde of a compound of formula (B) with a reducing agent to prepare a compound of formula (C) and converting the compound of formula (C) with a sulfating reagent to prepare a compound of formula (A). An objective of the present invention is to provide methods of preparing bile acid derivatives and novel intermediates. A use of the methods and intermediates described relates to the synthesis of bile acid derivatives which activate both FXR and TGR5.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: July 27, 2021
    Assignee: Intercept Pharmaceuticals, Inc.
    Inventors: Kevin Schaab, Paul E. Whitley, Flavio Chavez Lopez, Kayla R. Iorga
  • Method for degrading perfluorinated compounds
    Patent number: 11072574
    Abstract: The present invention discloses a method for degrading perfluorinated compounds (PFCs) and belongs to the field of degradation of persistent pollutants. According to the present invention, cetyltrimethylammonium bromide (CTAB), indoleacetic acid (IAA) and PFCs are mixed to form compact self-assembled micelles, and the self-assembled micelles are illuminated, so that PFCs are rapidly degraded and defluorinated in the micelles, thereby realizing the degradation of PFCs by using a novel self-assembled micelle system and improving the degradation efficiency of PFCs.
    Type: Grant
    Filed: July 9, 2020
    Date of Patent: July 27, 2021
    Assignee: NANJING UNIVERSITY
    Inventors: Cheng Gu, Zhanghao Chen, Chen Li
  • Carbonylation process for the production of methyl acetate
    Patent number: 11046633
    Abstract: A process for the production of methyl acetate by carbonylating at a temperature of 250 to 350° C., in the presence of a zeolite catalyst, a feed comprising dimethyl ether, a gas comprising carbon monoxide and hydrogen at a molar ratio of hydrogen to carbon monoxide of at least 1, methyl acetate and one or more compounds containing a hydroxyl functional group.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: June 29, 2021
    Assignee: Ineos Acetyls UK Limited
    Inventors: Thomas Edward Clark, Nicholas John Hazel, John Glenn Sunley
  • High-purity carboxylic acid ester and method for producing same
    Patent number: 11046634
    Abstract: A method for producing a high-purity carboxylic acid ester, the method including bringing a crude carboxylic acid ester that contains anionic impurities and Ag, Al, Au, Ca, Cr, Cu, Fe, K, Mg, Na, Sn, and Zn metal impurities into contact with a cation-exchange resin, followed by bringing the crude carboxylic acid ester into contact with an anion-exchange resin to obtain to provide a high-purity carboxylic acid ester in which the Ag, Al, Au, Ca, Cr, Cu, Fe, K, Mg, Na, Sn, and Zn metal impurity content are each less than 1 ppb and the anionic impurity content is less than 1 ppm.
    Type: Grant
    Filed: September 10, 2019
    Date of Patent: June 29, 2021
    Assignee: MITSUBISHI GAS CHEMICAL COMPANY, INC.
    Inventor: Kuniaki Muneyasu
  • Preparation of 2,5,6-trihydroxy-3-hexenoic acid and 2,5-dihydroxy-3-pentenoic acid and esters thereof from C6 and C5 sugars
    Patent number: 11040934
    Abstract: Preparation of 2,5,6-trihydroxy-3-hexenoic acid and 2,5-dihydroxy-3-pentenoic acid and esters thereof from C6 and C5 sugars in the presence of a Lewis Acid material, wherein the yield of the 2,5,6-trihydroxy-3-hexenoic acid or 2,5-dihydroxy-3-pentenoic acid or esters thereof exceeds 15%. The process including the steps of contacting a saccharide composition including one or more C6 and/or C5 saccharide units with a Lewis Acid material; and recovering 2,5,6-trihydroxy-3-hexenoic acid and/or 2,5-dihydroxy-3-pentenoic acid or the esters thereof.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: June 22, 2021
    Assignee: HALDOR TOPSØE A/S
    Inventors: Esben Taarning, Irantzu Sadaba Zubiri, Sebastian Meier
  • Light colored modified isocyanate mixture and preparation method thereof
    Patent number: 11034651
    Abstract: Disclosed is a light colored modified isocyanate mixture and a preparation method thereof. The method comprises the following steps: a) reacting isocyanate groups of a raw material isocyanate under the action of a phospholenecatalyst, and finally obtaining a modified isocyanate reaction solution containing carbodiimide and/or uretonimine derivatives; and b) adding a compounded terminator of a halosilane organic and a sulfonic anhydride to the reaction solution obtained in step a so as to terminate the reaction of carbodiimidization. The modified isocyanate prepared by the method has the characteristics of a liquid state at room temperature, being stable in storage at room temperature and high temperature, and low color number.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: June 15, 2021
    Inventors: Ye Zhou, Wenbo Wang, Yilu Xia, Hongke Zhang, Xiaogao Liu, Guiying Niu, Huihui Wang, Xueting Liu
  • Catalyst, acrylic acid production method, and catalyst production method
    Patent number: 11033891
    Abstract: An object of the present invention is to provide a catalyst ensuring that in the case of causing gas-phase catalytic oxidation of an unsaturated aldehyde and an oxygen-containing gas with use of the catalyst to produce a corresponding unsaturated carboxylic acid, the pressure loss can be kept low and an unsaturated carboxylic acid can be produced with high selectivity. The present invention relates to a ring-shaped or columnar catalyst, which is used at the time of producing a corresponding unsaturated carboxylic acid by causing gas-phase catalytic oxidation of an unsaturated aldehyde and an oxygen-containing gas, wherein the outer peripheral edge part is inclined relative to the center line.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: June 15, 2021
    Assignee: Mitsubishi Chemical Corporation
    Inventors: Kazuharu Tazawa, Yoshimune Abe, Mitsunobu Ito
  • Method for producing cis,cis-1,2,4-cyclohexane tricarboxylic acid crystal
    Patent number: 11021428
    Abstract: An object of the present invention is to provide a method for producing cis,cis-1,2,4-cyclohexanetricarboxylic acid crystals, from which high purity cis,cis-1,2,4-cyclohexanetricarboxylic acid crystals are obtained. The method for producing cis,cis-1,2,4-cyclohexanetricarboxylic acid crystals of the present invention comprises the following steps: Step 1: measuring a mass ratio (cis/trans ratio) of cis,cis-1,2,4-cyclohexanetricarboxylic acid to trans,trans-1,2,4-cyclohexanetricarboxylic acid in an aqueous starting material solution comprising the cis,cis-1,2,4-cyclohexanetricarboxylic acid to give an aqueous starting material solution for crystal precipitation having a cis/trans ratio of 10 or more; and Step 2: subjecting the aqueous starting material solution for crystal precipitation obtained in step 1 to crystal precipitation.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: June 1, 2021
    Assignee: MITSUBISHI GAS CHEMICAL COMPANY, INC.
    Inventors: Shinya Saito, Tatsuyuki Kumano