Patents Examined by Blaine Lankford
  • Patent number: 11903397
    Abstract: There is provided a method of treating hay for preventing and/or reducing heat damage in high moisture hay and as well to preserve the same, the method including adding to hay a hay preservative including a hay preserving and heat reducing effective amount of at least one enzyme having a chitinase activity, either alone or in combination with a hay preserving and heat reducing effective amount of a yeast of the genus Pichia or a bacteria of the genus Pediococcus. There is also provided a method of treating hay for preventing and/or reducing heat damage in high moisture hay and as well to preserve the same, the method including adding to hay a hay preservative including a hay preserving and heat reducing effective amount of yeast of the genus Pichia.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: February 20, 2024
    Assignee: DANSTAR FERMENT AG
    Inventors: Julien Sindou, Henri Durand
  • Patent number: 11896626
    Abstract: Provided herein are multi-strain population control systems, methods, kits, and compositions. Also provided are methods, systems, kits, and compositions for culturing bacterial cells in multi-strain ecosystems, and temporally arranged multi-strain ecosystems or cultures using a synchronized lysis circuit in combination with multiple toxin/antitoxin systems to cycle continuously over a long period of time.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: February 13, 2024
    Assignee: The Regents of the University of California
    Inventors: Jeff Hasty, Michael Julius Liao, Muhammad Omar Din
  • Patent number: 11890657
    Abstract: This present invention relates to compositions and methods of microbial enhanced oil recovery using Bacillus subtilis strains. The invention also relates to compositions and methods for performing oil degradation with Bacillus subtilis strains. The compositions and methods of the present invention are also used for enhanced commercial biosurfactant and enzyme production.
    Type: Grant
    Filed: February 17, 2020
    Date of Patent: February 6, 2024
    Assignee: Locus Solutions IPCo, LLC
    Inventors: Sean Farmer, Xiaozhou Zhang, Sharmistha Mazumder, Maja Milovanovic
  • Patent number: 11892447
    Abstract: The invention relates to biomarkers in children's skin, in particular in the skin of infants, the expression of which changes when the skin is dry. Such markers are particularly advantageous in that they allow the skin's response to dehydration to be monitored. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the effects of dehydration on children's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: February 6, 2024
    Assignee: Laboratoires Expanscience
    Inventors: Stephanie Bredif, Caroline Baudouin
  • Patent number: 11885792
    Abstract: Techniques and systems are disclosed for a bioassay that is an in vitro mimic of peripheral nerve generation using the sensory neurons that innervate the peripheral nervous system. In some embodiments, the techniques may assist in detecting the bioactivity or potency of nerve grafts (e.g., processed, acellular human allografts) for fostering or supporting peripheral nerve regeneration. In various embodiments, techniques comprise affixing a harvested sensory neuron (e.g., a DRG) to a nerve graft segment to form a test construct; culturing the test construct in a medium; analyzing the test construct to indicate the amount of outgrowing peripheral nerve structure; and determining the potency of the nerve graft from a metric derived from the analysis. In some embodiments, techniques and materials may be used to test the effect of a varied test condition on peripheral nerve growth.
    Type: Grant
    Filed: September 20, 2021
    Date of Patent: January 30, 2024
    Assignee: Axogen Corporation
    Inventor: Curt Deister
  • Patent number: 11884933
    Abstract: An elongated or fiber-supported multicellular aggregation of multipotent cells, wherein multipotent cells are arranged in an oblong or longish arrangement with an aspect ratio of a prolate dimension to a perpendicular dimension of at least 2:1, or supported by a fibrous structure, and wherein the aggregate contains cells at different stages of differentiation, and the aggregate contains polar cells; methods of generating such aggregates; methods of developing the aggregates further into tissue organoids and kits for such methods.
    Type: Grant
    Filed: January 11, 2017
    Date of Patent: January 30, 2024
    Assignee: IMBA—INSTITUT FÜR MOLEKULARE BIOTECHNOLOGIE GMBH
    Inventors: Jürgen Knoblich, Madeline A. Lancaster
  • Patent number: 11885724
    Abstract: A staining composition for staining cells and for use in a method of staining cells, a method of diagnosing mitotic activity and a method of diagnosing cancer. The composition comprises dried petunia petals at least partially dissolved in distilled water; and 400 milligrams of picric acid per gram of dried petunia petals. The method of staining cells includes rinsing a sample containing the cells with 10% of phosphotungistic acid or 10% of phosphomolybdic acid; staining the sample with the composition and dehydrating the samples with 100% Ethanol or Isopropanol. The method of diagnosing mitotic activity includes observing stained regions in the sample to identify mitotic activity indicated by stained regions. The method for diagnosing cancer includes quantifying mitotic figures in the sample which are identified by stained regions of the sample.
    Type: Grant
    Filed: March 12, 2020
    Date of Patent: January 30, 2024
    Assignee: United Arab Emirates University
    Inventor: Hayfaa Abd Ali Mohammed Alshamar
  • Patent number: 11879138
    Abstract: The present application provides a method for preparing mesenchymal stem cell-derived exosomes, the method including: obtaining a cell sample from mesenchymal stem cells and sub-culturing the cell sample, culturing the sub-cultured cells in a substrate medium containing a protein synthesis inhibitory enzyme, and then obtaining a cell culture solution, and isolating exosomes from the cell culture solution, and a cell culture solution produced therefrom. The method for preparing exosomes of the present application has an advantage in that high purity and high concentration exosomes can be isolated.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: January 23, 2024
    Assignee: CK-EXOGENE CO., LTD.
    Inventors: Jae Young Kim, Yong Joon Chwae
  • Patent number: 11866730
    Abstract: The present invention relates to a cytopheretic cartridge for use in treating and/or preventing inflammatory conditions within a subject and to related methods. More particularly, the invention relates to a cytopheretic cartridge that includes a housing and, disposed within the housing, a solid support capable of sequestering activated leukocytes and/or platelets.
    Type: Grant
    Filed: September 13, 2021
    Date of Patent: January 9, 2024
    Assignee: SeaStar Medical, Inc.
    Inventors: H. David Humes, Deborah A. Buffington, Christopher J. Pino
  • Patent number: 11856944
    Abstract: An ex-vivo lung solution for machine perfusion of donor lungs on OCS. The solution may be mixed with whole blood or packed red blood cells to form the OCS lung perfusion solution.
    Type: Grant
    Filed: July 20, 2022
    Date of Patent: January 2, 2024
    Assignee: TRANSMEDICS, INC.
    Inventors: Waleed H. Hassanein, Ihab Abdel Fattah, Paul Lezberg, Tamer I. Khayal, Robert Havener, Anas Abdelazim
  • Patent number: 11859210
    Abstract: Disclosed herein are methods of producing chondrocytes from pluripotent stem cells. The invention further provides methods of regenerating cartilaginous tissue.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: January 2, 2024
    Assignee: SCRIPPS HEALTH
    Inventors: Darryl D. D'Lima, Tsaiwei Olee, Clifford W. Colwell
  • Patent number: 11859235
    Abstract: According to one embodiment, a sensor for detecting a target substance in gas a sample includes a target substance uptake unit that brings an acetylcholine aqueous solution into contact with a gas sample to dissolve a target substance in the gas sample into the acetylcholine aqueous solution, a reaction unit that holds acetylcholinesterase and brings the solution delivered from the target substance uptake unit into contact with the acetylcholinesterase, and a detection unit that measures a change in an amount of acetylcholine decomposition product produced in the solution delivered from the reaction unit.
    Type: Grant
    Filed: March 11, 2021
    Date of Patent: January 2, 2024
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Tatsuro Saito, Yoshiaki Sugizaki
  • Patent number: 11845976
    Abstract: Phenotypic antimicrobial susceptibility testing (AST), the gold-standard diagnostic that indicates whether an antimicrobial will be clinically effective, often suffer the slowest times-to-result for the most resistant pathogens. Here we introduce novel assays to be performed in parallel with standard AST assays that provide additional resistance information and enable rapid, same-shift reporting of AST results for a plurality of pathogens.
    Type: Grant
    Filed: August 27, 2020
    Date of Patent: December 19, 2023
    Assignee: SELUX DIAGNOSTICS, INC.
    Inventors: Kelly Flentie, Eric Stern
  • Patent number: 11839596
    Abstract: Provided are methods for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin. Pharmaceutical compositions suitable for such treatments are also provided.
    Type: Grant
    Filed: September 8, 2021
    Date of Patent: December 12, 2023
    Assignee: United Therapeutics Corporation
    Inventors: Roger Jeffs, Thomas Petersen, Roger M. Ilagan, Michael Wade
  • Patent number: 11839629
    Abstract: Embodiments of the methods and compositions provided herein relate to inducing hair growth in a subject. Some embodiments include screening for agents to modulate hair growth.
    Type: Grant
    Filed: May 22, 2020
    Date of Patent: December 12, 2023
    Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    Inventor: Alexey V. Terskikh
  • Patent number: 11839618
    Abstract: The invention provides an agent for promoting adhesion of a corneal endothelial cell, containing a Rho kinase inhibitor, as well as a culture medium for a corneal endothelial cell, a solution for preservation of cornea, and a method of producing a corneal endothelial preparation, which includes culturing the corneal endothelial cell using the aforementioned culture medium.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: December 12, 2023
    Assignees: SENJU PHARMACEUTICAL CO., LTD.
    Inventors: Noriko Koizumi, Shigeru Kinoshita, Morio Ueno
  • Patent number: 11839631
    Abstract: The current application is directed to a method for treating pulmonary arterial hypertension (PAH), comprising: providing isolated endothelial progenitor cells (EPCs); treating the EPCs with prostacyclin, wherein the treated EPCs exhibit a hyperproliferative phenotype with enhanced angiogenic property; and administering a composition comprising the treated EPCs into a subject suffering from PAH.
    Type: Grant
    Filed: October 16, 2020
    Date of Patent: December 12, 2023
    Assignee: United Therapeutics Corporation
    Inventors: Roger Jeffs, Thomas Petersen, Roger M. Ilagan, Michael Wade
  • Patent number: 11825856
    Abstract: Provided is a composition for preventing or ameliorating a functional gastrointestinal disorder whose active ingredient is Bifidobacterium breve MCC1274 (FERM BP-11175). A composition for preventing or ameliorating a functional gastrointestinal disorder in the present technology can prevent or improve constipation or frequent bowel movements, regulate the number of bowel movements, improve stool quality, prevent or improve constipation, prevent or ameliorate bloating, or prevent or improve abdominal discomfort. Disclosed is a composition for preventing or ameliorating a functional gastrointestinal disorder accompanied by anxiety disorder. A composition for preventing or ameliorating a functional gastrointestinal disorder in the present technology can be used in a pharmaceutical composition or in a food or beverage composition.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: November 28, 2023
    Assignee: Morinaga Milk Industry Co., Ltd.
    Inventors: Mai Murata, Junichi Minami, Hazuki Maehata
  • Patent number: 11825808
    Abstract: A composition and methods of using the composition for the control of mollusks are provided, which include an effective amount of one or more isolated Phasmarhabditis nematodes, wherein at least one of the isolated nematodes is P. californica, P. papillosa or P. hermaphrodita, and wherein the P. hermaphrodita does not comprise Moraxella osloensis.
    Type: Grant
    Filed: August 28, 2020
    Date of Patent: November 28, 2023
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Irma Tandingan De Ley, Rory McDonnell, Timothy Paine
  • Patent number: 11821006
    Abstract: The present invention relates to a method of isolating a mesenchymal stem cell population from the amniotic membrane of the umbilical cord, the method comprising cultivating umbilical cord tissue in a culture medium comprising DMEM (Dulbecco's modified eagle medium), F12 (Ham's F12 Medium), M171 (Medium 171) and FBS (Fetal Bovine Serum). The invention also relates to a mesenchymal stem population isolated from the amniotic membrane of the umbilical cord, wherein at least about 90% or more cells of the stem cell population express each of the following markers: CD73, CD90 and CD105 and lack expression of the following markers: CD34, CD45 and HLA-DR. The invention also relates to a pharmaceutical composition of this mesenchymal stem population.
    Type: Grant
    Filed: March 2, 2021
    Date of Patent: November 21, 2023
    Assignee: CELLRESEARCH CORPORATION PTE. LTD.
    Inventor: Toan Thang Phan