Patents Examined by Blaine Lankford
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Patent number: 11959840Abstract: A tissue sample that has been removed from a subject can be evaluated. A change in speed of the energy traveling through the sample is evaluated to monitor changes in the biological sample during processing. The monitoring can detect movement of fluid with the sample and cross-linking. A system for performing the method can include a transmitter that outputs the energy and a receiver configured to detect the transmitted energy.Type: GrantFiled: December 19, 2019Date of Patent: April 16, 2024Assignee: Ventana Medical System, Inc.Inventors: Jefferson Curtis Taft, David Chafin, Michael Otter, Benjamin Stevens
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Patent number: 11959903Abstract: Techniques and systems are disclosed for a bioassay that is an in vitro mimic of peripheral nerve generation using the sensory neurons that innervate the peripheral nervous system. In some embodiments, the techniques may assist in detecting the bioactivity or potency of nerve grafts (e.g., processed, acellular human allografts) for fostering or supporting peripheral nerve regeneration. In various embodiments, techniques comprise affixing a harvested sensory neuron (e.g., a DRG) to a nerve graft segment to form a test construct; culturing the test construct in a medium; analyzing the test construct to indicate the amount of outgrowing peripheral nerve structure; and determining the potency of the nerve graft from a metric derived from the analysis. In some embodiments, techniques and materials may be used to test the effect of a varied test condition on peripheral nerve growth.Type: GrantFiled: September 17, 2021Date of Patent: April 16, 2024Assignee: Axogen CorporationInventor: Curt Deister
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Patent number: 11950590Abstract: The present disclosure provides methods to improve the viability of an organ, or organs, by continuously administering a composition comprising NOx gas directly to the organ(s).Type: GrantFiled: June 28, 2021Date of Patent: April 9, 2024Assignee: Mallinckrodt Pharmaceuticals Ireland LimitedInventor: Jim Potenziano
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Patent number: 11940441Abstract: Provided herein relates to systems and methods for producing and using a body having a central channel separated by one or more membranes. The membrane(s) are configured to divide the central channel into at least one mesochannel and at least one microchannel. The height of the mesochannel is substantially greater than the height of the microchannel. A gaseous fluid can be applied through the mesochannel while a liquid fluid flowing through the microchannel. The systems and methods described herein can be used for various applications, including, e.g., growth and differentiation of primary cells such as human lung cells, as well as any other cells requiring low shear and/also stratified structures, or simulation of a microenvironment in living tissues and/or organs (to model physiology or disease states, and/or to identify therapeutic agents and/or vaccines). The systems and methods can also permit co-culture with one or more different cell types.Type: GrantFiled: September 11, 2020Date of Patent: March 26, 2024Assignee: President and Fellows of Harvard CollegeInventors: Donald E. Ingber, Kambez Hajipouran Benam, Remi Villenave, Geraldine A. Hamilton, Bryan Hassell, Christopher D. Hinojosa, Carolina Lucchesi
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Patent number: 11938173Abstract: Provided are methods for repairing a wound or inducing the proliferative phase of a wound comprising administering a composition comprising a protease mixture comprising collagenases and a neutral protease to the wound in an amount effective for repair of wound tissue or for inducing the proliferative phase in the wound.Type: GrantFiled: December 10, 2015Date of Patent: March 26, 2024Assignee: SMITH & NEPHEW, INC.Inventors: Ira Herman, Vincent Ronfard, Lei Shi
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Patent number: 11932843Abstract: A device for aseptically obtaining a physical sample of an adherent cell culture substrate from an adherent cell culture bioreactor. This enables the operator to directly evaluate e.g., cell density/confluence on the substrate without contaminating the cell culture.Type: GrantFiled: November 9, 2017Date of Patent: March 19, 2024Assignee: TRIZELL LTD.Inventors: Vesa Turkki, Nigel Parker
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Patent number: 11932584Abstract: The method grows a mycelial mass over a three-dimensional lattice such that a dense network of oriented hyphae is formed on the lattice. Growth along the lattice results in mycelium composite with highly organized hyphae strands and allows the design and production of composites with greater strength in chosen directions due to the organized nature of the supporting mycelia structure.Type: GrantFiled: October 23, 2019Date of Patent: March 19, 2024Assignee: ECOVATIVE DESIGN LLCInventors: Eben Bayer, Gavin McIntyre
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Patent number: 11918609Abstract: The present invention provides a method for treating wounds by applying cells as described in this application. In one aspect the method provides treatment for cutaneous wounds. In general embodiments the cells are delivered to the wound without being attached to a functionalized substrate in the delivery vehicle.Type: GrantFiled: April 5, 2021Date of Patent: March 5, 2024Assignees: ABT HOLDING COMPANY, KATHOLIEKE UNIVERSITEIT LEUVENInventors: Aernout Luttun, Robert J. Deans
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Patent number: 11918674Abstract: The present invention relates to the novel trypsin ZT isoforms. In particular, the invention relates to the use of trypsin ZT isoforms in medical devices, pharmaceuticals and cosmetics.Type: GrantFiled: October 15, 2021Date of Patent: March 5, 2024Assignee: ENZYMATICA ABInventors: Agusta Gudmundsdottir, Asgeir Asgeirsson, Bjarki Stefansson
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Patent number: 11903397Abstract: There is provided a method of treating hay for preventing and/or reducing heat damage in high moisture hay and as well to preserve the same, the method including adding to hay a hay preservative including a hay preserving and heat reducing effective amount of at least one enzyme having a chitinase activity, either alone or in combination with a hay preserving and heat reducing effective amount of a yeast of the genus Pichia or a bacteria of the genus Pediococcus. There is also provided a method of treating hay for preventing and/or reducing heat damage in high moisture hay and as well to preserve the same, the method including adding to hay a hay preservative including a hay preserving and heat reducing effective amount of yeast of the genus Pichia.Type: GrantFiled: November 24, 2015Date of Patent: February 20, 2024Assignee: DANSTAR FERMENT AGInventors: Julien Sindou, Henri Durand
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Patent number: 11896626Abstract: Provided herein are multi-strain population control systems, methods, kits, and compositions. Also provided are methods, systems, kits, and compositions for culturing bacterial cells in multi-strain ecosystems, and temporally arranged multi-strain ecosystems or cultures using a synchronized lysis circuit in combination with multiple toxin/antitoxin systems to cycle continuously over a long period of time.Type: GrantFiled: June 7, 2019Date of Patent: February 13, 2024Assignee: The Regents of the University of CaliforniaInventors: Jeff Hasty, Michael Julius Liao, Muhammad Omar Din
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Patent number: 11890657Abstract: This present invention relates to compositions and methods of microbial enhanced oil recovery using Bacillus subtilis strains. The invention also relates to compositions and methods for performing oil degradation with Bacillus subtilis strains. The compositions and methods of the present invention are also used for enhanced commercial biosurfactant and enzyme production.Type: GrantFiled: February 17, 2020Date of Patent: February 6, 2024Assignee: Locus Solutions IPCo, LLCInventors: Sean Farmer, Xiaozhou Zhang, Sharmistha Mazumder, Maja Milovanovic
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Patent number: 11892447Abstract: The invention relates to biomarkers in children's skin, in particular in the skin of infants, the expression of which changes when the skin is dry. Such markers are particularly advantageous in that they allow the skin's response to dehydration to be monitored. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the effects of dehydration on children's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.Type: GrantFiled: December 16, 2016Date of Patent: February 6, 2024Assignee: Laboratoires ExpanscienceInventors: Stephanie Bredif, Caroline Baudouin
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Patent number: 11885792Abstract: Techniques and systems are disclosed for a bioassay that is an in vitro mimic of peripheral nerve generation using the sensory neurons that innervate the peripheral nervous system. In some embodiments, the techniques may assist in detecting the bioactivity or potency of nerve grafts (e.g., processed, acellular human allografts) for fostering or supporting peripheral nerve regeneration. In various embodiments, techniques comprise affixing a harvested sensory neuron (e.g., a DRG) to a nerve graft segment to form a test construct; culturing the test construct in a medium; analyzing the test construct to indicate the amount of outgrowing peripheral nerve structure; and determining the potency of the nerve graft from a metric derived from the analysis. In some embodiments, techniques and materials may be used to test the effect of a varied test condition on peripheral nerve growth.Type: GrantFiled: September 20, 2021Date of Patent: January 30, 2024Assignee: Axogen CorporationInventor: Curt Deister
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Patent number: 11885724Abstract: A staining composition for staining cells and for use in a method of staining cells, a method of diagnosing mitotic activity and a method of diagnosing cancer. The composition comprises dried petunia petals at least partially dissolved in distilled water; and 400 milligrams of picric acid per gram of dried petunia petals. The method of staining cells includes rinsing a sample containing the cells with 10% of phosphotungistic acid or 10% of phosphomolybdic acid; staining the sample with the composition and dehydrating the samples with 100% Ethanol or Isopropanol. The method of diagnosing mitotic activity includes observing stained regions in the sample to identify mitotic activity indicated by stained regions. The method for diagnosing cancer includes quantifying mitotic figures in the sample which are identified by stained regions of the sample.Type: GrantFiled: March 12, 2020Date of Patent: January 30, 2024Assignee: United Arab Emirates UniversityInventor: Hayfaa Abd Ali Mohammed Alshamar
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Patent number: 11884933Abstract: An elongated or fiber-supported multicellular aggregation of multipotent cells, wherein multipotent cells are arranged in an oblong or longish arrangement with an aspect ratio of a prolate dimension to a perpendicular dimension of at least 2:1, or supported by a fibrous structure, and wherein the aggregate contains cells at different stages of differentiation, and the aggregate contains polar cells; methods of generating such aggregates; methods of developing the aggregates further into tissue organoids and kits for such methods.Type: GrantFiled: January 11, 2017Date of Patent: January 30, 2024Assignee: IMBA—INSTITUT FÜR MOLEKULARE BIOTECHNOLOGIE GMBHInventors: Jürgen Knoblich, Madeline A. Lancaster
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Patent number: 11879138Abstract: The present application provides a method for preparing mesenchymal stem cell-derived exosomes, the method including: obtaining a cell sample from mesenchymal stem cells and sub-culturing the cell sample, culturing the sub-cultured cells in a substrate medium containing a protein synthesis inhibitory enzyme, and then obtaining a cell culture solution, and isolating exosomes from the cell culture solution, and a cell culture solution produced therefrom. The method for preparing exosomes of the present application has an advantage in that high purity and high concentration exosomes can be isolated.Type: GrantFiled: June 29, 2020Date of Patent: January 23, 2024Assignee: CK-EXOGENE CO., LTD.Inventors: Jae Young Kim, Yong Joon Chwae
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Patent number: 11866730Abstract: The present invention relates to a cytopheretic cartridge for use in treating and/or preventing inflammatory conditions within a subject and to related methods. More particularly, the invention relates to a cytopheretic cartridge that includes a housing and, disposed within the housing, a solid support capable of sequestering activated leukocytes and/or platelets.Type: GrantFiled: September 13, 2021Date of Patent: January 9, 2024Assignee: SeaStar Medical, Inc.Inventors: H. David Humes, Deborah A. Buffington, Christopher J. Pino
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Patent number: 11859210Abstract: Disclosed herein are methods of producing chondrocytes from pluripotent stem cells. The invention further provides methods of regenerating cartilaginous tissue.Type: GrantFiled: June 5, 2020Date of Patent: January 2, 2024Assignee: SCRIPPS HEALTHInventors: Darryl D. D'Lima, Tsaiwei Olee, Clifford W. Colwell
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Patent number: 11859235Abstract: According to one embodiment, a sensor for detecting a target substance in gas a sample includes a target substance uptake unit that brings an acetylcholine aqueous solution into contact with a gas sample to dissolve a target substance in the gas sample into the acetylcholine aqueous solution, a reaction unit that holds acetylcholinesterase and brings the solution delivered from the target substance uptake unit into contact with the acetylcholinesterase, and a detection unit that measures a change in an amount of acetylcholine decomposition product produced in the solution delivered from the reaction unit.Type: GrantFiled: March 11, 2021Date of Patent: January 2, 2024Assignee: Kabushiki Kaisha ToshibaInventors: Tatsuro Saito, Yoshiaki Sugizaki