Patents Examined by Blaine Lankford
  • Patent number: 11226330
    Abstract: The present invention provides a method for capturing specific cells (e.g. many types of cancer cells, including cancer cells not expressing EpCAM) and a method for analysis of specific cells involving the method. Included is a method for capturing specific cells present in blood or biological fluid, the method including: subjecting sampled blood or biological fluid to enrichment; and capturing specific cells therefrom onto a hydrophilic polymer layer in a flow field.
    Type: Grant
    Filed: January 16, 2019
    Date of Patent: January 18, 2022
    Inventors: Yasuhisa Minagawa, Masaru Tanaka, Takashi Hoshiba, Haruka Emura, Masaki Mori, Hirofumi Yamamoto, Naotsugu Haraguchi
  • Patent number: 11219643
    Abstract: A method comprising obtaining a first cell sample from a first subject; obtaining a second cell sample from a second subject; culturing the first cell sample in the presence of at least a portion of a culture media of the second cell sample for a time period ranging from about 24 hours to about 6 weeks to produce a restoring composition; and contacting the restoring composition with the second cell sample for a period of time ranging from about 24 hours to about 6 weeks to produce a restored composition.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: January 11, 2022
    Assignee: Advanced Regen Medical Technologies, LLC
    Inventor: Vincent C. Giampapa
  • Patent number: 11220467
    Abstract: A process for fermenting and recycling food waste that is fully enclosed, eliminating noxious odors, and therefore installable in a wide variety of urban settings at scale. Generally the steps of the process include intake, shredding and grinding, inoculation and acceleration, heterolactic fermentation, separation of solids and liquids, drying and distillation, and post-processing of liquid and solid byproducts. The result of the process includes useful goods such as nutrient-rich soil fertilizer, household cleaning agent, energy in the form of current or hydrogen, and treated water. The process is energy efficient and self-contained, resulting in the processing of food waste within 7 days, thus dramatically reducing the time of traditional fermentation processes to produce desired byproducts.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: January 11, 2022
    Assignee: Recycle Track Systems, Inc.
    Inventors: Amanda Weeks, Brett Van Aalsburg, Erik Vosburgh, Maria del Pilar Sanchez Rodriguez
  • Patent number: 11207353
    Abstract: Provided herein is a placental product comprising an immunocompatible amniotic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: December 28, 2021
    Inventors: Samson Tom, Alla Danilkovitch, Dana Yoo, Timothy Jansen, Jin-Qiang Kuang, Jennifer Michelle Marconi
  • Patent number: 11208340
    Abstract: A multi-step method for producing an algae product comprising, a microorganism consumption step, another step, and an algae product collection step. The microorganism consumption step comprises, combining a liquid growth medium comprising microorganisms with a phagotrophic algae capable of producing a desired algae product, consuming said microorganisms by said phagotrophic algae, and growing said phagotrophic algae. Another step comprises either a microorganism growth step or a photosynthetic algal growth step. A microorganism growth step comprises providing a liquid growth medium comprising nutrients and microorganisms capable of said consuming said nutrients, consuming said nutrients by said microorganisms, and growing said microorganisms. A photosynthetic algal growth step comprises providing a substantially organic nutrient depleted liquid medium, providing a microorganism population comprising said phagotrophic algae, photosynthetic growth of said phagotrophic algae.
    Type: Grant
    Filed: December 30, 2008
    Date of Patent: December 28, 2021
    Assignee: University of Akron
    Inventor: Lu-Kwang Ju
  • Patent number: 11207511
    Abstract: The invention relates to methods of treating baldness, treating alopecia, promoting hair growth, and/or promoting hair follicle development and/or activation or stimulation on an area of the skin of a subject (for example, a human) by subjecting said area of the skin to integumental perturbation. Integumental perturbation can be used in combination with other treatments for promoting hair growth. The invention provides devices for integumental perturbation for promoting hair growth, and provides pharmaceutical compositions for use in combination with integumental perturbation for promoting hair growth.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: December 28, 2021
    Assignee: Follica, Inc.
    Inventors: Shikha P. Barman, William D. Ju, Scott C. Kellogg, Stephen M. Prouty, Eric Schweiger, Seth Lederman, Mary Osbakken, Alan D. Schinazi
  • Patent number: 11198893
    Abstract: Provided is a method for producing an unsaturated fatty acid oxide (e.g. ?3 fatty acid oxide) that is new and has more beneficial features compared to conventional technologies. This method uses a lipoxygenase-containing composition (e.g. a lipoxygenase-containing composition derived from beans) as a lipoxygenase enzyme, and also uses a freezing method with organic solvent extraction. The present invention makes it possible to produce an unsaturated fatty acid oxide (e.g. ?3 fatty acid oxide) efficiently and at a low cost. The present invention also provides a pharmaceutical composition containing an ?3 fatty acid oxide isolated and purified by this method as an active ingredient.
    Type: Grant
    Filed: June 19, 2017
    Date of Patent: December 14, 2021
    Assignee: Bizen Chemical Co., Ltd.
    Inventors: Shiho Saito, Yoshihisa Misawa, Naomichi Baba, Hiroshi Tabata, Tadahiro Tsushima, Jun Fujii
  • Patent number: 11186852
    Abstract: This disclosure provides methods for fermentation of sugar substrates by acid-tolerant bacteria for producing acetic and lactic acids, and methods for further processing of these products to obtain acetate and propionate biodegradable deicers. Methods are also disclosed on the use of acid tolerant bacteria to produce acetate and propylene glycol deicing compounds.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: November 30, 2021
    Inventors: Alexander P. Mathews, Sathyanarayanan Sevilimedu Veeravalli
  • Patent number: 11181448
    Abstract: Methods and techniques for controlled printing of a cell sample for karyotyping are provided. The methods can involve matrix printing using on-the-fly printing or dispensing to accurately spread cells within at least one cell sample on a surface in preparation for karyotyping, and further analysis. Advantageously, the methods result in a uniform distribution of chromosomes of the cell suspension or sample on the surface of a substrate which can be substantially discretely identified, and also provide for efficiency in a subsequent staining process and any further analysis of the stained chromosomes using a microscope or other imaging device.
    Type: Grant
    Filed: November 4, 2013
    Date of Patent: November 23, 2021
    Assignee: BIODOT, INC.
    Inventors: Brian L. Kirk, Anthony V. Lemmo, Thomas C. Tisone
  • Patent number: 11179498
    Abstract: Medical devices having engineered mechanically functional cartilage from adult human mesenchymal stem cells and method for making same.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: November 23, 2021
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Sarindr Bhumiratana, Gordana Vunjak-Novakovic
  • Patent number: 11179311
    Abstract: The present invention relates to the novel trypsin ZT isoforms. In particular, the invention relates to the use of trypsin ZT isoforms in medical devices, pharmaceuticals and cosmetics.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: November 23, 2021
    Assignee: ENZYMATICA AB
    Inventors: Agusta Gudmundsdottir, Asgeir Asgeirsson, Bjarki Stefansson
  • Patent number: 11167286
    Abstract: A sensor for selectively capturing a targeted cell type in a fluid includes an engineered surface. The engineered surface includes a substrate, a non-adhesive element disposed on at least a portion of a substrate, and an adhesive element disposed on the substrate. The sensor also includes a flow channel in operative contact with the engineered surface; and a detector configured to detect the targeted cell type captured on the engineered surface. Also described is a method for selectively capturing target cell types using the engineered surface.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: November 9, 2021
    Inventors: Maria M. Santore, Kathleen Arcaro, Surachate Kalasin
  • Patent number: 11166451
    Abstract: A method for platelet preservation comprising placing a composition comprising platelets in a gas mixture comprising xenon and oxygen under pressure of about 0-10 Bars at a first temperature of about 18° C.-37° C. for a first period of time, and then subsequently cooling the composition to a second temperature of about 0,1° C.-6° C., and holding the composition under the pressure and in the second temperature for a second period of time.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: November 9, 2021
    Assignee: Rich Technologies Holding Company, LLC
    Inventors: Ilya Ilyin, Semyon Kogan, William E. Grieshober, Jr., James S. Jones, Alexander N. Shumeev, Stanislav A. Kolchanov, Yana A. Filkina, Yuriy Punin, Natella I. Enukashvily
  • Patent number: 11156595
    Abstract: Techniques and systems are disclosed for a bioassay that is an in vitro mimic of peripheral nerve generation using the sensory neurons that innervate the peripheral nervous system. In some embodiments, the techniques may assist in detecting the bioactivity or potency of nerve grafts (e.g., processed, acellular human allografts) for fostering or supporting peripheral nerve regeneration. In various embodiments, techniques comprise affixing a harvested sensory neuron (e.g., a DRG) to a nerve graft segment to form a test construct; culturing the test construct in a medium; analyzing the test construct to indicate the amount of outgrowing peripheral nerve structure; and determining the potency of the nerve graft from a metric derived from the analysis. In some embodiments, techniques and materials may be used to test the effect of a varied test condition on peripheral nerve growth.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: October 26, 2021
    Assignee: Axogen Corporation
    Inventor: Curt Deister
  • Patent number: 11149293
    Abstract: This invention provides a fermentation method of producing gellan gum, wherein a certain amount of fermentation broth is retained in the fermentor as a seed for next batch fermentation or transferred to another fermentor as a seed for next batch fermentation in that fermentor. The fermentation method of this invention reduces fermentation cost of gellan gum and lowers contamination risk during seed cultivation.
    Type: Grant
    Filed: November 1, 2018
    Date of Patent: October 19, 2021
    Assignees: Zhejiang DSM Zhongken Biotechnology Co. Ltd, DSM IP Assets B.V.
    Inventors: Jie Zhao, Wouter Adrianus Van Winden, Rogier Meulenberg, Zhihui Gao
  • Patent number: 11141393
    Abstract: Provided are methods for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin. Pharmaceutical compositions suitable for such treatments are also provided.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: October 12, 2021
    Assignee: United Therapeutics Corporation
    Inventors: Roger Jeffs, Thomas Petersen, Roger M. Ilagan, Michael Wade
  • Patent number: 11141468
    Abstract: The invention is related to a new method for treating liquid and solid cancers, in a mammal, including human, wherein methioninase is administered before asparaginase. The invention also encompasses the use of a dietary methionine deprivation, possibly combined with methioninase administration, in advance of asparaginase treatment. Methioninase and asparaginase may be used in particular under free form, pegylated form or encapsulated into erythrocytes.
    Type: Grant
    Filed: January 2, 2017
    Date of Patent: October 12, 2021
    Assignee: ERYTECH PHARMA
    Inventors: Karine Aguera, Willy Berlier, Fabien Gay, Yann Godfrin
  • Patent number: 11124756
    Abstract: Embodiments provide methods to produce an assembly that mimics in vitro the human microenvironment of a primary tumor site, a secondary distant organ, and circulation. Methods and apparatuses that provide a platform for the isolation of primary tumor, invasive, and metastatic cells to be used for evaluation of therapeutic efficacy and diagnostics as applied to metastatic cancers are also provided.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: September 21, 2021
    Assignee: zPredicta, Inc.
    Inventors: Julia Kirshner, Mukti Rajen Parikh
  • Patent number: 11124762
    Abstract: A pH-modulating poly(glycerol sebacate) composition includes poly(glycerol sebacate) and at least one pH-modulating agent associated with the poly(glycerol sebacate). A process of making a pH-modulating poly(glycerol sebacate) composition includes forming a poly(glycerol sebacate) by a water-mediated reaction from glycerol and sebacic acid and associating at least one pH-modulating agent with the poly(glycerol sebacate). A process of modulating a pH of a buffered aqueous solution includes placing a pH-modulating poly(glycerol sebacate) composition in a buffered aqueous solution. The pH-modulating agent is released into the buffered aqueous solution during degradation of the poly(glycerol sebacate) to reduce a decrease in pH of the buffered aqueous solution caused by degradation of the poly(glycerol sebacate).
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: September 21, 2021
    Inventors: Peter D. Gabriele, Jeremy J. Harris, Charles Brendan Nicholson, Steven Lu, Brian Ginn
  • Patent number: 11124758
    Abstract: The present invention has publicized a bacteria culture medium. In common bacteria culture medium, one kind or several kinds of ?-lactam antibiotics and/or the salts thereof were premixed. The ?-lactam antibiotics and/or the salts thereof premixed in the bacteria culture medium is slightly soluble in water at 25° C. and the solubility is less than 10 mg/ml. The concentrations of the ?-lactam antibiotics premixed in the culture medium are greater than the solubility of the used ?-lactam antibiotics at 25° C., but are less than 100 mg/ml. The bacteria culture medium can be used to selectively culture bacteria with ?-lactam antibiotic resistance and can be stored for a long time.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: September 21, 2021
    Inventors: Botao Zhao, Chunhai Cai, Guoquan Zhou, Dehua Yang, Jin Liu