Patents Examined by Blessing M. Fubara
  • Patent number: 10980748
    Abstract: There is provided a solid pharmaceutical composition for delivering by oral administration a pharmaceutically active binding polypeptide to a region of the intestinal tract comprising a compressed core, wherein the compressed core comprises a pharmaceutically active binding polypeptide and wherein the compressed core is coated with a pH sensitive enteric coating.
    Type: Grant
    Filed: August 7, 2020
    Date of Patent: April 20, 2021
    Assignee: VHsquared Ltd.
    Inventors: Scott Crowe, Mike West, Kevin Roberts, Tim Carlton, Luana Maggiore, Marion Cubitt, Gary Whale, John Wahlich, Mike Frodsham
  • Patent number: 10967346
    Abstract: Provided is an organic solvent-free method for producing a plurality of microsphere having an average diameter of less than 500 ?m in diameter and having average contact angle ?c greater than 140°, consisting essentially of a biocompatible hot-melt carrier vehicle and a payload substance to be delivered, including melting and mixing a polymer carrier vehicle which is solid at room temperature and at least one payload substance, and dispensing microportions of the molten mixture through a droplet-forming space onto a cooled solid superoleophobic surface.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: April 6, 2021
    Assignee: Shenkar Engineering Design Art
    Inventors: Dan Lewitus, Tal Shpigel Shtauber
  • Patent number: 10960105
    Abstract: The present invention relates to improved hemostatic compositions comprising cellulose-based fibers supplemented with compounds, preparation and use thereof.
    Type: Grant
    Filed: February 6, 2020
    Date of Patent: March 30, 2021
    Assignees: Omrix Biopharmaceuticals Ltd., Ethicon, Inc.
    Inventors: Erez Ilan, Omri Faingold, Nataly Freizus, Ronen Eavri, Dwayne Looney, Sridevi Dhanaraj, James Galloway, Walter Danker
  • Patent number: 10961352
    Abstract: A Crosslinked Aminosilicone Polymer is useful in personal care applications, particularly hair care or textile treatment. A process for making the Crosslinked Aminosilicone Polymer is also described.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: March 30, 2021
    Assignee: Dow Silicones Corporation
    Inventors: Kimmai Nguyen, Qian Feng, Nisaraporn Suthiwangcharoen, Hannah Wedge, Severine Cauvin, Jonathan Thill, Bethany Johnson
  • Patent number: 10960109
    Abstract: The present invention relates to an Autologous Bone Graft Substitute composition (ABGS) for inducing new bone formation, promoting bone growth and treating of bone defect, a preparation method of the Autologous Bone Graft Substitute composition, and a kit for preparing the Autologous Bone Graft Substitute composition of implant. In a particular aspect, the invention relates to an injectable/extrudable/implantable Autologous Bone Graft Substitute composition for use in treatment of bone defects, inducing new bone formation and promoting bone growth for bone fracture healing, spinal fusions and to repair bone defects in bone reconstructive procedures of orthopedic and oral maxillofacial-dental surgeries.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: March 30, 2021
    Assignee: Perform Biologies, Inc.
    Inventors: Slobodan Vukicevic, Kuber T. Sampath, Lovorka Grgurevic, Charles Cohen, Hermann Oppermann
  • Patent number: 10940119
    Abstract: In one aspect, methods of preparing composite nanoparticle compositions are described herein. For example, in some embodiments, a method comprises providing a zein solution stream, an organic fluid stream including at least one additive and at least one buffer fluid stream. The zein solution stream, organic fluid stream and buffer fluid stream are delivered to a chamber for mixing at one or more rates sufficient to flash precipitate composite nanoparticles including the additive encapsulated by a shell comprising the zein.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: March 9, 2021
    Assignee: The Trustees of Princeton University
    Inventors: Nikolas T. Weissmueller, Robert K. Prud'Homme
  • Patent number: 10933028
    Abstract: The invention discloses a preparation method of pH/reduction responsive polyamino acid zwitterionic nanoparticles, which belongs to the technical field of polymer synthesis and biomedical materials. In the invention aliphatic amines are used to initiate ring-opening polymerization of ?-benzyl-L-glutamate-N-carboxylic anhydride, and the obtained poly(?-benzyl-L-glutamate) reacts with L-lysine to form azwitterionic polymer. The zwitterionic polymer is crosslinked by cysteamine, producing pH/reduction responsive polyamino acid zwitterionic nanoparticles after purification. The nanoparticles are pH responsive and resistant to non-specific protein adsorption. Because cysteamine contains disulfide bonds, the nanoparticles have sensitive reductive responsiveness and can load anticancer drugs for controlled release at the target site of cancer.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: March 2, 2021
    Inventors: Liping Zhang, Caihua Ni, Ren Liu, Dawei Wang, Gang Shi, Xinxin Sang, Xiaofeng Xia
  • Patent number: 10933092
    Abstract: An object is to provide an external composition for skin capable of easily enhancing body balance ability even for ordinary people such as housewives, students, middle-aged and mature-aged males and females, and elderly persons who do not aggressively exercise on a routine basis other than athletes. The object has been solved by an external composition for skin including a rhodochrosite extract extracted from rhodochrosite with water, a hematite extract extracted from hematite with water, a smithsonite extract extracted from smithsonite with water, and an olivine extract extracted from olivine with water, and the like.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: March 2, 2021
    Assignee: TEIKOKU CO., LTD.
    Inventor: Kenichiro Hatakeyama
  • Patent number: 10925282
    Abstract: A process is provided for the time dependent reduction and kill of cellular bacteria in a fluid by sequential exposure to nitrites and a low concentration of biocide. Oilfield water containing sulfate-reducing bacteria can be supplied with a timed sequential exposure of nitrite and biocide. The timed sequential addition of the biocide following exposure to the nitrite provides enhanced kill of the sulfate-reducing bacteria at concentrations of biocide that are lower than would be possible using simultaneous addition of these materials.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: February 23, 2021
    Inventor: Gary Jenneman
  • Patent number: 10918630
    Abstract: The present invention discloses stable delayed release multiparticulate powder for oral suspension of proton pump inhibitor compounds comprising: a) a core with an effective amount of proton pump inhibitor and at least one or more pharmaceutical excipients, b) at least one water-soluble seal coating over core c) at least one enteric coating layer over the seal coat wherein the core is free of a surfactant. The prior art discloses restrictive formulation techniques and suggests higher amounts of various excipients to achieve desired technical attributes. The prepared test formulations exhibited desired pharmaceutical technical attributes like drug release, assay, stability, no polymorphic change, reduced sticking to nasogastric and gastronomy tubes, and packaging material.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: February 16, 2021
    Inventors: Kamal Surendrakumar Mehta, Saurabh Srivastava, Dinesh Kumar, Amit Kumar Jha, Subash Chandra Mohanta, Sunil Kumar Panda, Ganesh Vinayak Gat
  • Patent number: 10918583
    Abstract: The present invention relates to a cosmetic or dermatological composition comprising, in a physiologically acceptable support: a) at least one oily phase and b) at least one merocyanine compound of formula (1) defined hereinbelow and c) at least one organic UVB-screening agent chosen from: v) a liquid lipophilic organic UVB-screening agent vi) a hydrophilic organic UVB-screening agent vii) a triazine UVB-screening agent and viii) mixtures thereof; and d) at least one organic UVA-screening agent other than the said merocyanine compound; when the said UVB-screening agent is liquid and lipophilic, the said composition contains less than 2% by weight of cyclohexasiloxane relative to the total weight of the composition. Another subject of the present invention consists of a non-therapeutic cosmetic process for caring for and/or making up a keratin material, comprising the application, to the surface of the said keratin material, of at least one composition according to the invention as defined above.
    Type: Grant
    Filed: January 20, 2014
    Date of Patent: February 16, 2021
    Assignee: L'OREAL
    Inventors: Angelina Roudot, Didier Candau
  • Patent number: 10918593
    Abstract: A personal lubricant disk is described. The personal lubricant disk typically comprises a composition that is solid at ambient room temperature and melts into a liquid when placed and moved around the bodily surface of a human person. The composition of the personal lubricant disk typically comprises at least one of an emollient, a low melting point wax, a low melting point oil, and a water based lubricant. Variations of the personal lubricant disk composition can also include ingredients the stimulate different sensory reactions when the personal lubricant disk is placed and moved around the bodily surface, such as a warming or cooling sensation, as well as various pleasant tastes or scents.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: February 16, 2021
    Inventor: Amy M. Spring
  • Patent number: 10898440
    Abstract: The present disclosure relates to aqueous composition comprising hydroxypropyl methyl cellulose acetate succinate (HPMCAS) polymer dispersed in water, wherein the dispersed polymer is partially neutralized with at least one alkaline material. The instant disclosure also relates to compositions for use in methods of making capsule shells endowed with bulk enteric properties. The present disclosure also relates to capsules made according with the compositions and methods of the present disclosure.
    Type: Grant
    Filed: October 22, 2019
    Date of Patent: January 26, 2021
    Assignee: Capsugel Belgium NV
    Inventors: Dominique Nicolas Cade, Hugues Straub
  • Patent number: 10869533
    Abstract: The present invention relates to a cosmetic composition applicator comprising a urethane foam obtained by foaming a polyurethane, wherein the urethane foam has a structure comprising a membrane structure and a net structure. According to the present invention, the cosmetic composition applicator has improved transfer ability due to the simple absorption and discharge of a cosmetic composition and, simultaneously, can smoothly apply a cosmetic composition to the skin without caking.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: December 22, 2020
    Inventor: Jung Sun Choi
  • Patent number: 10857261
    Abstract: A solidifying prepolymeric implant composition comprising a biocompatible prepolymer and an optional filler. One such implant composition is a polyurethane implant composition comprising an isocyanate, such as hydroxymetbylenediisocyanate (HMDI) and an alcohol, such as polycaprolactonediol (PCL diol). The compositions of the invention are useful for improving bone structure in patients by applying the solidifying implant composition to bone, reinforcing bone structure, improving load bearing capacity and/or aiding healing of microfractures.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: December 8, 2020
    Assignee: 206 ORTHO, Inc.
    Inventors: Jeffrey A. D'Agostino, Andrew J. Carter, Craig M. Jones, Arthur C. Watterson
  • Patent number: 10849929
    Abstract: The present disclosure provides compositions and methods useful in the deactivation of allergens. The compositions can comprise a peroxide and can particularly be at a relatively low pH (e.g., less than 5). The compositions exhibit efficacy for deactivation of a wide variety of allergens and are suitable for application to one or more types of surfaces to provide for deactivation of at least a portion of allergens present on the surface.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: December 1, 2020
    Assignee: Chuch & Dwight Co., Inc.
    Inventors: Steven T. Adamy, Timothy C. Morris
  • Patent number: 10849834
    Abstract: A cosmetic gel sheet suitable for a cosmetic field or a medical field is provided. The cosmetic gel sheet of the present invention contains carboxy group-containing water-soluble polymer, polyalcohol, and acid as essential constituent components. Carboxy group-containing polysaccharide can be suitably used as the carboxy group-containing water-soluble polymer. Water content in the gel sheet is 30% by weight, but it is more preferable if the water content is 10% by weight or less. In the cosmetic gel sheet of the present invention, the gel sheet can be manufactured by drying an aqueous solution containing carboxy group-containing water-soluble polymer, polyalcohol, and acid as essential components. Wherein, it is desirable that content of the acid in the aqueous solution is adjusted to a value appropriate for setting pH of the aqueous solution to 2.0-4.0.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: December 1, 2020
    Inventors: Naoko Kondou, Ying-shu Quan, Fumio Kamiyama
  • Patent number: 10842908
    Abstract: A hemostatic composition is provided. The hemostatic composition includes a hemostatically effective amount of a hemostatic agent that includes a nanoparticle and a polyphosphate polymer attached to the nanoparticle. Also provided are medical devices and methods of use to promote blood clotting.
    Type: Grant
    Filed: April 22, 2019
    Date of Patent: November 24, 2020
    Assignees: The Regents of the University of California, The Board of Trustees of the University of Illinois
    Inventors: Damien Kudela, Galen D Stucky, Anna May-Masnou, Gary Bernard Braun, James H Morrissey, Stephanie A Smith
  • Patent number: 10842839
    Abstract: Compositions and methods for treating and/or preventing hangover are disclosed. In certain embodiments, the compositions include at least one B vitamin, activated charcoal, at least one mineral, and at least one herbal extract.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: November 24, 2020
    Assignee: RVRS, LLC
    Inventor: Nader George Mikhail
  • Patent number: 10828397
    Abstract: Disclosed are a regenerative medical material for promoting the repair of soft and hard tissues, a preparation method therefor, and the use thereof. The regenerative medical material has a three-dimensional network structure and is a composite material composed of inorganics and organics, wherein the mass ratio of the inorganics to the organics is 2:1-4:1. Based on the total mass of the inorganics, the inorganics contain 12-38% SiO2, 3-5% Na2O, 15-29% CaO, 10-32.5% P2O5, 1-5% inositol hexaphosphate, 1-5% cyclohexanhexol phosphate, and the balance of impurities, with the content of impurities being less than 0.5%. Based on the total mass of the organics, the organics contain 30-60% carboxymethyl chitosan and 30-60% sodium hyaluronate. The regenerative medical material has a composition and properties better suited to the human body and plays a key role in cell repair and bonding, cell proliferation, and promoting the growth of hair follicles.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: November 10, 2020
    Inventor: Fang Hu