Patents Examined by Brandon Fetterolf
  • Catalyst, method of preparing the same, and method of preparing aromatic carbonate from dialkyl carbonate using the same
    Patent number: 8759561
    Abstract: The present invention provides a catalyst for synthesizing an aromatic carbonate, a method of preparing the same, and a method of preparing an aromatic carbonate from dialkyl carbonate using the catalyst. The catalyst has a unit structure consisting of Formulae 1a, 1b or 1c: wherein R1 is C1-C5 alkyl, R2 is substituted or unsubstituted phenyl.
    Type: Grant
    Filed: October 16, 2012
    Date of Patent: June 24, 2014
    Assignee: Cheil Industries Inc.
    Inventors: Mie Ock Kim, Chang Hoon Lee, Dong Baek Kim
  • Process for the preparation of a composition comprising meso-tartaric acid
    Patent number: 8759574
    Abstract: The present invention relates to a process for the preparation of a composition comprising tartaric acid wherein between 55 and 90% by weight of the tartaric acid is meso-tartaric acid, comprising the steps of (i) preparing an aqueous mixture comprising between 35 and 65% by weight of a di-alkali metal salt of L-tartaric acid, a di-alkali metal salt of D-tartaric acid, a mixture of di-alkali metal salts of L-tartaric acid, D-tartaric acid, and optionally meso-tartaric acid, and between 2 and 15% by weight of an alkali metal or alkaline metal hydroxide, and (ii) stirring and heating the aqueous mixture to a temperature of between 100° C. and its boiling point until between 55 and 90% by weight of tartaric acid has been converted to meso-tartaric acid.
    Type: Grant
    Filed: May 27, 2010
    Date of Patent: June 24, 2014
    Assignee: Akzo Nobel Chemicals International B.V.
    Inventors: Hendrikus Wilhelmus Bakkenes, Roberto Aloysius Gerardus Maria Bergevoet, Johannes Albertus Maria Meijer, Maria Steensma
  • Method for producing ?-hydroxycarboxylic acid ester
    Patent number: 8759566
    Abstract: Provided is a process for producing ?-hydroxycarboxylic esters from ?-hydroxycarboxylic amides and aliphatic alcohols, wherein it is a production process which is inhibited in a production cost and enhanced in a conversion rate and a selectivity and which is industrially advantageous. To be specific, it is a production process for ?-hydroxycarboxylic ester characterized by subjecting ?-hydroxycarboxylic amide and aliphatic alcohol to a gas phase reaction in the presence of a zirconium dioxide catalyst. A catalyst lifetime is improved to a large extent by using a zirconium dioxide catalyst containing a specific element.
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: June 24, 2014
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Hideho Matsuda, Yuuichi Sugano, Yoshikazu Shima, Masaki Takemoto, Genki Nogami
  • Synthesis of azo bonded immunoregulatory compounds
    Patent number: 8754197
    Abstract: Methods are disclosed for preparing compounds of Formula I: where R1, R3, and R4 are independently hydrogen or C1 to C4 alkyl, and R2 is: where R5 is selected from the group consisting of hydrogen and C1 to C4 alkyl, or where R6, R7 and R8 are independently hydrogen or C1 to C4 alkyl; or the esters or pharmacologically acceptable salts thereof. The compounds and or their metabolites can be used to treat or prevent various diseases, particularly inflammatory conditions of the GI tract.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: June 17, 2014
    Assignee: Biocon Limited
    Inventors: Jennifer A. Riggs-Sauthier, Nnochiri N. Ekwuribe
  • Method for the synthesis of an omega-amino acid or ester starting from a monounsaturated fatty acid or ester
    Patent number: 8748651
    Abstract: The invention relates to a method for the synthesis of ?-amino alkanoic acids or esters thereof starting from unsaturated natural fatty acids passing through an ?-unsaturated nitrile intermediate compound.
    Type: Grant
    Filed: November 17, 2009
    Date of Patent: June 10, 2014
    Assignee: Arkema France
    Inventor: Jean-Luc Dubois
  • Method for production of N-carboxy amino acid anhydride and amino acid carbamate compound
    Patent number: 8748650
    Abstract: A method for production of an N-carboxy amino acid anhydride with efficiency is provided. The method for production of an N-carboxy amino acid anhydride includes a step of reaction of an amino acid organic salt compound with a carbonic acid diester.
    Type: Grant
    Filed: August 26, 2009
    Date of Patent: June 10, 2014
    Assignee: JSR Corporation
    Inventors: Takeshi Endo, Koichi Koga, Atsushi Sudo
  • Process for producing optically active bicyclo [3.1.0] hexane derivative using enzyme
    Patent number: 8742161
    Abstract: There is provided a process for producing a bicyclo [3.1.0] hexane derivative represented by the formula (I) and a salt thereof including; causing an enzyme to act on an optically inactive compound represented by the formula (II) causing an asymmetric acylation reaction and a highly-stereoselective conversion to an optically active compound represented by the formula (III); and converting the compound represented by the formula (III) to the compound represented by the formula (I) or a salt thereof.
    Type: Grant
    Filed: November 18, 2010
    Date of Patent: June 3, 2014
    Assignee: Taisho Pharmaceutical Co., Ltd
    Inventor: Joji Sasaki
  • Indole derivatives and methods for antiviral treatment
    Patent number: 8735414
    Abstract: The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.
    Type: Grant
    Filed: April 5, 2010
    Date of Patent: May 27, 2014
    Assignee: PTC Therapeutics, Inc.
    Inventors: Malcolm MacCoss, F. George Njoroge, Amin Nomeir, Guangming Chen, Song Xiao Huang, Ramesh Kakarla, Gary Mitchell Karp, William Joseph Lennox, Chunshi Li, Ronggang Liu, Yalei Liu, Christie Morrill, Steven D. Paget, Sean W Smith, James Takasugi, Anthony A. Turpoff, Hongyu Ren, Nanjing Zhang, Xiaoyan Zhang, Jin Zhu
  • Infusion and injection solution of levodopa
    Patent number: 8735382
    Abstract: An infusion or injection solution of Levodopa containing at least 10 mg/mL of Levodopa, or at least 5 mg/mL of Levodopa together with at least 0.5 mg/mL of at least one inhibitor of a Levodopa-metabolising enzyme is disclosed. The solution further contains a buffer, a physiologically acceptable sugar, such as glucose, a physiologically acceptable acid, such as hydrochloric acid, and optionally a stabilizer, and has a pH of lower than or equal to 6. There are also described a disposable syringe containing an infusion or injection solution of Levodopa, optionally together with a Levodopa-metabolising enzyme, and an infusion pump cassette containing an infusion or injection solution of Levodopa optionally together with a Levodopa-metabolising enzyme.
    Type: Grant
    Filed: August 12, 2011
    Date of Patent: May 27, 2014
    Assignee: Dizlin Medical Design AB
    Inventor: Nil Dizdar Segrell
  • Preparation of carbamates with solid catalysts
    Patent number: 8735621
    Abstract: Carbamate preparation process comprising, the reaction between at least: an amine or polyamines, an organic carbonate of formula (OR)(OR?)C?O, a catalyst which is formed by at least a support selected from at least a metal oxide, a microporous material, a mesoporous material, an anionic laminar compound of hydrotalcite type or their derivatives or an organic polymer and which may further contain a metal from groups 8, 9, 10 and 11 of the periodical system. The carbonates obtained can be transformed in their corresponding isocyanates.
    Type: Grant
    Filed: December 16, 2008
    Date of Patent: May 27, 2014
    Assignees: Consejo Superior de Investigaciones Cientificas, Universidad Politecnica de Valencia
    Inventors: Avelino Corma Canós, Raquel Juarez Marin, Hermenegildo Garcia Gomez
  • Compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same
    Patent number: 8729273
    Abstract: The present invention relates to novel compounds which are effective as an inhibitor for xanthine oxidase, a process for preparing the same, and a pharmaceutical composition comprising a therapeutically effective amount of the same.
    Type: Grant
    Filed: October 4, 2010
    Date of Patent: May 20, 2014
    Assignee: LG Life Sciences Ltd.
    Inventors: Jeong Uk Song, Geun Tae Kim, Sung Pil Choi, Cheol Kyu Jung, Deok Seong Park, Eun Sil Choi, Tae Hun Kim, Hyun Jung Park, Wan Su Park, Heui Sul Park, Ki Chul Koo, Vasily Artemov
  • Method of making glycerol
    Patent number: 8729290
    Abstract: Method of producing glycerol that includes mixing a peroxide stream with an olefenic alcohol stream to form a feed stream; processing the feed stream in a high shear device to produce a high shear dispersion of peroxide and olefinic alcohol, wherein the high shear device is configured with a rotor and a stator separated by a shear gap; and contacting the high shear dispersion with a catalyst in a reactor to produce glycerol.
    Type: Grant
    Filed: August 13, 2012
    Date of Patent: May 20, 2014
    Assignee: H R D Corporation
    Inventors: Abbas Hassan, Ebrahim Bagherzadeh, Rayford Anthony, Gregory Borsinger, Aziz Hassan
  • Therapeutic, dietary or cosmetic use of compounds with specific anti-apoptotic activity toward caspase-3, and compositions containing these compounds
    Patent number: 8729033
    Abstract: This invention regards the use of zeaxanthin and/or rutin, as such or further combined with spermidine, as the active principle in a pharmaceutical, dietary, or cosmetic composition, acting to inhibit caspase-3 and therefore to control apoptosis by preventing programmed cell death. The indication for this composition according to the invention is primarily the treatment of scalp disorders characterized by excessive cellular turnover including chemotherapy-induced alopecia, alopecia areata, androgenetic alopecia and telogen effluvium.
    Type: Grant
    Filed: October 30, 2009
    Date of Patent: May 20, 2014
    Assignee: Giuliani S.p.A.
    Inventors: Giammaria Giuliani, Anna Benedusi, Sergio Baroni
  • Leaven-based mixture
    Patent number: 8729049
    Abstract: An embodiment is a mixture obtainable by a process comprising the following steps: a) adding a culture comprising sprouted rye grains and water to a rye fine or coarse meal and subjecting the mixture to a process of heating to 30-34° C. within 3 to 5 hours, a strong maltose formation being initiated from enzymatic reactions; b) followed by a further addition of rye fine or coarse meal, water and a bacteriological inoculum from the group of heterofermentative lactic-acid bacteria; c) acidifying the mixture until the metabolic activity of the microorganisms ceases, and optionally pasteurizing at 90-95° C.; d) separating the mixture by centrifugation into a solution and a precipitate, after which the solution is optionally filtered at least once.
    Type: Grant
    Filed: September 28, 2010
    Date of Patent: May 20, 2014
    Assignee: woresan GmbH
    Inventor: Gabrielle Wolf
  • Heterocyclic compound
    Patent number: 8722660
    Abstract: Provided is a compound useful for the prophylaxis or treatment of cancer. The present invention relates to a compound represented by formula (I): wherein each symbol in the formula is as defined in the specification, or a salt thereof or a prodrug thereof, which is useful for the prophylaxis or treatment of cancer.
    Type: Grant
    Filed: February 16, 2011
    Date of Patent: May 13, 2014
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Misaki Homma, Toru Miyazaki
  • Quinazolinedione derivatives, preparation thereof and various therapeutic uses thereof
    Patent number: 8722659
    Abstract: The subject matter of the invention is quinazolinedione derivatives of formula (I), methods for obtaining same and therapeutic uses thereof, such as cancer, diabetes, muscle diseases, bone diseases, cardiovascular diseases, central nervous system diseases, peripheral nervous system diseases, inter alia.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: May 13, 2014
    Assignee: Sanofi
    Inventors: Annie Clauss, Christophe Glaess, Gilbert Marciniak, Jean-Francois Nave, Bertrand Vivet
  • Method for pretreating and regenerating catalysts used in a process for making fluoroiodoalkanes
    Patent number: 8722945
    Abstract: A process for the preparation of a fluoroiodoalkane represented by the structural formula CF3(CF2)n—I, wherein n is 0 or 1. The process has the step of reacting a source of iodine with a compound represented by the structural formula CF3(CF2)n—Y, wherein Y is selected from H, Cl, Br and COOH and wherein n is 0 or 1. The reaction is carried out at a temperature from about 100° C. to about 750° C. and at a pressure from about 0.001 to about 100 atm for a contact time from about 0.001 second to about 300 hours in the presence a catalyst.
    Type: Grant
    Filed: November 4, 2008
    Date of Patent: May 13, 2014
    Assignee: Honeywell International Inc.
    Inventors: Shuwu Yang, Hsueh Sung Tung
  • Animal treatments
    Patent number: 8722636
    Abstract: Compositions and methods for the treatment and control of various conditions in an animal which comprises administering to said animal an effective amount of a immediate release composition of about 0.5% to 50% wt/wt of active ingredient together with excipients to a total of about 100%, wherein said compositon dissolves in a relatively short period of time, e.g., 75 seconds or less, 5 seconds or less, or 3 seconds or less, upon administration to said animal.
    Type: Grant
    Filed: January 4, 2012
    Date of Patent: May 13, 2014
    Assignee: New Market Pharmaceuticals, LLC
    Inventors: David Rock, Mark Ridall
  • Methods for integrating the production of cellulose nanofibrils with the production of cellulose nanocrystals
    Patent number: 8710213
    Abstract: Methods for integrating the production of cellulose nanocrystals (CNC) and cellulose nanofibrils (CNF) from cellulose are provided. The methods use milder acid hydrolysis conditions than those for maximal CNC production to achieve reduced degradation of cellulose into soluble sugars. Also provided are negatively charged cellulosic solid residues (CSRs) in the form of cellulose fibers (CF) and/or cellulose microfibrils (CMF) during the acid hydrolysis, as well as CNFs fabricated from the CSRs.
    Type: Grant
    Filed: May 15, 2012
    Date of Patent: April 29, 2014
    Assignee: The United States of America as Represented by the Secretary of Agriculture
    Inventors: JunYong Zhu, Richard S. Reiner
  • Compounds and compositions for treating chemical warfare agent-induced injuries
    Patent number: 8710052
    Abstract: Compounds and compositions for treating injuries caused by exposure to chemical warfare agents are described herein.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: April 29, 2014
    Assignee: Hydra Biosciences, Inc.
    Inventor: Jayhong A. Chong