Abstract: Some embodiments disclosed herein relate to medical connectors with a housing comprising a proximal body member and a base member that form an internal cavity with a proximal abutment surface. An elastomeric seal with a collar and without a guide member is positioned within the internal cavity. A rigid, hollow elongated portion is located within the internal cavity such that in an open configuration, a tip of the elongated portion is more proximal than a proximal surface of the elastomeric seal.

Abstract: In some embodiments, a tube portion can be configured to be fluidically coupled to a patient access component. A source of pressurized fluid can be coupled to the tube portion and can be configured to deliver fluid to the tube portion at a source pressure. A fluid pressure regulating device can include an expandable reservoir and can be coupled to the tube portion such that the expandable reservoir is in fluidic communication with the tube portion. The fluid pressure regulating device can be configured such that, when fluid is delivered from the source of pressurized fluid to the lumen of the tube portion at the source pressure, the expandable reservoir of the fluid pressure regulating device can receive fluid such that the expandable reservoir of the fluid pressure regulating device expands and fluid is delivered from the lumen of the tube portion to the patient via the patient access component.

Abstract: Various approaches for microbubble-enhanced ultrasound treatment of target tissue include retrieving a treatment plan stored in memory; causing administration of an exogenous agent in accordance with the treatment plan; causing, in accordance with the treatment plan, an ultrasound transducer to transmit ultrasound waves to the target tissue and generate a focus therein in the presence of administered exogenous agent; receiving, from a monitoring system, a measured parameter value indicating a treatment condition in response to administration of the exogenous agent and transmission of the ultrasound waves during treatment; and adjusting the treatment plan based at least in part on the measured parameter value.

Abstract: An antiseptic dead-end cap includes a base having first and second sides, a first annular wall extending from the first side of the base, a cylindrical center plug extending from the first side of the base, and a second annular wall extending from the second side of the base. The first annular wall has an outer and an inner surface. The cylindrical center plug has an outer and an inner surface, and is positioned within the first annular wall to form an annular chamber. The second annular wall has an outer and an inner surface, and defines a second chamber having an open end. The second chamber is further defined by the inner surface of the cylindrical center plug. An antiseptic material is on at least one of the first annular wall inner surface, second annular wall inner surface, second annular wall outer surface, and cylindrical center plug outer surface.

Abstract: A medical stopcock includes a main body having an input port and an output port, a valve body having a handle and a syringe port, with the valve body moveable relative to the main body and defining a valve passageway. The valve body includes a first position where the input port and the output port are in fluid communication via the valve passageway, a second position where the syringe port and the output port are in fluid communication via the valve passageway, and a third position where the syringe port and the input port are in fluid communication via the valve passageway. Rotation of the syringe port is configured to move the valve body relative to the main body.

Abstract: A connector assembly may include an inner housing and an outer housing surrounding the inner housing. The inner housing may include a fluid flow path extending between a proximal port and a distal port. An exterior surface of the inner housing may include a first electrically conductive exterior surface and a second electrically conductive exterior surface. An interior surface of the outer housing may include a first electrically conductive interior surface and a second electrically conductive interior surface. The outer housing may be configured to move radially and rotationally relative to the inner housing. A processer may determine, based on whether the electrically conductive exterior surfaces contact the exterior electrically conductive interior surfaces, radial data associated with a radial position of the outer housing relative to the inner housing and rotational data associated with a rotational position of the outer housing relative to the inner housing.

Abstract: A system for attachment of a device to a bone is provided. The system includes an internal axial rod with a proximal and distal end that is configured to be inserted and secured into a bone cavity's distal end. The system can also include an internal-external transfer rod with a proximal and distal end mounted into the distal end of the axial rod and a central channel extending through the transfer rod from the proximal end to the distal end and a plurality of attachment rings for attaching at least one tissue or muscle group to the transfer rod. The system also includes a bio-compatible and bio-occlusive artificial membranes (BIOCAMS) lamina, wherein the lamina includes either a polyetheretherketone (PEEK) mesh, a biocompatible polymer, a carbon fiber polymer, an artificial tissue polymer, molded donor tissue, allogenic tissue, a collagen/hyaluronic acid-based tissue, or connective tissue biosynthetic substrate material suitable as webbing.

Abstract: Methods of securely dispensing a substance to an intended user are provided. In some instances, a method of securely dispensing a substance to an intended user includes moving a valve of a locking cap fixedly secured to a housing containing the substance to an open state that allows the substance to be dispensed from the housing to the intended user; determining that a unique biometric attribute of the intended user is detected; and dispensing the substance from the housing to the intended user in response to determining that the unique biometric attribute of the intended user is detected.

Abstract: The disclosure relates to a syringe support for supporting an axial position of a syringe relative to a housing of an autoinjector. The syringe support comprises a projecting portion, which projects from the syringe support in a distal direction and a flexible portion which axially adjoins the projecting portion. The flexible portion is adapted to axially bias the syringe in the distal direction within the housing. The disclosure further relates to an autoinjector.

Abstract: A manually operated mechanical pump for drug infusion through a syringe including a plunger slidable within a syringe body to cause drug contained within the syringe body to exit a front opening of the syringe. The pump has a pump body with an open front end, to which the syringe attaches, and an open rear end, at which a drive member is associated movably relative to the pump body. A pair of thrust members are provided between the drive member and the syringe to impart longitudinal thrust in a distal direction onto the plunger to cause the drug to exit the front opening. An elastic element is provided between the thrust members to store and release elastic energy when the first thrust member proximal to the drive member is manually actuated, thus causing the second thrust member proximal to the syringe to advance as the drug exits the front opening.

Abstract: A syringe with a tube having an open proximal end and a sealed, truncated, distal end fluidly communicating via a stepped lumen. The syringe has a distal intravenous cannula; and a shaft supporting a distal, fluid sealing disc and a finger pad at opposite ends moveably disposed within said tube. The syringe features a syringe body which is economically thermoformed from an extruded tube.

Abstract: One embodiment includes a catheter apparatus, including an elongated deflectable element including a distal end, a coupler connected to the distal end, a pusher including a distal portion, and configured to be advanced and retracted through the deflectable element, a nose connector connected to the distal portion, and including a distal receptacle having an inner surface and a distal facing opening, and an expandable assembly including flexible polymer circuit strips, each strip including electrodes disposed thereon, the strips being disposed circumferentially around the distal portion of the pusher, with first ends of the strips being connected to the coupler and second ends of the strips including respective hinges entering the distal facing opening and connected to the inner surface of the distal receptacle, the strips being configured to bow radially outward when the pusher is retracted expanding the expandable assembly from a collapsed form to an expanded form.

Abstract: An implantable medical device for delivering therapeutic fluid to, and withdrawing cerebrospinal fluid (CSF) from, a CSF-containing space, includes a first inlet configured to be accessed by a needle of an aspiration device; a first outlet; a first fluid pathway extending from the first inlet to the first outlet; a second inlet; a second outlet; and a second fluid pathway extending from the second inlet to the second outlet. The first fluid pathway is free of a filter configured to prevent passage of a microbe.

Abstract: A catheter system that is actuatable to a deployed state and includes a catheter body and a dilator positioned at least partially within the lumen of the catheter. A distal end of the dilator can be releasably connected to a distal tip of the catheter body. The dilator can be retractable to expand and invert the distal tip and form a funnel shape in the deployed state.

Abstract: A device for injecting a medicament is provided. The device has a housing with a container within it which can hold a medicament. At its proximal end the container has a needle and a stopper. The device includes a plunger which at one end can engage the stopper. At the opposite end, the plunger can engage a first resilient member to move the stopper within the container to inject the medicament from the container. The device includes a collar with distal and proximal ends, the distal end engaging with a carriage and causing its rotation and the proximal end engaging with a second resilient member. The second resilient member can engage with a skin sensor which has distal and proximal ends. At the proximal end, the skin sensor can contact an injection site. The housing has a cap which can reduce or prevent movement of the skin sensor.

Abstract: A medical device for the diagnosis or treatment of tissue in a body and method for fabricating the same are provided. The device includes comprises a first shaft and a second shaft. The first shaft includes a longitudinal axis, and the second shaft includes a second shaft axial end disposed within the first shaft. The second shaft is connected to the first shaft by a first nested lap joint formed between the first shaft and the second shaft.

Abstract: Described is a medicament delivery device comprising a case adapted to hold a container with a medicament and having a needle, a needle sleeve telescopically coupled to the case and having a first extended position relative to the case in which the needle is covered, a retracted position relative to the case in which the needle is exposed, and a second extended position relative to the case in which the needle is covered, a first indicia disposed on the needle sleeve which is visible in the first extended position and the second extended position, and a second indicia disposed on the needle sleeve and not visible in the first extended position and visible the second extended position.

Abstract: A fixing device of a nasogastric tube contains: an adhesion member, a connection member, and a retainer. The adhesion member includes an adhesive face, a circular column, and an engagement portion. The connection member includes a connecting sheet, a locating post, and a spherical portion. The connecting sheet has a rectangular slot and an annular orifice, such that the annular orifice accommodates the engagement portion of the adhesion member, the rectangular slot slidably receives the circular column of the adhesion member, an end of the connecting sheet proximate to the annular orifice is connected with the locating post, and the other end of the locating post is connected with the spherical portion. The retainer includes a coupling bar and a joining knob. The retainer further includes a clamp section and two press portions. Furthermore, the clamp section has a hollowly circular space defined therein.

Abstract: A puncture visualization device can include a guidewire having a proximal section, a distal section, and a distal tip. The device can include a needle having a needle lumen configured to receive the guidewire. The device can include a lock, and the lock can engage with the guidewire. For instance, engagement of the lock with the guidewire can inhibit relative motion between the guidewire and the needle. The device can include an optical sensor, for example located at the distal tip of the guidewire. The optical sensor can be locked into a position, for instance by the lock. In an example, the device provides a distal field of view from a location within the needle and near a distal end of the needle for visualization to facilitate puncturing a target with the distal end of the needle.

Abstract: A plunger for use with a syringe includes a plunger body defining a central longitudinal axis and having a proximal end, a distal end, and a circumferential sidewall connecting the proximal end and the distal end. The plunger further includes at least one retaining member associated with and extending proximally from the plunger body. The at least one retaining member has a first end connected to the plunger body, a second end proximal to the first end and radially and resiliently deflectable relative to the first end, and at least one catch on the second end. A fluid injector system includes a piston having a plunger engagement mechanism configured for interacting with the at least one retaining element of the plunger to releasably engage the plunger for reciprocally driving the plunger within a barrel of the syringe.