Abstract: A prefilled syringe includes a barrel body, a gasket that seals a proximal end side of a medicine chamber of the barrel body, and a cap that is attached to a tip and seals a distal end side of the medicine chamber. The cap includes a surface area increasing member that extends to the proximal end side, is inserted into a flow path of the tip, and protrudes to the medicine chamber to increase a surface area of a medicine solidified in a lump in the medicine chamber.

Abstract: A hub defines a lumen with a longitudinal axis along the length of the hub. An outer surface of a distal portion of the hub tapers inwardly toward the longitudinal axis as the distal portion extends distally. A strain relief includes a proximal portion configured to receive the distal portion of the hub. The strain relief defines a lumen that substantially aligns with the hub lumen when the proximal portion receives the hub. The hub and/or strain relief are configured to be fixedly attached to a catheter body such that a catheter body lumen substantially aligns with the hub lumen and the strain relief lumen when the strain relief receives the distal portion of the hub. Outer surfaces of the strain relief and hub define substantially similar distances to the longitudinal axis along an interface between the two outer surfaces when the strain relief receives the hub.

Abstract: Rapidly insertable central catheters (“RICCs”) including catheter assemblies and methods thereof are disclosed. For example, a RICC assembly includes a RICC and an introducer. The RICC includes a catheter tube, a catheter hub, and one or more extension legs coupled in the foregoing order. The catheter tube includes a side aperture that opens into an introducing lumen that extends from at least the side aperture to a distal end of the RICC. The introducer includes a retractable-needle device, a syringe, and a coupling hub that couples the retractable-needle device and the syringe together proximal of the side aperture in a ready-to-deploy state of the RICC assembly. The retractable-needle device includes an introducer needle. A needle tip in a distal-end portion of a shaft of the introducer needle extends beyond the distal end of the RICC when the RICC assembly is in the ready-to-deploy state of the RICC assembly.

Abstract: A collar for reinforcing a barrel outlet spout of an applicator, syringe or the like, the barrel having a substantially cylindrical main body, with the outlet spout at one end thereof, wherein the collar includes: a spout engagement portion; and a main body engagement portion.

Abstract: Apparatus for delivering a therapeutic agent to a uterine cavity including an elongated member having a fluid channel for passage of the therapeutic agent into the uterine cavity, a dispensing member extending distally of the elongated member and having at least one perforation for passage of the therapeutic agent into the uterine cavity into contact with the endometrium. An infusion line is in communication with the fluid channel for passage of a fluid into the uterine cavity to assess leakage to determine integrity of the uterine cavity prior to passage of the therapeutic agent into the uterine cavity.

Abstract: A fixture for filling a hypodermic syringe includes a vial support and a finger flange support that are substantially coplanar with each other. The vial support holds a vial while the needle of a hypodermic syringe is inserted through the top of the vial. The syringe is then positioned so that the plunger side of one of the finger flanges engages a finger flange support. The finger flange support resists movement of the syringe while the plunger is withdrawn, filling the barrel of the syringe from the vial. The vial and needle are at least partially supported throughout the filling process.

Abstract: Described are methods, systems, devices for facilitation of intraluminal medical procedures within the neurovasculature. A catheter advancement device includes a flexible elongate body having a proximal end, a distal end, and a single lumen extending therebetween. The flexible elongate body has a proximal segment, an intermediate segment, and a tip segment. The proximal segment includes a hypotube coated with a polymer. The intermediate segment includes an unreinforced polymer having a durometer of no more than 72 D. The tip segment is formed of a polymer different from the intermediate segment and has a durometer of no more than about 35 D and a length of at least 5 cm. The tip segment has a tapered portion that tapers distally from a first outer diameter to a second outer diameter over a length of between 1 and 3 cm.

Abstract: A container for an injectable medicament can include an elongated body having a tubular-shaped sidewall extending along a longitudinal axis and having a distal end and a proximal end. The container can include an outlet at the distal end. The container can include a bung arranged inside the elongated body, sealingly engaged with the sidewall and slidable along the longitudinal axis relative to the sidewall. The container can include an interior volume to receive the injectable medicament and being confined by the sidewall, the outlet, and the bung. The container can include a measuring arrangement arranged in or on the bung. The measuring arrangement can include a signal generator configured to emit an electromagnetic measurement signal into or through the interior volume and a signal receiver configured to detect a feedback signal being indicative of an interaction of the measurement signal with at least one of the sidewall, the outlet or the interior volume.

Abstract: Described are methods, systems, devices for facilitation of intraluminal medical procedures within the neurovasculature. A catheter advancement device includes a flexible elongate body having a proximal end, a distal end, and a single lumen extending therebetween. The flexible elongate body has a proximal segment, an intermediate segment, and a tip segment. The proximal segment includes a hypotube coated with a polymer. The intermediate segment includes an unreinforced polymer having a durometer of no more than 72D. The tip segment is formed of a polymer different from the intermediate segment and has a durometer of no more than about 35D and a length of at least 5 cm. The tip segment has a tapered portion that tapers distally from a first outer diameter to a second outer diameter over a length of between 1 and 3 cm.

Abstract: An intrathecal drug delivery system configured to improve dispersion of medicament with cerebral spinal fluid in a subarachnoid space of a patient. The intrathecal drug delivery system including an implantable medical pump and a catheter having a wall defining a lumen extending between a proximal end in fluid communication with the implantable pump and structure defining a medicament exit positionable within the subarachnoid space of the patient, the wall further defining at least one feature configured to generate vortices within the cerebrospinal fluid for the purpose of improving intrathecal drug dispersion.

Abstract: A closure assembly for a medical dispenser including a cover and a tip cap removably disposed therein. A flexible retaining member including a plurality of flexible fingers is/are angularly positioned within the cover in both a retaining relation and a blocking position, which respectively restrict removal of the tip cap from the cover and a reinsertion of the tip cap, back into the cover, subsequent to its removal. Structurally distinguishable but similarly operable embodiments include the plurality of flexible fingers connected to and extending angularly outward from an interior of the cover or connected to an exterior of the tip cap.

Abstract: Ingestible devices capable of delivering a dispensable substance, such as, for example, a therapeutic agent, as well as related components, systems and methods, are disclosed. A removably attachable storage reservoir configured to be used with an ingestible device and capable of storing dispensable substance, such as, for example, a therapeutic agent, as well as related components, systems and methods, are also disclosed.

Abstract: A luer connector including a rigid housing having a first end and a second end. The housing further including a rigid tubular male portion at the first end, a rigid tubular female portion at the second end, and a longitudinal opening therethrough. The male portion is configured to be engageable with a female connector. The female portion is configured to be engageable with a male connector and to prevent the disengagement of the male connector from the female portion. In some embodiments, the female portion is configured to maintain a fixed rotational position when the male connector is being threaded therewith, but to rotate with the male connector once the male connector has become fully engaged with the female portion so as to prevent the male connector from becoming unthreaded from the female portion.

Abstract: The present application relates to high flow rate isolated regional treatment of cancer and proliferative disorders and conditions. For example, provided are methods, systems and devices for treating a cancer in a region of a subject using high flow rate isolated infusion.

Abstract: Described are means for the direct and continuous connection of a catheter to the lumen of any tubular anatomical structure, or ductus, without medically significant leakage. A port implanted at the body surface with piping to a periductal collar allows drug or radionuclide delivery that bypasses the upstream lumen. The port allows injection, infusion, aspiration, or attachment of an automatic ambulatory pump. A superparamagnetic nanoparticle carrier-bound drug, for example, can be introduced into the lumen to pass downstream until the particles, with or without the drug still bound, are drawn into the lumen wall by a magnetized jacket surrounding the ductus. Such constitutes a method of drug targeting whereby a segment of a vessel or the territory supplied by a branch of that segment can be circumscribed for exposure to the drug. A jacket with side-entry connector positioned in surrounding relation to a lesion requiring treatment can itself be magnetized.

Abstract: This patent document discloses accessory devices and associated methods for catheter and guidewire management in a surgical setting. Implementations can include an accessory device having a manually deformable body that includes proximal and distal surfaces. The body may further define at least first and second apertures, each aperture extending through the body. The first aperture can be engageable with a proximal end portion of a first elongate medical device, and the second aperture can be configured to receive a second elongate medical device. The body can be slidable along the proximal end portion of the first elongate medical device and/or the second elongate medical device, and the proximal surface of the body may include a funnel leading into the first aperture, the second aperture, or both. The body may be incorporated into, or attached to, a proximal side of a hemostasis valve utilized for a medical operation.

Abstract: The disclosure relates to a syringe support for supporting an axial position of a syringe relative to a housing of an autoinjector. The syringe support comprises a projecting portion, which projects from the syringe support in a distal direction and a flexible portion which axially adjoins the projecting portion. The flexible portion is adapted to axially bias the syringe in the distal direction within the housing. The disclosure further relates to an autoinjector.

Abstract: In some embodiments, a system can include a fluid delivery assembly and a drive assembly. The fluid delivery assembly is configured to be releasably mechanically and, optionally, electrically coupled to the drive assembly. When the fluid delivery assembly is releasably coupled to the drive assembly, the drive assembly can control delivery of fluid from the fluid delivery assembly (e.g., to a patient). For example, the drive assembly can be releasably coupled to the fluid delivery assembly to control delivery of fluid from the fluid delivery assembly to provide continuous (e.g., non-pulsatile) fluid flow from the fluid delivery assembly.

Abstract: A catheter assembly for navigation including a flexible catheter having a proximal portion adjacent a proximal end and a distal portion adjacent a distal end and defining a longitudinal axis, the flexible catheter defining a lumen extending therethrough along a longitudinal axis and configured to enable translation of an instrument from the proximal end to the distal end. The flexible catheter defines a compound curve formed on the distal portion, wherein the compound curve includes an elbow bend and a radially curved portion. The elbow bend deflecting the distal portion of the flexible catheter from the longitudinal axis, while the radially curved portion extends from the elbow bend farther deflecting the distal portion about a center point. The catheter guide assembly for navigation includes a control handle disposed at the proximal end of the flexible catheter and is configured to advance and rotate the flexible catheter within a luminal structure.

Abstract: A method for operating a dialysis machine to conduct a dialysis treatment on a patient (e.g., a peritoneal dialysis machine) may include transferring dialysate from a first bag, and automatically determining the dialysate from the first bag has completely transferred. After determining the dialysate has completely transferred from the first bag, switching from the first bag to a second bag of dialysate. The method may further include transferring dialysate from the second bag in response to the detection of the completed transfer of the first bag, and automatically determining the dialysate from the second bag has completely transferred. The method may further include determining if the respective first or second bag has completely transferred by comparing a dialysate bag volume transferred to the patient to a detected volume of the respective first or second bag. Systems with dialysis machines for performing such a method are disclosed as well.