Patents Examined by Brian Gulledge
  • Patent number: 11129803
    Abstract: The present invention provides a method of inhibiting tolerance to an opioid by a human subject in need thereof. The method comprises administering an effective amount of a pharmaceutical composition to the subject during opioid therapy. The pharmaceutical composition comprises a) a non-steroidal anti-inflammatory drug (NSAID); and b) a co-agent selected from the group consisting of: fexofenadine, ketotifen, desloratadine, cetirizine, salts thereof and combinations thereof.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: September 28, 2021
    Assignee: SEN-JAM PHARMACEUTICAL LLC
    Inventors: Jacqueline Iversen, Thomas A. Dahl
  • Patent number: 11116844
    Abstract: Embodiments of the invention are directed to a macromolecular chemotherapeutic. A non-limiting example of the macromolecular chemotherapeutic includes a block copolymer. The block copolymer can include a water-soluble block, a cationic block, and a linker, wherein the linker is connected to the water-soluble bock and the charged block.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: September 14, 2021
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY
    Inventors: Dylan Boday, Wei Cheng, Jeannette M. Garcia, James Hedrick, Nathaniel H. Park, Rudy J. Wojtecki, Chuan Yang, YiYan Yang
  • Patent number: 11103449
    Abstract: The present invention relates to methods and compositions for anti-aging therapy and for the treatment and prophylaxis of age-related diseases and disorders in a human subject in need of such therapy or treatment, the methods comprising the pulmonary administration to the subject, preferably via inhalation, of composition comprising rapamycin, or a prodrug or derivative thereof.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: August 31, 2021
    Assignee: AI Therapeutics, Inc.
    Inventors: Thomas Armer, Lawrence S. Melvin, Jr., Jonathan M. Rothberg, Henri Lichenstein
  • Patent number: 11102979
    Abstract: An antimicrobial article that includes: an antimicrobial composite region that includes a matrix comprising a polymeric material, and a first plurality of particles within the matrix. The particles include a phase-separable glass with a copper-containing antimicrobial agent. The antimicrobial composite region can be a film containing the first plurality of particles that is subsequently laminated to a bulk element. The first plurality of particles can also be pressed into the film or a bulk element to define an antimicrobial composite region. An exposed surface portion of the antimicrobial composite region can exhibit at least a log 2 reduction in a concentration of at least one of Staphylococcus aureus, Enterobacter aerogenes, and Pseudomonas aeruginosa bacteria under a Modified EPA Copper Test Protocol.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: August 31, 2021
    Assignee: Corning Incorporated
    Inventors: Dayue Jiang, Kevin Andrew Vasilakos, Frederic Christian Wagner, Carlo Anthony Kosik Williams
  • Patent number: 11083689
    Abstract: A composition for lubricant formulations is disclosed. The composition may include hypochlorite, dimethicone, and an emulsifier for improvement of lubricity. Methods of making and using the lubricant formulations are also disclosed.
    Type: Grant
    Filed: November 1, 2019
    Date of Patent: August 10, 2021
    Assignee: REOXCYN, LLC
    Inventors: Kurt Richards, Andrew Hoover
  • Patent number: 11083676
    Abstract: Disclosed is a method of preparing a product composition comprising steps of: Preparing a mixture composition comprising a surfactant and a high melting point fatty compound and benefit agent; Separately preparing an aqueous base composition comprising a surfactant, a high melting point fatty compound, and an aqueous carrier and wherein the aqueous base composition is substantially free of detersive surfactant; Mixing the mixture composition and the aqueous base composition to form a discrete particle of the mixture composition dispersed in the aqueous base composition. Alternatively, the method comprises steps of preparing a discrete particle of the mixture composition; and mixing it with the aqueous composition. The methods of the present invention provide a product composition with at least one the followings: more flexibility in the product composition rheology; improved stability in the product composition; improved deposition of benefit agents; and improved visual/aesthetic appearance.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: August 10, 2021
    Assignee: The Procter and Gamble Company
    Inventors: Junichi Yokogi, XinHao Zhu, Jorge Max Sunkel
  • Patent number: 11058621
    Abstract: Disclosed is a product composition comprising: a discrete particle of a mixture composition, wherein the mixture composition comprises a surfactant and a high melting point fatty compound and a benefit agent; and an aqueous base composition comprising an aqueous carrier and water soluble polymer, wherein the base composition is substantially free of a detersive surfactant selected from anionic surfactants, zwitterionic surfactant, amphoteric surfactant, and combinations thereof. The product composition of the present invention provides at least one the followings: more flexibility in the product composition rheology; improved stability in the product composition; improved deposition of benefit agents; and improved visual/aesthetic appearance.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: July 13, 2021
    Assignee: The Procter and Gamble Company
    Inventors: Junichi Yokogi, XinHao Zhu, Jorge Max Sunkel
  • Patent number: 11058792
    Abstract: Novel surgical sutures and novel medical devices made from novel semi-crystalline, glycolide-rich A-B-A triblock copolymers of glycolide and lactide, wherein said B-segment is a fully amorphous random copolymer of glycolide and lactide, for long term medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, meshes and other medical devices, especially for patients with compromised healing. The novel sutures have improved properties and improved breaking strength retention, while still substantially absorbing within about a 120-day period post-implantation.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: July 13, 2021
    Assignee: Ethicon, Inc.
    Inventors: Dennis D. Jamiolkowski, Christopher DeFelice, Sasa Andjelic, Brian M. Kelly, Marc Wisnudel, Daniel Steiger, Gaoyuan Gavin Chen
  • Patent number: 11058620
    Abstract: Disclosed is a product composition comprising: a discrete particle of a mixture composition, wherein the mixture composition comprises a surfactant and a high melting point fatty compound and a benefit agent; and an aqueous base composition comprising a surfactant, a high melting point fatty compound, and an aqueous carrier, and wherein the aqueous base composition is substantially free of detersive surfactant. The product composition of the present invention provides at least one the followings: more flexibility in the product composition rheology; improved stability in the product composition; improved deposition of benefit agents; and improved visual/aesthetic appearance.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: July 13, 2021
    Assignee: The Procter and Gamble Company
    Inventors: Junichi Yokogi, XinHao Zhu, Jorge Max Sunkel
  • Patent number: 11052173
    Abstract: The present disclosure relates to a biocompatible, electrically conductive polymer capable of carrying the electrical potential of a cardiac impulse. The present disclosure also relates to treatments using the electrically conductive polymer, such as for atrial fibrillation.
    Type: Grant
    Filed: May 22, 2019
    Date of Patent: July 6, 2021
    Assignee: University Health Network
    Inventor: Ren-Ke Li
  • Patent number: 11045554
    Abstract: The present invention relates to lipid-coated particles for treating viral infections, including viral encephalitis infections. In particular, an antiviral compound can be disposed within the lipid-coated particle, thereby providing an antiviral carrier. Methods of making and using such carriers are described herein.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: June 29, 2021
    Assignee: National Technology & Engineering Solutions of Sandia, LLC
    Inventors: Oscar Negrete, C. Jeffrey Brinker, Torri Rinker, Annette Estelle LaBauve
  • Patent number: 11028203
    Abstract: Disclosed is agents and methods that target metabolism malfunctions, inborne as well as acquired, as well as methods for preparation of the agents. In particular, the invention relates to methods for preparing molecular imprinted polymers with high binding capacity for phenylalanine or tyrosine, MIPs that bind phenylalanine or tyrosine, and methods for treating phenylketonuria, alkaptonuria, and hypertyrosinemia.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: June 8, 2021
    Assignee: Mipsalus APS
    Inventors: Klaus Gregorius, Nicolas Otto Krogh
  • Patent number: 11028264
    Abstract: Techniques regarding guanidinium functionalized polylysine polymers that can have antimicrobial and/or anticancer activity are provided. For example, one or more embodiments described herein can comprise a chemical composition, which can comprise a polymer comprising a molecular backbone covalently bonded to a pendent guanidinium functional group, wherein the molecular backbone can comprise a polylysine structure.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: June 8, 2021
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Nathaniel H. Park, James L. Hedrick, Victoria A. Piunova, Gavin Jones, Yi Yan Yang, Pang Kern Jeremy Tan, Chuan Yang, Cherylette Anne Alexander
  • Patent number: 11026889
    Abstract: Provided are compositions and nanoparticle formulations that may be used, e.g., to deliver a therapeutic compound to a subject. In some embodiments, the nanoparticles may be used to deliver one or more chemotherapeutic agents to treat a cancer such, e.g., as a pancreatic ductal adenocarcinoma.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: June 8, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: Chun Li, Jun Zhao, Jason Fleming
  • Patent number: 11021576
    Abstract: The present invention provides compositions of a therapeutic agent and a polymeric stabilizing agent for stabilizing the reservoir of an implantable drug delivery system. The present invention also includes an implantable drug delivery system incorporating the composition of the present invention, as well as methods of treating diabetes using the compositions and implantable drug delivery system of the present invention.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: June 1, 2021
    Assignee: Nano Precision Medical, Inc.
    Inventors: Adam Mendelsohn, Au Duong, Kathleen Fischer, Wouter Roorda
  • Patent number: 11020491
    Abstract: The present invention provides a biocompatible conjugate for treating a disease or an injury. The conjugate contains a polymer covalently linked to one or more moieties each containing a polymerizable functional group. The conjugate forms a cross-linked polymer network after being exposed to an elevated level of free radicals associated with the disease or injury.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: June 1, 2021
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Christopher Lowe, David I. Shreiber, Emily DiMartini, Adam Gormley
  • Patent number: 11007215
    Abstract: A shear-thinning hydrogel composition includes: a first polymer chain including: (i) a first plurality of units each having at least one of a monosaccharide and an amino acid; and (ii) a cross-linking group bound to the at least one of the monosaccharide and the amino acid of one of the first plurality of units via conversion of a carboxyl group of the unit to a peptide bond; a second polymer chain including a second plurality of the units; and a cross-linking additive connecting one of the second plurality of units to the first polymer chain via the cross-linking group.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: May 18, 2021
    Assignee: OUROTECH, INC.
    Inventors: Duleeka Nimantha Bandara Ranatunga, Andrew Christopher Wenger, Zhi Yuan (William) Lin
  • Patent number: 11007148
    Abstract: The present invention provides an amphiphilic block copolymer for drug delivery and a controlled release system comprising the same copolymer. The copolymer comprises at least one hydrophilic block and at least one hydrophobic block, wherein the hydrophobic block is selected from the group consisting of acrylates, methacrylates, acrylamides, methacrylamides, vinylethers and their aromatic derivatives, wherein at least one hydrophobic block contains an aryl group, which is bound to the hydrophobic block with a degradable linker. The controlled release system of the invention shows high stability and high drug retention when administered in vivo enabling accumulation and drug release at the site of action.
    Type: Grant
    Filed: August 11, 2015
    Date of Patent: May 18, 2021
    Assignee: Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen
    Inventors: Wilhelmus Everhardus Hennink, Yang Shi, Cornelus Franciscus van Nostrum
  • Patent number: 10973948
    Abstract: An absorbable iron-based device includes an iron-based matrix and degradable polyester in contact with the surface of the iron-based matrix. The mass fraction of a low-molecular-weight part of the degradable polyester is less than or equal to 5%, and the molecular weight of the low-molecular-weight part is less than 10,000; or the mass fraction of a residual monomer in the degradable polyester is less than or equal to 2%.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: April 13, 2021
    Assignee: Biotyx Medical (Shenzhen) Co., Ltd
    Inventors: Jun Hu, Deyuan Zhang, Hongtao Sun, Liping Chen
  • Patent number: 10961184
    Abstract: Disclosed are dendritic anionic lipids which are compounds of Formula (I): wherein R and R1 are non-polar groups, L is a linking moiety, and Dm is a dendritic moiety of m generations, each as defined herein. These dendritic anionic lipids are useful for delivery and expression of m RNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: March 30, 2021
    Assignee: Translate Bio, Inc.
    Inventors: Michael Heartlein, Frank DeRosa, Shrirang Karve