Abstract: Clay delivery systems for providing antimicrobial compositions are provided. The delivery systems include a two-part active excipient system that delivers clay for various applications of use, including topical applications. The two-part delivery system can include a first part comprising suspending agent(s), poloxamer and optionally a gellant, and a second part that is simultaneously delivered therewith comprising one or more nonionic EO-PO block copolymers in a water-based system. The delivery systems beneficially provide clays in a stable system that also unexpectedly accelerate the release of the clay into the water system for activation and delivery that is enhanced by the poloxamers into the tissue or organ of the body in need of treatment thereof.

Abstract: The present invention provides an oil-based cosmetic which is excellent in terms of a matte texture, while being highly stable. An oil-based cosmetic which is characterized by containing the following components (a)-(e). (a) a crosslinked organopolysiloxane (b) an amorphous anhydrous silicic acid (c) an oil-based gelling agent having a sugar skeleton (d) a liquid oil (e) a powder.

Abstract: A non-Newtonian, lyophilic colloid comprised of (i) at least one anionic, non-sulfated glycosaminoglycan (ANSG) having a molecular weight greater than about 500 kDa and (ii) glycerin.

Abstract: A branched type hetero monodispersed polyethylene glycol represented by formula (1) where X1, Y1, n, E, L1, L2 and L3 are as defined herein.

Abstract: A clear personal cleansing composition having an anionic surfactant, a cationic deposition polymer, an aqueous carrier and a level of inorganic salt of from about 0 to about 1 wt %. The composition is substantially free of sulfates and has a % T of greater than about 80%. The composition can further comprise amphoteric surfactants. The composition remains phase stable and minimizes coacervate formulation until after dilution with water.

Abstract: A depilatory wax additive and process. The depilatory wax additive may modify a depilatory hard wax composition to include visual, olfactory, or skin treatment components. A depilatory wax additive may include molded hard wax component and glitter, a color modifier, a scent modifier, or a skin treatment. A preexisting hard wax composition of solid particles may be heated to a liquid. The depilatory wax additive may be added to the liquefied preexisting hard wax composition, mixed, and heated to disperse the glitter, a color modifier, a scent modifier, or a skin treatment in the wax mixture.

Abstract: The present disclosure provides a polyetheramine alkoxylate compound containing aromatic groups in the hydrophobe allowing the compound to exhibit unique functionality, high performance and low cost, but without the toxicity and/or skin and eye irritation problems associated with conventional polyetheramine compounds.

Abstract: Novel surgical sutures and novel medical devices made from novel semi-crystalline, glycolide-rich A-B-A triblock copolymers of glycolide and lactide, wherein said B-segment is a fully amorphous random copolymer of glycolide and lactide, for long term medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, meshes and other medical devices, especially for patients with compromised healing. The novel sutures have improved properties and improved breaking strength retention, while still substantially absorbing within about a 120-day period post-implantation.

Abstract: The present invention relates a microcapsule that comprises an active pharmaceutical ingredient and a polymeric shell comprised of polymeric materials such as polyether, polyester, polyamine, polyamide, polyurea, polyurethane, polythiocarbamate, and polythiocarbonate. The outer surface of shell comprises surface functional groups such as hydroxide, primary amine, carboxylic acid, or protected forms thereof. These surface functional groups may be reacted further with reactants to place specific organic groups on the surface of the microcapsule. Such microcapsules are prepared by a modified interfacial condensation polymerization.

Abstract: A discrete dispensed product comprising a first portion; and a second portion at least partially surrounding the first portion provides a premium and distinct appearance to consumers.

Abstract: Disclosed herein are pharmaceutical compositions having a mixture of at least one active agent and an ion exchange resin, such that the composition releases about 75% or more of the at least one active agent within about 1 hour as measured by in-vitro dissolution in a USP Apparatus 2 (paddle) at about 50 rpm in about 900 ml 0.1N HCl at about 37° C. and related methods. Also disclosed herein are pharmaceutical compositions having a mixture of a drug susceptible to abuse, a non-opioid analgesic and an ion exchange resin, the composition further including at least one gelling agent and related methods.

Abstract: A preparation method and use of an artificial exosome complex are provided. Raw materials for preparing the artificial exosome complex include linear polyethyleneimine (PEI) and hyaluronic acid (HA). The linear PEI can be obtained through the HA-PEI preparation process of the present disclosure, and most PEI is branched currently. According to the HA-PEI preparation method, HA-PEI with a specific molecular weight can be quantitatively prepared. The preparation process involves controllable operation steps, and thus can be used for large-scale industrial production. The prepared HA-PEI can promote the absorption of an encapsulated active substance by deep skin cells through the ligand activity of HA and the membrane permeability of linear PEI.

Abstract: The present invention relates to nano-resin particles that are suitable for pharmaceutical use and their use in the pharmaceutical field. The present invention provides nano-sized resin particles having a particle size distribution characterized in that D90 value is between 200 nanometers to 900 nanometer and D10 value is not less than 50 nanometers, wherein the nano-resin particles are in pure form and safe for pharmaceutical use. The present invention further relates to pharmaceutical compositions comprising these purified nano-resin particles and their use in the treatment of diseases.

Abstract: The present disclosure is directed to methods for tuning the release profile of a biologic disposed in a hydrogel. Parameters that can be used for the tuning include a molar ratio of a nucleophilic group to an electrophilic group, the number of the nucleophilic groups in the first precursor, the number of the electrophilic groups in the second precursor, the molecular weight of the first precursor, the molecular weight of the second precursor, a weight ratio of the biologic and excipient to the hydrogel, a weight percentage of the biologic in a solid state formulation, and a ratio of surface area to volume of the hydrogel. The methods described herein allow the formation of hydrogel with different release profiles suitable for different therapeutic applications.

Abstract: A skin care, wound care, or oral care device, comprising an essential oil stabilized into a polymerizable substance.

Abstract: The invention relates to an anhydrous cosmetic or dermatological formulation comprising a viscose lipid-containing preparation and propellant gas consisting essentially of one or more substances selected from hydrofluorocarbons, n-butane, isobutane and propane. The formulation permits application to the skin by spraying of an otherwise nonsprayable preparation. The formulation is free from readily volatile solvents, surfactants, and preferably free from silicones.

Abstract: Described herein is an aqueous composition including particles coated with at least one non-amphoteric, quaternizable polymer which is water soluble at 20° C., and at least one dispersing component, where the dispersing component includes a dispersing agent selected from an amphiphilic graft polymer based on water-soluble polyalkylene oxides (A) as a graft base and side chains formed by polymerization of a vinyl ester component (B), the polymer having an average of ?1 graft site per 50 alkylene oxide units and a mean molar mass Mw of from 3000 to 100 000.

Abstract: Skin tightening compositions for application to the skin for providing an instantaneous and dramatic improvement to the appearance of skin. The skin tightening compositions typically include about 5 to about 45 wt. % or more of one or more hydrophobic film-forming polymers comprising acrylates/stearyl methacrylate copolymer; about 0.5 to about 20 wt. % of a mineral thickening agent; about 1 to about 15 wt. % of a silicone elastomer; and about 30 to about 85 wt. % of a volatile hydrocarbon oil, wherein all percentages by weight are based on the total weight of the skin tightening composition. Additionally, the skin tightening composition may have a weight ratio of the total amount of hydrophobic film-forming polymers to the total amount of mineral thickening agent is 1:1 to 10:1 and a weight ratio of the total amount of silicone elastomer to the total amount of mineral thickening agent is 1:2 to 8:1.

Abstract: A dispersion containing a dispersed phase comprising drops and a continuous aqueous phase, preferably in the form of gel, in which the drops comprise a fatty phase containing at least one gelling agent, and in which the fatty phase comprises at least one non-volatile hydrocarbon oil H1 containing more than 90%, and preferably more than 95%, fatty acids having at least 18 carbon atoms and preferably at least 20 carbon atoms.

Abstract: A polyurethane elastomeric rubber composition containing a bio-based polyol cross-linked with a bio-based isocyanate using a urethanation catalyst such as a bismuth catalyst in the presence of a cosmetic emollient is disclosed. The cross-linked polyurethane elastomer rubber is in further aspect of the invention included in a gel after being milled in the presence of a bio-based emollient or mixture of bio-based emollients. The polyurethane elastomeric gel has good compatibility with cosmetic and natural oils and can be used as a gelling agent for these oils among other desirable cosmetic formulary roles.