Abstract: The invention relates to a method of forming a very accurate vascular map or road map to be associated with the current X-ray image during an invasive vascular intervention. The vascular map is derived from a four-dimensional model of the vascular tree, that is, from a spatially three-dimensional, time-dependent model, the time dependency relating to natural motions of the body such as notably the heartbeat and/or the respiration. In particular the rhythm of the heartbeat or the respiration can be determined by means of a sensor so as to be used for synchronized selection and display of the corresponding three-dimensional vascular model.

Abstract: A two-dimensional (2D) chemical shift correlated MR spectroscopic (COSY) sequence integrated into a new volume localization technique (90°-180°-90°) for whole body MR Spectroscopy. Using the product operator formalism, a theoretical calculation of the volume localization as well as the coherence transfer efficiencies in 2D MRS is presented. A combination of different MRI transmit/receive rf coils is used. The cross peak intensities excited by the proposed 2D sequence are asymmetric with respect to the diagonal peaks. Localized COSY spectra of cerebral frontal and occipital gray/white matter regions in fifteen healthy controls are presented.

Abstract: According to certain embodiments of the present invention, there is provided a mounting arrangement for a magnetoencephalography (MEG) system headrest assembly forming a portion of a SQUID dewar and having a fixed headrest and an array of sensors, wherein a sensor array plate positions the sensors relative to the headset. A plurality of first rods interconnecting the array plate and the movable mounting member. A plurality of second rods are fixed at one of their ends relative to the dewar and are connected at their opposite ends to the movable mounting member.

Abstract: A sensitivity encoding method (SENSE) is used to acquire an MR image having a reduced field of view. The number of aliased replicates caused by surrounding object boundaries is calculated for each image pixel location to obtain optimal aliasing artifact suppression without reducing image SNR.

Abstract: Intravascular device for matching impedances of portions of an intravascular circuit and limiting RF signal-induced heating of intravascular conductors. An intravascular device includes alternating conductive and dielectric layers and an electrically conductive coil in a configuration that effects an impedance-matching circuit. Another embodiment of an intravascular device has cylindrical inner and outer walls formed of an expandable, electrically conductive material, the inner and outer walls being separated by a compressible dielectric material. Varying the pressure in the lumen defined by the inner wall changes the spacing between the inner and outer walls, thereby changing the capacitance between the inner and outer wall. Another embodiment of an intravascular device includes one or more coaxial chokes for limiting heating caused by currents induced by RF signals. A conductive shield of the choke is formed of a conductive polymer to further reduce heating effects.

Abstract: The invention relates to a method for computer-assisted medical navigation and/or pre-operative treatment planning, wherein the current position of a patient or a part of a patient's body and the positions of medical treatment devices or treatment-assisting devices are detected by means of a position detection unit, and wherein said detected positional data are assigned to body structure data, in order to jointly use said body structure data in assignment with said positional data, within the context of assisting the treatment, wherein body structure data are used which are obtained based on a generic model which has been adapted by linking it with patient-characteristic detection data.

Abstract: A method and apparatus for treating Alzheimer's disease is disclosed. The method comprises delivering indomethacin or nonsteroidal anti-inflammatory agents having cyclooxygenase inhibitor action directly to the hippocampus or the lateral ventricle through an implanted catheter. The catheter has a flexible distal end that is implanted directly in the hippocampus or lateral ventricle as the preferred embodiment. The distal end has either a porous tip or a closed end. Where the distal end is closed, or a plurality of elution holes are present indomethacin is delivered to the hippocampus or lateral ventricle through either the porous tip or the elution holes.

Abstract: The invention described herein provides systems and methods for multi-modal imaging with light and a second form of imaging. Light imaging involves the capture of low intensity light from a light-emitting object. A camera obtains a two-dimensional spatial distribution of the light emitted from the surface of the subject. Software operated by a computer in communication with the camera may then convert two-dimensional spatial distribution data from one or more images into a three-dimensional spatial representation. The second imaging mode may include any imaging technique that compliments light imaging. Examples include magnetic resonance imaging (MRI) and computer topography (CT). An object handling system moves the object to be imaged between the light imaging system and the second imaging system, and is configured to interface with each system.

Abstract: A technique is set forth for MR spectroscopy that is capable of reducing signal overlap between metabolite signals for improved clinical analysis of metabolite content. The technique includes varying an echo time across a scanning dimension. Once a span of echo time for an acquisition dimension is determined, and the number of acquisition data points is known, a variance between echo times can be determined. A pulse sequence with differing echo times is then applied for each frame, and after data is acquired, an image is reconstructed that significantly improves metabolite signal separation.

Abstract: Methods are disclosed for assessing the condition of a cartilage in a joint and assessing cartilage loss, particularly in a human knee. The methods include converting an image such as an MRI to a three dimensional map of the cartilage. The cartilage map can be correlated to a movement pattern of the joint to assess the affect of movement on cartilage wear. Changes in the thickness of cartilage over time can be determined so that therapies can be provided. The amount of cartilage tissue that has been lost, for example as a result of arthritis, can be estimated.

Abstract: An injection system for medical examinations to control the manual injection of a substance into a patient with a manually operated injector that has an arrangement to detect the fill state of a container filled with a substance to be injected. To detect the fill state, the volume occupied by the substance can be directly measured, can be indirectly determined by measuring the position of a component of the injection device that is correlated to the occupied volume.

Abstract: A fluorescent image obtaining apparatus for obtaining as an image the data relating to the fluorescent light emitted from a measurement portion upon the irradiation thereof by an excitation light, wherein by amplifying only the intensity of the fluorescent light, the S/N ratio of the fluorescent image based thereon is improved, is provided. The statistical quantities of a fluorescent image obtained by a wide-band fluorescent image obtaining element and a narrow-band fluorescent image obtaining element are computed by a statistical quantity computing means. If the statistical quantity is smaller than a predetermined value, the magnification rate of the imaging optical system is controlled by a magnification rate control means so that the fluorescent image is reduced and focused on the wide-band fluorescent image obtaining element and the narrow-band fluorescent image obtaining element.

Abstract: Intense environmental or working conditions can impede an individual's evaporative cooling mechanism normally responsible for thermoregulation during exercise or exertion. Non-invasive physiological monitoring capabilities are needed to more precisely define the cardiovascular responses and identify markers of impending failure of compensatory mechanisms prior to collapse or onset of irreversible pathology. The oxymetry method and system of the present invention provides non-invasive, continuous remote monitoring and analysis of cardiovascular and pulmonary function that overcomes accuracy and monitoring deficiencies of current oximetry systems.

Abstract: A method for sensing a disturbance in a transmission path of a converging ultrasound energy beam transmitted by a transducer in a focussed ultrasound system comprises transmitting a burst of ultrasound energy from the transducer, detecting whether a reflected portion of the ultrasound energy burst is received at the transducer within a certain time period following transmission of the burst, and, if so, analyzing the received reflected portion to determine a characteristic of the disturbance.

Abstract: For the purpose of providing an RF coil that enables satisfactory imaging of the prostate, the RF coil is composed of a first saddle coil and a second saddle coil. The first saddle coil has two loop portions opposed to each other so that they can sandwich the inferior abdomen of a human body antero-posteriorly. The second saddle coil has two loop portions opposed to each other so that they will permit insertion of the inferior limbs of a human body thereinto and can sandwich the inferior abdomen thereof laterally.

Abstract: A system and method for using hyperpolarized noble gases together with an appropriately designed and optimized magnetic resonance imaging pulse sequence to rapidly acquire static or dynamic magnetic resonance images. The strong magnetic resonance signal from hyperpolarized gases, combined with the present magnetic resonance imaging technique, presents the opportunity for the imaging of gases with both high spatial and high temporal resolution. One potential application for such a method is the direct, dynamic visualization of gas flow, which would be extremely useful for characterizing a variety of fluid systems. In the medical field, one such system of substantial importance is the lung. The system and method provides for visualizing regional ventilatory patterns throughout the respiratory cycle with high temporal and high spatial resolution. The low sensitivity to susceptibility artifacts permits good image quality to be obtained in various orientations.

Abstract: Apparatus for performing a medical procedure on a tissue within a body of a subject includes a wireless tag which is fixed to the tissue and includes a first sensor coil. A second sensor coil is fixed to a medical device for use in performing the procedure. An integral processing and display unit includes a plurality of radiator coils, along with processing circuitry and a display. The radiator coils generate electromagnetic fields in a vicinity of the tissue, thereby causing currents to flow in the sensor coils. The processing circuitry processes the currents so as to determine coordinates of the tag relative to the medical device. The display is driven by the processing circuitry so as to present a visual indication to an operator of the medical device of an orientation of the device relative to the tag.

Abstract: An impedance model of tissue is useful for describing conductivity reconstruction in tissue. Techniques for determining and mapping conductivity distribution in tissue supply useful information of anatomical and physiological status in various medical applications. Electrical Impedance Tomography (EIT) techniques are highly suitable for analyzing conductivity distribution. Electrical characteristics of tissue include resistive elements and capacitive elements. EIT techniques involve passing a low frequency current through the body to monitor various anatomical and physiological characteristics. The system can interrogate at multiple frequencies to map impedance. Analytical techniques involve forward and inverse solutions to boundary value analysis to tissue characteristics.

Abstract: A patient support table for breast MRI systems, the table including a base configured to slide into and out of the bore of an MRI system; a patient support member attached to the base and having a top surface shaped to support a patient in a prone position; two breast openings in the patient support member, the breast openings being sized and positioned to permit the patient's breasts to extend downward beneath the patient support member, at least a pair of breast immobilization paddles, one on each side of a breast opening, the immobilization paddles comprising a grid of breast contact elements that contact the breast while providing a plurality of openings through which a surgical tool may be inserted into the breast, and the paddles having a convex curvature along the Z direction (head to toe) so that the breast contacting surface of each paddle is further from the Y-axis center line of the breast opening midway along the Z extent of the paddle than at the Z extremities of the paddle.

Abstract: The present invention provides a system and method of improved homogeneity whereby at least a portion of an RF coil is filled with homogeneity enhancing material. Disposing the homogeneity enhancing material, such as perfluorocarbon, within the RF coil, implementation of thick saturation pads may be avoided altogether or thinner pads may be used to fill any voids between the patient and the coil. The present invention is particularly useful in a CTL coil assembly for acquiring diagnostic data of the neck region of a patient. However, the advantages achieved by the present invention may be incorporated into other surface coils for other anatomical regions where control of the susceptibility is desired. Additionally, the homogeneity enhancing material also acts as a heat sink for any hot spots on the coil.